USO DE MULTIMEDIA WEBLOG EN LA ENSEÑANZA APRENDIZAJE EN LOS DOCENTES DE LAS INSTITUCIONES EDUCATIVAS URBANAS, YUNGAY, 2017

El uso de la red mundial es un recurso esencial que permite a muchos docentes facilitar en proceso educativo mediante la publicación de recursos y materiales relacionados a un área específica. Los profesores y educandos pueden publicar artículos, documentos, realizar comentarios y opiniones a un determinado tema. El manejo de los Weblogs está facilitando la publicación de artículos en la red mundial aumentando los niveles de interactividad de los sitios Web, permitiéndonos escribir artículos y publicaciones. Los Weblogs son diarios digitales en el cual los autores publican ideas, artículos y reflexiones sobre un tema específico. Aquí se pueden publicar artículos de amplia información y de actualidad estas herramientas tienen mucho impacto en el periodismo, sector empresarial y aprendizaje en línea. Con la presente monografía, se dará a conocer la naturaleza e implicancias de los de los weblogs en el proceso de aprendizaje.Trabajo de investigació

Uso de redes sociales y rendimiento académico en estudiantes de quinto de secundaria en una IE de secundaria de Yungay – 2019

Como sabemos las Tic han contribuido de manera sustancial la transformación de la vida del hombre, en esos tiempos se hace ineludible el uso de ellas, han logrado incursionar en todas las formas de la existencia del ser humano, la educación no está al margen de esos cambios que se están efectuando y de manera muy acelerada, el manejo de esas nuevas tecnologías ha de contribuir desarrollar nuevas formas de aprendizaje, la intención final si es que el uso de las mismas tienen impacto el rendimiento académico estudiantil. Se ha hecho uso como instrumento de un cuestionario del manejo de esas herramientas tecnológicas y los promedios obtenidos en las diferentes áreas hasta el bimestre II de 2019. La muestra en la cual se ha efectuado esta investigación estuvo conformada por 46 estudiantes del quinto grado de secundaria de la indicada IE, el diseño empleado en la presente investigación fue el correlacional, la muestra fue de carácter no probabilístico, se ha trabajado con un muestreo intencionado. En los resultados se ha encontrado que si existe relación entre el uso de las redes sociales y el rendimiento académico en estudiantes de quinto grado de secundaria de la IEP 86648 "Santo Domingo de Guzmán” de Yungay – Segundo bimestre 2019, al haberse obtenido r = 0.806 y p = 1.3541E-11, lo cual se interpreta como una correlación directa, muy fuerte y además con significancia estadística. También se ha demostrado que existe relación moderada entre las dimensiones de las redes sociales genéricas, profesionales y temáticas con el rendimiento académico ya que se escribieron los valores r de 0.683, 0.632 y 0.630 y los p valores fueron: 1.6776E-7, 0.000002 y 0.000003 con lo que resulta evidente que deben rechazarse las hipótesis nulas y aceptarse las correspondientes hipótesis alterna.Tesi

The narrative of the migrant student in school inclusion

La educación -y todo tipo de proceso escolar en la actualidad- está pasando por distintas transformaciones sociales, económicas, políticas, culturales y pedagógicas que inciden directamente en las diversas maneras de vida dentro de la escuela y en las comunidades que hacen parte de ella. Si bien es cierto que el fenómeno migratorio es una de las principales causas que contribuye a estos cambios dentro de los sistemas educativos, desde la llegada de estudiantes migrantes venezolanos en las escuelas se han generado ciertos desafíos para desarrollar buenos procesos de acogida e integración de esta población, así como garantizar su permanencia en las instituciones y finalmente desarrollar procesos de formación de calidad. Esta investigación pretende reconocer el proceso de Inclusión Escolar desde la voz del niño, niña y adolescente (NNA en adelante) migrante venezolano, en la Básica Secundaria del Colegio Eduardo Santos, Institución Educativa Distrital de la ciudad de Bogotá. Para ello emplea una metodología cualitativa con un enfoque histórico narrativo, donde se conocen, interpretan y se reconfiguran los relatos de la población migrante sujeto de esta investigación, (6) seis estudiantes migrantes pertenecientes a dicha institución. Dentro de las conclusiones más importantes destacan factores emocionales indiscutibles asociados a la huella que dejan los procesos migratorios en los estudiantes y que repercuten posteriormente para construir su identidad; de igual manera, se destacan dinámicas escolares que se quedan cortas para garantizar procesos de inclusión satisfactorios, así como la indiferencia o la invisibilización de la población migrante por parte de otros miembros de la comunidad educativa.Estudiantes migrantes venezolanosEducation - and all forms of schooling in the present day - is undergoing various social, economic, political, cultural, and pedagogical transformations that directly impact the diverse ways of life within the school and the communities of which it is a part. While it is true that migratory phenomena represent one of the primary causes contributing to these changes within educational systems, the arrival of Venezuelan migrant students in schools has posed certain challenges in developing effective processes of reception and integration for this population, as well as ensuring their continued enrollment in institutions and ultimately fostering high-quality educational processes. This research aims to recognize the process of School Inclusion from the voice of the Venezuelan migrant child and adolescent (NNA hereinafter), in the Basic Secondary School of the Eduardo Santos School, District Educational Institution of the city of Bogotá. To achieve this, it employs a qualitative methodology with a historical-narrative approach, where the narratives of the migrant population subject to this investigation – six migrant students from this institution – are explored, interpreted, and reconfigured. Among the most significant conclusions are the undeniable emotional factors associated with the impact of migratory processes on students, which subsequently influence the construction of their identity. Likewise, shortcomings in school dynamics are highlighted in ensuring satisfactory inclusion processes, as well as the indifference or invisibility of the migrant population by other members of the educational community.Magíster en EducaciónMaestrí

Zinc associated nanomaterials and their intervention in emerging respiratory viruses: Journey to the field of biomedicine and biomaterials.

Respiratory viruses represent a severe public health risk worldwide, and the research contribution to tackle the current pandemic caused by the SARS-CoV-2 is one of the main targets among the scientific community. In this regard, experts from different fields have gathered to confront this catastrophic pandemic. This review illustrates how nanotechnology intervention could be valuable in solving this difficult situation, and the state of the art of Zn-based nanostructures are discussed in detail. For virus detection, learning from the experience of other respiratory viruses such as influenza, the potential use of Zn nanomaterials as suitable sensing platforms to recognize the S1 spike protein in SARS-CoV-2 are shown. Furthermore, a discussion about the antiviral mechanisms reported for ZnO nanostructures is included, which can help develop surface disinfectants and protective coatings. At the same time, the properties of Zn-based materials as supplements for reducing viral activity and the recovery of infected patients are illustrated. Within the scope of noble adjuvants to improve the immune response, the ZnO NPs properties as immunomodulators are explained, and potential prototypes of nanoengineered particles with metallic cations (like Zn2+) are suggested. Therefore, using Zn-associated nanomaterials from detection to disinfection, supplementation, and immunomodulation opens a wide area of opportunities to combat these emerging respiratory viruses. Finally, the attractive properties of these nanomaterials can be extrapolated to new clinical challenges

Zinc associated nanomaterials and their intervention in emerging respiratory viruses:Journey to the field of biomedicine and biomaterials

Respiratory viruses represent a severe public health risk worldwide, and the research contribution to tackle the current pandemic caused by the SARS-CoV-2 is one of the main targets among the scientific community. In this regard, experts from different fields have gathered to confront this catastrophic pandemic. This review illustrates how nanotechnology intervention could be valuable in solving this difficult situation, and the state of the art of Zn-based nanostructures are discussed in detail. For virus detection, learning from the experience of other respiratory viruses such as influenza, the potential use of Zn nanomaterials as suitable sensing platforms to recognize the S1 spike protein in SARS-CoV-2 are shown. Furthermore, a discussion about the antiviral mechanisms reported for ZnO nanostructures is included, which can help develop surface disinfectants and protective coatings. At the same time, the properties of Zn-based materials as supplements for reducing viral activity and the recovery of infected patients are illustrated. Within the scope of noble adjuvants to improve the immune response, the ZnO NPs properties as immunomodulators are explained, and potential prototypes of nanoengineered particles with metallic cations (like Zn(2+)) are suggested. Therefore, using Zn-associated nanomaterials from detection to disinfection, supplementation, and immunomodulation opens a wide area of opportunities to combat these emerging respiratory viruses. Finally, the attractive properties of these nanomaterials can be extrapolated to new clinical challenges

植物由来の刺激が生理応答に及ぼす影響

研究科: 千葉大学大学院園芸学研究科学位:千大院園博乙第農25号博士(農学)千葉大

HypoxamiRs Profiling Identify miR-765 as a Regulator of the Early Stages of Vasculogenic Mimicry in SKOV3 Ovarian Cancer Cells

Vasculogenic mimicry (VM) is a novel cancer hallmark in which malignant cells develop matrix-associated 3D tubular networks with a lumen under hypoxia to supply nutrients needed for tumor growth. Recent studies showed that microRNAs (miRNAs) may have a role in VM regulation. In this study, we examined the relevance of hypoxia-regulated miRNAs (hypoxamiRs) in the early stages of VM formation. Data showed that after 48 h hypoxia and 12 h incubation on matrigel SKOV3 ovarian cancer cells undergo the formation of matrix-associated intercellular connections referred hereafter as 3D channels-like structures, which arose previous to the apparition of canonical tubular structures representative of VM. Comprehensive profiling of 754 mature miRNAs at the onset of hypoxia-induced 3D channels-like structures showed that 11 hypoxamiRs were modulated (FC>1.5; p < 0.05) in SKOV3 cells (9 downregulated and 2 upregulated). Bioinformatic analysis of the set of regulated miRNAs showed that they might impact cellular pathways related with tumorigenesis. Moreover, overall survival analysis in a cohort of ovarian cancer patients (n = 485) indicated that low miR-765, miR-193b, miR-148a and high miR-138 levels were associated with worst patients outcome. In particular, miR-765 was severely downregulated after hypoxia (FC < 32.02; p < 0.05), and predicted to target a number of protein-encoding genes involved in angiogenesis and VM. Functional assays showed that ectopic restoration of miR-765 in SKOV3 cells resulted in a significant inhibition of hypoxia-induced 3D channels-like formation that was associated with a reduced number of branch points and patterned tubular-like structures. Mechanistic studies confirmed that miR-765 decreased the levels of VEGFA, AKT1 and SRC-α transducers and exerted a negative regulation of VEGFA by specific binding to its 3‘UTR. Finally, overall survival analysis of a cohort of ovarian cancer patients (n = 1435) indicates that high levels of VEGFA, AKT1 and SRC-α and low miR-765 expression were associated with worst patients outcome. In conclusion, here we reported a novel hypoxamiRs signature which constitutes a molecular guide for further clinical and functional studies on the early stages of VM. Our data also suggested that miR-765 coordinates the formation of 3D channels-like structures through modulation of VEGFA/AKT1/SRC-α axis in SKOV3 ovarian cancer cells

A collaboratively derived environmental research agenda for Galapagos

Galápagos is one of the most pristine archipelagos in the world and its conservation relies upon research and sensible management. In recent decades both the interest in, and the needs of, the islands have increased, yet the funds and capacity for necessary research have remained limited. It has become, therefore, increasingly important to identify areas of priority research to assist decision-making in Galápagos conservation. This study identified 50 questions considered priorities for future research and management. The exercise involved the collaboration of policy makers, practitioners and researchers from more than 30 different organisations. Initially, 360 people were consulted to generate 781 questions. An established process of preworkshop voting and three rounds to reduce and reword the questions, followed by a two-day workshop, was used to produce the final 50 questions. The most common issues raised by this list of questions were human population growth, climate change and the impact of invasive alien species. These results have already been used by a range of organisations and politicians and are expected to provide the basis for future research on the islands so that its sustainability may be enhanced. </jats:p

Evolving trends in the management of acute appendicitis during COVID-19 waves. The ACIE appy II study

Background: In 2020, ACIE Appy study showed that COVID-19 pandemic heavily affected the management of patients with acute appendicitis (AA) worldwide, with an increased rate of non-operative management (NOM) strategies and a trend toward open surgery due to concern of virus transmission by laparoscopy and controversial recommendations on this issue. The aim of this study was to survey again the same group of surgeons to assess if any difference in management attitudes of AA had occurred in the later stages of the outbreak. Methods: From August 15 to September 30, 2021, an online questionnaire was sent to all 709 participants of the ACIE Appy study. The questionnaire included questions on personal protective equipment (PPE), local policies and screening for SARS-CoV-2 infection, NOM, surgical approach and disease presentations in 2021. The results were compared with the results from the previous study. Results: A total of 476 answers were collected (response rate 67.1%). Screening policies were significatively improved with most patients screened regardless of symptoms (89.5% vs. 37.4%) with PCR and antigenic test as the preferred test (74.1% vs. 26.3%). More patients tested positive before surgery and commercial systems were the preferred ones to filter smoke plumes during laparoscopy. Laparoscopic appendicectomy was the first option in the treatment of AA, with a declined use of NOM. Conclusion: Management of AA has improved in the last waves of pandemic. Increased evidence regarding SARS-COV-2 infection along with a timely healthcare systems response has been translated into tailored attitudes and a better care for patients with AA worldwide

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)