Atmospheric drag model calibrations for spacecraft lifetime prediction

Although solar activity prediction uncertainty normally dominates decay prediction error budget for near-Earth spacecraft, the effect of drag force modeling errors for given levels of solar activity needs to be considered. Two atmospheric density models, the modified Harris-Priester model and the Jacchia-Roberts model, to reproduce the decay histories of the Solar Mesosphere Explorer (SME) and Solar Maximum Mission (SMM) spacecraft in the 490- to 540-kilometer altitude range were analyzed. Historical solar activity data were used in the input to the density computations. For each spacecraft and atmospheric model, a drag scaling adjustment factor was determined for a high-solar-activity year, such that the observed annual decay in the mean semimajor axis was reproduced by an averaged variation-of-parameters (VOP) orbit propagation. The SME (SMM) calibration was performed using calendar year 1983 (1982). The resulting calibration factors differ by 20 to 40 percent from the predictions of the prelaunch ballistic coefficients. The orbit propagations for each spacecraft were extended to the middle of 1988 using the calibrated drag models. For the Jaccia-Roberts density model, the observed decay in the mean semimajor axis of SME (SMM) over the 4.5-year (5.5-year) predictive period was reproduced to within 1.5 (4.4) percent. The corresponding figure for the Harris-Priester model was 8.6 (20.6) percent. Detailed results and conclusions regarding the importance of accurate drag force modeling for lifetime predictions are presented

Evolution of E2 transition strength in deformed hafnium isotopes from new measurements on 172^{172}Hf, 174^{174}Hf, and 176^{176}Hf

The available data for E2 transition strengths in the region between neutron-deficient Hf and Pt isotopes are far from complete. More and precise data are needed to enhance the picture of structure evolution in this region and to test state-of-the-art nuclear models. In a simple model, the maximum collectivity is expected at the middle of the major shell. However, for actual nuclei, this picture may no longer be the case, and one should use a more realistic nuclear-structure model. We address this point by studying the spectroscopy of Hf. We remeasure the 2^+_1 half-lives of 172,174,176Hf, for which there is some disagreement in the literature. The main goal is to measure, for the first time, the half-lives of higher-lying states of the rotational band. The new results are compared to a theoretical calculation for absolute transition strengths. The half-lives were measured using \gamma-\gamma and conversion-electron-\gamma delayed coincidences with the fast timing method. For the determination of half-lives in the picosecond region, the generalized centroid difference method was applied. For the theoretical calculation of the spectroscopic properties, the interacting boson model is employed, whose Hamiltonian is determined based on microscopic energy-density functional calculations. The measured 2^+_1 half-lives disagree with results from earlier \gamma-\gamma fast timing measurements, but are in agreement with data from Coulomb excitation experiments and other methods. Half-lives of the 4^+_1 and 6^+_1 states were measured, as well as a lower limit for the 8^+_1 states. We show the importance of the mass-dependence of effective boson charge in the description of E2 transition rates in chains of nuclei. It encourages further studies of the microscopic origin of this mass dependence. New data on transition rates in nuclei from neighboring isotopic chains could support these studies.Comment: 16 pages, 16 figures, 7 tables; Abstract shortened due to character limi

Antenna Technology Shuttle Experiment (ATSE)

Numerous space applications of the future will require mesh deployable antennas of 15 m in diameter or greater for frequencies up to 20 GHz. These applications include mobile communications satellites, orbiting very long baseline interferometry (VLBI) astrophysics missions, and Earth remote sensing missions. A Lockheed wrap rip antennas was used as the test article. The experiments covered a broad range of structural, control, and RF discipline objectives, which is fulfilled in total, would greatly reduce the risk of employing these antenna systems in future space applications. It was concluded that a flight experiment of a relatively large mesh deployable reflector is achievable with no major technological or cost drivers. The test articles and the instrumentation are all within the state of the art and in most cases rely on proven flight hardware. Every effort was made to design the experiments for low cost

Compact Quad-band Meandered Implantable PIFA for Wireless Brain Care

In the growing efforts of promoting patients' life quality through health technology solutions, implantable wireless biomedical telemetry systems have been identified as one of the frontrunners. In these systems, the design of implantable antennas is of prime importance in establishing the wireless data link. Small multitasking implantable antennas are an evolving wireless health technology for monitoring medical conditions. These implantable antennas are intended for different functions including wireless data transmission at Medical Device Radiocommunication Service (MedRadio) band (401-406 MHz) and Wireless Medical Telemetry Service (WMTS) bands (1395-1400, and 1427-1432), wireless power transfer, and control signals between sleep/wake-up modes at Industrial, Scientific, and Medical (ISM) bands (902-928 MHz and 2400-2483.5 MHz), respectively. In this paper, we present a meandered quad-band planar inverted-F antenna (PIFA) for wireless brain care. Employing the meandering miniaturizing technique, shorting the radiator to the ground plane, and high-permittivity substrate/superstrate layers (Rogers RO3210; varepsilon {r}=10.2, tan delta=0.003, h=0.635 mm) lead to downsizing the antenna volume greatly to 11 times 20.5 times 1.8 mm{3} that includes the biocompatible silicone coating. We developed and characterized the proposed antenna numerically utilizing a 7-layer human head model in full-wave electromagnetic field simulation, where the antenna was implanted in the cerebrospinal fluid (CSF) layer at the depth of 13.25 mm in the cranial cavity. Overall, we achieve a compact quad-band implantable PIFA with-42.3 dBi of gain with a radiation efficiency of 0.003 % at 402 MHz,-22.7 dBi gain with a radiation efficiency of 0.1 % at 902 MHz,-23.7 dBi gain with a radiation efficiency of 0.1 % at 1430 MHz, and-29.7 dBi gain with a radiation efficiency of 0.02 % at 2450 MHz. To our knowledge, this is the first self-matched quad-band antenna proposed for wireless implant communications.Peer reviewe

Systemic Inflammatory Effects of Traumatic Brain Injury, Femur Fracture, and Shock: An Experimental Murine Polytrauma Model

Objective. Despite broad research in neurotrauma and shock, little is known on systemic inflammatory effects of the clinically most relevant combined polytrauma. Experimental investigation in an animal model may provide relevant insight for therapeutic strategies. We describe the effects of a combined injury with respect to lymphocyte population and cytokine activation. Methods. 45 male C57BL/6J mice (mean weight 27 g) were anesthetized with ketamine/xylazine. Animals were subjected to a weight drop closed traumatic brain injury (WD-TBI), a femoral fracture and hemorrhagic shock (FX-SH). Animals were subdivided into WD-TBI, FX-SH and combined trauma (CO-TX) groups. Subjects were sacrificed at 96 h. Blood was analysed for cytokines and by flow cytometry for lymphocyte populations. Results. Mortality was 8%, 13% and 47% for FX-SH, WD-TBI and CO-TX groups (P < 0.05). TNFα (11/13/139 for FX-SH/WD-TBI/CO-TX; P < 0.05), CCL2 (78/96/227; P < 0.05) and IL-6 (16/48/281; P = 0.05) showed significant increases in the CO-TX group. Lymphocyte populations results for FX-SH, WD-TBI and CO-TX were: CD-4 (31/21/22; P = n.s.), CD-8 (7/28/34, P < 0.05), CD-4-CD-8 (11/12/18; P = n.s.), CD-56 (36/7/8; P < 0.05). Conclusion. This study shows that a combination of closed TBI and femur-fracture/ shock results in an increase of the humoral inflammation. More attention to combined injury models in inflammation research is indicated

The Optical Design and Characterization of the Microwave Anisotropy Probe

The primary goal of the MAP satellite, now in orbit, is to make high fidelity polarization sensitive maps of the full sky in five frequency bands between 20 and 100 GHz. From these maps we will characterize the properties of the cosmic microwave background (CMB) anisotropy and Galactic and extragalactic emission on angular scales ranging from the effective beam size, <0.23 degree, to the full sky. MAP is a differential microwave radiometer. Two back-to-back shaped offset Gregorian telescopes feed two mirror symmetric arrays of ten corrugated feeds. We describe the prelaunch design and characterization of the optical system, compare the optical models to the measurements, and consider multiple possible sources of systematic error.Comment: ApJ in press; 22 pages with 11 low resolution figures; paper is available with higher quality figures at http://map.gsfc.nasa.gov/m_mm/tp_links.htm

Within study comparisons and risk of bias in international development: Systematic review and critical appraisal

Background Many systematic reviews incorporate nonrandomised studies of effects, sometimes called quasi‐experiments or natural experiments. However, the extent to which nonrandomised studies produce unbiased effect estimates is unclear in expectation or in practice. The usual way that systematic reviews quantify bias is through “risk of bias assessment” and indirect comparison of findings across studies using meta‐analysis. A more direct, practical way to quantify the bias in nonrandomised studies is through “internal replication research”, which compares the findings from nonrandomised studies with estimates from a benchmark randomised controlled trial conducted in the same population. Despite the existence of many risks of bias tools, none are conceptualised to assess comprehensively nonrandomised approaches with selection on unobservables, such as regression discontinuity designs (RDDs). The few that are conceptualised with these studies in mind do not draw on the extensive literature on internal replications (within‐study comparisons) of randomised trials. Objectives Our research objectives were as follows: Objective 1: to undertake a systematic review of nonrandomised internal study replications of international development interventions. Objective 2: to develop a risk of bias tool for RDDs, an increasingly common method used in social and economic programme evaluation. Methods We used the following methods to achieve our objectives. Objective 1: we searched systematically for nonrandomised internal study replications of benchmark randomised experiments of social and economic interventions in low‐ and middle‐income countries (L&MICs). We assessed the risk of bias in benchmark randomised experiments and synthesised evidence on the relative bias effect sizes produced by benchmark and nonrandomised comparison arms. Objective 2: We used document review and expert consultation to develop further a risk of bias tool for quasi‐experimental studies of interventions (ROBINS‐I) for RDDs. Results Objective 1: we located 10 nonrandomised internal study replications of randomised trials in L&MICs, six of which are of RDDs and the remaining use a combination of statistical matching and regression techniques. We found that benchmark experiments used in internal replications in international development are in the main well‐conducted but have “some concerns” about threats to validity, usually arising due to the methods of outcomes data collection. Most internal replication studies report on a range of different specifications for both the benchmark estimate and the nonrandomised replication estimate. We extracted and standardised 604 bias coefficient effect sizes from these studies, and present average results narratively. Objective 2: RDDs are characterised by prospective assignment of participants based on a threshold variable. Our review of the literature indicated there are two main types of RDD. The most common type of RDD is designed retrospectively in which the researcher identifies post‐hoc the relationship between outcomes and a threshold variable which determines assignment to intervention at pretest. These designs usually draw on routine data collection such as administrative records or household surveys. The other, less common, type is a prospective design where the researcher is also involved in allocating participants to treatment groups from the outset. We developed a risk of bias tool for RDDs. Conclusions Internal study replications provide the grounds on which bias assessment tools can be evidenced. We conclude that existing risk of bias tools needs to be further developed for use by Campbell collaboration authors, and there is a wide range of risk of bias tools and internal study replications to draw on in better designing these tools. We have suggested the development of a promising approach for RDD. Further work is needed on common methodologies in programme evaluation, for example on statistical matching approaches. We also highlight that broader efforts to identify all existing internal replication studies should consider more specialised systematic search strategies within particular literatures; so as to overcome a lack of systematic indexing of this evidence

Prevalence and definition of drooling in Parkinson’s disease: a systematic review

Drooling (saliva loss) is a frequently reported symptom in patients with Parkinson’s disease (PD), but an accurate estimate of the prevalence of drooling is lacking. The aim of this study was to systematically review the prevalence of drooling in published research papers. A systematic PubMed and CINAHL search was done, including studies published until January 2009. Eight studies were found, presenting prevalence rates of drooling based on responses of PD patients to questionnaires. The statistical heterogeneity was highly significant (P < 0.0001), with prevalence rates ranging from 32 to 74%. The pooled prevalence estimate with random effect analysis was of 56% (95% CI 44–67) for PD patients and 14% (95% CI 3–25) for healthy controls; the pooled relative risk (RR) with random effect analysis was 5.5 (95% CI 2.1–14.4). All studies reported data of community dwelling idiopathic PD patients, with a mean age around 65 years and mild PD in 50–60% of the cases. Heterogeneity was mainly caused by differences in definition or frequency of drooling. The highest prevalence rates included nocturnal drooling where others noted only diurnal drooling. Analysis of the data of two studies showed that drooling is reported frequently by 22–26% of the patients. Prevalence rates were lower in milder PD patients. The summarized findings demonstrate that drooling can be present in half of all PD patients. In about a quarter of PD patients, drooling appears to be a frequently occurring problem. We recommend to report drooling in future studies with more detailed consideration of severity, frequency and nocturnal versus diurnal complaints

Neurofibromatosis

Neurofibromatosis (NF) is one of the most common genetic disorders. Inherited in an autosomal dominant fashion, this phacomatosis is classified into two genetically distinct subtypes characterized by multiple cutaneous lesions and tumors of the peripheral and central nervous system. Neurofibromatosis type 1 (NF1), also referred to as Recklinghausen's disease, affects about 1 in 3500 individuals and presents with a variety of characteristic abnormalities of the skin and the peripheral nervous system. Neurofibromatosis type 2 (NF2), previously termed central neurofibromatosis, is much more rare occurring in less than 1 in 25 000 individuals. Often first clinical signs of NF2 become apparent in the late teens with a sudden loss of hearing due to the development of bi-or unilateral vestibular schwannomas. In addition NF2 patients may suffer from further nervous tissue tumors such as meningiomas or gliomas. This review summarizes the characteristic features of the two forms of NF and outlines commonalities and distinctions between NF1 and NF2