[18F]FDG-PET/CT in Hodgkin Lymphoma: Current Usefulness and Perspectives

Functional imaging using 18-fluorodeoxyglycose ([18F]FDG) positron emission tomography combined with computed tomography (PET/CT) has become a major imaging modality in Hodgkin lymphoma. This imaging modality allows for a significant improvement in staging, increased sensitivity, which involves differentiating residual tumors from fibrosis during assessment, and highly impacts treatment decisions into new PET-driven strategies. This review presents the main scientific data concerning the current applications of [18F]FDG-PET/CT in Hodgkin lymphoma at baseline, interim, and the end of treatment evaluation along with the main PET-driven trials for therapeutic decisions. The emergence of total metabolic tumor volume as a new functional prognostic factor will also be discussed

Analyse quantitative de la prostate en TEP/TDM à la F-Fluorocholine guidée par l'IRM multimodale lors de la récidive biochimique du cancer prostatique

Objectif : Décrire le comportement métabolique en TEP à la 18F-Fluorocholine (FCH) des territoires prostatiques identifiés par l'IRM (zone périphérique, zone centrale, tumeur) et évaluer les relations entre le métabolisme prostatique et les paramètres IRM. Matériel et méthodes : Trente et un patients présentant une récidive biochimique d un cancer de la prostate après traitement par radiothérapie (PSA médian : 3,5 ng/ml) furent inclus rétrospectivement. Chaque patient bénéficia d un examen TEP/TDM (Philips Gemini TF) consistant en une acquisition dynamique de 8 minutes centrée sur le pelvis immédiatement après injection de 4 MBq/Kg de FCH suivie d'une acquisition corps entier, et d une IRM multimodalités (séquences T1, T2, diffusion, perfusion et spectroscopie multivoxels) centrée sur le pelvis (Siemens TrioTIM). Les images TDM furent utilisées comme référence pour un recalage rigide avec l'IRM. A partir des images IRM, les régions d intérêt suivantes furent définies dans chaque prostate : zone centrale (ZC), zone périphérique (ZP) et zone tumorale (ZT), définie selon les critères de la Société Européenne d Urologie (ESUR). Résultats : Une récidive tumorale intra-prostatique (ZT) fut identifiée chez 16 patients sur l IRM. La ZT présentait un métabolisme (SUVmoy) significativement supérieur à la ZP (2,65 vs 1,52 ; p0,05). La ZC présentait également un métabolisme supérieur à la ZP (2,07 vs 1,52 ; p<0,001). Il n'y avait pas de différence significative entre les 3 zones concernant la cinétique précoce d accumulation de la FCH (pente initiale 1-2 min et finale 2-8 minutes). Les paramètres IRM n'étaient pas significativement corrélés avec le métabolisme. Conclusion : En cas de récidive locale de cancer prostatique après radiothérapie initiale, il ne semble pas exister de différence métabolique entre la tumeur et la zone centrale saine. La sensibilité de détection de la récidive en zone centrale apparaît donc plus limitée, sans retrouver d'apport supplémentaire des acquisitions TEP dynamiques.DIJON-BU Médecine Pharmacie (212312103) / SudocSudocFranceF

[18F]FDG-PET/CT in Hodgkin Lymphoma: Current Usefulness and Perspectives

International audienceFunctional imaging using 18-fluorodeoxyglycose ([18F]FDG) positron emission tomography combined with computed tomography (PET/CT) has become a major imaging modality in Hodgkin lymphoma. This imaging modality allows for a significant improvement in staging, increased sensitivity, which involves differentiating residual tumors from fibrosis during assessment, and highly impacts treatment decisions into new PET-driven strategies. This review presents the main scientific data concerning the current applications of [18F]FDG-PET/CT in Hodgkin lymphoma at baseline, interim, and the end of treatment evaluation along with the main PET-driven trials for therapeutic decisions. The emergence of total metabolic tumor volume as a new functional prognostic factor will also be discussed

FDG-PET/CT in Lymphoma: Where Do We Go Now?

International audience18F-fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT) is an essential part of the management of patients with lymphoma at staging and response evaluation. Efforts to standardize PET acquisition and reporting, including the 5-point Deauville scale, have enabled PET to become a surrogate for treatment success or failure in common lymphoma subtypes. This review summarizes the key clinical-trial evidence that supports PET-directed personalized approaches in lymphoma but also points out the potential place of innovative PET/CT metrics or new radiopharmaceuticals in the future

Beth Israel Plugin for FIJI: A free and open source software tool for PET/CT processing in research

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Learning optimal shape representations for multi-modal image registration

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Regularized Multi-Label Fast Marching and Application to Whole-Body Image Segmentation

International audienceIn this paper, we propose a computationally efficient regularization strategy for the Fast Marching (FM) segmentation of multiple organs. Segmentation is based on interactive seeds placements, where the seeds define either organs of interest or the background. Regularization efficiently compensates for the sensitivity of the FM to narrow bridges between different organs with similar intensities. It also leads to segmentations that are far less sensitive to seeds location than by using the standard FM cost. The driving motivation of our work is the quantitative analysis of Chronic Lymphocytic Leukemia (CLL), which is the most common B-cell malignancy and mostly affects elderly people. This requires the segmentation of more than ten organs in whole-body Magnetic Resonance images. The disease path and progression being highly heterogeneous with important inter-patient variability, the segmentation is highly based on clinician experience, which is difficult to automatically reproduce. In this context, the proposed segmentation algorithm compares very favourably to the tools usually available for clinicians

Dual Diagnostic Role of 123I-MIBG Scintigraphy in Inverted-Takotsubo Pattern Cardiomyopathy

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Semi-automatic segmentation of whole-body images in longitudinal studies

International audienceWe propose a semi-automatic segmentation pipeline designed for longitudinal studies considering structures with large anatomical variability, where expert interactions are required for relevant segmentations. Our pipeline builds on the regularized Fast Marching (rFM) segmentation approach by Risser et al (2018). It consists in transporting baseline multi-label FM seeds on follow-up images, selecting the relevant ones and finally performing the rFM approach. It showed increased, robust and faster results compared to clinical manual segmentation. Our method was evaluated on 3D synthetic images and patients' whole-body MRI. It allowed a robust and flexible handling of organs longitudinal deformations while considerably reducing manual interventions