The Challenges and Benefits of Employing a Mobile Research Fellow to Faciliate Team Work on a large, interdisciplinary, multi-sited Project

Over the last few years research funding has increasingly moved in favour of large, multi-partner, interdisciplinary and multi-site research projects. This article explores the benefits and challenges of employing a full-time research fellow to work across multiple field sites, with all the local research teams, on an international, interdisciplinary project. The article shows how such a ‘floating’ research fellow can play a valuable role in facilitating communication between research teams and project leaders, as well as in building capacity and introducing disciplinary specific skills. It also highlights some key challenges, including problems of language and translation, and the complex power relations within which such a researcher is inevitably embedded. This article contributes to the development of strategies for collaborative projects to facilitate coordination between research teams. It is based on a five-site, cross-cultural project, involving nine partners with a mixture of natural and social science backgrounds, researching aquatic resource use, rural livelihoods, work and education in China, Vietnam and India

The many assembly histories of massive void galaxies as revealed by integral field spectroscopy

We present the first detailed integral field spectroscopy study of nine central void galaxies with M*>10¹⁰Mʘ using the Wide Field Spectrograph to determine how a range of assembly histories manifest themselves in the current day Universe.While the majority of these galaxies are evolving secularly, we find a range of morphologies, merger histories and stellar population distributions, though similarly low Hα-derived star formation rates (10¹⁰Mʘ have similarly low star formation rates

Effects of laboratory salmon louse infection on mortality, growth, and sexual maturation in Atlantic salmon

Elevated salmon louse infection pressure generated by salmon farming represents a major threat for wild Atlantic salmon (Salmo salar). This study explored the effect of salmon lice on mortality, and body and gonad growth in F1 wild Atlantic salmon. Mature males (jacks) and immature fish were either infected with two different louse infection intensities (LIIs, 0.08 or 0.35 lice g−1) or kept as uninfected controls. Fish maturation was thereafter environmentally stimulated in seawater, followed by transfer to freshwater for 38 d to simulate river ascendance. No females matured, while 99% of the initially immature males started puberty. Jacks had high, and immature and maturing fish low, seawater mortality, independent of lice. The parasites had an LII-dependent negative effect on growth in length, weight, and condition factor in seawater. In freshwater, after the lice had detached, fish that were previously infected in seawater had reduced growth in length but not weight when compared to the uninfected control. The parasites did not affect relative gonad size in any fish phenotypes. The present results show that Atlantic salmon has a complex, and unexplored, regulation of growth when recovering from lice infection under laboratory settings. Further, the results suggest that possible negative effects of salmon louse on reproductive success in Atlantic salmon is most likely governed by the reduced body size and condition. However, further work on possible effects of salmon louse on semen quality is encouraged.publishedVersio

Flecainide Paradoxically Activates Cardiac Ryanodine Receptor Channels under Low Activity Conditions: A Potential Pro-Arrhythmic Action.

Cardiac ryanodine receptor (RyR2) mutations are implicated in the potentially fatal catecholaminergic polymorphic ventricular tachycardia (CPVT) and in atrial fibrillation. CPVT has been successfully treated with flecainide monotherapy, with occasional notable exceptions. Reported actions of flecainide on cardiac sodium currents from mice carrying the pro-arrhythmic homozygotic RyR2-P2328S mutation prompted our explorations of the effects of flecainide on their RyR2 channels. Lipid bilayer electrophysiology techniques demonstrated a novel, paradoxical increase in RyR2 activity. Preceding flecainide exposure, channels were mildly activated by 1 mM luminal Ca2+ and 1 µM cytoplasmic Ca2+, with open probabilities (Po) of 0.03 ± 0.01 (wild type, WT) or 0.096 ± 0.024 (P2328S). Open probability (Po) increased within 0.5 to 3 min of exposure to 0.5 to 5.0 µM cytoplasmic flecainide, then declined with higher concentrations of flecainide. There were no such increases in a subset of high Po channels with Po ≥ 0.08, although Po then declined with ≥5 µM (WT) or ≥50 µM flecainide (P2328S). On average, channels with Po < 0.08 were significantly activated by 0.5 to 10 µM of flecainide (WT) or 0.5 to 50 µM of flecainide (P2328S). These results suggest that flecainide can bind to separate activation and inhibition sites on RyR2, with activation dominating in lower activity channels and inhibition dominating in more active channels

Learning from the GP-consultant exchange scheme: a qualitative evaluation.

Collaborative working across primary and secondary care is crucial to providing high quality patient care. There is still a lack of communication and understanding between primary and secondary care, which can impede collaborative working. The experience of observing colleagues in a different speciality can prompt insight, improve morale and promote collaborative working. The GP-Consultant Exchange Scheme aimed to improve professional understanding, foster deeper partnerships, and ignite opportunities for innovation and/or quality improvement (QI) with co-owned local solutions. This paper gives an overview of how the scheme works and sets out some of the outcomes reported by some 200 Consultants and GPs participants to date. Overall, the participants found the scheme an enjoyable way to reconnect clinicians and allowed them to learn about the challenges faced in different areas within the NHS. This low-cost intervention needs motivated individuals to drive the project forward and make it sustainable, but it can be replicated within any organisation or profession in the NHS

Irruptions: evidence for breeding season habitat limitation in Piping Plover (Charadrius melodus)

Effective management of wildlife populations requires identification of the factors limiting their growth. The Piping Plover (Charadrius melodus) is an imperiled, disturbance-dependent, shorebird species that nests on broad, sparsely vegetated beaches, sandbars, and lakeshores. In areas minimally affected by human use, plover habitat loss occurs through vegetation encroachment and erosion. Alternatively, habitat availability may be increased by sand deposition caused by storm- or flood-induced sediment transport or scouring that removes vegetation, or by receding lake levels. To test the hypothesis that plover populations are limited by available breeding habitat, we estimated the amount of habitat available before and after four significant storm and flooding events (i.e., disturbance) by classifying pre- and postdisturbance aerial imagery. We then evaluated the population changes that occurred after disturbance-related habitat alterations. Additionally, we report on population changes from four population increases that occurred after habitat creation events for which we did not have imagery suitable for classification. The storm and flood effects considered were those from hurricanes and nor’easters on barrier islands of Virginia, North Carolina, New York, and Maryland, USA, and those from floods and high water output from the Gavins Point Dam on the Missouri River between South Dakota and Nebraska, USA. The amount of nesting habitat increased 27–950% at these sites, and plover populations increased overall 72–622% after these events (increase of 8–217 pairs in 3 to 8 years after the disturbance, average 12–116% increase annually). The demographic changes were driven by productivity in some cases and probably by increases in immigration in others, and occurred simultaneously with regional increases. Our results support our hypothesis that the focal plover populations were at or near carrying capacity and are habitat limited. Currently, human interventions such as beach stabilization, the construction of artificial dunes, and dams reduce natural disturbance, and therefore, the carrying capacity, in many plover breeding areas. If these interventions were reduced or modified in such a way as to create and improve habitat, plover populations would likely reach higher average numbers and the potential for achieving recovery goals would be increased