It’s the Experience Not the Format: Successful Techniques to Transition Social Justice Coursework To a Distance Delivery Format

“Research on multicultural learning has focused on formal and local settings, such as schools, but young people are interacting with, and therefore learning from, informal settings and nonlocal contexts, including online platforms.” (Kim, 2016, p. 1). The instructor must be vigilant in selecting online teaching pedagogy when offering sensitive topics of courses because face-to-face intimacy is usually a component of more traditional courses in diversity (Matloob Haghanikar, 2019). The purpose of this current paper is to align critical parts of an experiential race relations curriculum (Clarke, 2019; Kranz & Lund, 2004) in a face-to-face setting with digital technologies available for use in distance education, specifically synchronous and asynchronous online delivery. We outline the original course components and show how technology can be aligned

Biology of human respiratory syncytial virus: a review

Acute lower respiratory tract infection is one of the major causes of mortality and morbidity in young children worldwide. Respiratory syncytial virus (RSV) is the single most important viral cause of lower respiratory tract infection during infancy and early childhood worldwide. Respiratory syncytial virus belongs to the Pneumovirinae subfamily of the Paramyxoviridae family of enveloped single stranded negative sense RNA viruses. The virus accounts for approximately 50% of all pneumonia and up to 90% of the reported cases of bronchiolitis in infancy. It is a common community–acquired respiratory pathogen without ethnic, socioeconomic, gender, age or geographic boundaries. Moreover, the epidemiological and ecological relationships between Human Respiratory syncytial virus, man and environment have aroused increasing interest in this viral, specie. The present review looks at the nature of this virus with the view to provide more information about its biology which may be useful to the present and future researchers

Budesonide Foam Has a Favorable Safety Profile for Inducing Remission in Mild-to-Moderate Ulcerative Proctitis or Proctosigmoiditis.

BackgroundBudesonide foam, a rectally administered, second-generation corticosteroid with extensive hepatic first-pass metabolism, is efficacious for the treatment of mild-to-moderate ulcerative proctitis and ulcerative proctosigmoiditis.AimThe aim of this study was to comprehensively assess the safety and pharmacokinetic profile of budesonide foam.MethodsData from five phase III studies were pooled to further evaluate safety, including an open-label study (once-daily treatment for 8 weeks), an active-comparator study (once-daily treatment for 4 weeks), and two placebo-controlled studies and an open-label extension study (twice-daily treatment for 2 weeks, then once daily for 4 weeks). Data from the placebo-controlled studies and two phase I studies (i.e., patients with mild-to-moderate ulcerative colitis and healthy volunteers) were pooled to evaluate the pharmacokinetics of budesonide foam.ResultsA similar percentage of patients reported adverse events in the budesonide foam and placebo groups, with the majority of adverse events being mild or moderate in intensity (93.3 vs 96.0%, respectively). Adverse events occurred in 41.4 and 36.3% of patients receiving budesonide foam and placebo, respectively. Mean morning cortisol concentrations remained within the normal range for up to 8 weeks of treatment; there were no clinically relevant effects of budesonide foam on the hypothalamic-pituitary-adrenal axis. Population pharmacokinetic analysis demonstrated low systemic exposure after budesonide foam administration.ConclusionsThis integrated analysis demonstrated that budesonide foam for the induction of remission of distal ulcerative colitis is safe overall, with no clinically relevant effects on the hypothalamic-pituitary-adrenal axis

Open Access Repositories - maximizing and measuring research impact through university and research-funder open-access self-archiving mandates

No research institution can afford all the journals its researchers may need, so all articles are losing research impact (usage and citations) from would-be users whose institutions cannot afford paid access. Articles that are made “Open Access,” by self-archiving them on the web are cited twice as much, but only about 15 percent of articles are being spontaneously self-archived. The only institutions approaching 100 percent self-archiving are those that mandate it. Surveys show that majority of authors (95%) will comply with a self-archiving mandate

Seroprevalence of human parainfluenza virus type 2 infection among children (1-5years) in Zaria, Kaduna state, Nnigeria

Serological survey was carried out to determine the level of Human Parainfluenza virus type 2 (HPIV-2) IgG antibodies in children aged 1-5 years. Blood samples were collected from 379 children who met the selection criteria in selected hospitals in Zaria. Serum IgG antibody level for Human Parainfluenza virus type 2 was measured using commercial ELISA Kits obtained from VIRION-SERION ELISA Classic GmbH Germany. Of the total number of 379 samples, 176 (46.4%) were seropositive for parainfluenza virus type 2 antibody. There is statistical significance between age and seropositivity. Highest seropositivity (69.0%) was seen in the sera of those in age group 4- 5 yearss and lowest seropositivity (23.2%) in age group 0 – 1 year (X2 = 38.734; P.value 0.05). There was no association between the presence of cough and catarrh/running nose with seropositivity (P >0.05). The results also showed that there was no association between the presence of sickle cell disease and parental smoking with seropositivity (P >0.05). Preventive programs against HPIV – 2 infection should be promoted especially in younger children and research why reinfection occurs even in the presence of neutralizing antibodies should be undertaken

First results of an Hα based search of classical Be stars in the Perseus Arm and beyond

We investigate a region of the Galactic plane, between 120° ≤ l ≤ 140° and-1° ≤ b≤+4°, and uncover a population of moderately reddened (E(B-V) ~ 1) classical Be stars within and beyond the Perseus and Outer Arms. 370 candidate emission-line stars (13≲r≲16) selected from the Isaac Newton Telescope Photometric Ha Survey of the Northern Galactic plane have been followed up spectroscopically. A subset of these, 67 stars with properties consistent with those of classical Be stars, have been observed at sufficient spectral resolution (δλ ≈ 2-4 Å) at blue wavelengths to narrow down their spectral types. We determine these to a precision estimated to be ±1 subtype and then we measure reddenings via spectral energy distribution fitting with reference to appropriate model atmospheres. Corrections for contribution to colour excess from circumstellar discs are made using an established scaling to Ha emission equivalent width. Spectroscopic parallaxes are obtained after luminosity class has been constrained via estimates of distances to neighbouring A/F stars with similar reddenings. Overwhelmingly, the stars in the sample are confirmed as luminous classical Be stars at heliocentric distances ranging from 2 kpc up to ~12 kpc. However, the errors are presently too large to enable the cumulative distribution function with respect to distance to distinguish between models placing the stars exclusively in spiral arms, or in a smooth exponentially declining distribution.Peer reviewe

Galactic Plane Hα\alpha Surveys: IPHAS & VPHAS+

The optical Galactic Plane H$\alpha$ surveys IPHAS and VPHAS+ are dramatically improving our understanding of Galactic stellar populations and stellar evolution by providing large samples of stars in short lived, but important, evolutionary phases, and high quality homogeneous photometry and images over the entire Galactic Plane. Here I summarise some of the contributions these surveys have already made to our understanding of a number of key areas of stellar and Galactic astronomy.Comment: 5 pages, 2 figures, refereed proceeding of the "The Universe of Digital Sky Surveys" conference, November 2014, to be published in the Astrophysics and Space Science Proceeding

The intersection of DNA replication with antisense 3' RNA processing in Arabidopsis FLC chromatin silencing.

Funder: Wellcome TrustHow noncoding transcription influences chromatin states is still unclear. The Arabidopsis floral repressor gene FLC is quantitatively regulated through an antisense-mediated chromatin silencing mechanism. The FLC antisense transcripts form a cotranscriptional R-loop that is dynamically resolved by RNA 3' processing factors (FCA and FY), and this is linked to chromatin silencing. Here, we investigate this silencing mechanism and show, using single-molecule DNA fiber analysis, that FCA and FY are required for unimpeded replication fork progression across the Arabidopsis genome. We then employ the chicken DT40 cell line system, developed to investigate sequence-dependent replication and chromatin inheritance, and find that FLC R-loop sequences have an orientation-dependent ability to stall replication forks. These data suggest a coordination between RNA 3' processing of antisense RNA and replication fork progression in the inheritance of chromatin silencing at FLC

International Society of Sports Nutrition position stand: beta-alanine

Position statement: The International Society of Sports Nutrition (ISSN) provides an objective and critical review of the mechanisms and use of beta-alanine supplementation. Based on the current available literature, the conclusions of the ISSN are as follows: 1) Four weeks of beta-alanine supplementation (4–6 g daily) significantly augments muscle carnosine concentrations, thereby acting as an intracellular pH buffer; 2) Beta-alanine supplementation currently appears to be safe in healthy populations at recommended doses; 3) The only reported side effect is paraesthesia (tingling), but studies indicate this can be attenuated by using divided lower doses (1.6 g) or using a sustained-release formula; 4) Daily supplementation with 4 to 6 g of beta-alanine for at least 2 to 4 weeks has been shown to improve exercise performance, with more pronounced effects in open end-point tasks/time trials lasting 1 to 4 min in duration; 5) Beta-alanine attenuates neuromuscular fatigue, particularly in older subjects, and preliminary evidence indicates that beta-alanine may improve tactical performance; 6) Combining beta-alanine with other single or multi-ingredient supplements may be advantageous when supplementation of beta-alanine is high enough (4–6 g daily) and long enough (minimum 4 weeks); 7) More research is needed to determine the effects of beta-alanine on strength, endurance performance beyond 25 min in duration, and other health-related benefits associated with carnosine