Mieloma no secretor

A non-secretory myeloma is an exceptional form of myeloma (1% of cases). It is a subtype that does not present mono-clonal gammopathy in serum or urine. The study of free light chains in serum is also negative. Bone fragility and bone pain, mainly if associated with anemia, hypercalcemia, and kidney failure, suggest its presence. We present a 76-year-old woman with vertebral compression fractures and diffuse bone pain, finally diagnosed with advanced non-secretory myeloma. This case intends to raise awareness about a rare entity to make an early diagnosis and treatment.El mieloma no secretor constituye una forma excepcional de mieloma (1% de los casos). Se trata de un subtipo que no presenta pico monoclonal ni en suero ni en orina. El estudio de cadenas ligeras libres en suero también resulta negativo. La fragilidad ósea y dolor óseo, especialmente si asocian anemia, hipercalcemia e insuficiencia renal, orientan hacia su existencia. Se presenta el caso de una mujer de 76 años con aplastamientos vertebrales y dolor óseo difuso finalmente diagnosticada de mieloma no secretor en fase avanzada. De esta forma, se pretende concienciar sobre la existencia para un diagnóstico y tratamiento precoces.

Estrategias de inserción laboral y de emprendimiento a través de las Prácticas Externas del Grado en Historia del Arte

Visibilidad de las Prácticas Externas como medio eficaz y necesario para la formación académica y el futuro laboral del alumnado. Mediante las experiencias de otros/as compañeros/as que ya las han realizado e instituciones ofertadas.Depto. de Historia del ArteFac. de Geografía e HistoriaFALSEOficina para la Calidad, UCMsubmitte

Clinical validation of risk scoring systems to predict risk of delayed bleeding after EMR of large colorectal lesions

[Background and Aims]: The Endoscopic Resection Group of the Spanish Society of Endoscopy (GSEED-RE) model and the Australian Colonic Endoscopic Resection (ACER) model were proposed to predict delayed bleeding (DB) after EMR of large superficial colorectal lesions, but neither has been validated. We validated and updated these models.[Methods]: A multicenter cohort study was performed in patients with nonpedunculated lesions ≥20 mm removed by EMR. We assessed the discrimination and calibration of the GSEED-RE and ACER models. Difficulty performing EMR was subjectively categorized as low, medium, or high. We created a new model, including factors associated with DB in 3 cohort studies.[Results]: DB occurred in 45 of 1034 EMRs (4.5%); it was associated with proximal location (odds ratio [OR], 2.84; 95% confidence interval [CI], 1.31-6.16), antiplatelet agents (OR, 2.51; 95% CI, .99-6.34) or anticoagulants (OR, 4.54; 95% CI, 2.14-9.63), difficulty of EMR (OR, 3.23; 95% CI, 1.41-7.40), and comorbidity (OR, 2.11; 95% CI, .99-4.47). The GSEED-RE and ACER models did not accurately predict DB. Re-estimation and recalibration yielded acceptable results (GSEED-RE area under the curve [AUC], .64 [95% CI, .54-.74]; ACER AUC, .65 [95% CI, .57-.73]). We used lesion size, proximal location, comorbidity, and antiplatelet or anticoagulant therapy to generate a new model, the GSEED-RE2, which achieved higher AUC values (.69-.73; 95% CI, .59-.80) and exhibited lower susceptibility to changes among datasets.[Conclusions]: The updated GSEED-RE and ACER models achieved acceptable prediction levels of DB. The GSEED-RE2 model may achieve better prediction results and could be used to guide the management of patients after validation by other external groups. (Clinical trial registration number: NCT 03050333.)Research support for this study was received from “La Caixa/Caja Navarra” Foundation (ID 100010434;project PR15/11100006)

New ABA-Hypersensitive Arabidopsis Mutants Are Affected in Loci Mediating Responses to Water Deficit and Dickeya dadantii Infection

On water deficit, abscisic acid (ABA) induces stomata closure to reduce water loss by transpiration. To identify Arabidopsis thaliana mutants which transpire less on drought, infrared thermal imaging of leaf temperature has been used to screen for suppressors of an ABA-deficient mutant (aba3-1) cold-leaf phenotype. Three novel mutants, called hot ABA-deficiency suppressor (has), have been identified with hot-leaf phenotypes in the absence of the aba3 mutation. The defective genes imparted no apparent modification to ABA production on water deficit, were inherited recessively and enhanced ABA responses indicating that the proteins encoded are negative regulators of ABA signalling. All three mutants showed ABA-hypersensitive stomata closure and inhibition of root elongation with little modification of growth and development in non-stressed conditions. The has2 mutant also exhibited increased germination inhibition by ABA, while ABA-inducible gene expression was not modified on dehydration, indicating the mutated gene affects early ABA-signalling responses that do not modify transcript levels. In contrast, weak ABA-hypersensitivity relative to mutant developmental phenotypes suggests that HAS3 regulates drought responses by both ABA-dependent and independent pathways. has1 mutant phenotypes were only apparent on stress or ABA treatments, and included reduced water loss on rapid dehydration. The HAS1 locus thus has the required characteristics for a targeted approach to improving resistance to water deficit. In contrast to has2, has1 exhibited only minor changes in susceptibility to Dickeya dadantii despite similar ABA-hypersensitivity, indicating that crosstalk between ABA responses to this pathogen and drought stress can occur through more than one point in the signalling pathway

EscriVid 2020. Reflexiones y escrituras en torno a pandemia(s) y asilamiento(s)

La publicación de EscriVid 2020. Reflexiones en torno a pandemia(s) y aislamiento(s), ha sido posible gracias al trabajo de las coordinadoras del volumen, Guadalupe Reinoso y Alicia Vaggione, especialmente convocadas por el Área de Publicaciones de la Facultad de Filosofía y Humanidades de la Universidad Nacional de Córdoba para esta tarea. Ha sido posible también gracias al trabajo de María Angélica Bella que estuvo a cargo del diseño de interior, de Manuel Coll que estuvo a cargo del diseño de las imágenes y del diseño de tapa y al trabajo impecable (y muy respetuoso) de corrección que hicieron Florencia Colombetti y Lucía Bima. Ha sido posible también gracias al interés deseante de lxs autorxs puestos a estudiar, leer, pensar, escribir. La Oficina de Conocimiento Abierto ha registrado en este Repositorio el aporte de cada autor / autora disponiendo los metadatos que identifican a cada trabajo y el acceso a los textos completos de cada uno de ellos.Fil: Reinoso, Guadalupe. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Filosofía; Argentina.Fil: Reinoso, Guadalupe. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Centro de Investigaciones Maria Saleme Burnichón; Argentina.Fil: Reinoso, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Vaggione, Alicia. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades; Argentina.Fil: Vaggione, Alicia. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina

Matemáticas : complementos de formación disciplinar

Resumen basado en el de la publicaciónSe ofrece una visión rápida y sintética del currículo de Matemáticas en la Educación Secundaria Obligatoria. Se exponen las diferentes ramas de las Matemáticas que se estudian y también, se complementan y revisan los contenidos matemáticos que se imparten en los currículos educativos. La competencia docente se basa en un conocimiento de los contenidos que hay que trabajar en el aula. Las actividades que se incorporan tienen la finalidad de colaborar en la construcción de ese conocimiento necesario para el desarrollo profesional.CataluñaBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín, 5 - 3 planta; 28014 Madrid; Tel. +34917748000; [email protected]

Corticosteroid Injection for the Treatment of Morton's Neuroma: a Prospective, Double-Blinded, Randomized, Placebo-Controlled Trial

BACKGROUND: The effectiveness of corticosteroid injection for the treatment of Morton's neuroma is unclear. In addition, most of the studies related to it are case-control or retrospective case series. The purpose of this study was to compare the effectiveness between corticosteroid injection associated with local anesthetic and local anesthetic alone (placebo control group) for the treatment of Morton's neuroma. METHODS: Forty-one patients with a diagnosis of Morton's neuroma were randomized to receive 3 injections of either a corticosteroid plus a local anesthetic or a local anesthetic alone. The patients and the researcher who collected data were blinded to the treatment groups. The visual analog scale for pain and the American Orthopaedic Foot & Ankle Score (metatarsophalangeal/interphalangeal score) were obtained at baseline, after each injection, and at 3 and 6 months after the last injection. RESULTS: There were no significant between-group differences in terms of pain and function improvement at 3 and 6 months after treatment completion in comparison with baseline values. At the end of the study, 17 (48.5%) patients requested surgical excision of the neuroma: 7 (44%) in the experimental group and 10 (53%) in the control group ( P = 1.0). CONCLUSION: The injection of a corticosteroid plus a local anesthetic was not superior to a local anesthetic alone in terms of pain and function improvement in patients with Morton's neuroma

Clip Closure After Resection of Large Colorectal Lesions With Substantial Risk of Bleeding

[Background & Aims]: It is not clear whether closure of mucosal defects with clips after colonic endoscopic mucosal resection (EMR) prevents delayed bleeding, although it seems to have no protective effects when risk is low. We performed a randomized trial to evaluate the efficacy of complete clip closure of large (≥2 cm) nonpedunculated colorectal lesions after EMR in patients with an estimated average or high risk of delayed bleeding.[Methods]: We performed a single-blind trial at 11 hospitals in Spain from May 2016 through June 2018, including 235 consecutive patients who underwent EMR for large nonpedunculated colorectal lesions with an average or high risk of delayed bleeding (based on Spanish Endoscopy Society Endoscopic Resection Group score). Participants were randomly assigned to groups that received closure of the scar with 11-mm through-the-scope clips (treated, n = 119) or no clip (control, n = 116). The primary outcome was proportion of patients in each group with delayed bleeding, defined as evident hematochezia that required medical intervention within 15 days after colonoscopy.[Results]: In the clip group, complete closure was achieved in 68 (57%) cases, with partial closure in 33 (28%) cases and failure to close in 18 (15%) cases. Delayed bleeding occurred in 14 (12.1%) patients in the control group and in 6 (5%) patients in the clip group (absolute risk difference, reduction of 7% in the clip group; 95% confidence interval, –14.7% to 0.3%). After completion of the clip closure, there was only 1 (1.5%) case of delayed bleeding (absolute risk difference, reduction of 10.6%; 95% confidence interval, –4.3% to 17.9%).[Conclusions]: In a randomized trial of patients with large nonpedunculated colorectal lesions undergoing EMR, we found that clip closure of mucosal defects in patients with a risk of bleeding can be a challenge, but also reduces delayed bleeding. Prevention of delayed bleeding required complete clip closure. ClinicalTrials.gov ID: NCT02765022.This work was supported by a grant from the Spanish Society of Digestive Endoscopy. Micro-Tech Endoscopy (Nanjing, China) contributed the clips needed for the study. The authors declare no conflicts of interest with this company or any other that relates to the topic addressed in this study. The first author received a grant from “La Caixa/Caja Navarra” Foundation (ID 100010434; Project PR15/11100006)