Violencia en la crianza de niños con trastornos del neurodesarrollo: una revisión sistemática

La presente investigación tiene como objetivo conocer la prevalencia de la violencia en la crianza de niños con trastornos del neurodesarrollo. Como también conocer los tipos de violencia involucrados en la crianza de niños con algún tipo de discapacidad dentro del trastorno del neurodesarrollo y conocer quién de los padres ejerce mayor violencia en la crianza de niños con trastornos del neurodesarrollo. La investigación es de diseño cualitativo, de tipo básica, tiene como categorías: violencia y trastorno del neurodesarrollo, la búsqueda de artículos se realizó en: Scopus, Google Académico, Scielo, Redalyc y Gale on file. Se utilizó una ficha técnica para reunir los datos de la investigación, teniendo como resultado 14 fuentes de información. Se obtuvo, que la violencia prevalece a lo largo de los años, encontrando con más frecuencia en las fuentes recolectadas los tipos de violencia física y psicológica

EoE CONNECT, the European Registry of Clinical, Environmental, and Genetic Determinants in Eosinophilic Esophagitis: rationale, design, and study protocol of a large-scale epidemiological study in Europe

Background: The growing prevalence of eosinophilic esophagitis (EoE) represents a considerable burden to patients and health care systems. Optimizing cost-effective management and identifying mechanisms for disease onset and progression are required. However, the paucity of large patient cohorts and heterogeneity of practice hinder the defining of optimal management of EoE. Methods: EoE CONNECT is an ongoing, prospective registry study initiated in 2016 and currently managed by EUREOS, the European Consortium for Eosinophilic Diseases of the Gastrointestinal Tract. Patients are managed and treated by their responsible specialists independently. Data recorded using a web-based system include demographic and clinical variables; patient allergies; environmental, intrapartum, and early life exposures; and family background. Symptoms are structurally assessed at every visit; endoscopic features and histological findings are recorded for each examination. Prospective treatment data are registered sequentially, with new sequences created each time a different treatment (active principle, formulation, or dose) is administered to a patient. EoE CONNECT database is actively monitored to ensure the highest data accuracy and the highest scientific and ethical standards. Results: EoE CONNECT is currently being conducted at 39 centers in Europe and enrolls patients of all ages with EoE. In its aim to increase knowledge, to date EoE CONNECT has provided evidence on the effectiveness of first- and second-line therapies for EoE in clinical practice, the ability of proton pump inhibitors to induce disease remission, and factors associated with improved response. Drug effects to reverse fibrous remodeling and endoscopic features of fibrosis in EoE have also been assessed. Conclusion: This prospective registry study will provide important information on the epidemiological and clinical aspects of EoE and evidence as to the real-world and long-term effectiveness and safety of therapy. These data will potentially be a vital benchmark for planning future EoE health care services in Europe

Accurate and timely diagnosis of Eosinophilic Esophagitis improves over time in Europe. An analysis of the EoE CONNECT Registry

BACKGROUND: Poor adherence to clinical practice guidelines for eosinophilic esophagitis (EoE) has been described and the diagnostic delay of the disease continues to be unacceptable in many settings. OBJECTIVE: To analyze the impact of improved knowledge provided by the successive international clinical practice guidelines on reducing diagnostic delay and improving the diagnostic process for European patients with EoE. METHODS: Cross‐sectional analysis of the EoE CONNECT registry based on clinical practice. Time periods defined by the publication dates of four major sets of guidelines over 10 years were considered. Patients were grouped per time period according to date of symptom onset. RESULTS: Data from 1,132 patients was analyzed and median (IQR) diagnostic delay in the whole series was 2.1 (0.7‐6.2) years. This gradually decreased over time with subsequent release of new guidelines (p < 0.001), from 12.7 years up to 2007 to 0.7 years after 2017. The proportion of patients with stricturing of mixed phenotypes at the point of EoE diagnosis also decreased over time (41.3% vs. 16%; p < 0.001), as did EREFS scores. The fibrotic sub‐score decreased from a median (IQR) of 2 (1‐2) to 0 (0‐1) when patients whose symptoms started up to 2007 and after 2017 were compared (p < 0.001). In parallel, symptoms measured with the Dysphagia Symptoms Score reduced significantly when patients with symptoms starting before 2007 and after 2012 were compared. A reduction in the number of endoscopies patients underwent before the one that achieved an EoE diagnosis, and the use of allergy testing as part of the diagnostic workout of EoE, also reduced significantly over time (p = 0.010 and p < 0.001, respectively). CONCLUSION: The diagnostic work‐up of EoE patients improved substantially over time at the European sites contributing to EoE CONNECT, with a dramatic reduction in diagnostic delay

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure &lt; 100 mmHg (n = 1127), estimated glomerular filtration rate &lt; 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Diagnóstico del nivel de fidelización de los clientes de la empresa Mi Buen Amigo E.I.R.L. en la ciudad de Trujillo en el año 2016

El autor no autorizó la publicación de la tesi

A survey on experimental elicitation of creativity in economics

The interplay between individual creative ability and the way to enhance it is an issue with tremendous potential for economic analysis. In this survey, we dwell into the issue by focusing on the methodological advantages of economic experiments. We provide a review of the literature in experimental economics on creativity, identifying seven main objects of study. Namely, the impact on creativity of: (1) low vs. high monetary incentives, (2) the interplay of monetary incentives and tasks, (3) within-group competition, (4) within-group cooperation, (5) cultural factors, (6) non-monetary social incentives, and (7) strategic behavior. We also classify the studies in our review according to key features of standard experimental procedures in economics, as the type of creative task, the way it is assessed, and the specific subject pool. This multidimensional comparison allows us to conclude that the current lack of robust findings on the determinants of creativity in economics might be due to the absence of comparable experimental studies under the same experimental conditions. Our review also highlights the crucial role of previous research on creativity in the psychological literature in shaping procedures of elicitation of creativity in experimental economics

Contabilidad Intermedia-CP40-201901

Descripción:El curso Contabilidad Intermedia realiza una primera revisión de los ciclos de negocio básicos de una empresa desarrollando sus efectos desde la parte financiera asimismo explora los principales conceptos contables que serán base para esta revisión concluyendo con la demostración del resultado contable de todas las transacciones resultantes de la revisión de los procesos visualizando ese efecto en los estados financieros utilizando como herramienta de apoyo la investigación por parte de los alumnos en una empresa real de todos los temas revisados. Propósito:El curso Contabilidad Intermedia ha sido diseñado con el propósito de instruir los conocimientos básicos al estudiante para que logre su aplicación un ambiente empresarial buscando constantemente su intervención del aluno para contribuir con la verificación de lo aprendido en escenarios reales. El curso contribuye directamente al desarrollo de las competencias generales de Razonamiento Cuantitativo y Manejo de la información; y la competencia específica de Soluciones integrales; todas a un nivel 1

Quimica - ME120 201502

Curso general de la Carrera de Medicina de carácter teórico-práctico dirigido a los estudiantes del primer ciclo que busca desarrollar la competencia general de Pensamiento Crítico. Así, el curso pretende desarrollar en los alumnos las habilidades cognitivas y procedimentales que les permitan lograr el éxito académico y profesional

Contabilidad Intermedia-CP40-201702

Curso de especialidad en la carrera de Contabilidad de carácter teórico-práctico dirigido a los estudiantes del tercer ciclo que busca desarrollar las competencias generales de razonamiento cuantitativo manejo de la información y la competencia específica de soluciones integrales.Las empresas informan a sus diferentes usuarios la información financiera con el correcto registro de sus operaciones en base al Plan Contable General Empresarial (PCGE) y la aplicación de las Normas Internacionales de Información Financiera (NIIFs). El desarrollo del curso busca dar orientación en conceptos y procesos contables dentro del desarrollo de una empresa para la elaboración de sus Estados Financieros