Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity

The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) enhances oxidative metabolism in skeletal muscle. Excessive lipid oxidation and electron transport chain activity can, however, lead to the accumulation of harmful metabolites and impair glucose homeostasis. Here, we investigated the effect of over-expression of PGC-1α on metabolic control and generation of insulin desensitizing agents in extensor digitorum longus (EDL), a muscle that exhibits low levels of PGC-1α in the untrained state and minimally relies on oxidative metabolism. We demonstrate that PGC-1α induces a strictly balanced substrate oxidation in EDL by concomitantly promoting the transcription of activators and inhibitors of lipid oxidation. Moreover, we show that PGC-1α enhances the potential to uncouple oxidative phosphorylation. Thereby, PGC-1α boosts elevated, yet tightly regulated oxidative metabolism devoid of side products that are detrimental for glucose homeostasis. Accordingly, PI3K activity, an early phase marker for insulin resistance, is preserved in EDL muscle. Our findings suggest that PGC-1α coordinately coactivates the simultaneous transcription of gene clusters implicated in the positive and negative regulation of oxidative metabolism and thereby increases metabolic flexibility. Thus, in mice fed a normal chow diet, over-expression of PGC-1α does not alter insulin sensitivity and the metabolic adaptations elicited by PGC-1α mimic the beneficial effects of endurance training on muscle metabolism in this context

Hydrogen storage in the form of metal hydrides

Reversible reactions between hydrogen and such materials as iron/titanium and magnesium/ nickel alloy may provide a means for storing hydrogen fuel. A demonstration model of an iron/titanium hydride storage bed is described. Hydrogen from the hydride storage bed powers a converted gasoline electric generator

On FRW Model in Conformal Teleparallel Gravity

In this paper we use the conformal teleparallel gravity to study an isotropic and homogeneous Universe which is settled by the FRW metric. We solve the field equations and we obtain the behavior of some cosmological parameters such as scale factor, deceleration parameter and the energy density of the perfect fluid which is the matter field of our model. The field equations, that we called modified Friedmann equations, allow us to define a dark fluid, with dark energy density and dark pressure, responsible for the acceleration in the Universe.Comment: Accepted in EPJ

Bifurcations in the theory of current transfer to cathodes of dc discharges and observations of transitions between different modes

General scenarios of transitions between different spot patterns on electrodes of dc gas discharges and their relation to bifurcations of steady-state solutions are analyzed. In the case of cathodes of arc discharges, it is shown that any transition between different modes of current transfer is related to a bifurcation of steady-state solutions. In particular, transitions between diffuse and spot modes on axially symmetric cathodes, frequently observed in the experiment, represent an indication of the presence of pitchfork or fold bifurcations of steady-state solutions. Experimental observations of transitions on cathodes of dc glow microdischarges are analyzed and those potentially related to bifurcations of steady-state solutions are identified. The relevant bifurcations are investigated numerically and the computed patterns are found to conform to those observed in the course of the corresponding transitions in the experiment

On the functional form of the metallicity-giant planet correlation

It is generally accepted that the presence of a giant planet is strongly dependent on the stellar metallicity. A stellar mass dependence has also been investigated, but this dependence does not seem as strong as the metallicity dependence. Even for metallicity, however, the exact form of the correlation has not been established. In this paper, we test several scenarios for describing the frequency of giant planets as a function of its host parameters. We perform this test on two volume-limited samples (from CORALIE and HARPS). By using a Bayesian analysis, we quantitatively compared the different scenarios. We confirm that giant planet frequency is indeed a function of metallicity. However, there is no statistical difference between a constant or an exponential function for stars with subsolar metallicities contrary to what has been previously stated in the literature. The dependence on stellar mass could neither be confirmed nor be discarded.Comment: 5 pages, 2 figures, accepted in A&

ARES v2 - new features and improved performance

Aims: We present a new upgraded version of ARES. The new version includes a series of interesting new features such as automatic radial velocity correction, a fully automatic continuum determination, and an estimation of the errors for the equivalent widths. Methods: The automatic correction of the radial velocity is achieved with a simple cross-correlation function, and the automatic continuum determination, as well as the estimation of the errors, relies on a new approach to evaluating the spectral noise at the continuum level. Results: ARES v2 is totally compatible with its predecessor. We show that the fully automatic continuum determination is consistent with the previous methods applied for this task. It also presents a significant improvement on its performance thanks to the implementation of a parallel computation using the OpenMP library.Comment: 4 pages, 2 Figures; accepted in A&A; ARES Webpage: www.astro.up.pt/~sousasag/are