Nitro-fatty acid formation and metabolism

Nitro-fatty acids (NO 2 -FA) are pleiotropic modulators of redox signaling pathways. Their effects on inflammatory signaling have been studied in great detail in cell, animal and clinical models primarily using exogenously administered nitro-oleic acid. While we know a considerable amount regarding NO 2 -FA signaling, endogenous formation and metabolism is relatively unexplored. This review will cover what is currently known regarding the proposed mechanisms of NO 2 -FA formation, dietary modulation of endogenous NO 2 -FA levels, pathways of NO 2 -FA metabolism and the detection of NO 2 -FA and corresponding metabolites.Fil: Buchan, Gregory J.. University of Pittsburgh; Estados UnidosFil: Bonacci, Gustavo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Fazzari, Marco. University of Pittsburgh; Estados Unidos. Fondazione Ri.Med; ItaliaFil: Salvatore, Sonia Rosana. University of Pittsburgh; Estados UnidosFil: Gelhaus Wendell, Stacy. University of Pittsburgh; Estados Unido

Editorial

In recent years, global society has faced a range of technical, environmental, economic, and social sustainability challenges. Sustainable development in this ever-changing business environment is one of the biggest issues for any economy, and it is influenced by the interaction between the key actors of the socio-economic syste

Revisiting the helium isotope-shift puzzle with improved uncertainties from nuclear structure corrections

Measurements of the difference between the squared charge radii of the helion ($^3$He nucleus) and the $\alpha$-particle ($^4$He nucleus) have been characterized by longstanding tensions, recently spotlighted in the 3.6 $\sigma$ discrepancy of the extractions from ordinary atoms versus those from muonic atoms. Here, we present a novel analysis of uncertainties in nuclear structure corrections that must be supplied by theory to enable the extraction of the difference in radii from spectroscopic experiments. We use modern Bayesian inference techniques to quantify uncertainties stemming from the truncation of the chiral effective field theory expansion of the nuclear force for both muonic and ordinary atoms. With the new nuclear structure input, the helium isotope-shift puzzle cannot be explained, rather it is reinforced to a 4 $\sigma$ discrepancy.Comment: 5 pages, 3 figures, 2 table

European Union legislation overview about used vegetable oils recycling: the spanish and italian case studies

The employment of used vegetable oils (UVOs) as raw materials in key sectors as energy production or bio-lubricant synthesis represents one of the most relevant priorities in the European Union (EU) normative context. In many countries, the development of new production processes based on the circular economy model, as well as the definition of future energy and production targets, involve the utilization of wastes as raw material. In this context, the main currently applied EU regulations are presented and discussed. As in the EU, the general legislative process consists of the definition in each State Member of specific legislation, which transposes the EU indications. Two relevant countries are herein considered: Italy and Spain. Through the analysis of the conditions required in both countries for UVOs’ collection, disposal, storage, and recycling, a wide panorama of the current situation is provided

Uncertainty quantification in electromagnetic observables of nuclei

We present strategies to quantify theoretical uncertainties in modern ab initio calculations of electromagnetic observables in light and medium-mass nuclei. We discuss how uncertainties build up from various sources, such as the approximations introduced by the few- or many-body solver and the truncation of the chiral effective field theory expansion. We review the recent progress encompassing a broad range of electromagnetic observables in stable and unstable nuclei