2,4-Bis(4-fluoro­phen­yl)-3-aza­bicyclo­[3.3.1]nonan-9-one

In the title compound, C20H19F2NO, a crystallographic mirror plane bis­ects the mol­ecule, passing through the N, O and two C atoms of the central ring system. The mol­ecule exists in a twin-chair conformation with equatorial dispositions of the 4-fluoro­phenyl groups on both sides of the secondary amino groups; the dihedral angle between the aromatic ring planes is 28.67 (3)°

2,4-Bis(3-chloro­phen­yl)-3-aza­bicyclo­[3.3.1]nonan-9-one

In the mol­ecular structure of the title compound, C20H19Cl2NO, the bicyclic system adopts a twin-chair conformation with equatorial orientations of both substituents. The dihedral angle between the aromatic rings is 43.60 (2)° with respect to each other. The crystal structure is stabilized by weak N—H⋯O and strong C—H⋯O inter­actions

Molecular survey and genetic characterization of tick-borne pathogens in dogs in metropolitan Recife (north-eastern Brazil).

To identify DNA of the main tick-borne pathogens in dogs from Recife (Brazil), polymerase chain reactions were carried out on blood samples of dogs treated at the Veterinary Hospital of the Universidade Federal Rural de Pernambuco from March 2007 to June 2008. The detection of DNA was performed using specific primers. Amplicons were analyzed through electrophoresis and sequencing. A phylogenetic tree was constructed using the UPGMA method, revealing that the sequences were closely related to those of strains from other geographic regions. Among the 205 blood samples analyzed, 48.78% was positive for Anaplasma platys; 38.04% was positive for Ehrlichia canis; 7.31% was positive for Babesia canis vogeli; and 0.49% was positive for Hepatozoon canis and Mycoplasma haemocanis. Coinfection of two or three pathogens was found in 23.9% (49/205) of the dogs. The subspecies B. canis vogeli was identified. Infection by H. canis and M. haemocanis is reported for the first time in dogs in the state of Pernambuco (Brazil). The data indicate that the main tick-borne pathogens in dogs in this region are E. canis and/or A. platys, followed by B. canis vogeli

Extending MAM5 Meta-Model and JaCalIVE Framework to Integrate Smart Devices from Real Environments

[EN] This paper presents the extension of a meta-model (MAM5) and a framework based on the model (JaCalIVE) for developing intelligent virtual environments. The goal of this extension is to develop augmented mirror worlds that represent a real and virtual world coupled, so that the virtual world not only reflects the real one, but also complements it. A new component called a smart resource artifact, that enables modelling and developing devices to access the real physical world, and a human in the loop agent to place a human in the system have been included in the meta-model and framework. The proposed extension of MAM5 has been tested by simulating a light control system where agents can access both virtual and real sensor/actuators through the smart resources developed. The results show that the use of real environment interactive elements (smart resource artifacts) in agent-based simulations allows to minimize the error between simulated and real system.This work is partially supported by the TIN2009-13839-C03-01, TIN2011-27652-C03-01, 547CSD2007-00022, COST Action IC0801, FP7-294931 and the FPI grant AP2013-01276 548 awarded to Jaime-Andres Rincon.Rincón Arango, JA.; Poza Luján, JL.; Julian Inglada, VJ.; Posadas Yagüe, JL.; Carrascosa Casamayor, C. (2016). Extending MAM5 Meta-Model and JaCalIVE Framework to Integrate Smart Devices from Real Environments. PLoS ONE. 11(2):1-27. https://doi.org/10.1371/journal.pone.0149665S127112Luck, M., & Aylett, R. (2000). Applying artificial intelligence to virtual reality: Intelligent virtual environments. Applied Artificial Intelligence, 14(1), 3-32. doi:10.1080/088395100117142Barella A, Ricci A, Boissier O, Carrascosa C. MAM5: Multi-Agent Model For Intelligent Virtual Environments. 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Stratégie pour la Durabilité Environnementales du Milieu Côtier Transfrontalier

En prens

Permanent Genetic Resources added to Molecular Ecology Resources Database 1 August 2010-30 September 2010

This article documents the addition of 229 microsatellite marker loci to the Molecular Ecology Resources Database. Loci were developed for the following species: Acacia auriculiformis × Acacia mangium hybrid, Alabama argillacea, Anoplopoma fimbria, Aplochiton zebra, Brevicoryne brassicae, Bruguiera gymnorhiza, Bucorvus leadbeateri, Delphacodes detecta, Tumidagena minuta, Dictyostelium giganteum, Echinogammarus berilloni, Epimedium sagittatum, Fraxinus excelsior, Labeo chrysophekadion, Oncorhynchus clarki lewisi, Paratrechina longicornis, Phaeocystis antarctica, Pinus roxburghii and Potamilus capax. These loci were cross-tested on the following species: Acacia peregrinalis, Acacia crassicarpa, Bruguiera cylindrica, Delphacodes detecta, Tumidagena minuta, Dictyostelium macrocephalum, Dictyostelium discoideum, Dictyostelium purpureum, Dictyostelium mucoroides, Dictyostelium rosarium, Polysphondylium pallidum, Epimedium brevicornum, Epimedium koreanum, Epimedium pubescens, Epimedium wushanese and Fraxinus angustifolia