Examining the effect rate of offers system on state and foreign consumer’s satisfaction (Case study: A trading company)

The most known device to achieve participation is the offers system which is an important factor in changing work conditions, creating field appropriate for personnel participation, creating dynamism and improving process and quality of the products or services.In this article, it was attempted to execute offers system in a great trading company with several branches in different ports of Iran where there are loading, warehousing, goods release and other services to deal with the effect of offers system on state and foreign consumer’s satisfaction. In this study, the consumer’s satisfaction was measured by Servqual model before and after offers system execution. Having executed the offers system, the consumers (State and foreign) satisfaction increased and it was clear that the foreign (Main) satisfaction increased more than the state (Personnel) consumers' indicating offers  system influences the former more than the latter

Examining the effect rate of offers system on state and foreign consumer’s satisfaction (Case study: A trading company)

The most known device to achieve participation is the offers system which is an important factor in changing work conditions, creating field appropriate for personnel participation, creating dynamism and improving process and quality of the products or services.In this article, it was attempted to execute offers system in a great trading company with several branches in different ports of Iran where there are loading, warehousing, goods release and other services to deal with the effect of offers system on state and foreign consumer’s satisfaction. In this study, the consumer’s satisfaction was measured by Servqual model before and after offers system execution. Having executed the offers system, the consumers (State and foreign) satisfaction increased and it was clear that the foreign (Main) satisfaction increased more than the state (Personnel) consumers' indicating offers  system influences the former more than the latter

PTEN and p53 Gene Expressions in Breast Cancer Specimens and their Clinicopathological Significance

Background: Breast cancer is the second leading cause of cancer death after lung cancer. Discovering molecular biomarkers is necessary for disease management that includes prognosis prediction and preventive treatment. The aim of this study is to evaluate the expression value of p53 and PTEN as molecular biomarkers of breast cancer and their relation with clinicopathological characteristics. Methods: In this study, 100 breast cancer and 20 normal samples were subjected to investigation. Total RNA was isolated and we measured RNA expression by realtime RT-PCR. Data were analyzed by REST 2009 and SPSS. Results: Gene expression results showed up-regulation of P53 in 53 breast cancer subjects and PTEN in 52 breast cancer subjects compared with normal controls. However, there was lower P53 expression in 25 breast cancer samples compared to normal tissues. PTEN expression was lower in 26 breast cancer samples than normal tissues. p53 showed a significant relationship to HER2 receptor (P=0.024) and menopausal status (P=0.013); no significant relationships existed with other clinicopathological parameters (P>0.05). PTEN had the only significant correlation with lymphatic invasion (P=0.046) without any relation with other clinicopathological features (P>0.05). PTEN expression had no significant association with p53 expression in the studied population (P=0.074). Conclusion: Combined detection of PTEN and p53 may have the potential to estimate the pathobiological behavior and prognosis of breast cancer. Due to the heterogeneous nature of cancer and the presence of different factors involved in the clinical situation of breast cancer, we suggest a study of a larger population and more biomarkers

Pivotal Impacts of Retrotransposon Based Invasive RNAs on Evolution

RNAs have long been described as the mediators of gene expression; they play a vital role in the structure and function of cellular complexes. Although the role of RNAs in the prokaryotes is mainly confined to these basic functions, the effects of these molecules in regulating the gene expression and enzymatic activities have been discovered in eukaryotes. Recently, a high-resolution analysis of the DNA obtained from different organisms has revealed a fundamental impact of the RNAs in shaping the genomes, heterochromatin formation, and gene creation. Deep sequencing of the human genome revealed that about half of our DNA is comprised of repetitive sequences (remnants of transposable element movements) expanded mostly through RNA-mediated processes. ORF2 encoded by L1 retrotransposons is a cellular reverse transcriptase which is mainly responsible for RNA invasion of various transposable elements (L1s, Alus, and SVAs) and cellular mRNAs in to the genomic DNA. In addition to increasing retroelements copy number; genomic expansion in association with centromere, telomere, and heterochromatin formation as well as pseudogene creation are the evolutionary consequences of this RNA-based activity. Threatening DNA integrity by disrupting the genes and forming excessive double strand breaks is another effect of this invasion. Therefore, repressive mechanisms have been evolved to control the activities of these invasive intracellular RNAs. All these mechanisms now have essential roles in the complex cellular functions. Therefore, it can be concluded that without direct action of RNA networks in shaping the genome and in the development of different cellular mechanisms, the evolution of higher eukaryotes would not be possible