Incidence and outcome of no flow after primary percutaneous coronary intervention in acute myocardial infarction

  Background: Mechanical revascularization of the infarct-related artery (IRA) is the most effective treatment modality in ST-segment elevation myocardial infarction (STEMI).No flow occurs in ∼8.8-10% of cases of primary percutaneous coronary intervention(PCI) in STEMI patients. Our aim was to study     actual incidence and outcome of no flow patients. Methods: Five hundred and eighty primary PCI patients were studied over a period of two years i.e. January 2016 to December 2017. Drug eluting stents were used in all cases. Majority of our patients(>90%) came  6 hours  after onset of chest pain. There were many patients where there was  no flow even after mechanical thrombus aspiration and pharmacological vasodilator therapy. We have studied primary outcome(mortality) of no flow in those patients.                                                                                                                 Results: There were 44 cases of  no flow in our series(7.75%). Left anterior descending artery(LAD )was involved in eighteen patients. Right coronary artery(RCA) was culprit in twenty four cases. Only two cases were seen in LCX territory. One month mortality rate in no flow group was 50% and 6.25% in successful recanalization group. One year mortality was 12.5% in successful recanalization group and 66% in no flow group. Conclusion: Refractory no flow during primary PCI in STEMI is associated with high mortality and morbidity. There is no established strategy to solve this phenomenon.   &nbsp

Colour based nutraceutical potential of some traditional rice (Oryza sativa L. ssp. indica) varieties of India

153-157Consumption of unpolished grain, rather than polished grain has become a modern trend and consumers are mainly putting their thoughts and effort to consume products with more antioxidant capacity. Rice is the main staple food and apart from being considered as the main source of energy, it contains many nutraceutical properties because of its enriched secondary metabolites. This study is an effort to bring back the indigenous traditional rice landraces that almost disappeared from the farm fields after the advent of the Green Revolution in India. This article focuses on colour-based nutritional properties of six coloured and four non-coloured indigenous rice varieties based on antioxidant potential, total phenol and flavonoid content along with secondary metabolites profiling by high performance liquid chromatography. The biochemical uniqueness of these varieties has been explored that opens the gate for the conservation of more indigenous rice varieties for food security, as a cheap source of nutritional food and to construct a better niche for public health in developing country like India

Colour based nutraceutical potential of some traditional rice (Oryza sativa L. ssp. indica) varieties of India

Consumption of unpolished grain, rather than polished grain has become a modern trend and consumers are mainly putting their thoughts and effort to consume products with more antioxidant capacity. Rice is the main staple food and apart from being considered as the main source of energy, it contains many nutraceutical properties because of its enriched secondary metabolites. This study is an effort to bring back the indigenous traditional rice landraces that almost disappeared from the farm fields after the advent of the Green Revolution in India. This article focuses on colour-based nutritional properties of six coloured and four non-coloured indigenous rice varieties based on antioxidant potential, total phenol and flavonoid content along with secondary metabolites profiling by high performance liquid chromatography. The biochemical uniqueness of these varieties has been explored that opens the gate for the conservation of more indigenous rice varieties for food security, as a cheap source of nutritional food and to construct a better niche for public health in developing country like India

Non‐Identical Stepwise Reversible Double‐Redox Coupled Bond Activation Reactions

This work presents a stepwise reversible two‐electron transfer induced hydrogen shift leading to the conversion of a bis‐pyrrolinium cation to an E ‐diaminoalkene and vice versa. Remarkably, the forward and the reverse reaction, which are both reversible, follow two completely different reaction pathways. Establishing such unprecedented property in this type of processes was possible by developing a novel synthetic route towards the starting dication. All intermediates involved in both the forward and the backward reactions were comprehensively characterized by a combination of spectroscopic, crystallographic, electrochemical, spectroelectrochemical, and theoretical methods. The presented synthetic route opens up new possibilities for the generation of multi‐pyrrolinium cation scaffold‐based organic redox systems, which constitute decidedly sought‐after molecules in contemporary chemistry

THE SPLICEOSOMAL PROTEIN SnRNP F BINDS TO BOTH U3 AND U14 CLASS OF snoRNA IN Giardia lamblia

Small nuclear Ribonucleo Protein F (snRNP F) is a spliceosomal protein that binds with U1, U2, U4/U6 and U5 small nuclear RNA (snRNA) to form spliceosomal complexes responsible for pre mRNA processing. This study reports the unusual interaction of giardial snRNP F with small nucleolar RNAs (snoRNA) that are responsible for pre rRNA processing. Electrophoretic Mobility Shift Assay was used to demonstrate the interaction of this protein with U3 and U14 class snoRNA of the early branching eukaryote Giardia lamblia. It was also evident from our study that snRNP F in Giardia is evolutionary distinct from its other eukaryotic orthologues

Discovery and Optimisation of a Compound Series active against Trypanosoma cruzi, the causative agent of Chagas’ Disease

Chagas disease is caused by the protozoan parasite; Trypanosoma cruzi; . It is endemic in South and Central America and recently has been found in other parts of the world, due to migration of chronically infected patients. The current treatment for Chagas disease is not satisfactory, and there is a need for new treatments. In this work, we describe the optimization of a hit compound resulting from the phenotypic screen of a library of compounds against; T. cruzi; . The compound series was optimized to the level where it had satisfactory pharmacokinetics to allow an efficacy study in a mouse model of Chagas disease. We were able to demonstrate efficacy in this model, although further work is required to improve the potency and selectivity of this series