A development of the training curriculum for learning design to promote sexuality education awareness for students of teachers at the high school level

The purpose of this research aimed to study develop a curriculum and evaluate the effectiveness of a curriculum for learning design promoting sexuality education awareness. The sample used in the research consisted of 8 high school teachers from 8 subject groups in semester 1 of the academic year 2022 at Kowit Thamrong School, Chiang Mai. The research tools consisted of courses and user manuals, as well as a teacher competency assessment form and Satisfaction Survey Form. The data were analyzed by finding the mean and standard deviation. Together with the content analysis, Analysis data by Descriptive statistics and Content Analysis. The research results were found as follows; 1. The training curriculum development model to promote teachers' awareness of sexuality education consisted of 4 components: (1) curriculum principles, (2) objectives, (3) curriculum development process, and (4) measurement and evaluation. 2. During the curriculum assessment, it was established that educators had a dual focus. Firstly, they concentrated on facilitating learning methods that highlighted effective educational approaches (2.1). Secondly, they required a learning design that emphasized observation (2.2). This approach aligns with an educational model wherein curriculum development nurtures learners to comprehend the model in terms of perspective and efficiency

Nanopore-based complete genome sequence of a Sri Lankan cassava mosaic virus (Geminivirus) strain from Thailand

Sri Lankan cassava mosaic virus is an emerging pathogen in Southeast Asia. Here, we report the complete genome of a Thai isolate obtained using Nanopore technology. The isolate was collected in 2019 from the northeastern province of Surin, soon after disease eradication was reported in the country

Solubility of Cyclodextrins and Drug/Cyclodextrin Complexes

Publisher's version (útgefin grein)Cyclodextrins (CDs), a group of oligosaccharides formed by glucose units bound together in a ring, show a promising ability to form complexes with drug molecules and improve their physicochemical properties without molecular modifications. The stoichiometry of drug/CD complexes is most frequently 1:1. However, natural CDs have a tendency to self-assemble and form aggregates in aqueous media. CD aggregation can limit their solubility. Through derivative formation, it is possible to enhance their solubility and complexation capacity, but this depends on the type of substituent and degree of substitution. Formation of water-soluble drug/CD complexes can increase drug permeation through biological membranes. To maximize drug permeation the amount of added CD into pharmaceutical preparation has to be optimized. However, solubility of CDs, especially that of natural CDs, is affected by the complex formation. The presence of pharmaceutical excipients, such as water-soluble polymers, preservatives, and surfactants, can influence the solubilizing abilities of CDs, but this depends on the excipients’ physicochemical properties. The competitive CD complexation of drugs and excipients has to be considered during formulation studies.Peer Reviewe

Characterization and Evaluation of Ternary Complexes of Ascorbic Acid with γ-Cyclodextrin and Poly(vinyl Alcohol)

Publisher's version (útgefin grein)Ascorbic acid (AA) is a general antioxidant used in aqueous pharmaceutical formulations. However, in aqueous solutions, AA is unstable and easily oxidized when exposed to air, light and/or heat. Cyclodextrins are well known for their ability to form inclusion complexes with various compounds to improve their solubility and stability. Previous studies demonstrate that cyclodextrins preserve the antioxidant capacity of AA but data for γ-cyclodextrin (γCD) have not been reported. Poly(vinyl alcohol) (PVA) is a hydrophilic polymer widely used as a drug matrix in various pharmaceutical fields, but its application for drug stabilization is limited. This study aimed to investigate the protective ability of γCD on AA through the formation of ternary complexes with PVA. Binary (i.e., AA/γCD, AA/PVA and γCD/PVA) and ternary (i.e., AA/γCD/PVA) complexes were first confirmed. It was reported that those complexes were formed through interactions between the heterocyclic ring of AA, hydroxyl group of PVA and hydrophobic cavity of γCD. The hydrodynamic diameter of complexes was then studied. It was found that the diameter of γCD/PVA complexes increased with respect to the concentration of γCD. Higher γCD concentrations also resulted in increasing hydrodynamic diameters of the ternary complex. The presence of AA in ternary complexes interfered with the aggregation tendency of γCD/PVA binary complexes. Furthermore, the antioxidant capacity of AA in binary and ternary complexes was investigated. It was found that the presence of γCD preserved the antioxidant activity of AA, whereas PVA showed a contrasting effect. The influence of γCD and PVA concentration on antioxidant capacity was then studied through central composite design (CCD). Even though the concentration of γCD significantly affected the inhibition efficiency of the ternary complex, the insignificant influence of PVA could not be ignored. A promising protective ternary complex should consist of an optimized concentration of PVA and a high concentration of γCD.The authors would like to express their gratitude to sta?s at the Department of Manufacturing Pharmacy and Department of Pharmaceutical Technology ,College of Pharmacy, Rangsit University and Faculty of Pharmaceutical Sciences, University of Iceland.Peer Reviewe

Solubility of Cyclodextrins and Drug/Cyclodextrin Complexes

Publisher's version (útgefin grein)Cyclodextrins (CDs), a group of oligosaccharides formed by glucose units bound together in a ring, show a promising ability to form complexes with drug molecules and improve their physicochemical properties without molecular modifications. The stoichiometry of drug/CD complexes is most frequently 1:1. However, natural CDs have a tendency to self-assemble and form aggregates in aqueous media. CD aggregation can limit their solubility. Through derivative formation, it is possible to enhance their solubility and complexation capacity, but this depends on the type of substituent and degree of substitution. Formation of water-soluble drug/CD complexes can increase drug permeation through biological membranes. To maximize drug permeation the amount of added CD into pharmaceutical preparation has to be optimized. However, solubility of CDs, especially that of natural CDs, is affected by the complex formation. The presence of pharmaceutical excipients, such as water-soluble polymers, preservatives, and surfactants, can influence the solubilizing abilities of CDs, but this depends on the excipients’ physicochemical properties. The competitive CD complexation of drugs and excipients has to be considered during formulation studies.Peer Reviewe

Surveillance and diagnostics of the emergent Sri Lankan cassava mosaic virus (Fam. Geminiviridae) in Southeast Asia

Emergent agricultural pathogens cause severe damage worldwide and their invasive potential is significantly increased by global trade, crop intensification and climate change. Standard surveillance and diagnostic protocols need to be evaluated and implemented, particularly with diseases caused by a wide range of pathogens that induce similar symptoms. Such is the case with Cassava Mosaic Disease (CMD) present in Africa and Asia, and associated with mixed virus infections and recombinant and re-assorted virus strains. CMD has been recently reported in Southeast Asia (SEA) and is already widely spread throughout this region. This communication offers an update on protocols and tools used to track the distribution of CMD and to characterize the pathogen associated with it in SEA

การประดิษฐ์เครื่องประดับสตรีปรับเปลี่ยนรูปแบบด้วยกระจกล้านนา

โครงงานพิเศษ (คศ.บ.) -- มหาวิทยาลัยเทคโนโลยีราชมงคลพระนคร, 2562The special project study aims to create transformative jewellery for women from Lanna-style glass as well as to examine the satisfaction of the target groups on the jewellery. The different three design of the transformative jewellery were sketched based on the review information. The jewellery can be split into smaller pieces which are a necklace, earrings and a brooch. Then, a favourite design was considered by five experts. Some recommendations for better design were also provided. After that, the jewellery was created according to the selected sketching. The satisfactions on the jewellery were collected from two groups of people; 1) twenty-five jewellery entrepreneurs and 2) twenty-five working women aged 18-60 years (Ministry of Labor, 2019). The total data of fifty samples were analysed by using frequency, percentage, and mean. The results showed as following. Three of the five experts chose the design number three as the model was interesting. The necklace, earrings and brooch can be detached to suit an outfit perfectly. The experts preferred the transformation by studs and hooks. Furthermore, the colour tones are harmonious and can draw the human perception resulting in a variety application on an outfit. The satisfaction of two groups of people; 1) jewellery entrepreneurs 2) working women aged 18-60 years; were examined. It was found that for the style of the jewellery, both groups were satisfied with the creativity of the jewellery design at the highest level, the satisfaction means were 4.80, and 4.68 respectively. In terms of materials, the entrepreneurs were satisfied with the novelty, the strength and durability, and the safety of materials at the highest level, having the same means of 4.36. The working women were satisfied with the suitability of the materials at the highest level, with the mean of 4.52. In terms of utility, both groups had the satisfaction of wearing to parties at the highest level, with the mean of 4.56 and 4.44 respectively. Regarding the price, the entrepreneurs were satisfied with the price of 3,999 baht at the highest level, with the mean of 4.48. Also, the working women were satisfied with the price of 2,999 baht at a high level, with the mean of 4.20. For the place of distribution, both groups had the satisfaction of the jewellery stores at the highest level, with the mean of 4.96 and 4.52 respectively.Rajamangala University of Technology Phra Nako

Surveillance and diagnostics dataset on Sri Lankan cassava mosaic virus (Fam. Geminiviridae) and CMD in Thailand

Emergent agricultural pathogens cause severe damage worldwide. Standard surveillance and diagnostic protocols need to be evaluated and implemented at regional level, particularly with diseases caused by a wide range of pathogens that can induce similar symptoms. This dataset provides a description of surveillance and diagnostics data for CMD in Thailand (2019), indicating location of the surveyed fields, presence of visual symptoms, symptom severity and PCR-diagnostic results with two primer sets, both of them targeting the CP region. All samples were collected using a standard protocol as described in the associated manuscript. More information is available upon request