Advanced channel coding for space mission telecommand links

We investigate and compare different options for updating the error correcting code currently used in space mission telecommand links. Taking as a reference the solutions recently emerged as the most promising ones, based on Low-Density Parity-Check codes, we explore the behavior of alternative schemes, based on parallel concatenated turbo codes and soft-decision decoded BCH codes. Our analysis shows that these further options can offer similar or even better performance.Comment: 5 pages, 7 figures, presented at IEEE VTC 2013 Fall, Las Vegas, USA, Sep. 2013 Proc. IEEE Vehicular Technology Conference (VTC 2013 Fall), ISBN 978-1-6185-9, Las Vegas, USA, Sep. 201

El entrenamiento femenino en el medio fondo, ciclo menstrual y necesidades actuales

The introduction of women in the middle distance running, has been possible thanks to the constant search for changes in the relationship between women and high-performance in the sport, thereby establishing the bases of the process of female sports training; however, there are needs that the feminine physiology demands. Objective: to describe how sports training has been in female middle distance runners and to explain the need to include the menstrual cycle in female sports training. Development: there are morphological, physiological and psychological peculiarities in the female gender, for this reason in the runners; the menstrual cycle represents most of the symptoms that affect athletic performance. The fluctuation of a normal cycle is 28 days with variations between 20 and 38 days, with significant changes in relation to weight, heart rate, volume of oxygen and hemoglobin in blood in addition to mood changes and increased fatigue at certain times of the cycle. This confirms the need to investigate the effects of the menstrual cycle on sports training and on how athletes and coaches can use it for a double benefit.  Conclusions: Nowadays women in the middle-distance running, train in the same way as men, without taking into account the physiological characteristics of the gender. It is advisable to include the variations of the menstrual cycle in the planning of female physical activity.  La introducción de la mujer en el medio fondo, ha sido posible gracias a la búsqueda constante de cambios en la relación mujer y alto rendimiento en el deporte, logrando con ello, establecer las bases del proceso de entrenamiento deportivo femenino; sin embargo, existen necesidades que la propia fisiología femenina demanda. Objetivo: describir como ha sido el entrenamiento deportivo en mediofondistas femeninas y exponer la necesidad de incluir el ciclo menstrual en el entrenamiento deportivo femenino. Desarrollo: existen particularidades morfológicas, fisiológicas y psicológicas en el género femenino, por esta razón en las corredoras, el ciclo menstrual representa la mayoría de los síntomas que afectan el rendimiento deportivo. La fluctuación de un ciclo normal es de 28 días con variaciones entre los 20 y los 38 días, con cambios significativos en relación al peso, frecuencia cardiaca, volumen de oxígeno y hemoglobina en sangre además de los cambios de humor y mayor fatiga en ciertos momentos del mismo.  Esto  confirma la necesidad de indagar en los efectos del ciclo menstrual al entrenamiento deportivo y en el modo en que las atletas y entrenadores puedan utilizarlo para un doble beneficio. Conclusiones: hoy en día las mujeres en el medio fondo, entrenan del mismo modo que los varones, sin tomar en cuenta las características fisiológicas del género. Es recomendable incluir las variaciones del ciclo menstrual en las planificaciones de la actividad física femenina

Finalizing the CCSDS Space-Data Link Layer Security Protocol: Setup and Execution of the Interoperability Testing

The protection of data transmitted over the space-link is an issue of growing importance also for civilian space missions. Through the Consultative Committee for Space Data Systems (CCSDS), space agencies have reacted to this need by specifying the Space Data-Link Layer Security (SDLS) protocol which provides confidentiality and integrity services for the CCSDS Telemetry (TM), Telecommand (TC) and Advanced Orbiting Services (AOS) space data-link protocols. This paper describes the approach of the CCSDS SDLS working group to specify and execute the necessary interoperability tests. It first details the individual SDLS implementations that have been produced by ESA, NASA, and CNES and then the overall architecture that allows the interoperability tests between them. The paper reports on the results of the interoperability tests and identifies relevant aspects for the evolution of the test environment

Adaptación de la usabilidad del entorno de formación TELMA a las necesidades de los cirujanos expertos

Uno de los principales inconvenientes manifestados por los cirujanos a la hora de llevar a cabo su formación continuada es la elevada carga asistencial que les limita la posibilidad de asistir a cursos y estancias presenciales. Por tanto, los cirujanos necesitan otros métodos formativos distintos a la formación in situ y para ello son de gran utilidad las tecnologías web, como es el caso de la plataforma de e-Learning TELMA, que ofrezcan contenidos didácticos adaptados a cada usuario para que puedan complementar su formación con contenidos multimedia online. Estudios previos de validación de TELMA detectaron diferentes problemas respecto a su diseño y usabilidad, propiciando mayores dificultades de accesibilidad para los cirujanos expertos en relación a los cirujanos noveles. Para corregirlos, en este trabajo se han analizado las deficiencias encontradas y se han propuesto una serie de medidas fundamentadas en un conjunto de directivas de diseño web que se deberían adoptar en futuras versiones de la plataforma TELMA para tratar de solventar estas desigualdades, ofreciendo a todos los usuarios tanto expertos como noveles, las mismas facilidades de accesibilidad

Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue

Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-induced obese mice after a combined nutritional and exercise intervention. Although most obesity and overnutrition-related pathological features were successfully reverted, we observed a high degree of metabolic dysfunction in visceral white adipose tissue, characterized by abnormal mitochondrial morphology and functionality. Despite two sequential therapeutic interventions and an apparent global healthy phenotype, obesity triggered a cascade of events in visceral adipose tissue progressing from mitochondrial metabolic and proteostatic alterations to widespread cellular stress, which compromises its biosynthetic and recycling capacity. In humans, weight loss after bariatric surgery showed a transcriptional signature in visceral adipose tissue similar to our mouse model of obesity reversion. Overall, our data indicate that obesity prompts a lasting metabolic fingerprint that leads to a progressive breakdown of metabolic plasticity in visceral adipose tissue

No supportive evidence for TIA1 gene mutations in a European cohort of ALS-FTD spectrum patients

We evaluated the genetic contribution of the T cell-erestricted intracellular antigen-1 gene (TIA1) in a European cohort of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) patients. Exonic resequencing of TIA1 in 1120 patients (693 FTD, 341 ALS, 86 FTD-ALS) and 1039 controls identified in total 5 rare heterozygous missense variants, affecting the TIA1 low-complexity domain (LCD). Only 1 missense variant, p.Met290Thr, identified in a familial FTD patient with disease onset at 64 years, was absent from controls yet received a combined annotation-dependent depletion score of 11.42. By contrast, 3 of the 4 variants also detected in unaffected controls, p.Val294Glu, p.Gln318Arg, and p.Ala381Thr, had combined annotation-dependent depletion scores greater than 20. Our findings in a large European patient-control series indicate that variants in TIA1 are not a common cause of ALS and FTD. The observation of recurring TIA1 missense variants in unaffected individuals lead us to conclude that the exact genetic contribution of TIA1 to ALS and FTD pathogenesis remains to be further elucidated

Phenomenology of a light gluon resonance in top-physics at Tevatron and LHC

We present a phenomenological analysis of the recent Tevatron results on the $t \bar t$ forward-backward asymmetry and invariant-mass spectrum assuming a new contribution from an s-channel gluon resonance with a mass in the range from 700 to 2500 GeV. In contrast to most of the previous works, this analysis shows that for masses below ~1 TeV resonant New Physics could accommodate the experimental data. In general, we find that axial-like couplings are preferred for light and top quark couplings, and that only top quark couples strongly to New Physics. We find that composite model scenarios arise naturally from only phenomenological analyses of the experimental results. We show that our results are compatible with recent LHC limits in dijet and $t \bar t$ production, and find some tension for large resonance mass ~2.5 TeV. We indicate as best observables for discriminating a relatively light new gluon a better resolution in CDF forward-backward asymmetry, as well as the $t \bar t$ charge asymmetry and invariant-mass spectrum at the LHC.Comment: 22 pages with 5 figure

Lymphangioleiomyomatosis biomarkers linked to lung metastatic potential and cell stemness

Lymphangioleiomyomatosis (LAM) is a rare lung-metastasizing neoplasm caused by the proliferation of smooth muscle-like cells that commonly carry loss-of-function mutations in either the tuberous sclerosis complex 1 or 2 (TSC1 or TSC2) genes. While allosteric inhibition of the mechanistic target of rapamycin (mTOR) has shown substantial clinical benefit, complementary therapies are required to improve response and/or to treat specific patients. However, there is a lack of LAM biomarkers that could potentially be used to monitor the disease and to develop other targeted therapies. We hypothesized that the mediators of cancer metastasis to lung, particularly in breast cancer, also play a relevant role in LAM. Analyses across independent breast cancer datasets revealed associations between low TSC1/2 expression, altered mTOR complex 1 (mTORC1) pathway signaling, and metastasis to lung. Subsequently, immunohistochemical analyses of 23 LAM lesions revealed positivity in all cases for the lung metastasis mediators fascin 1 (FSCN1) and inhibitor of DNA binding 1 (ID1). Moreover, assessment of breast cancer stem or luminal progenitor cell biomarkers showed positivity in most LAM tissue for the aldehyde dehydrogenase 1 (ALDH1), integrin-ß3 (ITGB3/CD61), and/or the sex-determining region Y-box 9 (SOX9) proteins. The immunohistochemical analyses also provided evidence of heterogeneity between and within LAM cases. The analysis of Tsc2-deficient cells revealed relative over-expression of FSCN1 and ID1; however, Tsc2-deficient cells did not show higher sensitivity to ID1-based cancer inhibitors. Collectively, the results of this study reveal novel LAM biomarkers linked to breast cancer metastasis to lung and to cell stemness, which in turn might guide the assessment of additional or complementary therapeutic opportunities for LAM

Effectiveness of an mHealth intervention combining a smartphone app and smart band on body composition in an overweight and obese population: Randomized controlled trial (EVIDENT 3 study)

Background: Mobile health (mHealth) is currently among the supporting elements that may contribute to an improvement in health markers by helping people adopt healthier lifestyles. mHealth interventions have been widely reported to achieve greater weight loss than other approaches, but their effect on body composition remains unclear. Objective: This study aimed to assess the short-term (3 months) effectiveness of a mobile app and a smart band for losing weight and changing body composition in sedentary Spanish adults who are overweight or obese. Methods: A randomized controlled, multicenter clinical trial was conducted involving the participation of 440 subjects from primary care centers, with 231 subjects in the intervention group (IG; counselling with smartphone app and smart band) and 209 in the control group (CG; counselling only). Both groups were counselled about healthy diet and physical activity. For the 3-month intervention period, the IG was trained to use a smartphone app that involved self-monitoring and tailored feedback, as well as a smart band that recorded daily physical activity (Mi Band 2, Xiaomi). Body composition was measured using the InBody 230 bioimpedance device (InBody Co., Ltd), and physical activity was measured using the International Physical Activity Questionnaire. Results: The mHealth intervention produced a greater loss of body weight (–1.97 kg, 95% CI –2.39 to –1.54) relative to standard counselling at 3 months (–1.13 kg, 95% CI –1.56 to –0.69). Comparing groups, the IG achieved a weight loss of 0.84 kg more than the CG at 3 months. The IG showed a decrease in body fat mass (BFM; –1.84 kg, 95% CI –2.48 to –1.20), percentage of body fat (PBF; –1.22%, 95% CI –1.82% to 0.62%), and BMI (–0.77 kg/m2, 95% CI –0.96 to 0.57). No significant changes were observed in any of these parameters in men; among women, there was a significant decrease in BMI in the IG compared with the CG. When subjects were grouped according to baseline BMI, the overweight group experienced a change in BFM of –1.18 kg (95% CI –2.30 to –0.06) and BMI of –0.47 kg/m2 (95% CI –0.80 to –0.13), whereas the obese group only experienced a change in BMI of –0.53 kg/m2 (95% CI –0.86 to –0.19). When the data were analyzed according to physical activity, the moderate-vigorous physical activity group showed significant changes in BFM of –1.03 kg (95% CI –1.74 to –0.33), PBF of –0.76% (95% CI –1.32% to –0.20%), and BMI of –0.5 kg/m2 (95% CI –0.83 to –0.19). Conclusions: The results from this multicenter, randomized controlled clinical trial study show that compared with standard counselling alone, adding a self-reported app and a smart band obtained beneficial results in terms of weight loss and a reduction in BFM and PBF in female subjects with a BMI less than 30 kg/m2 and a moderate-vigorous physical activity level. Nevertheless, further studies are needed to ensure that this profile benefits more than others from this intervention and to investigate modifications of this intervention to achieve a global effect