Impact Of Ingrica Festival In The City Of Cuenca (Spain)

Ingrafica, International Festival of Contemporary Engraving City of Cuenca, is an international platform to support the creation, promotion and dissemination of contemporary printmaking and other forms of multiple art. Its purpose is to reflect on the engraving as an artistic discipline of XXI century, acting as a meeting point and consultation between the professionals and concerned citizens recorded in going in this artistic discipline and its variants. Ingráfica is the only non-commercial event with the world of graphic, which is held annually in Spain. The main aim of this paper is to determine the impact of Ingráfica in the city of Cuenca, with a view to taking appropriate strategies to the profile of the attendees. It also wants to know the satisfaction of visitors with different activities of Ingráfica

Análisis temporal de una base de datos de preguntas de autoevaluación para el aprendizaje de un lenguaje de programación

La plataforma AulaWeb lleva empleándose desde el curso 2000-01 como sistema de apoyo docente en la asignatura de Informática del Plan de Estudios de las titulaciones de Ingeniería Industrial e Ingeniería Química en la ETSII-UPM. Una de las funcionalidades más empleadas como recurso de aprendizaje-enseñanza es el módulo de autoevaluación, que se muestra imprescindible en asignaturas como ésta con un elevado número de alumnos matriculados. El sistema se emplea como evaluación continua conforme se avanza durante el periodo académico en la impartición de contenidos en las clases teóricas presenciales. El resultado de la actividad se considera en el cálculo de la calificación final de la asignatura. El módulo de evaluación se alimenta de una base de datos de más de 800 preguntas de diferentes tipos que ha permanecido invariable desde el curso 2004-05. En este trabajo se analiza la evolución de los resultados de la evaluación desde su implantación y la posible disminución de efectividad del sistema

Utilización de AulaWeb como apoyo docente en las asignaturas de Informática en el primer cuatrimestre del curso 2007-08

Se ha empleado una aplicación informática basada en el servicio web que sirve de apoyo, tanto a alumnos como a profesores, en el seguimiento de las asignaturas impartidas de forma presencial de los Planes de Estudios de diversas titulaciones de la Escuela Técnica Superior de Ingenieros Industriales de la Universidad Politécnica de Madrid (ETSII-UPM). El sistema se compone de un conjunto de módulos que facilitan tareas tales como la administración y gestión de los alumnos matriculados en las diferentes asignaturas, la publicación y recogida de material formativo, la petición y entrega de trabajos y prácticas, la configuración y realización de ejercicios de autoevaluación, el establecimiento de tutorías virtuales y la configuración de cuestionarios de evaluación del curso y del sistema. La aplicación se viene empleando desde el curso 1999-2000 en las asignaturas impartidas por la Unidad Docente de Informática Industrial en la ETSII-UPM. A modo de ejemplo en este informe se describe cómo se ha utilizado por dicha Unidad Docente en la asignatura de Informática de las titulaciones de Ingeniero Industrial y de Ingeniero Químico durante el primer cuatrimestre del curso 2007-08

¿Pierde eficiencia con el tiempo una base de datos de preguntas de un sistema de autoevaluación para el aprendizaje de un lenguaje de programación?

La plataforma AulaWeb lleva empleándose desde el curso 2000-01 como sistema de apoyo docente en la asignatura de Informática del Plan de Estudios de la titulación de Ingeniería Industrial en la ETSII-UPM. Una de las funcionalidades más empleadas como recurso de aprendizaje-enseñanza es el módulo de autoevaluación, que se muestra imprescindible en asignaturas como ésta con un elevado número de alumnos matriculados. El sistema se emplea como evaluación continua conforme se avanza en la impartición de contenidos en las clases teóricas presenciales. La actividad se considera en el cálculo de la calificación final de la asignatura al final del cuatrimestre. El módulo de evaluación se alimenta de una base de datos de más de 800 preguntas de diferentes tipos que ha permanecido invariable desde el curso 2004-05. En este trabajo se analiza la evolución de los resultados de la evaluación desde su implantación y la posible disminución de efectividad del sistema

An effective field theory approach to the QCD corrections to the large-mtm_t ZbbˉZb\bar b vertex

Using effective field theory techniques we discuss the QCD corrections to the large-$m_t$ contributions to the process $Z\rightarrow b \bar b$. In particular we obtain the \a correction to the non-universal $\log m_t$ contribution to the $Zb\bar b$ vertex.Comment: 12 pages + figures, LaTeX, Full postscript file available at ftp://xxx.lanl.gov/hep-ph/ps/9502/9502307.ps.

Dynamics of Emergency Cardiovascular Hospital Admissions and In-Hospital Mortality During the COVID-19 Pandemic: Time Series Analysis and Impact of Socioeconomic Factors

COVID-19; Síndrome coronario agudo; Insuficiencia cardiacaCOVID-19; Síndrome coronària aguda; Insuficiència cardíacaCOVID-19; Acute coronary syndrome; Heart failureAims: This study aimed to evaluate the decline in urgent cardiovascular hospital admissions and in-hospital mortality during the COVID pandemic in two successive waves, and to evaluate differences by sex, age, and deprivation index subgroups. Methods and Results: We obtained acute cardiovascular hospital episodes during the years 2019–2020 from region-wide data on public healthcare usage for the population of Catalonia (North-East Spain). We fitted time models to estimate the incidence rate ratios (IRRs) of the acute coronary syndrome (ACS) and acute heart failure (HF) admissions during the first pandemic wave, the between-waves period, and the second wave compared with the corresponding pre-COVID-19 periods and to test for the interaction with sex, age, and area-based socioeconomic level. We evaluated the effect of COVID-19 period on in-hospital mortality. ACS (n = 8,636) and HF (n = 27,566) episodes were defined using primary diagnostic ICD-10 codes. ACS and HF admissions decreased during the first wave (IRR = 0.66, 95%CI: 0.58–0.76 and IRR = 0.61, 95% CI: 0.55–0.68, respectively) and during the second wave (IRR = 0.80, 95%CI: 0.72–0.88 and IRR = 0.76, 95%CI: 0.69–0.84, respectively); acute HF admissions also decreased in the period between waves (IRR: 0.81, 95%CI: 0.74–0.89). The impact was similar in all sex and socioeconomic subgroups and was higher in older patients with ACS. In-hospital mortality was higher than expected only during the first wave. Conclusion: During the first wave of the COVID-19 pandemic, there was a marked decline in urgent cardiovascular hospital admissions that were attenuated during the second wave. Both the decline and the attenuation of the effect have been similar in all subgroups regardless of age, sex, or socioeconomic status. In-hospital mortality for ACS and HF episodes increased during the first wave, but not during the second wave.This study was funded with a grant from Sociedad Española de Cardiología y Fundación Española del Corazón (SEC/FEC-INV-CLI 21/017). The funder had no role in the study development

The biomedical abbreviation recognition and resolution (BARR) track: Benchmarking, evaluation and importance of abbreviation recognition systems applied to Spanish biomedical abstracts

Healthcare professionals are generating a substantial volume of clinical data in narrative form. As healthcare providers are confronted with serious time constraints, they frequently use telegraphic phrases, domain-specific abbreviations and shorthand notes. Efficient clinical text processing tools need to cope with the recognition and resolution of abbreviations, a task that has been extensively studied for English documents. Despite the outstanding number of clinical documents written worldwide in Spanish, only a marginal amount of studies has been published on this subject. In clinical texts, as opposed to the medical literature, abbreviations are generally used without their definitions or expanded forms. The aim of the first Biomedical Abbreviation Recognition and Resolution (BARR) track, posed at the IberEval 2017 evaluation campaign, was to assess and promote the development of systems for generating a sense inventory of medical abbreviations. The BARR track required the detection of mentions of abbreviations or short forms and their corresponding long forms or definitions from Spanish medical abstracts. For this track, the organizers provided the BARR medical document collection, the BARR corpus of manually annotated abstracts labelled by domain experts and the BARR-Markyt evaluation platform. A total of 7 teams submitted 25 runs for the two BARR subtasks: (a) the identification of mentions of abbreviations and their definitions and (b) the correct detection of short form-long form pairs. Here we describe the BARR track setting, the obtained results and the methodologies used by participating systems. The BARR task summary, corpus, resources and evaluation tool for testing systems beyond this campaign are available at: http://temu.inab.org .We acknowledge the Encomienda MINETAD-CNIO/OTG Sanidad Plan TL and Open-Minted (654021) H2020 project for funding.Postprint (published version

HLA and microtubule-associated protein tau H1 haplotype associations in anti-IgLON5 disease

We investigated the associations with HLA and microtubule-associated protein tau (MAPT) H1 haplotype in anti-IgLON5 disease, a recently identified disorder characterized by gait instability, brainstem dysfunction, and a prominent sleep disorder in association with IgLON5 antibodies and pathologic findings of a novel neuronal-specific tauopathy. We compared the HLA alleles and MAPT H1/H1 genotype of 35 patients with anti-IgLON5 with healthy controls. The on-line server tool NetMHCIIpan 3.1 was used to predict the IgLON5 peptide binding to HLA Class II molecules. The HLA-DRB1*10:01-DQB1*05:01 haplotype was overrepresented in patients with anti-IgLON5 disease (OR = 54.5; 95% CI: 22.2-133.9, p < 0.0001). In addition, HLA-DQA was genotyped in 27 patients, and 25 (92.6%) of them had DQ molecules composed by DQA1*01 and DQB1*05 chains compared with 148/542 (27.3%) controls (OR = 43.9; 95% CI: 10.4-185.5, p < 0.0001). Patients DRB1*10:01 positive developed more frequently sleep or bulbar symptoms than those carrying other HLA alleles (70.0% vs 26.7%; p = 0.011). Prediction algorithms identified 2 IgLON5 peptides (1 located in the signal sequence) that showed strong binding to HLA-DRB1*10:01 and other HLA-DRB1, but not to HLA-DQA and HLA-DQB molecules. The MAPT H1/H1 homozygous genotype was present in 20/24 (83.3%) anti-IgLON5 Caucasian patients compared with 54/116 (46.5%) healthy controls (p = 0.0007). The robust association of anti-IgLON5 disease with distinct HLA Class II molecules supports a primary autoimmune origin. The significant association of MAPT H1 haplotype also suggests that an underlying neurodegenerative process could be involved in anti-IgLON5 disease

Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor

Inhibidor de MNK1; OncologíaInhibidor de MNK1; OncologiaMNK1 inhibitor; OncologyTargeting the kinases MNK1 and MNK2 has emerged as a valuable strategy in oncology. However, most of the advanced inhibitors are acting in an adenosine triphosphate (ATP)-competitive mode, precluding the evaluation of different binding modes in preclinical settings. Using rational design, we identified and validated the 4,6-diaryl-pyrazolo[3,4-b]pyridin-3-amine scaffold as the core for MNK inhibitors. Signaling pathway analysis confirmed a direct effect of the hit compound EB1 on MNKs, and in line with the reported function of these kinases, EB1 only affects the growth of tumor but not normal cells. Molecular modeling revealed the binding of EB1 to the inactive conformation of MNK1 and the interaction with the specific DFD motif. This novel mode of action appears to be superior to the ATP-competitive inhibitors, which render the protein in a pseudo-active state. Overcoming this paradoxical activation of MNKs by EB1 represents therefore a promising starting point for the development of a novel generation of MNK inhibitors.This work was supported by the Instituto de Salud Carlos III (PI17/02247), (PI20/01687), and CIBERONC (CB16/12/00363). S.R.y.C. acknowledges support from the Generalitat de Catalunya (2017-9015-385045). E. Bou-Petit thanks the Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya (2017 FI_B2 00139) and the European Social Funds for her predoctoral fellowship

Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profile

SARS-CoV-2 infected pregnant women are at increased risk of severe COVID-19 than non-pregnant women and have a higher risk of adverse pregnancy outcomes like intrauterine/fetal distress and preterm birth. However, little is known about the impact of SARS-CoV-2 infection on maternal and neonatal immunological profiles. In this study, we investigated the inflammatory and humoral responses to SARS-CoV-2 in maternal and cord blood paired samples. Thirty-six pregnant women were recruited at delivery at Hospital Sant Joan de Déu, Barcelona, Spain, between April-August 2020, before having COVID-19 available vaccines. Maternal and pregnancy variables, as well as perinatal outcomes, were recorded in questionnaires. Nasopharyngeal swabs and maternal and cord blood samples were collected for SARS-CoV-2 detection by rRT-PCR and serology, respectively. We measured IgM, IgG and IgA levels to 6 SARS-CoV-2 antigens (spike [S], S1, S2, receptor-binding domain [RBD], nucleocapsid [N] full-length and C-terminus), IgG to N from 4 human coronaviruses (OC43, HKU1, 229E and NL63), and the concentrations of 30 cytokines, chemokines and growth factors by Luminex. Mothers were classified as infected or non-infected based on the rRT-PCR and serology results. Sixty-four % of pregnant women were infected with SARS-CoV-2 (positive by rRT-PCR during the third trimester and/or serology just after delivery). None of the newborns tested positive for rRT-PCR. SARS-CoV-2 infected mothers had increased levels of virus-specific antibodies and several cytokines. Those with symptoms had higher cytokine levels. IFN-? was increased in cord blood from infected mothers, and in cord blood of symptomatic mothers, EGF, FGF, IL-17 and IL-15 were increased, whereas RANTES was decreased. Maternal IgG and cytokine levels showed positive correlations with their counterparts in cord blood. rRT-PCR positive mothers showed lower transfer of SARS-CoV-2-specific IgGs, with a stronger effect when infection was closer to delivery. SARS-CoV-2 infected mothers carrying a male fetus had higher antibody levels and higher EGF, IL-15 and IL-7 concentrations. Our results show that SARS-CoV-2 infection during the third trimester of pregnancy induces a robust antibody and cytokine response at delivery and causes a significant reduction of the SARS-CoV-2-specific IgGs transplacental transfer, with a stronger negative effect when the infection is closer to delivery.Copyright © 2022 Rubio, Aguilar, Bustamante, Muñoz, Vázquez-Santiago, Santano, Vidal, Melero, Parras, Serra, Santamaria, Carolis, Izquierdo, Gómez-Roig, Dobaño, Moncunill and Mazarico