Kilpailunrajoituksista immateriaalioikeuksien näkökulmasta

Siirretty Doriast

Synthesis and applications of secondary amine derivatives of (+)-dehydroabietylamine in chiral molecular recognition

(+)-Dehydroabietylamine (1a), the novel derivatives (2a-6a) and their NTf2 salts (1b-6b) were tested as chiral NMR solvating agents for the resolution of enantiomers of the model compound Mosher's acid (7) and its n-Bu4N salt (8). Best enantiomeric discrimination of 7 was obtained using bisdehydroabietyl-amino-N-1, N-2-ethane-1,2-diamine (6a), and of 8 using N-(dehydroabietyl)-2-(dehydroabietylamino) ethanaminium bis((trifluoromethyl)-sulfonyl)-amide (6b). For the maximal resolution of enantiomers of 8, 1.0 eq. of 6b were needed. However, 0.5 eq. of 6a sufficed for the maximal resolution of enantiomers of 7. Enantiomeric excess studies were successfully conducted using 6a and 6b. The capability of 6a and 6b to recognize the enantiomers of various a-substituted carboxylic acids and their n-Bu4N salts were examined. Best resolutions were observed for aliphatic and aromatic carboxylic acids bearing an electronegative alpha-substituent. Now the ee studies on such non-aromatic carboxylic acids are also feasible.Peer reviewe

Incorporated Diffusion Ordered Heteronuclear Multiple Bond Correlation Spectroscopy, 3D iDOSY-HMBC. Merging of Diffusion Delay with Long Polarization Transfer Delay of HMBC

3D iDOSY-HMBC pulse sequences allow the simplification of HMBC data of mixtures via separation in the diffusion domain. The presented methods utilize incorporated DOSY approach, iDOSY, where the existing delays of the basic pulse sequence are utilized for diffusion attenuation. In the simplest form of the proposed 3D iDOSY-HMBC sequences, no extra delays or RF-pulses were required, only two diffusion gradients were added within HMBC polarization transfer delay.Peer reviewe

Synthesis of Tertiary and Quaternary Amine Derivatives from Wood Resin as Chiral NMR Solvating Agents

Chiral tertiary and quaternary amine solvating agents for NMR spectroscopy were synthesized from the wood resin derivative (+)-dehydroabietylamine (2). The resolution of enantiomers of model compounds [Mosher's acid (3) and its n-Bu4N salt (4)] (guests) by (+)-dehydroabietyl-N,N-dimethylmethanamine (5) and its ten different ammonium salts (hosts) was studied. The best results with 3 were obtained using 5 while with 4 the best enantiomeric resolution was obtained using (+)-dehydroabietyl-N,N-dimethylmethanaminium bis(trifluoromethane-sulfonimide) (6). The compounds 5 and 6 showed a 1:1 complexation behaviour between the host and guest. The capability of 5 and 6 to recognize the enantiomers of various -substituted carboxylic acids and their n-Bu4N salts in enantiomeric excess (ee) determinations was demonstrated. A modification of the RES-TOCSY NMR pulse sequence is described, allowing the enhancement of enantiomeric discrimination when the resolution of multiplets is insufficient.Peer reviewe

Inkjet-printed flexible silver electrodes on thiol-enes

Flexible and conductive silver electrodes were fabricated by inkjet printing on several different compositions of thiol-ene polymers. Conductive electrodes with resistivity down to 30 ??cm and good adhesion of the electrodes were obtained by optimizing the printing parameters. The maximum printing resolution was 100 ?m lines and 80 ?m gaps between the lines. Printing on top of cross-linked off-stoichiometric thiol-ene polymer was tested for compositions ranging from 30 % thiol excess to 5 % allyl (?ene?) excess. The roughness off the thiol-ene surfaces was shown to greatly improve the quality of the printed electodes: consistently high yield of conductive electrodes was obtained on rough surfaces (roughness ?1 ?m), whereas on smooth surfaces the electrodes were often cracked. The lowest resistivity values were obtained on electrodes printed on near stoichiometric thiol-ene substrates. The conductivity of the electrodes was retained after 5 % linear strain and after repeated bending with 1 mm radius of curvature, showing the potential for flexible sensors. The electrodes were also applied to electrical impedance-based monitoring of cell growth on thiol-ene surfaces, which showcased that the electrodes survive stressed cell culture conditions for at least 36 h.Peer reviewe

Synthesis, Stability and Relaxivity of TEEPO-Met : An Organic Radical as a Potential Tumour Targeting Contrast Agent for Magnetic Resonance Imaging

Cancer is a widespread and life-threatening disease and its early-stage diagnosis is vital. One of the most effective, non-invasive tools in medical diagnostics is magnetic resonance imaging (MRI) with the aid of contrast agents. Contrast agents that are currently in clinical use contain metals, causing some restrictions in their use. Also, these contrast agents are mainly non-specific without any tissue targeting capabilities. Subsequently, the interest has notably increased in the research of organic, metal-free contrast agents. This study presents a new, stable organic radical, TEEPO-Met, where a radical moiety 2,2,6,6-tetraethylpiperidinoxide (TEEPO) is attached to an amino acid, methionine (Met), as a potentially tumour-targeting moiety. We describe the synthesis, stability assessment with electron paramagnetic resonance (EPR) spectroscopy and relaxation enhancement abilities by an in vitro nuclear magnetic resonance (NMR) and phantom MRI studies of TEEPO-Met. The new compound proved to be stable notably longer than the average imaging time in conditions mimicking a biological matrix. Also, it significantly reduced the relaxation times of water, making it a promising candidate as a novel tumour targeting contrast agent for MRI.Peer reviewe

Lignin-Rich PHWE Hemicellulose Extracts Responsible for Extended Emulsion Stabilization

Peer reviewe

Chlorophyll tailored 20-trifluoroacetamide and its azacrown derivative as pH sensitive colorimetric sensor probe with response to AcO-, F- and CN- ions

Peer reviewe