Terminologia e tradução de textos especializados : da equivalência conceptual às convenções fraseológicas

Livro de homenagem à professora Maria Emília Ricardo Marque

Especificidades de um discurso

Livro de homenagem à professora Maria Emília Ricardo Marque

Determination of Acrylamide in Portuguese Bread by UPLC-MS/MS: metrological and chemometric tools

Acrylamide (AA) is known for its potential health hazards and it is present in processed potatoes, coffee, and bread. Wheat is still the most important cereal for bread making, however, the interest in its substitution by other grains is growing due to the consumer demand for novels and healthy foods, like oat and rye flour. The aim of this study was to analyze the AA content of confectioned bread in fifty-four different pastries and make an association of acrylamide contents and the place of production to identify the quality of the flour used. There was a wide variability in AA levels among different breads and within different bread varieties. The median of AA values was 787 μg/kg for whole grain bread, 783 μg/kg for oat bread and 253 μg/kg in rye bread. With the cluster analysis, it was possible to conclude that besides the factors like baking temperature-time and fermentation time which affects AA formation in bread products, several other parameters such as the formulation, flour quality and the varieties of processing techniques, among others, play a crucial role in the AA formation.MISAGE project (LISBOA-01-0145-FEDER-024172). This project has received financial support from the Fundação para a Ciência e a Tecnologia (FCT), Portugal. This work was supported by ELEMENTARIA-2013DAN850 project.info:eu-repo/semantics/publishedVersio

SÍNDROME DO ENVELHECIMENTO PRECOCE BUCAL: UMA REVISÃO BIBLIOGRÁFICA

The Premature Oral Aging Syndrome (POAS) is a major challenge in dentistry, mainly due to its multifactorial clinical characteristics that are responsible for its enormous complexity, requiring a multidisciplinary approach. Some of the etiological agents can be classified into: acid diet, psychiatric disorders, gastrointestinal diseases and sleep disorders. The clinical characteristics of the lesions are associated with the etiological factors present and with the stage of the lesion. The objective of this present study was to carry out a bibliographic review about the Premature Oral Aging Syndrome, its diagnosis, clinical manifestations, prevention and treatment. The literature review was carried out with searches in books and in the databases Pubmed, Scielo, BVS, REVodonto and other scientific annals, using the keywords: premature aging, dental wear and dental erosion. It is concluded that SEPB is the clinical manifestation of accelerated aging of the oral cavity and stomatognathic system, presenting a state of clinical non-normality of oral structures, with characteristics incompatible with the physiological (chronological) age of the individual, caused by systemic diseases of different origins, influence of new habits and/or lifestyle changes.El Síndrome de Envejecimiento Oral Prematuro (SEOP) constituye un gran desafío en odontología, principalmente por sus características clínicas multifactoriales que son responsables de su enorme complejidad, requiriendo un abordaje multidisciplinario. Algunos de los agentes etiológicos se pueden clasificar en: dieta ácida, trastornos psiquiátricos, enfermedades gastrointestinales y trastornos del sueño. Las características clínicas de las lesiones están asociadas con los factores etiológicos presentes y el estadio en el que se encuentra la lesión. El objetivo del presente estudio fue realizar una revisión bibliográfica sobre el Síndrome de Envejecimiento Oral Prematuro, su diagnóstico, manifestaciones clínicas, prevención y tratamiento. La revisión de la literatura se realizó con búsquedas en libros y bases de datos Pubmed, Scielo, BVS, REVodonto y otros anales científicos, utilizando las palabras clave: envejecimiento prematuro, desgaste dental y erosión dental. Se concluye que la SEPB es la manifestación clínica del envejecimiento acelerado de la cavidad bucal y del sistema estomatognático, presentando un estado de no normalidad clínica de las estructuras bucales, con características incompatibles con la edad fisiológica (cronológica) del individuo, causada por enfermedades sistémicas de diferente origen, influencia de nuevos hábitos y/o cambios en el estilo de vida.A Síndrome do Envelhecimento Precoce Bucal (SEPB) é um grande desafio na odontologia, principalmente pelas suas características clínicas multifatoriais que são responsáveis por sua enorme complexidade, precisando de uma abordagem multiprofissional. Alguns dos agentes etiológicos podem ser classificados em: dieta ácida, transtornos psiquiátricos, doenças gastrointestinais e distúrbios do sono. As características clínicas das lesões estão associadas aos fatores etiológicos presentes e com a etapa que a lesão se encontra. O objetivo deste presente estudo foi realizar uma revisão bibliográfica acerca da Síndrome do envelhecimento precoce bucal, seu diagnóstico, manifestações clínicas, prevenção e tratamento. A revisão de literatura foi realizada com buscas em livros e nas bases de dados Pubmed, Scielo, BVS, REVodonto e outros anais científicos, utilizando as palavras-chaves: envelhecimento precoce, desgaste dentário e erosão dentária. Conclui-se que a SEPB é a manifestação clínica do envelhecimento acelerado da cavidade bucal e do sistema estomatognático, apresentando estado de não normalidade clínica das estruturas bucais, com características incompatíveis com a idade fisiológica (cronológica) do indivíduo, provocada por doenças sistêmicas de diferentes origens, influência de novos hábitos e/ou mudança de estilo de vida

The Expression of NTAL and Its Protein Interactors Is Associated With Clinical Outcomes in Acute Myeloid Leukemia

Non–T cell activation linker (NTAL) membrane protein depletion from lipid rafts by alkylphospholipids or downregulation by shRNA knockdown decreases cell viability through regulation of the Akt/PI3K pathway in mantle cell lymphoma and acute promyelocytic leukemia cells. Here, we confirmed that the knockdown of NTAL in acute myeloid leukemia (AML) cell lines was associated with decreased cell proliferation and survival. Similarly, a xenograft model using AML cells transduced with NTAL–shRNA and transplanted into immunodeficient mice led to a 1.8-fold decrease in tumor burden. Using immunoprecipitation, LC–MS/MS analysis, and label-free protein quantification, we identified interactors of NTAL in two AML cell lines. By evaluating the gene expression signatures of the NTAL protein interactors using the PREdiction of Clinical Outcomes from Genomic Profiles database, we found that 12 NTAL interactors could predict overall survival in AML, in at least two independent cohorts. In addition, patients with AML exhibiting a high expression of NTAL and its interactors were associated with a leukemic granulocyte–macrophage progenitor–like state. Taken together, our data provide evidence that NTAL and its protein interactors are relevant to AML cell proliferation and survival and represent potential therapeutic targets for granulocyte–macrophage progenitor–like leukemias

ANÁLISE DOS DESAFIOS ENFRENTADOS PELO CIRURGIÃO-DENTISTA NO ATENDIMENTO DE PACIENTES COM TRANSTORNO DO ESPECTRO AUTISTA

Introduction: Autism or Autism Spectrum Disorder (ASD), is considered a behavioral neurodevelopmental syndrome. It is characterized by changes that affect behavior, communication and social interaction. Dental care for ASD patients is challenging due to repetitive behavioral patterns, communication difficulties, and refusal to follow commands. Objective: To review in the literature the importance of access to dental treatment for patients with ASD in Brazil and the challenges faced by professionals. Methodology: Literature searches were conducted in LILACS and PUBMED during March and April 2023. With the inclusion criteria, classic articles and ordinances that express correlation to the theme, in English and Portuguese. Publications that did not contemplate the methodological proposal were excluded, as well as course conclusion papers, dissertations and theses. Result: 84 studies were selected, eliminating 74 articles that did not fit the theme of the review, totaling 10 articles for the study. Conclusion: Patients with ASD need to be followed up by a multidisciplinary team. Parents and guardians have an essential role in supporting an autistic child, they can help ensure access to health and education. Dental treatment in patients with ASD is considered challenging for the dentist due to the associated difficulties.  Key words: Dentistry, Oral Health, Autism Spectrum Disorder. Introdução: O autismo ou Transtorno do Espectro Autista (TEA), é considerado uma síndrome comportamental de neurodesenvolvimento. Caracteriza-se por alterações que afeta o comportamento, a comunicação e a interação social. O atendimento odontológico para pacientes com TEA é desafiador devido aos padrões comportamentais repetitivos, dificuldades de comunicação e recusa em seguir comandos. Objetivo: Foi revisar na literatura a importância do acesso ao tratamento odontológico para pacientes com TEA no Brasil e os desafios enfrentados pelos profissionais. Metodologia: Foram realizadas pesquisas bibliográficas no LILACS e PUBMED durante março e abril de 2023. Com os critérios de inclusão, artigos clássicos e portarias que expressão correlação ao tema, nos idiomas inglês e português. Sendo excluídas publicações que não contemplaram a proposta metodológica, bem como trabalhos de conclusão de curso, dissertações e teses. Resultado: 84 estudos foram selecionados, eliminando-se 74 artigos que não se enquadravam no tema da revisão, totalizando 10 artigos para o estudo. Conclusão: Pacientes com TEA, precisam ser acompanhados por uma equipe multidisciplinar. Os pais e responsáveis têm um papel essencial no apoio a uma criança autista, eles podem ajudar a garantir o acesso à saúde e educação. O tratamento odontológico em pacientes com TEA é considerado desafiador para o cirurgião-dentista, devido às dificuldades associadas.  &nbsp

Crise sócioeconômica e processo de trabalho : à busca de uma relação teórica

Acesso ao livro na íntegra no endereço: http://acesso.mte.gov.br/data/files/8A7C816A2E7311D1012FEAA3403E09B2/TrabalhonaCapital.pdf.Este capítulo propõe-se a explorar questões como estas e suscitar hipóteses sobre a relação teórica das crises capitalistas com mudanças na organização do processo de trabalho, entendidas como tentativas de reorganizar o trabalho em função da crise, estratégias que permitam ao capital contornar a crise e voltar a trilhar os caminhos da acumulação, conduzindo possivelmente a novas formas de exploração do trabalho e de produção da mais-valia absoluta e relativa

New records and detailed distribution and abundance of selected arthropod species collected between 1999 and 2011 in Azorean native forests

[Background] In this contribution we present detailed distribution and abundance data for arthropod species identified during the BALA ¿ Biodiversity of Arthropods from the Laurisilva of the Azores (1999-2004) and BALA2 projects (2010-2011) from 18 native forest fragments in seven of the nine Azorean islands (all excluding Graciosa and Corvo islands, which have no native forest left).[New information] Of the total 286 species identified, 81% were captured between 1999 and 2000, a period during which only 39% of all the samples were collected. On average, arthropod richness for each island increased by 10% during the time frame of these projects. The classes Arachnida, Chilopoda and Diplopoda represent the most remarkable cases of new island records, with more than 30% of the records being novelties. This study stresses the need to expand the approaches applied in these projects to other habitats in the Azores, and more importantly to other less surveyed taxonomic groups (e.g. Diptera and Hymenoptera). These steps are fundamental for getting a more accurate assessment of biodiversity in the archipelago.AMCS was supported by a Marie Curie Intra-European Fellowship (IEF 331623 ‘COMMSTRUCT’) and by a Juan de la Cierva Fellowship (IJCI-2014-19502) funded by the Spanish ‘Ministerio de Economía y Competitividad’.Peer Reviewe

Building a Portuguese Coalition for Biodiversity Genomics

The diverse physiography of the Portuguese land and marine territory, spanning from continental Europe to the Atlantic archipelagos, has made it an important repository of biodiversity throughout the Pleistocene glacial cycles, leading to a remarkable diversity of species and ecosystems. This rich biodiversity is under threat from anthropogenic drivers, such as climate change, invasive species, land use changes, overexploitation or pathogen (re)emergence. The inventory, characterization and study of biodiversity at inter- and intra-specific levels using genomics is crucial to promote its preservation and recovery by informing biodiversity conservation policies, management measures and research. The participation of researchers from Portuguese institutions in the European Reference Genome Atlas (ERGA) initiative, and its pilot effort to generate reference genomes for European biodiversity, has reinforced the establishment of Biogenome Portugal. This nascent institutional network will connect the national community of researchers in genomics. Here, we describe the Portuguese contribution to ERGA’s pilot effort, which will generate high-quality reference genomes of six species from Portugal that are endemic, iconic and/or endangered, and include plants, insects and vertebrates (fish, birds and mammals) from mainland Portugal or the Azores islands. In addition, we outline the objectives of Biogenome Portugal, which aims to (i) promote scientific collaboration, (ii) contribute to advanced training, (iii) stimulate the participation of institutions and researchers based in Portugal in international biodiversity genomics initiatives, and (iv) contribute to the transfer of knowledge to stakeholders and engaging the public to preserve biodiversity. This initiative will strengthen biodiversity genomics research in Portugal and fuel the genomic inventory of Portuguese eukaryotic species. Such efforts will be critical to the conservation of the country’s rich biodiversity and will contribute to ERGA’s goal of generating reference genomes for European species.info:eu-repo/semantics/publishedVersio