Effect of nursing interventions on anxiety and vital signs in patients undergoing endoscopy: a randomized clinical trial study

زمینه و هدف: بیماری های دستگاه گوارش یکی از اختلالات شایع بوده و آندوسکوپی مهم ترین روش تشخیصی برای این اختلالات است که به علت تهاجمی بودن، می تواند باعث ترس و اضطراب بیماران گردد. اضطراب قبل از آندوسکوپی باعث کاهش تمایل بیماران و افزایش زمان انجام آندوسکوپی می شود. این مطالعه با هدف تعیین تأثیر مداخلات پرستاری بر میزان اضطراب و برخی علایم حیاتی بیماران کاندیدای آندوسکوپی انجام گرفت. روش بررسی: این مطالعه کارآزمایی بالینی تصادفی سازی شده به صورت یک سو کور بر روی 80 بیمار واجد شرایط آندوسکوپی مراجعه کننده به بیمارستان آیت الله طالقانی ارومیه در سال 1392 انجام شد. نمونه ها با روش نمونه گیری در دسترس انتخاب و به صورت تصادفی در دو گروه مساوی کنترل و مداخله تقسیم شدند. مداخلات پرستاری برای گروه مداخله قبل از آندوسکوپی و در روز آندوسکوپی اجرا گردید. میزان اضطراب، فشارخون و نبض قبل از مداخله و بلافاصله قبل از آندوسکوپی در دو گروه اندازه گیری شد. ابزار اندازه گیری اضطراب، پرسشنامه اضطراب آشکار اسپیل برگر بود. یافته ها: قبل از مداخله تفاوت آماری معنی داری بین دو گروه کنترل و مداخله از نظر متغیرهای جمعیت شناختی وجود نداشت (05/0P). نتیجه گیری: اجرای مداخلات پرستاری در بیماران کاندیدای آندوسکوپی می تواند باعث کاهش اضطراب بیماران قبل از انجام این روش تشخیصی شود. بنابراین می توان از تکنیک های مداخله ای پرستاری به عنوان یکی از روش های غیر دارویی برای کاهش اضطراب بیماران، قبل از انجام روش های تشخیصی تهاجمی استفاده کرد

Correction: Protective effects of hydroalcoholic extracts from an ancient apple variety 'Mela Rosa dei Monti Sibillini' against renal ischemia/reperfusion injury in rats.

Correction for 'Protective effects of hydroalcoholic extracts from an ancient apple variety 'Mela Rosa dei Monti Sibillini' against renal ischemia/reperfusion injury in rats' by Hasan Yousefi-Manesh et al., Food Funct., 2019, 10, 7544–7552

The Impact of problem-solving based learning education on the self-efficacy of nursing students

Abstract: Self-efficacy in applying scientific and professional knowledge and skills is important. One of the proposed ways to create such traits in students is teaching them with active and problem-oriented learning techniques such as problem-solving based learning. The aim of this study was to determine the effect of problembased learning education in nursing students' self-efficacy. Methods: This quasi-experimental study is included 80 fourth-year nursing students. 40 students was selected in the intervention and control groups equally. In the both of groups completed General Self-Efficacy-Schwarzer (GSES) questionnaire before education and a month after the education. Students in the intervention group attended in the five small groups in problem solving education classes for six sessions. Data analysis was done by SPSS software, t-independent and paired t-tests, chi-square. Results: The results of this study showed that mean score of students self-efficacy before and after problem solving education in the intervention group, have significant difference. T-independent test showed a logical statistical difference between mean score difference in the self-efficacy scores between the two groups, after intervention (p=0.002). Conclusions: Problem-solving based learning education program improve students self-efficacy. Thus, it is recommended to pay more attention to this educational method in higher education curriculum. [Masumeh Hemmati Maslakpak, Samira Orujlu

Evaluation of the serum concentrations of albumin and uric acid as a biomarker in patients with Parkinson\'s disease

Background: Parkinson's disease (PD) is a neurological disorder in which dopamine-producing neurons are destroyed. This disease is associated with aging. Our aim in this study was to measure the serum concentrations of albumin and uric acid (UA) as a biomarker for PD detection. Materials and Methods: In this case-control study, we recruited 40 Parkinson patients and 40 healthy individuals. Blood samples (5 ml) were collected from both groups and the serum was isolated. Serum albumin and UA levels were measured, and the data was analyzed by SPSS software, and graphs were prepared using Graphpad Prism. Results: Our results showed that the serum levels of albumin were significantly higher in the control group (5.69 ± 2.51 g/dl) compared to the patient group (4.12 ± 1.60 g/dl) (p˂ 0.001). On the other hand, the serum concentrations of UA in the control group (5.18 ± 1.28 mg/dl) were not statistically significantly different in comparison with the patient group (5.01 ± 1.34 mg/dl) (p= 0.56). The ROC analysis used to evaluate the diagnostic value of biomarkers for PD. Albumin was shown to have a high capability for separating patients from healthy subjects, with an area under the ROC curve 0.85, sensitivity 60% and specificity 97%. Conclusion: The findings of this study indicate that serum albumin levels in patients with PD are lower than healthy subject, and maybe in the future this can be used as diagnostic criteria

The serum lipid profile of Parkinsonś disease patients: A study from the Northwest of Iran

Background: Parkinsonchr('39')s disease (PD) is defined as a long-lasting, neurological illness. Low levels of serum lipid fractions are related with a high risk of PD. Current investigation was designed to evaluate the concentration blood lipid fractions in patients suffering from PD and compared with healthy subjects. Methods: This case-control study was conducted from February 2016 to September 2018 in Tabriz University of Medical Sciences, Tabriz, Iran. The present investigation consisted of 75 persons who had PD and 75 normal people. The blood levels of lipid fractions were measured by concentrations of total cholesterol (TC), serum triglycerides (TG), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), and total cholesterol. The results were analyzed with SPSS software using Kolmogorov-Smirnov, chi-square, and studentchr('39')s t-test. Results: Serum level of TG was remarkably lower in patients with PD (111.92±8.75 mg/dL) compared with healthy subjects (123.64±9.97 mg/dL, P=0.008).  Furthermore, we saw an important difference in the level of LDL-C (P=0.001) and TC (P=0.004) between the two groups. However, there was not any observed meaningful difference in the serum concentrations of HDL-C between the studied groups (P=0.135). Conclusion: Our results showed that the serum concentration of TG, LDL-C, and TC are noticeably lower in the PD suffering patients. Further investigations are needed to provide comprehensive information on the participantschr('39') cognitive layout and subsequent actions

Silver nanoparticle functionalized by glutamine and conjugated with thiosemicarbazide induces apoptosis in colon cancer cell line

Abstract The high mortality rate of colon cancer indicates the insufficient efficacy of current chemotherapy. Thus, the discussion on engineered metal nanoparticles in the treatment of the disease has been considered. In this study, silver nanoparticles were functionalized with glutamine and conjugated with thiosemiccarbazide. Then, anticancer mechanism of Ag@Gln-TSC NPs in a colon cancer cell line (SW480) was investigated. Characterizing Ag@Gln-TSC NPs by FT-IR, XRD, EDS-mapping, DLS, zeta potential, and SEM and TEM microscopy revealed that the Ag@Gln-TSC NPs were correctly synthesized, the particles were spherical, with surface charge of − 27.3 mV, high thermal stability and low agglomeration level. Using MTT assay we found that Ag@Gln-TSC NPs were significantly more toxic for colon cancer cells than normal fibroblast cells with IC50 of 88 and 186 µg/mL, respectively. Flow cytometry analysis showed that treating colon cancer cells with Ag@Gln-TSC NPs leads to a considerable increase in the frequency of apoptotic cells (85.9% of the cells) and increased cell cycle arrest at the S phase. Also, several apoptotic features, including hyperactivity of caspase-3 (5.15 folds), increased expression of CASP8 gene (3.8 folds), and apoptotic nuclear alterations were noticed in the nanoparticle treated cells. Furthermore, treating colon cancer cells with Ag@Gln-TSC NPs caused significant down-regulation of the HULC Lnc-RNA and PPFIA4 oncogene by 0.3 and 0.6 folds, respectively. Overall, this work showed that Ag@Gln-TSC NPs can effectively inhibit colon cancer cells through the activation of apoptotic pathways, a feature that can be considered more in studies in the field of colon cancer treatment

Integrated bio- and carbon-isotope stratigraphy of the Upper Cretaceous Gurpi Formation (Iran):A new reference for the eastern Tethys and its implications for large-scale correlation of stage boundaries

29 pagesInternational audienceA high-resolution stratigraphic analysis of the Upper Cretaceous Gurpi Formation has been undertaken in the Shahneshin section (Zagros Basin, Iran). New results on calcareous nannofossils, planktic foraminifers, dinoflagellate cysts and high-resolution carbon and oxygen stable isotopes form the basis of a reference section for the eastern Tethys that spans the upper Coniacian to the late Danian. Carbon-isotope correlation to Gubbio, Italy and the NW German chalk allows for the identification of many isotopic events as well as for the definition of new events in the Campanian and Maastrichtian. Our results allow for a review of the accurate position of the Coniacian/Santonian, Santonian/Campanian, and Campanian/Maastrichtian stage boundaries relative to carbon isotopes and plankton bioevents. The reliability of Coniacian to Maastrichtian planktic foraminifer, dinoflagellate cysts and calcareous nannofossil biohorizons is assessed