The first orbital solution for the massive colliding-wind binary HD93162 (=WR25)

Since the discovery, with the EINSTEIN satellite, of strong X-ray emission associated with HD93162 (=WR25), this object has been predicted to be a colliding-wind binary system. However, radial-velocity variations that would prove the suspected binary nature have yet to be found. We spectroscopically monitored this object to investigate its possible variability to address this discordance. We compiled the largest available radial-velocity data set for this star to look for variations that might be due to binary motion. We derived radial velocities from spectroscopic data acquired mainly between 1994 and 2006, and searched these radial velocities for periodicities using different numerical methods. For the first time, periodic radial-velocity variations are detected. Our analysis definitively shows that the Wolf-Rayet star WR25 is an eccentric binary system with a probable period of about 208 days.Comment: 7 pages, 4 figures, accepted by A+

Evidence of magnetic field decay in massive main-sequence stars

A significant fraction of massive main-sequence stars show strong, large-scale magnetic fields. The origin of these fields, their lifetimes, and their role in shaping the characteristics and evolution of massive stars are currently not well understood. We compile a catalogue of 389 massive main-sequence stars, 61 of which are magnetic, and derive their fundamental parameters and ages. The two samples contain stars brighter than magnitude 9 in the V band and range in mass between 5 and 100 Msun. We find that the fractional main-sequence age distribution of all considered stars follows what is expected for a magnitude limited sample, while that of magnetic stars shows a clear decrease towards the end of the main sequence. This dearth of old magnetic stars is independent of the choice of adopted stellar evolution tracks, and appears to become more prominent when considering only the most massive stars. We show that the decreasing trend in the distribution is significantly stronger than expected from magnetic flux conservation. We also find that binary rejuvenation and magnetic suppression of core convection are unlikely to be responsible for the observed lack of older magnetic massive stars, and conclude that its most probable cause is the decay of the magnetic field, over a time span longer than the stellar lifetime for the lowest considered masses, and shorter for the highest masses. We then investigate the spin-down ages of the slowly rotating magnetic massive stars and find them to exceed the stellar ages by far in many cases. The high fraction of very slowly rotating magnetic stars thus provides an independent argument for a decay of the magnetic fields.Comment: Accepted for publication on A&A; 9 pages, 8 figure

The VLT-FLAMES Tarantula Survey. VII. A low velocity dispersion for the young massive cluster R136

Detailed studies of resolved young massive star clusters are necessary to determine their dynamical state and evaluate the importance of gas expulsion and early cluster evolution. In an effort to gain insight into the dynamical state of the young massive cluster R136 and obtain the first measurement of its velocity dispersion, we analyse multi-epoch spectroscopic data of the inner regions of 30 Doradus in the Large Magellanic Cloud (LMC) obtained as part of the VLT-FLAMES Tarantula Survey. Following a quantitative assessment of the variability, we use the radial velocities of non-variable sources to place an upper limit of 6 km/s on the line-of-sight velocity dispersion of stars within a projected distance of 5 pc from the centre of the cluster. After accounting for the contributions of undetected binaries and measurement errors through Monte Carlo simulations, we conclude that the true velocity dispersion is likely between 4 and 5 km/s given a range of standard assumptions about the binary distribution. This result is consistent with what is expected if the cluster is in virial equilibrium, suggesting that gas expulsion has not altered its dynamics. We find that the velocity dispersion would be ~25 km/s if binaries were not identified and rejected, confirming the importance of the multi-epoch strategy and the risk of interpreting velocity dispersion measurements of unresolved extragalactic young massive clusters.Comment: 18 pages, 7 figures, accepted by A&

The BinaMIcS project: understanding the origin of magnetic fields in massive stars through close binary systems

It is now well established that a fraction of the massive (M>8 Msun) star population hosts strong, organised magnetic fields, most likely of fossil origin. The details of the generation and evolution of these fields are still poorly understood. The BinaMIcS project takes an important step towards the understanding of the interplay between binarity and magnetism during the stellar formation and evolution, and in particular the genesis of fossil fields, by studying the magnetic properties of close binary systems. The components of such systems are most likely formed together, at the same time and in the same environment, and can therefore help us to disentangle the role of initial conditions on the magnetic properties of the massive stars from other competing effects such as age or rotation. We present here the main scientific objectives of the BinaMIcS project, as well as preliminary results from the first year of observations from the associated ESPaDOnS and Narval spectropolarimetric surveys.Comment: To appear in New Windows on Massive Stars, proceedings of the IAU Symposium 30

The VLT-FLAMES Tarantula Survey XXI. Stellar spin rates of O-type spectroscopic binaries

The initial distribution of spin rates of massive stars is a fingerprint of their elusive formation process. It also sets a key initial condition for stellar evolution and is thus an important ingredient in stellar population synthesis. So far, most studies have focused on single stars. Most O stars are however found in multiple systems. By establishing the spin-rate distribution of a sizeable sample of O-type spectroscopic binaries and by comparing the distributions of binary sub-populations with one another as well as with that of presumed single stars in the same region, we aim to constrain the initial spin distribution of O stars in binaries, and to identify signatures of the physical mechanisms that affect the evolution of the massive stars spin rates. We use ground-based optical spectroscopy obtained in the framework of the VLT-FLAMES Tarantula Survey (VFTS) to establish the projected equatorial rotational velocities (\vrot) for components of 114 spectroscopic binaries in 30 Doradus. The \vrot\ values are derived from the full-width at half-maximum (FWHM) of a set of spectral lines, using a FWHM vs. \vrot\ calibration that we derive based on previous line analysis methods applied to single O-type stars in the VFTS sample. The overall \vrot\ distribution of the primary stars resembles that of single O-type stars in the VFTS, featuring a low-velocity peak (at \vrot < 200 kms) and a shoulder at intermediate velocities (200 < \vrot < 300 kms). The distributions of binaries and single stars however differ in two ways. First, the main peak at \vrot \sim100 kms is broader and slightly shifted toward higher spin rates in the binary distribution compared to that of the presumed-single stars. Second, the \vrot distribution of primaries lacks a significant population of stars spinning faster than 300 kms while such a population is clearly present in the single star sample.Comment: 16 pages, 16 figures, paper accepted in Astronomy & Astrophysic

The Wolf-Rayet binaries of the nitrogen sequence in the Large Magellanic Cloud: spectroscopy, orbital analysis, formation, and evolution

Massive Wolf-Rayet (WR) stars dominate the radiative and mechanical energy budget of galaxies and probe a critical phase in the evolution of massive stars prior to core-collapse. It is not known whether core He-burning WR stars (classical WR, cWR) form predominantly through wind-stripping (w-WR) or binary stripping (b-WR). With spectroscopy of WR binaries so-far largely avoided due to its complexity, our study focuses on the 44 WR binaries / binary candidates of the Large Magellanic Cloud (LMC, metallicity Z~0.5 Zsun), identified on the basis of radial velocity variations, composite spectra, or high X-ray luminosities. Relying on a diverse spectroscopic database, we aim to derive the physical and orbital parameters of our targets, confronting evolution models of evolved massive stars at sub-solar metallicity, and constraining the impact of binary interaction in forming them. Spectroscopy is performed using the Potsdam Wolf-Rayet (PoWR) code and cross-correlation techniques. Disentanglement is performed using the code Spectangular or the shift-and-add algorithm. Evolutionary status is interpreted using the Binary Population and Spectral Synthesis (BPASS) code, exploring binary interaction and chemically-homogeneous evolution. No obvious dichotomy in the locations of apparently-single and binary WN stars on the Hertzsprung-Russell diagram is apparent. According to commonly used stellar evolution models (BPASS, Geneva), most apparently-single WN stars could not have formed as single stars, implying that they were stripped by an undetected companion. Otherwise, it must follow that pre-WR mass-loss/mixing (e.g., during the red supergiant phase) are strongly underestimated in standard stellar evolution models.Comment: accepted to A&A on 10.05.2019; 69 pages (25 main paper + 44 appendix); Corrigendum: Shenar et al. 2020, A&A, 641, 2: An unfortunate typo in the implementation of the "transformed radius" caused errors of up to ~0.5dex in the derived mass-loss rates. This has now been correcte

The VLT-FLAMES Tarantula Survey XV. VFTS 822: A candidate Herbig B[e] star at low metallicity

We report the discovery of the B[e] star VFTS 822 in the 30 Doradus star-forming region of the Large Magellanic Cloud, classified by optical spectroscopy from the VLT-FLAMES Tarantula Survey and complementary infrared photometry. VFTS 822 is a relatively low-luminosity (log L = 4.04 ± 0.25 L⊙) B8[e] star. In this Letter, we evaluate the evolutionary status of VFTS 822 and discuss its candidacy as a Herbig B[e] star. If the object is indeed in the pre-main sequence phase, it would present an exciting opportunity to spectroscopically measure mass accretion rates at low metallicity, to probe the effect of metallicity on accretion rates

Presenilin-1 processing of ErbB4 in fetal type II cells is necessary for control of fetal lung maturation

AbstractMaturation of pulmonary fetal type II cells to initiate adequate surfactant production is crucial for postnatal respiratory function. Little is known about specific mechanisms of signal transduction controlling type II cell maturation. The ErbB4 receptor and its ligand neuregulin (NRG) are critical for lung development. ErbB4 is cleaved at the cell membrane by the γ-secretase enzyme complex whose active component is either presenilin-1 (PSEN-1) or presenilin-2. ErbB4 cleavage releases the 80kDa intracellular domain (4ICD), which associates with chaperone proteins such as YAP (Yes-associated protein) and translocates to the nucleus to regulate gene expression. We hypothesized that PSEN-1 and YAP have a development-specific expression in fetal type II cells and are important for ErbB4 signaling in surfactant production. In primary fetal mouse E16, E17, and E18 type II cells, PSEN-1 and YAP expression increased at E17 and E18 over E16. Subcellular fractionation showed a strong cytosolic and a weaker membrane location of both PSEN-1 and YAP. This was enhanced by NRG stimulation. Co-immunoprecipitations showed ErbB4 associated separately with PSEN-1 and with YAP. Their association, phosphorylation, and co-localization were induced by NRG. Confocal immunofluorescence and nuclear fractionation confirmed these associations in a time-dependent manner after NRG stimulation. Primary ErbB4-deleted E17 type II cells were transfected with a mutant ErbB4 lacking the γ-secretase binding site. When compared to transfection with wild-type ErbB4, the stimulatory effect of NRG on surfactant protein mRNA expression was lost. We conclude that PSEN-1 and YAP have crucial roles in ErbB4 signal transduction during type II cell maturation

The VLT-FLAMES Tarantula Survey XVII. Physical and wind properties of massive stars at the top of the main sequence

The evolution and fate of very massive stars (VMS) is tightly connected to their mass-loss properties. Their initial and final masses differ significantly as a result of mass loss. VMS have strong stellar winds and extremely high ionising fluxes, which are thought to be critical sources of both mechanical and radiative feedback in giant Hii regions. However, how VMS mass-loss properties change during stellar evolution is poorly understood. In the framework of the VLT-Flames Tarantula Survey (VFTS), we explore the mass-loss transition region from optically thin O to denser WNh star winds, thereby testing theoretical predictions. To this purpose we select 62 O, Of, Of/WN, and WNh stars, an unprecedented sample of stars with the highest masses and luminosities known. We perform a spectral analysis of optical VFTS as well as near-infrared VLT/SINFONI data using the non-LTE radiative transfer code CMFGEN to obtain stellar and wind parameters. For the first time, we observationally resolve the transition between optically thin O and optically thick WNh star winds. Our results suggest the existence of a kink between both mass-loss regimes, in agreement with recent MC simulations. For the optically thick regime, we confirm the steep dependence on the Eddington factor from previous theoretical and observational studies. The transition occurs on the MS near a luminosity of 10^6.1Lsun, or a mass of 80...90Msun. Above this limit, we find that - even when accounting for moderate wind clumping (with f = 0.1) - wind mass-loss rates are enhanced with respect to standard prescriptions currently adopted in stellar evolution calculations. We also show that this results in substantial helium surface enrichment. Based on our spectroscopic analyses, we are able to provide the most accurate ionising fluxes for VMS known to date, confirming the pivotal role of VMS in ionising and shaping their environments.Comment: Accepted for publication in A&A, 19 pages, 14 figures, 6 tables, (74 pages appendix, 68 figures, 4 tables

Applying Patient-Reported Outcome Methodology to Capture Patient-Reported Health Data: Report From an NIH Collaboratory Roundtable

Patient-reported health data provide information for pragmatic clinical trials that may not be readily available from electronic health records or administrative claims data. In this report, we present key considerations for collecting patient-reported health information in pragmatic clinical trials, which are informed by best practices from patient-reported outcome research. We focus on question design and administration via electronic data collection platforms with respect to 3 types of patient-reported health data: medication use, utilization of health care services, and comorbid conditions. We summarize key scientific literature on the accuracy of these patient-reported data compared with electronic health record data. We discuss question design in detail, specifically defining the concept to be measured, patient understanding of the concept, recall periods of the question, and patient willingness to report. In addition, we discuss approaches for question administration and data collection platforms, which are key aspects of successful patient-reported data collection