Production of biogas - a manner of manufacturing

Advertising is commonly criticised for being pervasive, offensive, manipulative, harmful and irresponsible. This thesis focuses on the subjective criticisms and complex issues related to taste, decency, morality and offence, particularly as applied to, and understood within, the public and non-profit contexts. It is positioned at the intersection of marketing communications, marketing ethics, and social and non-profit marketing and explores how shocking, offensive and/or controversial (SOC) advertising appeals are interpreted, regulated and contested, by divergent groups of people. The approach taken is inspired by stakeholder theory and its focus on ethical decision-making for the betterment of all stakeholders. A mixed methods research design was adopted, resulting in three studies and these are presented as three discrete articles. Article I maps the field of existing research into SOC advertising and identifies gaps in our knowledge by means of a systematic literature review. It offers a critical appraisal of the field by highlighting definitional tensions, limited interdisciplinary work and an overdependence on student samples, on quantitative analysis and on non-longitudinal methodologies. It then proposes a series of remedies to these shortcomings. The second and third papers continue this reparative work by conceptualising and analysing actual SOC advertising interpretations and contestations. Article II explores the interpretations and experiences of SOC advertising within the regulatory context by analysing evidence from complainants, advertisers and regulatory bodies. It then proposes and develops an interpretation of the implicit power dynamics through which their contradictory interests overlap. The methodology underpinning this chapter combines a thematic content analysis of a substantial archive of complaints submitted to the Advertising Standards Authority (ASA) with an interpretation of case adjudication reports influenced by the work of Michel Foucault. The findings suggest that the regulation of SOC advertising prioritises the interests of firms and advertisers by relegating the role of complainant to that of merely registering complaints. The focus of Article III moves from the regulatory framework to the complained-about advertisements themselves. It provides an innovative theoretical and methodological approach to analysing SOC advertisements, rooted in the classic Aristotelian notion of rhetorical appeals and figuration, by developing and analysing a carefully selected example in detail. The analysis reveals an implicit NFP sector-specific appeal to ethos and the importance of a complex appeal to pathos. Each of the papers offers a different level of analysis of the often-contradictory viewpoints represented by stakeholder groups involved in, or affected by, the use of SOC advertising tactics. These viewpoints include academics, general consumers, the vocal minority of complainants, the advertisers including the non-profit and public organisations and the advertising creatives, and the advertising regulator. Taken together, the papers amount to a thesis that makes an important contribution to debates about the appropriateness, ethics, and application of SOC themes, formats and imagery in social and non-profit advertising. By exploring the regulatory processes of the ASA, an exemplary advertising self-regulatory body, it further contributes to the discourse on self-regulatory practices and highlights an NFP sector-specific consequentialist approach that appears to stifle the voice of the offended complainant. On a practical level, this work has implications for advertising practitioners and advertising regulators who are involved in producing and regulating advertising that uses SOC tactics

Rationale and design of an independent randomised controlled trial evaluating the effectiveness of aripiprazole or haloperidol in combination with clozapine for treatment-resistant schizophrenia

<p>Abstract</p> <p>Background</p> <p>One third to two thirds of people with schizophrenia have persistent psychotic symptoms despite clozapine treatment. Under real-world circumstances, the need to provide effective therapeutic interventions to patients who do not have an optimal response to clozapine has been cited as the most common reason for simultaneously prescribing a second antipsychotic drug in combination treatment strategies. In a clinical area where the pressing need of providing therapeutic answers has progressively increased the occurrence of antipsychotic polypharmacy, despite the lack of robust evidence of its efficacy, we sought to implement a pre-planned protocol where two alternative therapeutic answers are systematically provided and evaluated within the context of a pragmatic, multicentre, independent randomised study.</p> <p>Methods/Design</p> <p>The principal clinical question to be answered by the present project is the relative efficacy and tolerability of combination treatment with clozapine plus aripiprazole compared with combination treatment with clozapine plus haloperidol in patients with an incomplete response to treatment with clozapine over an appropriate period of time. This project is a prospective, multicentre, randomized, parallel-group, superiority trial that follow patients over a period of 12 months. Withdrawal from allocated treatment within 3 months is the primary outcome.</p> <p>Discussion</p> <p>The implementation of the protocol presented here shows that it is possible to create a network of community psychiatric services that accept the idea of using their everyday clinical practice to produce randomised knowledge. The employed pragmatic attitude allowed to randomly allocate more than 100 individuals, which means that this study is the largest antipsychotic combination trial conducted so far in Western countries. We expect that the current project, by generating evidence on whether it is clinically useful to combine clozapine with aripiprazole rather than with haloperidol, provides physicians with a solid evidence base to be directly applied in the routine care of patients with schizophrenia.</p> <p>Trial Registration</p> <p><b>Clincaltrials.gov Identifier</b>: NCT00395915</p

Ground-motion simulations within ShakeMap methodology: application to the 2008 Iwate-Miyagi Nairiku (Japan) and 1980 Irpinia (Italy) earthquakes

ShakeMap package uses empirical Ground Motion Prediction Equations (GMPEs) to estimate the ground motion where recorded data are not available. Recorded and estimated values are then interpolated in order to produce a shaking map associated with the seismic event of interest. The ShakeMap approach better works in regions with dense stations coverage, where the observed ground motions adequately constrain the interpolation. On the other hand, in poorly instrumented regions, the ground motion estimate mainly relies on the GMPEs that account only for average characteristics of source and wave propagation processes. In this study we investigated the improvement of ShakeMap in the near-fault area accounting for source effects, at different level of approximation, and including synthetic estimates at sites where recordings are not available. We focus on the 2008, Mw 7.0, Iwate-Miyagi Nairiku (Japan) earthquake as a case study because of the large amount of recorded data. As first step, we calculated the shakemaps to be used as reference using all station recordings and simple source information such as the earthquake magnitude and fault geometry. We then removed several subsets of stations from the original data-set and computed the shakemaps (i) using the estimations of the ground motion obtained by GMPE and (ii) replacing them with the peak values from synthetic time-histories. Simulated seismograms are computed by a hybrid deterministic-stochastic method for extended fault, using rupture fault models with different degree of approximation of source properties. In fact, within few hours, a preliminary rupture model can be obtained from the inversion of teleseismic data, and after 24 hours a kinematic source inversion of strong-motion records can be available. We evaluate the deviations from the reference map and the sensitivity to the number of sites where recordings are not available. Our results show that shakemaps are more and more reliable as the coverage of stations is uniformly distributed in the near-source area. Moreover, the shakemaps obtained by the use of combination of slip inversion model and strong-motion simulations are more reliable than those obtained by the use of GMPEs. The accuracy of source model does not significantly affect the results, making the proposed methodology applicable to regions with sparse station coverage. As an example, we apply it to a poorly instrumented earthquake of similar magnitude, the 1980, Ms 6.9, Irpinia (Southern Italy) earthquake. When the peak motions inferred from synthetic seismograms are included in the database, the fit with respect to the observed Mercalli–Cancani–Sieberg intensities improves

OGS improvements in the year 2011 in running the Northeastern Italy Seismic Network

The Centro di Ricerche Sismologiche (CRS, Seismological Research Center) of the Istituto Nazionale di Oceanografia e di Geofisica Sperimentale - OGS (Italian National Institute for Oceanography and Experimental Geophysics) in Udine (Italy) after the strong earthquake of magnitude Mw = 6.4 occurred in 1976 in the Italian Friuli-Venezia Giulia region, started to operate the Northeastern Italy Seismic Network: it currently consists of 12 very sensitive broad band and 21 simpler short period seismic stations, all telemetered to and acquired in real time at the OGS-CRS data centre in Udine. Real time data exchange agreements in place with other Italian, Slovenian, Austrian and Swiss seismological institutes lead to a total number of 93 seismic stations acquired in real time, which makes the OGS the reference institute for seismic monitoring of Northeastern Italy, as shown in Fig. 1 (Bragato et al., 2011; Saraò et al., 2010). Since 2002 OGS-CRS is using the Antelope software suite as the main tool for collecting, analyzing, archiving and exchanging seismic data, initially in the framework of the EU Interreg IIIA project "Trans-national seismological networks in the South-Eastern Alps" (Bragato et al., 2010; Pesaresi et al., 2008). SeisComP is also used as a real time data exchange server tool. In order to improve the seismological monitoring of the Northeastern Italy area, at OGS-CRS we tuned existing programs and created ad hoc ones like: a customized web server named PickServer to manually relocate earthquakes, a script for automatic moment tensor determination, scripts for web publishing of earthquake parametric data, waveforms, state of health parameters and shaking maps, noise characterization by means of automatic spectra analysis, and last but not least scripts for email/SMS/fax alerting. A new OGS-CRS real time seismological website (<a href="http://rts.crs.inogs.it/" target="_blank">http://rts.crs.inogs.it/</a>) has also been operative since several years

Three Decades of Seismic Activity at Mt. Vesuvius: 1972–2000

We analyse the seismic catalogue of the local earthquakes which occurred at Somma-Vesuvius volcano in the past three decades (1972–2000). The seismicity in this period can be described ascomposed of a background level, characterised by a low and rather uniform rate of energy release and by sporadic periods of increased seismic activity. Such relatively intense seismicity periods are characterised by energy rates and magnitudes progressively increasing in the critical periods. The analysis of the b value in the whole period evidences a well-defined pattern, with values of b progressively decreasing, from about 1.8 at the beginning of the considered period, to about 1.0 at present. This steady variation indicates an increasing dynamics in the volcanic system. Within this general trend it is possible to identify a substructure in the time sequence of the seismic events, formed by the alternating episodes of quiescence and activity. The analysis of the source moment tensor of the largest earthquakes shows that the processes at the seismic source are generally not consistent with simple double-couples, but that they are compatible with isotropic components, mostly indicating volumetric expansion. These components are shown to be statistically significant for most of the analysed events. Such focal mechanisms can be interpreted as the effect of explosion phenomena, possibly related to volatile exsolution from the crystallising magma. The availability of a reduced amount of high quality data necessary for the inversion of the source moment tensor, the still limited period of systematic observation of Vesuvius micro-earthquakes and, above all, the absence of eruptive events during such interval of time, cannot obviously permit the outlining of any formal premonitory signal. Nevertheless, the analysis reported in this paper indicates a progressively evolving dynamics, characterised by a generally increasing trend in the seismic activity in the volcanic system and by a significant volumetric component of recent major events, thus posing serious concern for a future evolution towards eruptive activity.Published123-144partially_ope

Modelling of the seismic ground motion for the Umbria-Marche earthquake sequence (september 1997)

A first-order deterministic seismic zoning of Italy, based on the compution of synthetic seismograms [10,27,28] lead to theoretical peak values estimates for the Umbria-Marche region that are well in agreement with the peak values observed during the sequence started on september 26,1997