The construction of a test of design judgment

Thesis (Ed.M.)--Boston University 2" x 2" slides. In Audio-Visual Library.The purpose of this study is to construct a test of design judgment for use both as an evaluative and guidance device in the art classes of Grades VIII and IX of the Framingham Public Schools. This is to be known as the Framingham Design Judgement Test. Its objectives are (1) to help the art teachers of Grades VIII and IX evaluate one phase of the local art program; (2) to help select those pupils who, having demonstrated ability and interest in art in the earlier grades, should be encouraged ,to continue the subject in Grade IX; and (3) to help determine which students, by virtue of special talent, should elect the Art Major course at the beginning of Grade X, and which ones should be advised to pursue their art interests in the General Art course

Evaporation of a packet of quantized vorticity

A recent experiment has confirmed the existence of quantized turbulence in superfluid He3-B and suggested that turbulence is inhomogenous and spreads away from the region around the vibrating wire where it is created. To interpret the experiment we study numerically the diffusion of a packet of quantized vortex lines which is initially confined inside a small region of space. We find that reconnections fragment the packet into a gas of small vortex loops which fly away. We determine the time scale of the process and find that it is in order of magnitude agreement with the experiment.Comment: figure 1a,b,c and d, figure2, figure

Dynamics of vortex tangle without mutual friction in superfluid 4^4He

A recent experiment has shown that a tangle of quantized vortices in superfluid $^4$He decayed even at mK temperatures where the normal fluid was negligible and no mutual friction worked. Motivated by this experiment, this work studies numerically the dynamics of the vortex tangle without the mutual friction, thus showing that a self-similar cascade process, whereby large vortex loops break up to smaller ones, proceeds in the vortex tangle and is closely related with its free decay. This cascade process which may be covered with the mutual friction at higher temperatures is just the one at zero temperature Feynman proposed long ago. The full Biot-Savart calculation is made for dilute vortices, while the localized induction approximation is used for a dense tangle. The former finds the elementary scenario: the reconnection of the vortices excites vortex waves along them and makes them kinked, which could be suppressed if the mutual friction worked. The kinked parts reconnect with the vortex they belong to, dividing into small loops. The latter simulation under the localized induction approximation shows that such cascade process actually proceeds self-similarly in a dense tangle and continues to make small vortices. Considering that the vortices of the interatomic size no longer keep the picture of vortex, the cascade process leads to the decay of the vortex line density. The presence of the cascade process is supported also by investigating the classification of the reconnection type and the size distribution of vortices. The decay of the vortex line density is consistent with the solution of the Vinen's equation which was originally derived on the basis of the idea of homogeneous turbulence with the cascade process. The obtained result is compared with the recent Vinen's theory.Comment: 16 pages, 16 figures, submitted to PR

Superfluid turbulence

At low temperatures (below 5 Kelvin), helium is a liquid with a very low kinematic viscosity. It was proposed that wind tunnels could be built using liquid helium as the test fluid. The primary advantages of such wind tunnels would be a combination of large Reynolds numbers and a relatively small apparatus. It is hoped that this combination will allow the study of high Reynolds number flows in an academic setting. There are two basic types of liquid helium wind tunnels that can be built, corresponding to the two phases of liquid helium. The high temperature phase (between approximately 2 to 5 Kelvin) is called helium 1 and is a Navier-Stokes fluid. There are no unanswered scientific questions about the design or operation of a wind tunnel in the helium 1 phase. The low temperature phase (below approximately 2 Kelvin) of liquid helium is called helium 2. This is a quantum fluid, meaning that there are some properties of helium 2 which are directly due to quantum mechanical effects and which are not observed in Navier-Stokes fluids. The quantum effects that are relevant to this paper are: (1) helium 2 is well described as a superposition of two separate fluids called the superfluid and the normal fluid. The normal-fluid component is a Navier-Stokes fluid and the superfluid is an irrotational Euler fluid; and (2) circulation in the superfluid exists only in quantized vortex filaments. All quantized vortex filaments have identical circulations kappa and core size a. The objective of the research at CTR was to develop an understanding of the microscopic processes responsible for the observed Navier-Stokes behavior of helium 2 flows

Enzyme Kinetics of the Mitochondrial Deoxyribonucleoside Salvage Pathway Are Not Sufficient to Support Rapid mtDNA Replication

Using a computational model, we simulated mitochondrial deoxynucleotide metabolism and mitochondrial DNA replication. Our results indicate that the output from the mitochondrial salvage enzymes alone is inadequate to support a mitochondrial DNA replication duration of as long as 10 hours. We find that an external source of deoxyribonucleoside diphosphates or triphosphates (dNTPs), in addition to those supplied by mitochondrial salvage, is essential for the replication of mitochondrial DNA to complete in the experimentally observed duration of approximately 1 to 2 hours. For meeting a relatively fast replication target of 2 hours, almost two-thirds of the dNTP requirements had to be externally supplied as either deoxyribonucleoside di- or triphosphates, at about equal rates for all four dNTPs. Added monophosphates did not suffice. However, for a replication target of 10 hours, mitochondrial salvage was able to provide for most, but not all, of the total substrate requirements. Still, additional dGTPs and dATPs had to be supplied. Our analysis of the enzyme kinetics also revealed that the majority of enzymes of this pathway prefer substrates that are not precursors (canonical deoxyribonucleosides and deoxyribonucleotides) for mitochondrial DNA replication, such as phosphorylated ribonucleotides, instead of the corresponding deoxyribonucleotides. The kinetic constants for reactions between mitochondrial salvage enzymes and deoxyribonucleotide substrates are physiologically unreasonable for achieving efficient catalysis with the expected in situ concentrations of deoxyribonucleotides

Reconnection of superfluid vortex bundles

Using the vortex filament model and the Gross Pitaevskii nonlinear Schroedinger equation, we show that bundles of quantised vortex lines in helium II are structurally robust and can reconnect with each other maintaining their identity. We discuss vortex stretching in superfluid turbulence and show that, during the bundle reconnection process, Kelvin waves of large amplitude are generated, in agreement with the finding that helicity is produced by nearly singular vortex interactions in classical Euler flows.Comment: 10 pages, 7 figure

Mitochondrial-encoded membrane protein transcripts are pyrimidine-rich while soluble protein transcripts and ribosomal RNA are purine-rich

BACKGROUND: Eukaryotic organisms contain mitochondria, organelles capable of producing large amounts of ATP by oxidative phosphorylation. Each cell contains many mitochondria with many copies of mitochondrial DNA in each organelle. The mitochondrial DNA encodes a small but functionally critical portion of the oxidative phosphorylation machinery, a few other species-specific proteins, and the rRNA and tRNA used for the translation of these transcripts. Because the microenvironment of the mitochondrion is unique, mitochondrial genes may be subject to different selectional pressures than those affecting nuclear genes. RESULTS: From an analysis of the mitochondrial genomes of a wide range of eukaryotic species we show that there are three simple rules for the pyrimidine and purine abundances in mitochondrial DNA transcripts. Mitochondrial membrane protein transcripts are pyrimidine rich, rRNA transcripts are purine-rich and the soluble protein transcripts are purine-rich. The transitions between pyrimidine and purine-rich regions of the genomes are rapid and are easily visible on a pyrimidine-purine walk graph. These rules are followed, with few exceptions, independent of which strand encodes the gene. Despite the robustness of these rules across a diverse set of species, the magnitude of the differences between the pyrimidine and purine content is fairly small. Typically, the mitochondrial membrane protein transcripts have a pyrimidine richness of 56%, the rRNA transcripts are 55% purine, and the soluble protein transcripts are only 53% purine. CONCLUSION: The pyrimidine richness of mitochondrial-encoded membrane protein transcripts is partly driven by U nucleotides in the second codon position in all species, which yields hydrophobic amino acids. The purine-richness of soluble protein transcripts is mainly driven by A nucleotides in the first codon position. The purine-richness of rRNA is also due to an abundance of A nucleotides. Possible mechanisms as to how these trends are maintained in mtDNA genomes of such diverse ancestry, size and variability of A-T richness are discussed