Konstruksi Identitas Diri Virtual Melalui Instagram (Studi Pada Mahasiswi Jurusan Ilmu Komunikasi Angkatan 2015 Universitas Muhammadiyah Surakarta)

Identity is very important for every person in live. The purpose of this research is to find out what kind of self-identity that the students of Communication Science Faculty, Muhammadiyah University of Surakarta of 2015 want to build / construct in presenting themselves on Instagram social media. This research uses descriptive qualitative research methods with triangulation data collection techniques, by documentation study techniques, online observations, and in-depth interviews. Resource persons studied were 4 female students majoring in Communication Sciences, Muhammadiyah University of Surakarta, class of 2015, who were actively using Instagram social media. The results of this study is that the virtual identity that is built in social media Instagram is in accordance with their dreams such as Ikha becoming a photographer, Julia as an productive person at a young age and pioneering a career in politics, and Lia as a traveler. Three of the all informants, have a backstage that is the same as the front stage on Instagram, where they present their dreams in accordance with reality. And one of them has a little difference that is her dream to be an Instagram celebrity who has not been realized yet and does not match with reality

Hubungan kualitas hidup dan persepsi pasien tentang penyakit diabetes mellitus tipe 2 dengan komplikasi

Kualitas hidup merupakan acuan penilaian outcome pasien diabetes mellitus tipe 2 (DMT2). Kualitas hidup pasien DMT2 dapat semakin menurun akibat komplikasi yang menyertainya. Aspek penting dalam pertimbangan intervensi peningkatan kualitas hidup adalah persepsi tentang penyakit. Tujuan penelitian ini untuk pengaruh persepsi tentang penyakit terhadap kualitas hidup pasien DMT2 dengan komplikasi.Studi potong lintang terhadap populasi terjangkau berlangsung selama Juli-September 2015 di Poliklinik Penyakit Dalam Rumah Sakit PKU Muhammadiyah Bantul. Kuesioner Short Form-36  digunakan untuk mengukur kualitas hidup dan Brief-Illness Perceptions Questionnaire untuk persepsi tentang penyakit. Analisis uji T dan Anova satu jalan dilakukan untuk mengetahui perbedaan kualitas hidup dan persepsi tentang penyakit berdasarkan karakteristik dasar pasien (jenis kelamin, umur, pendidikan, pekerjaan, kadar gula darah sewaktu, tekanan darah, dan durasi diabetes), dan pengaruh persepsi tentang penyakit terhadap kualitas hidup.Penelitian melibatkan 51 pasien DMT2 dengan komplikasi. Subyek dengan tingkat pendidikan rendah memiliki peran fisik yang lebih buruk daripada subyek dengan pendidikan menengah dan tinggi (p=0,049). Persepsi subyek yang positif dapat meningkatkan kualitas hidup pada aspek; peran fisik (p=0,032), vitalitas (p=0,032), kesehatan mental (p=0,001), dan fungsi sosial (p=0,037).            Kualitas hidup pasien DMT2 dengan komplikasi dipengaruhi oleh tingkat pendidikan dan persepsi tentang penyakit

MODELING OF MICE AS TEST ANIMALS FOR A PRECLINICAL STUDY OF HYPOLIPIDEMIC AGENTS

Animal models suitable for preclinical research are necessary for the discovery of hypolipidemic agents. Various publications have presented alternative dyslipidemia animal models, but identifying a feasible and stable method would serve as a solid reference for researchers. This investigation aimed to establish a sustained dyslipidemia induction that persists after several days of intervention with a hypolipidemic agent. Six groups of mice, each consisting of five primary test animals and one reserve test animal, were used. After a seven-day acclimatization period, we induced each group for 14 days using three different methods: (1) 5% body weight of quail egg yolks (5% QEY), (2) 10% body weight of used cooking oil (10% UCOs), and (3) a combination of 5% QEY and 10% UCOs. Once all mice reached their peak lipid levels, we evaluated lipid performance through a seven-day intervention with simvastatin (0.026 mg/20-gram body weight) in one of the paired groups. A 14-day combined induction of 5% QEY and 10% UCOs resulted in a 39% elevation in mouse lipids compared to baseline levels. Our findings offer an alternative to traditional dyslipidemia models. However, the development of an animal model for dyslipidemia still poses challenges. Therefore, the identification of novel biomarkers capable of targeting dyslipidemia in humans is crucial

Isoniazid-induced liver injury risk level in different variants of N-acetyltransferase 2 (NAT2) polymorphisms: A literature review

Individual NAT2 genotype identity data should be enriched to prevent Isoniazid-induced liver injury (IDILI) and optimize the dose of Isoniazid (INH). Therefore, this study aims to present the level of IDILI risk for specific genotype alleles. The data collection involves literature indexed by Google Scholar, Scopus, and Pubmed databases. The search uses a combination of the following keyword variants “INH” OR “INH”, “liver injury” OR “hepatotoxicity”, “polymorphism” OR “pharmacogenomic”, and “N-acetyltransferase 2” OR “NAT2”. Furthermore, the screening results of library sources were narrowed to 11 original articles that met the inclusion criteria. The IDILI risk assessment analysis due to NAT2 enzyme polymorphism following the odds ratio has a 95% confidence interval. The results showed that the IDILI risk level of the slow acetylator group was 3.11 times higher than other populations. Meanwhile, the rapid and intermediate acetylator groups were not at risk. Three variants related to *6 allele were classified as high risk; *6A/*6A risk 5.76 times, *6A/*7B (5.54 times), and *6/*7 (4 times). The three allele configurations of the *5 and *7 were also classified as a risk; *5B/*7B (5 times), *7B/*7B (3.23 times), and *5/*7 (2,74 times)

Tinjauan Farmakovigilan Pada Terapi Obat Antihipertensi Di Rumah Sakit Umum Pusat Dr. Soeradji Tirtonegoro Klaten Periode Desember 2012 - Februari 2013

Seiring berkembangnya obat-obatan baru di pasaran, maka resiko kejadian reaksi obat yang tidak dikehendaki (ROTD) semakin meningkat. Beberapa publikasi melaporkan kejadian ROTD pada terapi antihipertensi. Mengingat prevalensi hipertensi secara nasional yang tinggi, maka perlu dilakukan penelitian untuk mengidentifikasi temuan dan manifestasi kejadian ROTD pada terapi obat antihipertensi. Desain penelitian adalah penelitian kualitatif jenis studi kasus. Penelitian bersifat observasional untuk menggali secara prospektif data primer dan menggunakan algoritma Naranjo untuk menilai kausalitas ROTD. Penelitian melibatkan sampel sebanyak 35 subyek penelitian yang menerima peresepan obat antihipertensi di Poliklinik Penyakit Dalam RSUP Dr. Soeradji Tirtonegoro Klaten. Berdasarkan studi tersebut ditemukan kejadian ROTD dengan kategori probable (besar kemungkinan), possible (mungkin) dan doubtful (meragukan). Diduga besar kemungkinan obat anti hipertensi telah menimbulkan reaksi disfungsi ereksi, dan frekuensi ekskresi urin, serta mungkin menyebabkan mual. Masing-masing manifestasi ditemukan kepada sejumlah 2,8% subyek penelitian

PERANCANGAN BUKU “KEDIRI, HERITAGE AND NATURE IN HARMONY” SEBAGAI MEDIA PROMOSI WISATA KEDIRI RAYA UNTUK MENDUKUNG PROGRAM CITY BRANDING

ABSTRAK Santoso, Donny Setiyo Budi. 2014. Perancangan Buku”Kediri, Heritage and Nature in Harmony“ Sebagai Media Promosi Wisata Kediri Raya Untuk Mendukung Program City Branding. Skripsi, Program Studi Desain Komunikasi Visual,Jurusan Seni danDesain, Fakultas Sastra, Universitas Negeri Malang. Pembimbing: (I)Rudi Irawanto, S.Pd, M.Sn, (II) Andreas Syah PahleviS.Sn.,M.Sn. Kata Kunci : Perancangan, Buku Wisata, Media Promosi, Kediri Raya, City Branding. Kediri Raya merupakan daerah yang terdiri dari wilayah Kabupaten dan Kota. Kediri Raya salah satu daerah yang mempunyai potensi pariwisata yang sangat tinggi dan dapat dikembangkan menjadi salah satu potensi wisata di Jawa Timur. Sangat disayangkan apabila potensi tersebut tidak di ketahui oleh khalayak orang banyak, khusunya para wisatawan sehingga dibutuhkan media promosi yang tepat untuk memberikan informasi secara lengkap dan informative mengenai potensi–potensi pariwisata yang berada di Kediri Raya. Untuk menjawab permasalahan tersebut dibutuhkan media promosi buku“ Kediri, heritage and nature in harmony” sebagai media promosi wisata di Kediri Raya., yang nantinya akan memudahkan para wisatawan untuk mengetahui potensi pari wisata Kediri Raya. Model perancangan yang digunakan dalam perancangan buku“ Kediri, heritage and nature in harmony” sebagai media promosi wisata di Kediri Rayaini adalah model perancangan prosedural yaitu yang bersifat deskritif, dimana harus mengikuti langkah – langkah yang harus di lakukan untuk menghasilkan sebuah produk. Sedangkan dalam menentukan identitas suatu daerah langkah pertama adalah melakukan identifikasi data sejarah dari pengelola, visi dan misi, struktur entitas, lokasi dan kontakentitas, kultur, nilai-nilai yang dikandung, keunggulan dan kelemahan, target pasar, identitas serta menganalisa data yang menghasilkan kata-kata kunci (keywords). Produk yang dihasilkan dalam perancangan ini adalah berupa buku“Kediri, heritage and nature in harmony” sebagai media promosi wisata di Kediri Raya. Buku ini berukuran 21 x 21cm dengan jumlah 84 halaman, cetak full color, bahan dari art paper 150 grm untuk isi dan 230 grm untuk cover berisi tentang objek – objek wisata yang ada di Kediri Raya , meliputi objek wisata sejarah, alam, seni budaya , liburan, kerajinan, kuliner dan objek yang mendukung adanya pariwisata tersebut, seperti rekomendasi penginapan dan transportasi. Buku ini diharapkan dapat mengenalkan dan mudahkan parawisatawan mengetahui potensi wisata Kediri Ray

Antecedents of willingness to provide pharmaceutical services for mental illness individuals

Pharmacists play a role in providing health care for mental illness patients such as medication management, providing drug information, medication counseling, and facilitating treatment adherence strategies. This study aimed to determine the effect of stigma, attitude and belief on the willingness to provide pharmaceutival services for mental illness individuals. This study design is a quantitative correlational study with a cross sectional approach. The sampling technique in this study used a purposive sampling approach. The sample used was 376 respondents with the inclusion criteria of undergraduate and diploma pharmacy students in Central Java, Indonesia. Data analysis were conducted in structural equation modeling - partial least square (SEM-PLS). The statistical results showed that attitudes had a positive effect on the willingness of pharmacy students to provide pharmaceutical services for mental illness individuals (p<0.05). However, stigma and belief do not affect the willingness of pharmacy students to provide pharmaceutical services for mental illness individuals (p>0.05). This study suggested conducting learning evaluations such as improving mental health literacy and interdisciplinary collaboration

The Weight Performance Stability of Mice on Modeling Obesity-Associated Hyperglycemia Induced by Dextrose Monohydrate

Previously, streptozotocin and alloxan were employed to imitate hyperglycemia in mice. High doses of sucrose were also induced as an alternative. Due to body mass index has been associated with hyperglycemia, the evidence of weight body index in various induction alternate kinds, however, have not been fully reported. Here-in, we report on the weight performance stability of mice body weight induced by dextrose, streptozotocin, and alloxan. To begin, all mice were divided into six groups of five, with one reserve in each. Following seven days of acclimatization, the mice were induced for nine days of hyperglycemia modeling; alloxan (Groups A and D), streptozotocin (Group B and E), dextrose monohydrate (Groups C and F). On preclinical research animals modelling related to obesity-associated hyperglycemia in mice, dextrose monohydrate induction was most successful than streptozocotin and alloxan induction, which performed best during the induction period (31% weight growth) and after metformin intervention (36% weight growth). Overall, dextrose monohydrate is most suitable to be used for modeling type 2 diabetes mellitus test animals rather than alloxan and streptozocotin