Influencia de las Especies Aromaticas en la Modificación de los Aromas del Vino

Las sustancias odorantes en la uva, constituyen un factor de calidad que distingue los vinos del nuevo mundo. Se pueden clasificar en aromas varietales, fermentativos y generados en la crianza del vino. A través de la asociación con especies aromáticas se logra potenciar estos compuestos. Las temperaturas elevadas del verano dilatan la esencia contenida en las estructuras secretoras de las aromáticas dispersando los componentes odoríferos volátiles al ambiente. Estas sustancias se fijan sobre la pruina, presente sobre la cutícula de las bayas de los racimos

Influencia de las especies aromáticas en la modificación de los aromas del vino.

Las sustancias odorantes en la uva, constituyen un factor de calidad que distingue los vinos del nuevo mundo. Se pueden clasificar en aromas varietales, fermentativos y generados en la crianza del vino. A través de la asociación con especies aromáticas se logra potenciar estos compuestos. Las temperaturas elevadas del verano dilatan la esencia contenida en las estructuras secretoras de las aromáticas dispersando los componentes odoríferos volátiles al ambiente. Estas sustancias se  fijan sobre la  pruina, presente  sobre la cutícula de las bayas de los racimos

Green Extraction Approaches for Carotenoids and Esters: Characterization of Native Composition from Orange Peel

Abstract: Orange peel is a by-product produced in large amounts that acts as a source of natural pigments such as carotenoids. Xanthophylls, the main carotenoid class found in citrus fruit, can be present in its free form or esterified with fatty acids, forming esters. This esterification modifies the compound’s chemical properties, affecting their bioavailability in the human body, and making it important to characterize the native carotenoid composition of food matrices. We aimed to evaluate the non-saponified carotenoid extracts of orange peel (cv. Pera) obtained using alternative green approaches: extraction with ionic liquid (IL), analyzed by high performance liquid chromatography coupled to a diode array detector with atmospheric pressure chemical ionization and mass spectrometry HPLC-DAD-APCI-MS, and supercritical fluid extraction (SFE), followed by supercritical fluid chromatography with atmospheric pressure chemical ionization and triple quadrupole mass spectrometry detection (SFC-APCI/QqQ/MS) in an online system. Both alternative green methods were successfully applied, allowing the total identification of five free carotenoids, one apocarotenoid, seven monoesters, and 11 diesters in the extract obtained with IL and analyzed by HPLC-DAD-APCI-MS, and nine free carotenoids, six carotenoids esters, 19 apocarotenoids, and eight apo-esters with the SFE-SFC-APCI/QqQ/MS approach, including several free apocarotenoids and apocarotenoid esters identified for the first time in oranges, and particularly in the Pera variety, which could be used as a fruit authenticity parameter.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Bioscience Department, Universidade Federal de São Paulo, Rua Silva Jardin 136, 11015-020 Santos, BrazilDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Polo Annunziata, Viale Annunziata, 98168 Messina, ItalyDepartment of Mathematical and Computer Science, Physical Sciences and Earth Sciences, University of Messina, 98168 Messina, ItalyFederal Institute of São Paulo, Av. Clara Gianotti de Souza 5180, 11900-000 Registro, BrazilChemistry Department, Federal University of São Carlos, Rodovia Washington Luíz, Km 235, 13565-905 São Carlos, BrazilChromaleont s.r.l., c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, ItalyBeSep s.r.l., c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, ItalyUnit of Food Science and Nutrition, Department of Medicine, University Campus Bio-Medico of Rome, 00128 Rome, ItalyDepartment of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Via Consolare Valeria, 98125 Messina, ItalyBioscience Department, Universidade Federal de São Paulo, Rua Silva Jardin 136, 11015-020 Santos, BrazilFAPESP: 2015/26789-5FAPESP: 2016/18910-1FAPESP: 2017/20861-1FAPESP: 2019/25303-

Influencia de las Especies Aromáticas en la Modificación de los Aromas del Vino

Los aromas del vino se modifican con influencia de los componentes volátiles odoríferos presentes en las especies aromáticas cercanas al viñedo; es inducido por las altas temperaturas del verano, que rompen los tricomas y glándulas esquizógenas por la dilatación de la esencia, dispersando los componentes volátiles al ambiente. Estas sustancias se fijan sobre la pruina, sustancia grasa dispuesta en forma de costras sobre la cutícula de la baya de los racimos expuestos al área de influencia de estos aromas. Las notas odoríferas de la esencia de eucalipto pasan al vino durante la fermentación. El objetivo de este trabajo fue determinar el perfil cromatográfico del vino obtenido del varietal Sangiovese, conducido en forma de parral, con una cortina de Eucaliptus camandulensis

First pilot case-control interventional study using autologous extracellular vesicles to treat chronic venous ulcers unresponsive to conventional treatments

Current therapeutic approaches for chronic venous ulcers (CVUs) still require evidence of effectiveness. Diverse sources of extracellular vesicles (EVs) have been proposed for tissue regeneration, however the lack of potency tests, to predict in-vivo effectiveness, and a reliable scalability have delayed their clinical application. This study aimed to investigate whether autologous serum-derived EVs (s-EVs), recovered from patients with CVUs, may be a proper therapeutic approach to improve the healing process. A pilot case-control interventional study (CS2/1095/0090491) has been designed and s-EVs recovered from patients. Patient eligibility included two or more distinct chronic lesions in the same limb with 11 months as median persistence of active ulcer before enrollment. Patients were treated three times a week, for 2 weeks. Qualitative CVU analysis demonstrated that s-EVs-treated lesions displayed a higher percentage of granulation tissue compared to the control group (Sham) (s-EVs 3 out of 5: 75–100 % vs Sham: none), further confirmed at day 30. s-EVs-treated lesions also displayed higher sloughy tissue reduction at the end of treatment even increased at day 30. Additionally, s-EV treatment led to a median surface reduction of 151 mm2 compared to 84 mm2 in the Sham group, difference even more evident at day 30 (s-EVs 385 mm2 vs Sham 106 mm2 p = 0.004). Consistent with the enrichment of transforming growth factor-β1 in s-EVs, histological analyses showed a regenerative tissue with an increase in microvascular proliferation areas. This study first demonstrates the clinical effectiveness of autologous s-EVs in promoting the healing process of CVUs unresponsive to conventional treatments

Multi-messenger prospects for black hole - neutron star mergers in the O4 and O5 runs

The existence of merging black hole-neutron star (BHNS) binaries has been ascertained through the observation of their gravitational wave (GW) signals. However, to date, no definitive electromagnetic (EM) emission has been confidently associated with these mergers. Such an association could help unravel crucial information on these systems, for example, their BH spin distribution, the equation of state (EoS) of NS and the rate of heavy element production. We model the multi-messenger (MM) emission from BHNS mergers detectable during the fourth (O4) and fifth (O5) observing runs of the LIGO-Virgo-KAGRA GW detector network, in order to provide detailed predictions that can help enhance the effectiveness of observational efforts and extract the highest possible scientific information from such remarkable events. Our methodology is based on a population synthesis-approach, which includes the modelling of the signal-to-noise ratio of the GW signal in the detectors, the GW-inferred sky localization of the source, the kilonova (KN) optical and near-infrared light curves, the relativistic jet gamma-ray burst (GRB) prompt emission peak photon flux, and the GRB afterglow light curves in the radio, optical and X-ray bands. The resulting prospects for BHNS MM detections during O4 are not promising, with a GW detection rate of $15.0^{+15.4}_{-8.8}$ yr$^{-1}$, but joint MM rates of $\sim 10^{-1}$ yr$^{-1}$ for the KN and $\sim 10^{-2}$ yr$^{-1}$ for the jet-related emission. In O5 we find an overall increase in expected detection rates by around an order of magnitude, owing to both the enhanced sensitivity of the GW detector network, and the coming online of future EM facilities. Finally, we discuss direct searches for the GRB radio afterglow with large-field-of-view instruments as a new possible follow-up strategy in the context of ever-dimming prospects for KN detection.Comment: Submitted to A&A. 17 pages, 11 figures, 2 tables. Comments are welcome

Ultralight vector dark matter search using data from the KAGRA O3GK run

Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM

Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo

Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level

Production and Maturation of Soaps with Non-Edible Fermented Olive Oil and Comparison with Classic Olive Oil Soaps

The study reports the alternative use of non-edible fermented olives for the production of high-quality natural soaps with a fast production process, low environmental impact, and without preliminary treatments for the raw material. Damaged olives, not used as food, were fermented naturally and the oil was extracted by mechanical extraction. The product obtained was not for human consumption due to its high acidity, but it had a low content of peroxides. The non-edible olive oil obtained and an extra virgin olive oil, produced from the same olive cultivar, were subjected to saponification with sodium hydroxide. The soaps were produced with complete (0% of non-neutralized fatty acids) and incomplete (5% of non-neutralized fatty acids) saponification; the amount of sodium hydroxide to be used was determined with the saponification index. The soaps were aged for six months by monitoring pH, color, and behavior in an aqueous solution. The results show that the olives’ fermentation improves and speeds up the soap production and maturation process since the oil obtained from fermented non-edible olives is more suitable for the saponification process than the oil obtained from non-fermented edible olives. Non-edible fermented olives can be used for obtaining natural and high-quality soaps, reusing drupes classified as food waste