Female fertility and environmental pollution

A realistic picture of our world shows that it is heavily polluted everywhere. Coastal regions and oceans are polluted by farm fertilizer, manure runoff, sewage and industrial discharges, and large isles of waste plastic are floating around, impacting sea life. Terrestrial ecosystems are contaminated by heavy metals and organic chemicals that can be taken up by and accumulate in crop plants, and water tables are heavily contaminated by untreated industrial discharges. As deadly particulates can drift far, poor air quality has become a significant global problem and one that is not exclusive to major industrialized cities. The consequences are a dramatic impairment of our ecosystem and biodiversity and increases in degenerative or man-made diseases. In this respect, it has been demonstrated that environmental pollution impairs fertility in all mammalian species. The worst consequences are observed for females since the number of germ cells present in the ovary is fixed during fetal life, and the cells are not renewable. This means that any pollutant affecting hormonal homeostasis and/or the reproductive apparatus inevitably harms reproductive performance. This decline will have important social and economic consequences that can no longer be overlooked

Finite State Automata As Conceptual Model for e-Service

Recently, a plethora of languages for modeling and specifying different facets of e-Services have been proposed, and some of them provide constructs for representing time. Time is needed in many contexts to correctly capture the dynamics of transactions and of composability between e-Services. However, to the best of our knowledge, all the proposed languages for representing e-Service behavior and temporal constraints lack both a clear semantics and an underlying conceptual model. In this paper, we propose a conceptual representation of e-Service behavior, taking time constraints into account, and a new XML-based language, namely WSTL (WEB SERVICE TRANSITION LANGUAGE), that integrates well with standard languages in order to completely specify e-Services. In particular, WSTL allows for specifying an e-Service starting from its conceptual representation, in a straightforward way

One-step replica symmetry breaking solution of the quadrupolar glass model

We consider the quadrupolar glass model with infinite-range random interaction. Introducing a simple one-step replica symmetry breaking ansatz we investigate the para-glass continuous (discontinuous) transition which occurs below (above) a critical value of the quadrupole dimension m*. By using a mean-field approximation we study the stability of the one-step replica symmetry breaking solution and show that for m>m* there are two transitions. The thermodynamic transition is discontinuous but there is no latent heat. At a higher temperature we find the dynamical or glass transition temperature and the corresponding discontinuous jump of the order parameter.Comment: 10 pages, 3 figure

Classification of ductile cast iron specimens based on image analysis and support vector machine

The ductile irons discovery in 1948 gave a new lease on life to the cast iron family. In fact, these cast irons are characterized both by a high castability and by high toughness values, combining cast irons and steel good properties. The high mechanical properties (especially ductility) are mainly due to the peculiar graphite elements shape: thanks to the addition of some elements like Mg, Ca, Ce, graphite elements shape can be near to spheres (nodules) instead to lamellae as in "normal" grey cast irons. In this work, the problem of classification of ductile cast irons specimens is addressed; first the nodules present in each specimen are identified determining their morphological shapes. These characteristics are suitable used to extract global features of the specimen. Then it is outlined a procedure to train a classifier based of these properties

Aneurysmal bone cyst of the nasal bone: case report

The aneurysmal bone cyst (ABC) is a solitary, expansile, non-neoplastic bone lesion, described as a distinct clinicopathological entity by Jaffe and Lichtenstein. We report a case of an ABC arising from the nasal bone in a adult male patient treated with complete surgical excision

Magnetic transfer function entropy and the 2009 Mw = 6.3 L'Aquila earthquake (Central Italy)

Abstract. With the aim of obtaining a deeper knowledge of the physical phenomena associated with the 2009 L'Aquila (Central Italy) seismic sequence, culminating with a Mw = 6.3 earthquake on 6 April 2009, and possibly of identifying some kind of earthquake-related magnetic or geoelectric anomaly, we analyse the geomagnetic field components measured at the magnetic observatory of L'Aquila and their variations in time. In particular, trends of magnetic transfer functions in the years 2006–2010 are inspected. They are calculated from the horizontal to vertical magnetic component ratio in the frequency domain, and are very sensitive to deep and lateral geoelectric characteristics of the measurement site. Entropy analysis, carried out from the transfer functions with the so called transfer function entropy, points out clear temporal burst regimes of a few distinct harmonics preceding the main shock of the seismic sequence. A possible explanation is that they could be related to deep fluid migrations and/or to variations in the micro-/meso-fracturing that affected significantly the conductivity (ordered/disordered) distribution in a large lithospheric volume under the seismogenic layer below L'Aquila area. This interpretation is also supported by the analysis of hypocentres depths before the main shock occurrence

Neoadjuvant eribulin mesylate following anthracycline and taxane in triple negative breast cancer: Results from the HOPE study

Background Eribulin mesylate (E) is indicated for metastatic breast cancer patients previously treated with anthracycline and taxane. We argued that E could also benefit patients eligible for neoadjuvant chemotherapy. Methods Patients with primary triple negative breast cancer 2 cm received doxorubicin 60 mg/m2 and paclitaxel 200 mg/m2 x 4 cycles (AT) followed by E 1.4 mg/m2 x 4 cycles. Primary endpoint was pathological complete response (pCR) rate; secondary and explorative endpoints included clinical/metabolic response rates and safety, and biomarker analysis, respectively. Using a two-stage Simon design, 43 patients were to be included provided that 4 of 13 patients had achieved pCR in the first stage of the study. Results In stage I of the study 13 women were enrolled, median age 43 years, tumor size 2–5 cm in 9/13 (69%), positive nodal status in 8/13 (61%). Main grade 3 adverse event was neutropenia (related to AT and E in 4 and 2 cases, respectively). AT followed by E induced clinical complete + partial responses in 11/13 patients (85%), pCR in 3/13 (23%). Median measurements of maximum standardized uptake value (SUVmax) resulted 13, 3, and 1.9 at baseline, after AT and E, respectively. Complete metabolic response (CMR) occurred after AT and after E in 2 and 3 cases, respectively. Notably, 2 of the 5 (40%) patients with CMR achieved pCR at surgery. Immunostaining of paired pre-/post-treatment tumor specimens showed a reduction of β-catenin, CyclinD1, Zeb-1, and c-myc expression, in the absence of N-cadherin modulation. The study was interrupted at stage I due to the lack of the required patients with pCR. Conclusions Despite the early study closure, preoperative E following AT showed clinical and biological activity in triple negative breast cancer patients. Furthermore, the modulation of β-catenin pathway core proteins, supposedly outside the domain of epithelial–mesenchymal transition, claims for further investigation. Trial registration EU Clinical Trial Register, EudraCT number 2012-004956-12

Growth inhibition of human ovarian carcinoma by a novel AvidinOX-anchored biotinylated camptothecin derivative

Oxidized form of avidin, named AvidinOX, provides stable fixation of biotinylated molecules in tissues thus representing a breakthrough in topical treatment of cancer. AvidinOX proved to be a stable receptor for radiolabeled biotin, biotinylated antibodies and cells. In order to expand applicability of the AvidinOX-based delivery platform, in the present study we investigated the possibility to hold biotinylated chemotherapeutics in AvidinOX-treated sites. A novel biotinylated gimatecan-derived camptothecin, coded ST8161AA1, was injected at suboptimal doses into human tumors xenografted in mice alone or pre-complexed to AvidinOX. Significantly higher growth inhibition was observed when the drug was anchored to AvidinOX suggesting the potential utility of this delivery modality for the local treatment of inoperable tumors

Magnetic transfer function entropy and the 2009 Mw = 6.3 L’Aquila earthquake (Central Italy)

With the aim of obtaining a deeper knowledge of the physical phenomena associated with the 2009 L’Aquila (Central Italy) seismic sequence, culminating with a Mw = 6.3 earthquake on 6 April 2009, and possibly of identifying some kind of earthquake-related magnetic or geoelectric anomaly, we analyse the geomagnetic field components measured at the magnetic observatory of L’Aquila and their variations in time. In particular, trends of magnetic transfer functions in the years 2006–2010 are inspected. They are calculated from the horizontal to vertical magnetic component ratio in the frequency domain, and are very sensitive to deep and lateral geoelectric characteristics of the measurement site. Entropy analysis, carried out from the transfer functions with the so called transfer function entropy, points out clear temporal burst regimes of a few distinct harmonics preceding the main shock of the seismic sequence. A possible explanation is that they could be related to deep fluid migrations and/or to variations in the micro-/meso-fracturing that affected significantly the conductivity (ordered/disordered) distribution in a large lithospheric volume under the seismogenic layer below L’Aquila area. This interpretation is also supported by the analysis of hypocentres depths before the main shock occurrence