New functional low-sugar and rich in bioactive compounds beverage. Optimisation of the process

[SPA] Actualmente, las bebidas a base de frutas y hortalizas, como por ejemplo con cítricos y frutos rojos, con bajo contenido en azúcar, son una prometedora forma de consumo de nutrientes promotores de la salud. El desarrollo de bebidas organolépticamente atractivas y seguras, enriquecidas en compuestos bioactivos y biodisponibles, que aporten alternativas a los carbohidratos de rápida absorción, con la finalidad de reducir el consumo de azúcares en la población, conlleva la necesidad de una evaluación de la seguridad de los nuevos productos y una optimización de su procesado. Para ello se han de estudiar diferentes alternativas basadas en tratamientos térmicos y no térmicos. Además es necesario un análisis de decisión multi-criterio que optimice los resultados obtenidos, junto con las estimaciones de costes de las mismas, que será útil para optimizar su elaboración a escala industrial. [ENG] Nowadays, low-sugar plant-based beverages, such as those citrus and red fruit-based, are a promising way to consume health-promoting nutrients. The development of safe and organoleptic attractive beverages, enriched in bioactive and bioavailable compounds, is of high interest. This, together, with providing alternatives to fast-absorbing carbohydrates, with the purpose of reducing the consumption of sugars, implies the need for an evaluation of the safety of the new products and an optimization of their processing. In order to cover this, the study of different alternatives based on thermal and non-thermal treatments is of interest. Furthermore, a multi-criteria decision analysis is necessary to optimize the results obtained, together with the estimated costs of the different alternatives, which will be useful to improve its implementation on an industrial scale.Este trabajo será financiado por el MINECO español a través del Proyecto de Investigación AGL2016-75332-C2-1-R (AEI / FEDER, UE). F.J. Salar tiene el apoyo de la subvención FPU (FPU18/ 00332) del Programa de Becas del Ministerio de Ciencia, Innovación y Universidades

Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice

Chromosomal translocations involving the MALT1 gene are hallmarks of mucosa-associated lymphoid tissue (MALT) lymphoma. To date, targeting these translocations to mouse B cells has failed to reproduce human disease. Here, we induced MALT1 expression in mouse Sca1(+)Lin(-) hematopoietic stem/progenitor cells, which showed NF-κB activation and early lymphoid priming, being selectively skewed toward B-cell differentiation. These cells accumulated in extranodal tissues and gave rise to clonal tumors recapitulating the principal clinical, biological, and molecular genetic features of MALT lymphoma. Deletion of p53 gene accelerated tumor onset and induced transformation of MALT lymphoma to activated B-cell diffuse large-cell lymphoma (ABC-DLBCL). Treatment of MALT1-induced lymphomas with a specific inhibitor of MALT1 proteolytic activity decreased cell viability, indicating that endogenous Malt1 signaling was required for tumor cell survival. Our study shows that human-like lymphomas can be modeled in mice by targeting MALT1 expression to hematopoietic stem/progenitor cells, demonstrating the oncogenic role of MALT1 in lymphomagenesis. Furthermore, this work establishes a molecular link between MALT lymphoma and ABC-DLBCL, and provides mouse models to test MALT1 inhibitors. Finally, our results suggest that hematopoietic stem/progenitor cells may be involved in the pathogenesis of human mature B-cell lymphomas

Treatment of peripheral neuropathies.

There are three general approaches to treatment of peripheral neuropathy. First, an attempt should be made to reverse the pathophysiological process if its nature can be elucidated. Second, nerve metabolism can be stimulated and regeneration encouraged. Third, even if the neuropathy itself cannot be improved, symptomatic therapy can be employed. This review outlines the options available for each approach