Combining the characteristics of sustainability, frugal innovations and washing machines in the industrial nations – A literature-based analysis of the common features for future sustainable developments

Sustainability is an internationally discussed topic in the development of products and services. Frugal innovations aim to conserve resources in the manufacture and use of such products and services. It can therefore be assumed that the areas of sustainability and frugal innovation overlap. This work is intended to show the connection between sustainability, frugal innovations and household appliances in the form of washing machines in industrialized countries. For the analysis, the characteristics of frugal innovations are compared with the requirements of washing machines in industrial nations and then the parallels to the social development goals (SDG) are determined as characteristics for sustainability. The existing literature will be reviewed for evaluation. The aim of the work is to show the connection and give an indication of the sustainable development of an everyday product as a frugal innovation in the industrialized countries

Structural and Functional Analysis of the Protein Network Controlling Centriole Biogenesis

Centrosomes function as microtubules organising centres in mitosis or as basal bodies in cilia and flagella formation. The duplication of centrioles, which are at the core of each centrosome, is tightly regulated and occurs only once per cell cycle, which allows for correct segregation of chromosomes. In C. elegans, only five proteins are essential for centriole duplication. How their Drosophila counterparts interact with each other on a molecular level still remains largely unknown. To further our understanding of the protein interactions governing centriole duplication, I applied in vivo and in vitro methods to design a protein interaction network at the centriole. I analysed mass spectrometry data from purifications of ProteinA-tagged centriole duplication proteins to identify in vivo protein complexes; and performed direct in vitro and in vivo protein-protein interaction assays. Additionally, I studied the Drosophila proteins Ana2 and Sas6; showing that Plk4 phosphorylates S318, S365, S370, and S373 of the Ana2-STAN motif; which identifies a direct substrate of Plk4. By in vitro interaction studies I show that Sas6 aa276-432 and Ana2-STAN interact directly, if the latter is phosphorylated by Plk4. The depletion of Ana2 or expression of Ana2-4A causes loss of centrosomes in Drosophila cell culture, which was not observed when expressing Ana2-4D. This supports the importance of Plk4-mediated phosphorylation of Ana2-STAN in centriole duplication. Mass spectrometry analysis of Sas6 purifications from cultured Drosophila cells identified the uncharacterised protein CG33052 (Dragon) and reciprocal purifications of tagged Dragon from Drosophila cell culture and syncytial embryos identified Sas6. By in vitro interaction studies I confirm that Dragon aa191-318/GoRab and Sas6 aa351-462/HsSas6 interact directly. The deletion mutant DragonΔaa260-286 does not interact with Sas6 in vitro or in vivo, and fails to rescue centriole duplication after Dragon depletion. Dragon localises to the trans-Golgi and co-localises with Sas6 at the centriole throughout the cell cycle

Copyright Implications Attendant upon the Use of Home Videotape Recorders

Copyright is the Cinderella of the law. Her rich older sisters, Franchises and Patents, long crowded her into the chimney-comer. Suddenly, the fairy godmother, Invention, endowed her with mechanical and electrical devices as magical as the pumpkin coach and the mice footmen. Now she whirls through the mad mazes of a glamorous ball

Barring Slayers\u27 Acquisition of Property Rights in Virginia: A Proposed Statute

The above passage by Justice Benjamin Cardozo clearly reflects the age-old maxim of the common law, Nullus commodurn caperepotest de injuria sua propria, which expounds the philosophy that no individual shall profit from his own wrong. The present Virginia statute concerning homicide and succession to property was enacted by the legislature to reflect this common law policy. However, because of the very narrow scope of the statute and the requirement that it be strictly construed, it is presently inadequate to respond to many of the issues facing our judges in Virginia. Section 64.1-18 of the Virginia Code states that no convicted murderer shall be allowed to acquire any interest in the estate of the person he murders either by descent or distribution or by will, nor shall he be allowed to receive any payment on a life insurance policy covering the victim\u27s life

Factors Influencing Consumer Behavior to Purchase Sustainable Cosmetic Products in a German Context

In today's markets, corporate social responsibility is a new consumer expectation. Organizations across all industries are trying to meet these expectations by building a positive reputation and sending a signal to their stakeholders. However, consumers’ environmental behavior is not always the result of their positive attitudes towards environmental issues. Potentially, their environmentally friendly attitudes are contradicted by their actual behavior. This means that people, who have positive attitudes about sustainable products and state that they would purchase them, may not actually buy them after all. In addition, consumers often do not wish to spend more money on buying sustainably, even if they have higher expectations towards sustainable products or companies. Further research is therefore needed to explain the gap between consumer awareness and actual purchasing behavior. In several contexts, environmentally friendly consumption, called sustainable consumption, has been explained by the theory of planned behavior (TPB), such as when buying food or apparel. Sustainable consumption often results from planned decisions rather than hedonic reasons.        &nbsp

A New Treatment for Aphasia? Borrowing from the Field of Foreign Language Learning

This is a report of a new type of aphasia treatment using a single subject design. The treatment was based on the principles of TPR (Total Physical Response), an innovative method for teaching language, whose main principle is that language is best learned when paired with movement and gesture. The underlying principle of TPR for aphasia treatment lies in the recruitment of the right hemisphere to help in language reorganization. We present a subject with severe fluent aphasia, 2 years post-stroke with no prior treatment, and report on his progress during TPR-based therapy

Rehabilitation der chinoloninduzierten Tendinopathie der Achillessehne

Copyright 2018 ThiemeHintergrund: Der Einsatz von Antibiotika gehört zum medizinischen Alltag. Ein dabei häufig eingesetzter Wirkstoff ist die Gruppe der Chinolone. Physiotherapeutisch relevant sind deren muskuloskeletale Nebenwirkungen, insbesondere auf das Sehnengewebe. Meist sind die Achillessehnen durch Tendinopathien oder Rupturen betroffen. Es besteht ein Mangel an Literatur bezüglich der Pathophysiologie als auch der Rehabilitation dieser klinischen Muster. Ziel: Diese Fallstudie evaluierte die Anwendung eines exzentrischen Trainingsprotokolls bei chinoloninduzierter Tendinopathie der Achillessehne. Methode: Die physiotherapeutische Rehabilitation einer 48-jährigen Frau mit unilateraler Tendinopathie der Achillessehne unter Einnahme des Antibiotikums Ciprofloxacin nach Lungentransplantation wird beschrieben. Dabei wurde ein kriterienbasierter Ansatz mit ausschließlich Hands-off-Therapie unter Einsatz eines exzentrischen Belastbarkeitsaufbaus der Achillessehne angewendet. Ergebnisse: Nach 9 Einzeltherapien fanden sich Verbesserungen beim 1-Minute-Sitz-Stand-Test, der Range of Motion bei Dorsalextension des oberen Sprunggelenks rechts, beidseitige Kraft von Knieextensoren und -flexoren, Dorsalextensoren und Plantarflexoren des oberen Sprunggelenks, beim VISA-A-Fragebogen sowie bei Schmerz und Partizipation. Schlussfolgerungen: Bei chinoloninduzierter Tendinopathie der Achillessehne ist ein exzentrisch betontes Trainingsprotokoll durchführbar und wirksam, wobei die zahlreichen Komorbiditäten der primär betroffenen Population zu beachten sind. Da Physiotherapeuten aufgrund der demografischen Entwicklung zunehmend mit hochkomplexen Fällen konfrontiert werden, ist es für sie wichtig, die unerwünschten Wirkungen von Medikamenten zu kennen

Let\u27s Cure Cancer!

From ancient Egypt to modern times, scientists have been learning new ways to prevent, diagnose, and treat cancer. In this book, you’ll learn about cancer and how veterinarians, veterinary technicians, physicians, and other scientists are working together to find a cure for cancer in people and their pets.https://docs.lib.purdue.edu/vetbooks/1003/thumbnail.jp