Daris, a low-frequency distributed aperture array for radio astronomy in space

DARIS (Distributed Aperture Array for Radio Astronomy in Space) is a radio astronomy space mission concept aimed at observing the low-frequency radio sky in the range 1-10 MHz. Because of the Earth's ionospheric disturbances and opaqueness, this frequency range can only be observed from space. The astronomical science cases include sensitive extragalactic surveys, radio transients such as Jupiter-like burst and Crab-like pulses, and coronal mass ejection tracking. The focus of the DARIS concept study is on feasibility aspects of a distributed aperture synthesis array in space, consisting of small satellite nodes and a mother-ship. The study selected suitable science cases, antenna concepts, communications, signal processing, orbital design, and mission analysis. With current-day technologies a satellite cluster can be built consisting of at least eight satellite nodes and a mother-ship, which could be launched with a Soyuz rocket from Kourou. Such a satellite cluster would open up the last unexplored frequency range for astronomy

Algorithms for Constructing Overlay Networks For Live Streaming

We present a polynomial time approximation algorithm for constructing an overlay multicast network for streaming live media events over the Internet. The class of overlay networks constructed by our algorithm include networks used by Akamai Technologies to deliver live media events to a global audience with high fidelity. We construct networks consisting of three stages of nodes. The nodes in the first stage are the entry points that act as sources for the live streams. Each source forwards each of its streams to one or more nodes in the second stage that are called reflectors. A reflector can split an incoming stream into multiple identical outgoing streams, which are then sent on to nodes in the third and final stage that act as sinks and are located in edge networks near end-users. As the packets in a stream travel from one stage to the next, some of them may be lost. A sink combines the packets from multiple instances of the same stream (by reordering packets and discarding duplicates) to form a single instance of the stream with minimal loss. Our primary contribution is an algorithm that constructs an overlay network that provably satisfies capacity and reliability constraints to within a constant factor of optimal, and minimizes cost to within a logarithmic factor of optimal. Further in the common case where only the transmission costs are minimized, we show that our algorithm produces a solution that has cost within a factor of 2 of optimal. We also implement our algorithm and evaluate it on realistic traces derived from Akamai's live streaming network. Our empirical results show that our algorithm can be used to efficiently construct large-scale overlay networks in practice with near-optimal cost

On the homology of several number-theoretic set families

This paper describes the homology of various simplicial complexes associated to set families from combinatorial number theory, including primitive sets, pairwise coprime sets, product-free sets, and coprime-free sets. We present a condition on a set family that results in easy computation of the homology groups, and show that the first three examples, among many others, admit such a structure. We then extend our techniques to address the complexes associated to coprime-free sets and a generalization of primitive sets.Comment: 17 pages, including two appendices. Final version submitted to journa

DARIS : a low-frequency distributed aperture array for radio astronomy in space

The frequency band below 30 MHz is one of the last unexplored bands in radio astronomy. This band is well suited for studying the early cosmos at high hydrogen redshifts, the so-called dark ages, extragalactic surveys, (extra) solar planetary bursts, and high energy particle physics. In addition, space research such as space weather tomography, are also areas of scientific interest. \ud \ud Due to ionospheric scintillation (below 30MHz) and its opaqueness (below 15MHz), earth-bound radio astronomy observations in these bands are either severely limited in sensitivity and spatial resolution or entirely impossible. A radio telescope in space obviously would not be hampered by the Earth's ionosphere. In the past, several (limited) studies have been conducted to explore possibilities for such an array in space. These studies considered aperture synthesis arrays in space, at the back-side of the Moon, or a satellite constellation operating in a coherent mode. \u

The Fungal Fast Lane: Common Mycorrhizal Networks Extend Bioactive Zones of Allelochemicals in Soils

Allelopathy, a phenomenon where compounds produced by one plant limit the growth of surrounding plants, is a controversially discussed factor in plant-plant interactions with great significance for plant community structure. Common mycorrhizal networks (CMNs) form belowground networks that interconnect multiple plant species; yet these networks are typically ignored in studies of allelopathy. We tested the hypothesis that CMNs facilitate transport of allelochemicals from supplier to target plants, thereby affecting allelopathic interactions. We analyzed accumulation of a model allelopathic substance, the herbicide imazamox, and two allelopathic thiophenes released from Tagetes tenuifolia roots, by diffusion through soil and CMNs. We also conducted bioassays to determine how the accumulated substances affected plant growth. All compounds accumulated to greater levels in target soils with CMNs as opposed to soils without CMNs. This increased accumulation was associated with reduced growth of target plants in soils with CMNs. Our results show that CMNs support transfer of allelochemicals from supplier to target plants and thus lead to allelochemical accumulation at levels that could not be reached by diffusion through soil alone. We conclude that CMNs expand the bioactive zones of allelochemicals in natural environments, with significant implications for interspecies chemical interactions in plant communities

Extension of Yeast Chronological Lifespan by Methylamine

Background: Chronological aging of yeast cells is commonly used as a model for aging of human post-mitotic cells. The yeast Saccharomyces cerevisiae grown on glucose in the presence of ammonium sulphate is mainly used in yeast aging research. We have analyzed chronological aging of the yeast Hansenula polymorpha grown at conditions that require primary peroxisome metabolism for growth. Methodology/Principal Findings: The chronological lifespan of H. polymorpha is strongly enhanced when cells are grown on methanol or ethanol, metabolized by peroxisome enzymes, relative to growth on glucose that does not require peroxisomes. The short lifespan of H. polymorpha on glucose is mainly due to medium acidification, whereas most likely ROS do not play an important role. Growth of cells on methanol/methylamine instead of methanol/ammonium sulphate resulted in further lifespan enhancement. This was unrelated to medium acidification. We show that oxidation of methylamine by peroxisomal amine oxidase at carbon starvation conditions is responsible for lifespan extension. The methylamine oxidation product formaldehyde is further oxidized resulting in NADH generation, which contributes to increased ATP generation and reduction of ROS levels in the stationary phase. Conclusion/Significance: We conclude that primary peroxisome metabolism enhanced chronological lifespan of H. polymorpha. Moreover, the possibility to generate NADH at carbon starvation conditions by an organic nitrogen source supports further extension of the lifespan of the cell. Consequently, the interpretation of CLS analyses in yeast should include possible effects on the energy status of the cell.

Multidisciplinary teams, and parents, negotiating common ground in shared-care of children with long-term conditions: A mixed methods study

Background: Limited negotiation around care decisions is believed to undermine collaborative working between parents of children with long-term conditions and professionals, but there is little evidence of how they actually negotiate their respective roles. Using chronic kidney disease as an exemplar this paper reports on a multi-method study of social interaction between multidisciplinary teams and parents as they shared clinical care. Methods. Phases 1 and 2: a telephone survey mapping multidisciplinary teams' parent-educative activities, and qualitative interviews with 112 professionals (Clinical-psychologists, Dietitians, Doctors, Nurses, Play-specialists, Pharmacists, Therapists and Social-workers) exploring their accounts of parent-teaching in the 12 British children's kidney units. Phase 3: six ethnographic case studies in two units involving observations of professional/parent interactions during shared-care, and individual interviews. We used an analytical framework based on concepts drawn from Communities of Practice and Activity Theory. Results: Professionals spoke of the challenge of explaining to each other how they are aware of parents' understanding of clinical knowledge, and described three patterns of parent-educative activity that were common across MDTs: Engaging parents in shared practice; Knowledge exchange and role negotiation, and Promoting common ground. Over time, professionals had developed a shared repertoire of tools to support their negotiations with parents that helped them accomplish common ground during the practice of shared-care. We observed mutual engagement between professionals and parents where a common understanding of the joint enterprise of clinical caring was negotiated. Conclusions: For professionals, making implicit knowledge explicit is important as it can provide them with a language through which to articulate more clearly to each other what is the basis of their intuition-based hunches about parents' support needs, and may help them to negotiate with parents and accelerate parents' learning about shared caring. Our methodology and results are potentially transferrable to shared management of other conditions. © 2013 Swallow et al.; licensee BioMed Central Ltd

The Mechanisms of Codon Reassignments in Mitochondrial Genetic Codes

Many cases of non-standard genetic codes are known in mitochondrial genomes. We carry out analysis of phylogeny and codon usage of organisms for which the complete mitochondrial genome is available, and we determine the most likely mechanism for codon reassignment in each case. Reassignment events can be classified according to the gain-loss framework. The gain represents the appearance of a new tRNA for the reassigned codon or the change of an existing tRNA such that it gains the ability to pair with the codon. The loss represents the deletion of a tRNA or the change in a tRNA so that it no longer translates the codon. One possible mechanism is Codon Disappearance, where the codon disappears from the genome prior to the gain and loss events. In the alternative mechanisms the codon does not disappear. In the Unassigned Codon mechanism, the loss occurs first, whereas in the Ambiguous Intermediate mechanism, the gain occurs first. Codon usage analysis gives clear evidence of cases where the codon disappeared at the point of the reassignment and also cases where it did not disappear. Codon disappearance is the probable explanation for stop to sense reassignments and a small number of reassignments of sense codons. However, the majority of sense to sense reassignments cannot be explained by codon disappearance. In the latter cases, by analysis of the presence or absence of tRNAs in the genome and of the changes in tRNA sequences, it is sometimes possible to distinguish between the Unassigned Codon and Ambiguous Intermediate mechanisms. We emphasize that not all reassignments follow the same scenario and that it is necessary to consider the details of each case carefully.Comment: 53 pages (45 pages, including 4 figures + 8 pages of supplementary information). To appear in J.Mol.Evo