Impairment of PGC-1 alpha up-regulation enhances nitrosative stress in the liver during acute pancreatitis in obese mice

Acute pancreatitis is an inflammatory process of the pancreatic tissue that often leads to distant organ dysfunction. Although liver injury is uncommon in acute pancreatitis, obesity is a risk factor for the development of hepatic complications. The aim of this work was to evaluate the role of PGC-1α in inflammatory response regulation in the liver and its contribution to the detrimental effect of obesity on the liver during acute pancreatitis. For this purpose, we induced acute pancreatitis by cerulein in not only wild-type (WT) and PGC-1α knockout (KO) mice, but also in lean and obese mice. PGC-1α levels were up-regulated in the mice livers with pancreatitis. The increased PGC-1α levels were bound to p65 to restrain its transcriptional activity toward Nos2. Lack of PGC-1α favored the assembly of the p65/phospho-STAT3 complex, which promoted Nos2 expression during acute pancreatitis. The increased transcript Nos2 levels and the pro-oxidant liver status caused by the down-regulated expression of the PGC-1α-dependent antioxidant genes enhanced nitrosative stress and decreased energy charge in the livers of the PGC-1α KO mice with pancreatitis. It is noteworthy that the PGC-1α levels lowered in the obese mice livers, which increased the Nos2 mRNA expression and protein nitration levels and decreased energy charge during pancreatitis. In conclusion, obesity impairs PGC-1α up-regulation in the liver to cause nitrosative stress during acute pancreatitis.This work was supported by Grant GV/2019/153 from the Generalitat Valenciana, Conselleria d’Educació, Investigació, Cultura I Esport

Infraestructura para la comunicación entre componentes Java en el estilo arquitectónico C2

En este trabajo se describe el diseñno y la implementación de una infraestructura para la comunicación entre componentes que sigan el estilo arquitectóonico C2 sobre una plataforma Java. Un requisito de esta infraestructura es que componentes y conectores se ejecuten cada uno en su propia máquina virtual (JVM) en el mismo nodo o en nodos diferentes. Se ha diseñado un conjunto de clases que proporcionan mecanismos para la comunicación entre componentes y conectores C2. Como parte del trabajo, se han evaluado las tecnologías disponibles para Java que permiten construir la infraestructura, habiéndose elegido la invocación remota a método (RMI) como la base para la comunicación entre los componentes del sistem

Optical router for optical fiber sensor networks based on a liquid crystal cell

Optical fiber sensor networks are evolving rapidly. They are used because of the inert nature of optical fibers allowing no electromagnetic interference and safe applications in inflammable atmospheres; other relevant characteristics are their low weights and wide bandwidths as a transmission medium. In any case, it is very interesting to have specific components such as optical routers for selecting a certain path in a network with no optical to electrical and electrical to optical conversions. In this paper, we propose an all-optical router based on liquid crystals, polarizers, and a spatial split polarization beam splitter. The implemented device is designed to operate with visible light and it has been tested with plastic optical fibers. It has a crosstalk of 14 dB between selected ON channels and nonoperative OFF channels and 11-dB insertion losses. An average switch time of 100 ms is measured. The device checks the optical power level in each channel and, in case of failure, automatically switches to an operative channel while an alarm is activated.Publicad

Control optoelectrónico en tiempo real de la transparencia de ventanas: Aplicaciones Domóticas

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Sexually Transmitted Infections and Associated Factors in Homosexuals and Bisexuals in Granada (Spain) during the Period 2000–2015

Sexually transmitted infections (STIs) are a major public health issue. Previous research shows the vulnerability of the homosexual and bisexual population, as well as the influence of economic, political, and cultural determinants. The aim of this study was to describe the socio-demographic healthcare profile and the main risk factors associated with STIs in homosexuals and bisexuals seen at the STI clinic in Granada (Spain) during the years 2000–2015. Infection prevalences were compared between the economic crisis period (2008–2014) and the rest of the years analysed. A cross-sectional observational and analytical study was conducted by reviewing 261 clinical records of individuals with suspected or present infection. Univariate, bivariate, and multivariate analyses were performed. 91.2% of the individuals were men, and 8.8% were women, with the mean age being 28.61 (SD = 9.35, Range = 17–74) years old. The prevailing sexual orientation identity was homosexual. 94.2% were single. The main reason for consultation was HIV. Differences in prevalence were found between crisis and non-crisis years (OR = 3.91; 95% CI = 1.73–9.19). In conclusion, their profile was that of a young, single man suspecting possible HIV infection. STI prevalence was significantly higher in the years of economic recession in comparison to the rest of the years

Dermatoses in Latin American immigrants seen in a tertiary hospital

Europe, and in particular Spain, has become the destination of a considerable number of immigrants, 50% come from Latin America. The purpose of this study was to describe the cases of dermatoses seen in the immigrant Latin American population and compare them with those found in the control Spanish population. Over a year all the visits of economic immigrants seen in the Dermatology Section of the Hospital General Universitario de Alicante were prospectively recorded. During the study period 706 Latin American patients were seen. The most frequent dermatoses were eczema (18.2%), acne (6.5%) and non-genital viral warts (6.3%). The comparative study of dermatoses adjusted for age and sex, found a greater frequency of eczema, alopecia, melasma, herpes simplex, pilar keratosis, xerosis, and scabies (p < 0.01) in the Latin American population. On the other hand, melanocytic nevi and melanoma were less frequent in these patients (p < 0.05). We may say that the skin type and socio-sanitary conditions of the Latin American immigrant population lead to a greater frequency of eczema, melasma and scabies. In addition, the skin type and younger age favour a lower frequency of skin tumours

Aprendizaje Basado en Retos en el campo de la geotecnia: reparación de un deslizamiento de ladera

Para mejorar las competencias en el área de geotecnia de los alumnos de la ETSI de Caminos de la UPM se ha llevado a cabo un Proyecto de Innovación Educativa basado en la metodología del Aprendizaje Basado en Retos. El objetivo principal fue proporcionar a los alumnos una experiencia profesional en el campo de la ingeniería geotécnica, de tal forma que aumentase su confianza en los conocimientos adquiridos de cara a su incorporación al mundo laboral. El reto planteado fue la reparación de una rotura de talud, y el proceso seguido asemejó al que se realizaría en una empresa de ingeniería. Para facilitar la labor del alumno y mejorar la calidad de la experiencia, se organizaron, a lo largo del trabajo, reuniones con especialistas del sector. En este artículo se describe la metodología planteada, así como los resultados obtenidos. Aunque los alumnos valoraron positivamente la propuesta, no se pudo completar la actividad debido al abandono generalizado aproximadamente a la mitad de la misma. En el documento se analizan las causas de este abandono, siendo la principal de ellas la elevada carga de trabajo de los alumnos en la época final del curso

Métodos de escalamiento aplicados a la priorización de necesidades de formación en organizaciones

Los criterios para priorizar las necesidades que justifican las acciones formativas a implantar no se suelen explicitar a priori en los programas de formación continua en contextos organizacionales. En este trabajo se proponen los métodos de escalamiento como procedimiento factible y útil para identificar criterios explícitos de priorización de necesidades, y se concreta cuál de ellos es más apropiado en este contexto de intervención. 404 empleados de una organización pública cumplimentaron un cuestionario ad hoc para priorizar necesidades formativas en diferentes áreas durante el período 2004 al 2006; concretamente, se ordenaron 117, 75 y 286 estímulos, respectivamente. Se calcularon y compararon las ordenaciones obtenidas con cuatro métodos de escalamiento: el método de Dunn-Rankin y tres métodos derivados de la Ley del Juicio Categórico de Thurstone, concretamente ordenación por rangos, intervalos sucesivos e intervalos aparentemente iguales. Con los resultados, se constata la factibilidad y utilidad de estos métodos de escalamiento para la solución de los problemas planteados; a partir de los métodos más precisos, se propone el uso del método de ordenación por rangos por su parsimonia (respecto a sencillez en su procedimiento); y se anticipan futuras líneas de actuación