2,515 research outputs found
A Search for Variations of Fundamental Constants using Atomic Fountain Clocks
Over five years we have compared the hyperfine frequencies of 133Cs and 87Rb
atoms in their electronic ground state using several laser cooled 133Cs and
87Rb atomic fountains with an accuracy of ~10^{-15}. These measurements set a
stringent upper bound to a possible fractional time variation of the ratio
between the two frequencies : (d/dt)ln(nu_Rb/nu_Cs)=(0.2 +/- 7.0)*10^{-16}
yr^{-1} (1 sigma uncertainty). The same limit applies to a possible variation
of the quantity (mu_Rb/mu_Cs)*alpha^{-0.44}, which involves the ratio of
nuclear magnetic moments and the fine structure constant.Comment: 4 pages, 3 figures, 1 table submitted to Phys. Rev. Let
Measurement of interaction energy near a Feshbach resonance in a 6Li Fermi gas
We investigate the strongly interacting regime in an optically trapped Li
Fermi mixture near a Feshbach resonance. The resonance is found at G
in good agreement with theory. Anisotropic expansion of the gas is interpreted
by collisional hydrodynamics. We observe an unexpected and large shift (G)
between the resonance peak and both the maximum of atom loss and the change of
sign of the interaction energy.Comment: 4 pages, 4 figure
Masses of the components of SB2 binaries observed with Gaia. II. Masses derived from PIONIER interferometric observations for Gaia validation
In anticipation of the Gaia astrometric mission, a sample of spectroscopic
binaries is being observed since 2010 with the Sophie spectrograph at the
Haute--Provence Observatory. Our aim is to derive the orbital elements of
double-lined spectroscopic binaries (SB2s) with an accuracy sufficient to
finally obtain the masses of the components with relative errors as small as 1
% when combined with Gaia astrometric measurements. In order to validate the
masses derived from Gaia, interferometric observations are obtained for three
SB2s in our sample with F-K components: HIP 14157, HIP 20601 and HIP 117186.
The masses of the six stellar components are derived. Due to its edge-on
orientation, HIP 14157 is probably an eclipsing binary. We note that almost all
the derived masses are a few percent larger than the expectations from the
standard spectral-type-mass calibration and mass-luminosity relation. Our
calculation also leads to accurate parallaxes for the three binaries, and the
Hipparcos parallaxes are confirmed.Comment: 10 pages, 3 figures, accepted by MNRA
Characterizing the spin state of an atomic ensemble using the magneto-optical resonance method
Quantum information protocols utilizing atomic ensembles require preparation
of a coherent spin state (CSS) of the ensemble as an important starting point.
We investigate the magneto-optical resonance method for characterizing a spin
state of cesium atoms in a paraffin coated vapor cell. Atoms in a constant
magnetic field are subject to an off-resonant laser beam and an RF magnetic
field. The spectrum of the Zeeman sub-levels, in particular the weak quadratic
Zeeman effect, enables us to measure the spin orientation, the number of atoms,
and the transverse spin coherence time. Notably the use of 894nm pumping light
on the D1-line, ensuring the state F=4, m_F=4 to be a dark state, helps us to
achieve spin orientation of better than 98%. Hence we can establish a CSS with
high accuracy which is critical for the analysis of the entangled states of
atoms.Comment: 12 pages ReVTeX, 6 figures, in v2 added ref. and corrected typo
Matter wave pulses characteristics
We study the properties of quantum single-particle wave pulses created by
sharp-edged or apodized shutters with single or periodic openings. In
particular, we examine the visibility of diffraction fringes depending on
evolution time and temperature; the purity of the state depending on the
opening-time window; the accuracy of a simplified description which uses
``source'' boundary conditions instead of solving an initial value problem; and
the effects of apodization on the energy width.Comment: 11 pages, 11 figure
Diatomic molecules in ultracold Fermi gases - Novel composite bosons
We give a brief overview of recent studies of weakly bound homonuclear
molecules in ultracold two-component Fermi gases. It is emphasized that they
represent novel composite bosons, which exhibit features of Fermi statistics at
short intermolecular distances. In particular, Pauli exclusion principle for
identical fermionic atoms provides a strong suppression of collisional
relaxation of such molecules into deep bound states. We then analyze
heteronuclear molecules which are expected to be formed in mixtures of
different fermionic atoms. It is found how an increase in the mass ratio for
the constituent atoms changes the physics of collisional stability of such
molecules compared to the case of homonuclear ones. We discuss Bose-Einstein
condensation of these composite bosons and draw prospects for future studies.Comment: 10 pages, 5 figure
Arrays of Nano-Electromechanical Biosensors Functionalized by Microcontact Printing
The biofunctionalization of nanoelectromechanical structures is critical for
the development of new classes of biosensors displaying improved performances
and higher-level of integration. We propose a modified microcontact printing
method for the functionalization and passivation of large arrays of
nanocantilevers in a single, self-aligned step. Using fluorescence microscopy
and resonant frequency measurements, we demonstrate (1) the bioactivity and the
anti-fouling property of deposited antibodies and BSA molecules and (2) the
preservation of the nanostructures' mechanical integrity.Comment: 20 pages, 5 figure
Precision medicine for suicidality: from universality to subtypes and personalization
Suicide remains a clear, present and increasing public health problem, despite being a potentially preventable tragedy. Its incidence is particularly high in people with overt or un(der)diagnosed psychiatric disorders. Objective and precise identification of individuals at risk, ways of monitoring response to treatments and novel preventive therapeutics need to be discovered, employed and widely deployed. We sought to investigate whether blood gene expression biomarkers for suicide (that is, a âliquid biopsyâ approach) can be identified that are more universal in nature, working across psychiatric diagnoses and genders, using larger cohorts than in previous studies. Such markers may reflect and/or be a proxy for the core biology of suicide. We were successful in this endeavor, using a comprehensive stepwise approach, leading to a wealth of findings. Steps 1, 2 and 3 were discovery, prioritization and validation for tracking suicidality, resulting in a Top Dozen list of candidate biomarkers comprising the top biomarkers from each step, as well as a larger list of 148 candidate biomarkers that survived Bonferroni correction in the validation step. Step 4 was testing the Top Dozen list and Bonferroni biomarker list for predictive ability for suicidal ideation (SI) and for future hospitalizations for suicidality in independent cohorts, leading to the identification of completely novel predictive biomarkers (such as CLN5 and AK2), as well as reinforcement of ours and others previous findings in the field (such as SLC4A4 and SKA2). Additionally, we examined whether subtypes of suicidality can be identified based on mental state at the time of high SI and identified four potential subtypes: high anxiety, low mood, combined and non-affective (psychotic). Such subtypes may delineate groups of individuals that are more homogenous in terms of suicidality biology and behavior. We also studied a more personalized approach, by psychiatric diagnosis and gender, with a focus on bipolar males, the highest risk group. Such a personalized approach may be more sensitive to gender differences and to the impact of psychiatric co-morbidities and medications. We compared testing the universal biomarkers in everybody versus testing by subtypes versus personalized by gender and diagnosis, and show that the subtype and personalized approaches permit enhanced precision of predictions for different universal biomarkers. In particular, LHFP appears to be a strong predictor for suicidality in males with depression. We also directly examined whether biomarkers discovered using male bipolars only are better predictors in a male bipolar independent cohort than universal biomarkers and show evidence for a possible advantage of personalization. We identified completely novel biomarkers (such as SPTBN1 and C7orf73), and reinforced previously known biomarkers (such as PTEN and SAT1). For diagnostic ability testing purposes, we also examined as predictors phenotypic measures as apps (for suicide risk (CFI-S, Convergent Functional Information for Suicidality) and for anxiety and mood (SASS, Simplified Affective State Scale)) by themselves, as well as in combination with the top biomarkers (the combination being our a priori primary endpoint), to provide context and enhance precision of predictions. We obtained area under the curves of 90% for SI and 77% for future hospitalizations in independent cohorts. Step 5 was to look for mechanistic understanding, starting with examining evidence for the Top Dozen and Bonferroni biomarkers for involvement in other psychiatric and non-psychiatric disorders, as a mechanism for biological predisposition and vulnerability. The biomarkers we identified also provide a window towards understanding the biology of suicide, implicating biological pathways related to neurogenesis, programmed cell death and insulin signaling from the universal biomarkers, as well as mTOR signaling from the male bipolar biomarkers. In particular, HTR2A increase coupled with ARRB1 and GSK3B decreases in expression in suicidality may provide a synergistic mechanistical corrective target, as do SLC4A4 increase coupled with AHCYL1 and AHCYL2 decrease. Step 6 was to move beyond diagnostics and mechanistical risk assessment, towards providing a foundation for personalized therapeutics. Items scored positive in the CFI-S and subtypes identified by SASS in different individuals provide targets for personalized (psycho)therapy. Some individual biomarkers are targets of existing drugs used to treat mood disorders and suicidality (lithium, clozapine and omega-3 fatty acids), providing a means toward pharmacogenomics stratification of patients and monitoring of response to treatment. Such biomarkers merit evaluation in clinical trials. Bioinformatics drug repurposing analyses with the gene expression biosignatures of the Top Dozen and Bonferroni-validated universal biomarkers identified novel potential therapeutics for suicidality, such as ebselen (a lithium mimetic), piracetam (a nootropic), chlorogenic acid (a polyphenol) and metformin (an antidiabetic and possible longevity promoting drug). Finally, based on the totality of our data and of the evidence in the field to date, a convergent functional evidence score prioritizing biomarkers that have all around evidence (track suicidality, predict it, are reflective of biological predisposition and are potential drug targets) brought to the fore APOE and IL6 from among the universal biomarkers, suggesting an inflammatory/accelerated aging component that may be a targetable common denominator
First observation of feshbach resonances at very low magnetic field in a 133Cs fountain.
7 pagesOne of the main limitations of cesium atomic fountains has been the cold collision frequency shift. By using a method based on a transfer of population by adiabatic passage allowing to prepare cold atomic samples with a well defined ratio of atomic density as well as atom number the collisional shift is controlled at the 10E-3 of its value. A calibration of Zeeman sub-states contribution to the clock shift as a function of the field has been performed. Feshbach resonances have been observed for the first time at very low magnetic field and with a very good resolution. A Monte Carlo simulation has been performed and could fit properly some of experimental data. This constrains some parameters of the theory of collisions
New Limits to the Drift of Fundamental Constants from Laboratory Measurements
We have remeasured the absolute - transition frequency in atomic hydrogen. A comparison with the result of the previous
measurement performed in 1999 sets a limit of Hz for the drift of
with respect to the ground state hyperfine splitting in Cs. Combining this result with the recently published
optical transition frequency in Hg against and a
microwave Rb and Cs clock comparison, we deduce separate limits
on yr and the
fractional time variation of the ratio of Rb and Cs nuclear magnetic moments
equal to
yr. The latter provides information on the temporal behavior of the
constant of strong interaction.Comment: 4 pages, 3 figures, LaTe
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