Jacob's disease secondary to coronoid process osteochondroma. A case report

The formation of a new joint between a pathologically elongated coronoid process and the body of the malar homolateral bone is known as Jacob's disease. Coronoid process hyperplasia was first described in 1853 by Von Langenbeck, and it was not until 1899 when Oscar Jacob described the disease that it was named after him. Jacobs's disease is an uncommon entity with only a few documented cases in the literature. The condition first manifests with progressive limitation of mouth opening and facial asymmetry. Pain is uncommon and it mainly affects young patients. Different factors have been postulated as possible causes, including temporal muscle hyperactivity, previous trauma, chronic disc displacement of the ipsilateral temporomandibular joint, endocrine stimuli, and genetic alterations. Definitive diagnosis is by histopathology and it is necessary to confirm bone hyperplasia, the presence of cartilage and synovial capsule forming the new joint between the malar bone and the coronoid process. We report a 52-year-old woman patient with a history of childhood trauma in the right preauricular region. She came to our department with a 2-year history of progressive limitation of mouth opening. Computed tomography (CT) revealed a right coronoid process elongation, in contact with the homolateral malar bone, causing it to deform. Surgery with general anesthesia was performed using an intraoral vestibular approach. Histopathology confirmed the diagnoses of Jacob's disease. © Medicina Oral S. L

Criterios para la localización de plantas de gestión de Residuos de Construcción y Demolición (RCD)

Location criteria for a Demolition Waste Processing Center. The recent social worry about ecological duties and conservation of the environment makes indispensable the correct treatment of demolition waste produced by construction sector. This document pretends the appliance of some general keys that could allow the selection of the best possible location for placing a waste processing center and a demolition waste dump. This facility should be able to have a classification and selection level and a treatment level therefore, the facility should be able to put the non-recoverable part on the dump area reserved for it. Later these items would be considered, classified and evaluated being analyzed by the corresponding evaluation matrix

Smartphone-interrogated test supports for the enzymatic determination of putrescine and cadaverine in food

Diamino-oxidase (DAO), horseradish peroxidase (HRP), and tetramethylbenzidine (TMB) have been immobilized into cellulose to obtain circular cellulose test supports (CCTSs) for the determination of cadaverine (Cad) and putrescine (Put). During the enzymatic reaction, TMB is oxidized and a blue spot is obtained. This color (RGB coordinates) is measured with a smartphone and a commercial application. The highest sensitivity is provided by the component R and a linear response is observed for low biogenic amine (BA) concentrations, but a second-order polynomial response better fits the experimental results for a wider concentration range. This has been successfully explained with a model developed to explain the RGB values obtained in this type of analytical system. Optimization studies enable CCTSs to be obtained for Put and Cad determination, which could be used (kept at 4 °C) for at least 45 days if a stabilizer (StabilCoat™ or StabilGuard™) is added during its synthesis. In these conditions, the R coordinate follows the model up to at least 4 × 10-4 M Put and/or Cad (both analytes give the same response). The method permits the Put and Cad determination from 5 × 10-5 M up to 4 × 10-4 M (RSD = 3%, n = 3). The CCTSs have been applied to Put + Cad determination in a tuna sample without any interference by other biogenic amines. The concentration found statistically agrees with that obtained using a HPLC-MS-validated method

Molecular Dynamics Simulations of the Interactions between Platinum Clusters and Carbon Platelets

Molecular dynamics simulations have been performed with two reactive force fields to investigate the structure of a Pt_(100) cluster adsorbed on the three distinct sides of a carbon platelet. A revised Reax force field for the carbon−platinum system is presented. In the simulations, carbon platelet edges both with and without hydrogen termination have been studied. It is found that the initial mismatch between the atomic structure of the platelet egde and the adsorbed face of the Pt_(100) cluster leads to a desorption of a few platinum atoms from the cluster and the subsequent restructuring of the cluster. Consequently, the average Pt−Pt bond length is enlarged in agreement with experimental results. This change in the bond length is supposed to play an important role in the enhancement of the catalytic activity, which is demonstrated by studying the changes in the bond order of the platinum atoms. We found an overall shift to lower values as well as a loss of the well-defined peak structure in the bond-order distribution

Scaling relations for implantation of size-selected Au, Ag, and Si clusters into graphite

The deposition of size-selected clusters represents a new route to the fabrication of truly nanometer-scale surface architectures, e.g., nanopores. We report a systematic experimental study, coupled with molecular dynamics simulations, of the implantation depths of size-selected Au7, Ag7, and Si7 clusters in the model graphite substrate. For impact energies between 1.0 and 5.5 keV, we find that the implantation depth scales linearly with the momentum of the clusters for all three types of cluster. This “universal” behavior is consistent with a (viscous) retarding force proportional to the velocity of the cluster, akin to Stokes’s law

Hydrolase–like catalysis and structural resolution of natural products by a metal–organic framework

The exact chemical structure of non–crystallising natural products is still one of the main challenges in Natural Sciences. Despite tremendous advances in total synthesis, the absolute structural determination of a myriad of natural products with very sensitive chemical functionalities remains undone. Here, we show that a metal–organic framework (MOF) with alcohol–containing arms and adsorbed water, enables selective hydrolysis of glycosyl bonds, supramolecular order with the so–formed chiral fragments and absolute determination of the organic structure by single–crystal X–ray crystallography in a single operation. This combined strategy based on a biomimetic, cheap, robust and multigram available solid catalyst opens the door to determine the absolute configuration of ketal compounds regardless degradation sensitiveness, and also to design extremely–mild metal–free solid–catalysed processes without formal acid protons.This work was supported by the Ministero dell’Istruzione, dell’Università e della Ricerca (Italy) and the MINECO (Spain) (Projects CTQ2016-75671-P, CTQ 2017-86735-P, RTC-2017-6331-5, Severo Ochoa program SEV-2016-0683 and Excellence Unit “Maria de Maeztu” MDM-2015-0538). R.B. thanks the MIUR (Project PON R&I FSE-FESR 2014–2020) for grant. L.B wishes to thank Italian MIUR for grant n. AIM1899391–1 in the framework of the project “Azione I.2, Mobilità dei Ricercatori, PON R&I 2014–2020”. Thanks are also extended to the “2019 Post-doctoral Junior Leader-Retaining Fellowship, la Caixa Foundation (ID100010434 and fellowship code LCF/BQ/PR19/11700011” (J. F.- S.). S. S.-N. thanks ITQ for the concession of a contract. D.A. acknowledges the financial support of the Fondazione CARIPLO/“Economia Circolare: ricerca per un futuro sostenibile” 2019, Project code: 2019–2090, MOCA. E.P. acknowledges the financial support of the European Research Council under the European Union’s Horizon 2020 research and innovation program/ERC Grant Agreement No. 814804, MOF-reactors

Tuning shape, composition and magnetization of three-dimensional cobalt nanowires grown by Focused Electron Beam Induced Deposition (FEBID)

Electron beam induced deposition of 3D cobalt nanowires with simultaneous high metallic content (≈80% at.) and small diameter (<100 nm) has been achieved by optimization of the growth parameters. Two different growth modes have been identified, denoted as radial and linear. In the radial mode, the wire diameter is at least  ≈120 nm and the Co content is greater than  ≈85% at. In the linear mode, the diameter is smaller than 80 nm and the Co content is at best  ≈80% at. A sharp transition between both growth modes can occur inside a single nanowire for certain experimental conditions. Electron holography measurements indicate that in optimized Co nanowires the magnetic induction is high enough for applications in spintronics, magnetic sensing and actuation at the nanoscale.This work was supported by the Spanish Ministry of Economy and Competitivity through projects No. MAT2014-51982C2-1-R, MAT2014-51982C2-2-R and MAT2015-69725-REDT, including FEDER funds and by the Aragon Regional Government (Construyendo Europa desde Aragón) through project E26, with FEDER funding. This work was conducted within the framework of the COST Action CM1301 (CELINA). AFP acknowledges funding from a EPSRC Early Career Fellowship EP/M008517/1 and from a Winton Fellowship. In order to comply with EPSRC policy on research data, all metadata associated to this publication can be accessed via https://doi.org/10.17863/CAM.8106. JP-N grant is funded by the Ayuda para Contratos Predoctorales para la Formación de Doctores, Convocatoria Res. 05/06/15 (BOE 12/06/15) of the Secretaría de Estado de Investigación, Desarrollo e Innovación in the Subprograma Estatal de Formación of the Spanish Ministry of Economy and Competitiveness (MINECO) with the participation of the European Social Fund

DNA copy number variation associated with anti-tumour necrosis factor drug response and paradoxical psoriasiform reactions in patients with moderate-to-severe psoriasis

Biological drugs targeting tumour necrosis factor are effective for psoriasis. However, 30–50% of patients do not respond to these drugs and may even develop paradoxical psoriasiform reactions. This study search-ed for DNA copy number variations that could predict anti-tumour necrotic factor drug response or the ap-pearance of anti-tumour necrotic factor induced pso-riasiform reactions. Peripheral blood samples were collected from 70 patients with anti-tumour necrotic factor drug-treated moderate-to-severe plaque pso-riasis. Samples were analysed with an Illumina 450K methylation microarray. Copy number variations were obtained from raw methylation data using conumee and Chip Analysis Methylation Pipeline (ChAMP) R packa-ges. One copy number variation was found, harbouring one gene (CPM) that was significantly associated with adalimumab response (Bonferroni-adjusted p-value < 0.05). Moreover, one copy number variation was identified harbouring 3 genes (ARNT2, LOC101929586 and MIR5572) related to the development of paradoxical psoriasiform reactions. In conclusion, this study has identified DNA copy number variations that could be good candidate markers to predict response to ada-limumab and the development of anti-tumour necrotic factor paradoxical psoriasiform reactions.This study was supported by Instituto de Salud Carlos III PI 13/01598 and the Ministry of Science and Innovation and the European Regional Development’s funds (FEDER). Conflicts of interest. FA-S has been a consultant or investigator in clinical trials sponsored by the following pharmaceutical companies: Abbott, Alter, Chemo, Farmalíder, Ferrer, GlaxoSmithKline, Gilead, Janssen-Cilag, Kern, Normon, Novartis, Servier, Teva, and Zambon. ED has potential conflicts of interest (advisory board member, consultant, grants, research support, participation in clinical trials, honoraria for speaking, and research support) with the following pharmaceutical companies: AbbVie (Abbott), Amgen, Janssen-Cilag, Leo Pharma, Novartis, Pfizer, MSD, Lilly and Celgene. ML-V has potential conflicts of interest as she has participated in clinical trials or as consultant with Abbvie (Abbott), Galderma, Janssen-Cilag, Leo Pharma, Pfizer, Novarties, Lilly, Almirall and Celgene. MCO-B has potential conflicts of interest (honoraria for speaking and research support) with Janssen-Cilag and Leo Pharma. The other authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. AS-T has served as a consultant and/or paid speaker for and/or participated in clinical trials sponsored by companies that manufacture drugs used for the treatment of psoriasis, including AbbVie, Celgene, Janssen-Cilag, LEO Pharma, Lilly, Novartis and Pfizer. RB-E has served as a consultant and/or paid speaker for and/or participated in clinical trials sponsored by companies that manufacture drugs used for the treatment of psoriasis, including AbbVie, Celgene, Janssen-Cilag, LEO Pharma, Lilly, Novartis and Pfizer

Brote de legionelosis en Murcia en julio de 2001. La óptica de sanidad ambiental

The measures of intervention adopted for the study and control of the outbreak are exposed. 126 systems with risk were found (45 of them high risk): 70 water cooling towers or similar, 35 decorative fountains, 1 building site with earth movement and 20 air-water closed systems, distributed by risk criteria.Immediately were stopped: decorative fountains, washing down of streets, spray irrigation in parks and the building site.486 inspections and 1040 sample taking were executed, the cleaning and disinfection of water cooling towers and similar systems were ordered and closing if necessary.Afterwards, fills were replaced in water cooling tower which tested Lp positive.After the investigation of 339 systems, 57 (16.9%) tested Lp positive culture, 23 (6.8 %) water cooling towers and 31 (9.1 %) drinking water taps.Distribution by serotypes: LpS1 (62’3%), serotypes 2-14 (36’68%).LpS1Olda Olda (21’74%) was the most abundant followed by LpS1 Pontiac Philadelphia Lugano (18’84%), in contrast to LpS1 Pontiac Philadelphia Glasgow (1’45%), found only in one case although isolated in the 18 samples of patients.Culture and PCR were available in 355 cases, resulting in 30,8% sensitivity (confidence interval 95%, 25,1) and specificity 99,4±0,8.There are a big percentage of samples positives to Lp Sg1 and between them prevail Lp Pontiac Philadelphia, basically Lugano kind.The first disinfection doesn ́t eradicate all the contamination. The finding of 14 Lp positive systems after cleaning and disinfection process, with previous negative cultures, suggests a high analytical results variability and/or an inefficient first cleaning and disinfections of the system.The previous conclusions and the low sensitivity of the PCR test must be considered in future cases.Se exponen las medidas de intervención adoptadas para el estudio y control del brote. Se encontraron 126 instalaciones con riesgo (45 de ellas de alto): 70 torres de refrigeración y similares, 35 fuentes ornamentales, 1 obra con movimiento de tierra y 20 sistemas con circuito cerrado aire-agua, que se distribuyeron por categorías de riesgo.De forma inmediata se clausuraron: las fuentes ornamentales, el baldeo de calles y riegos por aspersión de parques y la obra.Se realizaron un total de 486 inspecciones y 1040 toma de muestras, ordenando la limpieza y desinfección de torres de refrigeración y similares y su clausura en caso necesario. Posteriormente, se cambio de relleno en torres de refrigeración positivas a Lp.Del total de instalaciones investigadas (339), en 57 (16’9%) se encontró un cultivo positivo a Lp. Distribución por tipo de instalación con cultivo positivo a Lp: en torres de refrigeración 23 (6’8%), en fuentes ornamentales 3 (7,32%) y en agua sanitaria 31 (9’1%).Distribución por serogrupos: LpS1 (62’3%), serogrupos 2-14 (36’68%).LpS1Olda Olda (21’74%) fue la mas abundante seguida de LpS1 Pontiac Filadelfia Lugano (18’84%) frente a LpS1 Pontiac Filadelfia Glasgow (en 1 ocasión, 1’45%), esta ultima fue la aislada en las 18 muestras de enfermos.En 355 ocasiones se dispone de cultivo y PCR, encontrándose una sensibilidad de 30,8% (Intervalo de confianza al 95%, de 25,1) y una especificidad del 99,4±0,8. Hay que considerar la eventual influencia en los resultados aportada por la posible aparición de dos falsos negativos en el cultivo.Se encuentra un elevado porcentaje de muestras correspondientes a Legionella pneumophilla serogrupo 1, dentro de estas prevalecen las tipo Pontiac Philadelphia, y dentro de estas las tipo Lugano.La primera desinfección no erradicó la contaminación en su totalidad. Abundando en lo anterior, el hallazgo de un número considerable de torres de refrigeración positivas a Lp tras limpieza y desinfección, con cultivos previos negativos redunda en la variabilidad de los resultados analíticos y/o en la ineficacia de las primeras limpiezas y desinfecciones realizadas por empresas.Lo expuesto anteriormente unido a la baja sensibilidad de la PCR deben de ser tenidos en cuenta en futuros incidentes