15 research outputs found
The Physical Demands of NCAA Division I Women\u27s College Soccer
Extensive research into women\u27s collegiate soccer is scarce, leaving gaps in the literature with little information available detailing the physical demands at different standards of play. Our purpose was to elucidate the physical demands of the Division I collegiate level and identify differences between playing positions. Twenty-three field players were observed during four competitive seasons using 10-Hz GPS units (Catapult Sports, Melbourne, Australia). Descriptive statistics and 95% confidence intervals were used to determine group and position-specific physical demands. Linear mixed modelling (LMM) was used to compare attacker, midfielder, and defender position groups. Total distance, high-speed distance, and sprint distance were 9486 ± 300 m, 1014 ± 118 m, and 428 ± 70 m, respectively. Furthermore, attackers were observed to cover the greatest distance at all speeds compared to midfielders and defenders. Our findings suggest that the physical demands of Division I women\u27s soccer differ by position and appear lower compared to higher standards of play. Therefore, coaches and sports scientists responsible for the physical training of Division I collegiate players should consider the specific physical demands of the collegiate level and playing position when prescribing training, as well as in the development of their annual training programs
Cluster Set Loading in the Back Squat: Kinetic and Kinematic Implications
Cluster set loading in the back squat: Kinetic and kinematic implications. J Strength Cond Res XX(X): 000–000, 2018—As athletes become well trained, they require greater stimuli and variation to force adaptation. One means of adding additional variation is the use of cluster loading. Cluster loading involves introducing interrepetition rest during a set, which in theory may allow athletes to train at higher absolute intensities for the same volume. The purpose of this study was to investigate the kinetic and kinematic implications of cluster loading as a resistance training programming tactic compared with traditional loading (TL). Eleven resistance-trained men (age = 26.75 ± 3.98 years, height = 181.36 ± 5.96 cm, body mass = 89.83 ± 10.66 kg, and relative squat strength = 1.84 ± 0.34) were recruited for this study. Each subject completed 2 testing sessions consisting of 3 sets of 5 back squats at 80% of their 1 repetition maximum with 3 minutes of interset rest. Cluster loading included 30 seconds of interrepetition rest with 3 minutes of interset rest. All testing was performed on dual-force plates sampling at 1,000 Hz, and the barbell was connected to 4 linear position transducers sampling at 1,000 Hz. Both conditions had similar values for peak force, concentric average force, and eccentric average force (p = 0.25, effect size (ES) = 0.09, p = 0.25, ES = 0.09, and p = 0.60, ES = 0.04, respectively). Cluster loading had significantly higher peak power (PP) (p \u3c 0.001, ES = 0.77), peak and average velocities (p \u3c 0.001, ES = 0.77, and p \u3c 0.001, ES = 0.81, respectively), lower times to PP and velocity (p \u3c 0.001, ES = −0.68, and p \u3c 0.001, ES = −0.68, respectively) as well as greater maintenance of time to PP (p \u3c 0.001, ES = 1.57). These results suggest that cluster loading may be superior to TL when maintaining power output and time point variables is the desired outcome of training
Repetition-to-Repetition Differences Using Cluster and Accentuated Eccentric Loading in the Back Squat
The current investigation was an examination of the repetition-to-repetition magnitudes and changes in kinetic and kinematic characteristics of the back squat using accentuated eccentric loading (AEL) and cluster sets. Trained male subjects (age = 26.1 ± 4.1 years, height = 183.5 ± 4.3 cm, body mass = 92.5 ± 10.5 kg, back squat to body mass ratio = 1.8 ± 0.3) completed four load condition sessions, each consisting of three sets of five repetitions of either traditionally loaded straight sets (TL), traditionally loaded cluster sets (TLC), AEL cluster sets (AEC), and AEL straight sets where only the initial repetition had eccentric overload (AEL1). Eccentric overload was applied using weight releasers, creating a total eccentric load equivalent to 105% of concentric one repetition maximum (1RM). Concentric load was 80% 1RM for all load conditions. Using straight sets (TL and AEL1) tended to decrease peak power (PP) (d = −1.90 to −0.76), concentric rate of force development (RFDCON) (d = −1.59 to −0.27), and average velocity (MV) (d = −3.91 to −1.29), with moderate decreases in MV using cluster sets (d = −0.81 to −0.62). Greater magnitude eccentric rate of force development (RFDECC) was observed using AEC at repetition three (R3) and five (R5) compared to all load conditions (d = 0.21⁻0.65). Large within-condition changes in RFDECC from repetition one to repetition three (∆REP1⁻3) were present using AEL1 (d = 1.51), demonstrating that RFDECC remained elevated for at least three repetitions despite overload only present on the initial repetition. Overall, cluster sets appear to permit higher magnitude and improved maintenance of concentric outputs throughout a set. Eccentric overload with the loading protocol used in the current study does not appear to potentiate concentric output regardless of set configuration but may cause greater RFDECC compared to traditional loading
Repetition-to-Repetition Differences Using Cluster and Accentuated Eccentric Loading in the Back Squat
The current investigation was an examination of the repetition-to-repetition magnitudes and changes in kinetic and kinematic characteristics of the back squat using accentuated eccentric loading (AEL) and cluster sets. Trained male subjects (age = 26.1 ± 4.1 years, height = 183.5 ± 4.3 cm, body mass = 92.5 ± 10.5 kg, back squat to body mass ratio = 1.8 ± 0.3) completed four load condition sessions, each consisting of three sets of five repetitions of either traditionally loaded straight sets (TL), traditionally loaded cluster sets (TLC), AEL cluster sets (AEC), and AEL straight sets where only the initial repetition had eccentric overload (AEL1). Eccentric overload was applied using weight releasers, creating a total eccentric load equivalent to 105% of concentric one repetition maximum (1RM). Concentric load was 80% 1RM for all load conditions. Using straight sets (TL and AEL1) tended to decrease peak power (PP) (d = −1.90 to −0.76), concentric rate of force development (RFDCON) (d = −1.59 to −0.27), and average velocity (MV) (d = −3.91 to −1.29), with moderate decreases in MV using cluster sets (d= −0.81 to −0.62). Greater magnitude eccentric rate of force development (RFDECC) was observed using AEC at repetition three (R3) and five (R5) compared to all load conditions (d = 0.21–0.65). Large within-condition changes in RFDECC from repetition one to repetition three (∆REP1–3) were present using AEL1 (d = 1.51), demonstrating that RFDECC remained elevated for at least three repetitions despite overload only present on the initial repetition. Overall, cluster sets appear to permit higher magnitude and improved maintenance of concentric outputs throughout a set. Eccentric overload with the loading protocol used in the current study does not appear to potentiate concentric output regardless of set configuration but may cause greater RFDECCcompared to traditional loadin
Atomic X-ray Spectroscopy of Accreting Black Holes
Current astrophysical research suggests that the most persistently luminous
objects in the Universe are powered by the flow of matter through accretion
disks onto black holes. Accretion disk systems are observed to emit copious
radiation across the electromagnetic spectrum, each energy band providing
access to rather distinct regimes of physical conditions and geometric scale.
X-ray emission probes the innermost regions of the accretion disk, where
relativistic effects prevail. While this has been known for decades, it also
has been acknowledged that inferring physical conditions in the relativistic
regime from the behavior of the X-ray continuum is problematic and not
satisfactorily constraining. With the discovery in the 1990s of iron X-ray
lines bearing signatures of relativistic distortion came the hope that such
emission would more firmly constrain models of disk accretion near black holes,
as well as provide observational criteria by which to test general relativity
in the strong field limit. Here we provide an introduction to this phenomenon.
While the presentation is intended to be primarily tutorial in nature, we aim
also to acquaint the reader with trends in current research. To achieve these
ends, we present the basic applications of general relativity that pertain to
X-ray spectroscopic observations of black hole accretion disk systems, focusing
on the Schwarzschild and Kerr solutions to the Einstein field equations. To
this we add treatments of the fundamental concepts associated with the
theoretical and modeling aspects of accretion disks, as well as relevant topics
from observational and theoretical X-ray spectroscopy.Comment: 63 pages, 21 figures, Einstein Centennial Review Article, Canadian
Journal of Physics, in pres
Observing Supermassive Black Holes across cosmic time: from phenomenology to physics
In the last decade, a combination of high sensitivity, high spatial
resolution observations and of coordinated multi-wavelength surveys has
revolutionized our view of extra-galactic black hole (BH) astrophysics. We now
know that supermassive black holes reside in the nuclei of almost every galaxy,
grow over cosmological times by accreting matter, interact and merge with each
other, and in the process liberate enormous amounts of energy that influence
dramatically the evolution of the surrounding gas and stars, providing a
powerful self-regulatory mechanism for galaxy formation. The different
energetic phenomena associated to growing black holes and Active Galactic
Nuclei (AGN), their cosmological evolution and the observational techniques
used to unveil them, are the subject of this chapter. In particular, I will
focus my attention on the connection between the theory of high-energy
astrophysical processes giving rise to the observed emission in AGN, the
observable imprints they leave at different wavelengths, and the methods used
to uncover them in a statistically robust way. I will show how such a combined
effort of theorists and observers have led us to unveil most of the SMBH growth
over a large fraction of the age of the Universe, but that nagging
uncertainties remain, preventing us from fully understating the exact role of
black holes in the complex process of galaxy and large-scale structure
formation, assembly and evolution.Comment: 46 pages, 21 figures. This review article appears as a chapter in the
book: "Astrophysical Black Holes", Haardt, F., Gorini, V., Moschella, U and
Treves A. (Eds), 2015, Springer International Publishing AG, Cha
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
The Clean Pull and Snatch Pull: Proper Technique for Weightlifting Movement Derivatives
The clean pull and snatch pull are exercises that use the double knee bend and triple extension involved in weightlifting movements. As a result, these pulling movements are used with the purpose of making an athlete more efficient at producing force with an overload stimulus. In addition, these exercises can be used as a teaching modality for the progressive development of the full clean or snatch
Quantifying Changes in Squat Jump Height Across a Season of Men\u27s Collegiate Soccer
The purposes of this study were to examine the effectiveness of an athlete monitoring program in managing athlete neuromuscular fatigue across a men\u27s collegiate soccer season as measured by changes in squat jump (SJ) height and to compare possible changes with the session rating of perceived exertion (sRPE) training load (TL). Eighteen outfield Division I men\u27s college soccer players performed SJ testing before each game of the fall season in addition to a baseline measurement at the start of preseason. The athletes provided sRPE values after all training sessions, weight-training, and games. Linear mixed modeling was used to compare changes in SJ height across the season with the baseline, and a correlation coefficient and single-lag cross-correlation coefficient were calculated between TL and changes in SJ height. No statistically significant decreases in SJ height occurred across the season, although a moderate practical decline occurred after the preseason (−1.6 cm, effect size = −0.70). The correlation between TL and changes in SJ height was statistically nonsignificant, whereas the cross-correlation was significant (r = 0.18, p = 0.48 and r = 0.55, p = 0.02, respectively). The athlete monitoring program was successful in managing the athletes\u27 neuromuscular fatigue across the season as evidenced by the maintenance of SJ height and positive relationship between TL and changes in SJ height. Thus, SJ monitoring may serve as a useful fatigue monitoring tool for collegiate soccer athletes. Future study is needed, relating changes in vertical jump performance to other markers of athlete preparedness and performance
Using the Session Rating of Perceived Exertion to Quantify Training Load in a Men\u27s College Soccer Team
Using the session rating of perceived exertion to quantify training load in a men\u27s college soccer team. J Strength Cond Res 34(10): 2793-2799, 2020-The purpose of this study was to examine the training load (TL) programming of 3 training groups of a National Collegiate Athletic Association Division I men\u27s college soccer team across a season. Thirty athletes were classified as starters (S), substitutes (NS), or redshirts (RS) based on the percentage of possible minutes played during the season. Training load was quantified at the season, phasic, and weekly levels by the session rating of perceived exertion. Between-group differences were observed at the season level (p \u3c 0.001), and group-by-time interactions for average weekly TL were found at both the phasic (p = 0.04) and weekly levels (p \u3c 0.001). In general, S accumulated greater TL than NS (effect size range for all analyses: -0.59 \u3c d \u3c 1.91) and RS (0.17 \u3c d \u3c 3.67), and NS accumulated greater TL than RS (-0.54 \u3c d \u3c 2.34). Within-group variation at the phasic level was less apparent (-0.35 \u3c d \u3c 1.44); however, all 3 groups displayed training variation at the weekly level (-1.80 \u3c d \u3c 3.24). The session rating of perceived exertion can serve as a low-cost, valid means of quantifying TL in men\u27s college soccer athletes. Practitioners should be especially aware of the possibility of insufficient loading in NS