Computational Study of Hypersonic Flow Past Spiked Blunt Body Using RANS and DSMC Method

AbstractHypersonic vehicles when moving at very high speeds experience the problem of drag and heating. One of the ways to reduce this drag and heating is by the use of an aerospike. In the present study, the flow around a blunted body fitted with an aerospike is analyzed using a commercial software ANSYS Fluent and an open source Direct Simulation Monte Carlo (DSMC) code, called as dsmcFoam in OpenFOAM, at a high Mach number (M=6) at different length to diameter ratios (L/D = 1.5, 2) at an angle of attack 0o. The aerospike placed in front of the body replaces the strong detached shock wave ahead of the body with a system of weaker oblique shock waves. A recirculation region is developed between the shock and the blunt body, which acts like a streamlined profile, thus reducing the drag and wall heat flux

BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY A N I N T E R N A T I O N A L J O U R N A L In vitro Anticancer Property of Yellow Pigment from Streptomyces griseoaurantiacus JUACT 01

ABSTRAC

In vitro Anticancer Property of Yellow Pigment fromStreptomyces griseoaurantiacus JUACT 01

ABSTRACT Despite the complications in isolation of pigments, microbial pigments are increasingly gaining the attention of researchers because of their broad range therapeutic potentials, especially against cancer. In this study the cytotoxic and anti proliferative potentials of yellow pigment from Streptomyces griseoaurantiacus JUACT 01 isolated from soil are investigated. The effect of pigment treatment on the growth and proliferation of in vitro cervical cancer cells (HeLa) and liver cancer cells (Hep G2) was tested by various methods. Significant cytotoxicity was observed with IC 50 values as low as 1.5 and 1.8 µg /mL with HeLa and Hep G2 cells respectively. The pigment exhibited non toxic effects on human lymphocytes. Decrease in the number of viable cells, presence of apoptotic bodies, nuclear condensation and sheared DNA were distinctly observed in pigment treated cancer cells. The biochemical test and the infrared (IR) spectra indicated the probable carotenoid presence in the TLC purified pigment fraction. High Performance Liquid Chromatography (HPLC) analysis of the TLC purified yellow pigment showed a single large peak with a retention time of 9.90 min and m/z value corresponding to the peak was found to be 413.22 showing 100% relative abundance