硬質粒子被膜を有する高機能タップ工具の開発

Tohoku University堀切川一男課

Promotion of Community Based Education through Community Based Art Projects

科学研究費助成事業 研究成果報告書：基盤研究(C)2011-2014 課題番号：2352014

地域在住女性高齢者における直線および曲線歩行能力と歩行関連自己効力感について : 高い社会機能を有する前期高齢者と後期高齢者の比較

Background: The characteristics of both straight- and curved-path walking abilities and walking self-efficacy among older women aged ≥ 75 years with high social functioning are not clear. This study aimed to clarify the characteristics of walking ability and self-efficacy among young-old (age 65-74 years) and old-old women (age ≥ 75 years) with high social functioning. Methods: The participants in this cross-sectional study were 36 community-dwelling older women (mean age ± standard deviation: 73.4 ± 5.2 years) recruited using a convenience sampling method. The 5-m and Figure-of-8 Walk Tests were used to evaluate straight- and curved-path walking abilities. Waking self-efficacy was evaluated using the modified Gait Efficacy Scale. The participants were divided into two age groups: 65-74 (n = 22) and ≥ 75 years (n = 14). The results of the 5-m and Figure-of-8 Walk Tests and the modified Gait Efficacy Scale were compared between groups using an unpaired t-test and the Mann-Whitney U test. The relationships between the evaluation items were analyzed using Pearson\u27s product-moment correlation coefficient and Spearman\u27s rank correlation coefficient. Results: Significant differences were found between the two groups in the 5-m Walk Test (p = 0.011) and Figure-of-8 Walk Test (p = 0.016); however, no significant differences were seen in modified Gait Efficacy Scale scores (p = 0.311). The correlation coefficients between modified Gait Efficacy Scale scores and walking abilities were lower in the group aged ≥ 75 years. Conclusions: The present study found that, compared with women aged 65-74 years, those aged ≥ 75 years with high social functioning showed no decline in walking self-efficacy or straight- and curved-path walking abilities.首都大学東京学位論文甲第965号副論

動作タイミングと協調性に着目した簡易なホームエクササイズが健常高齢者の下肢機能に与える効果について : 準ランダム化比較試験

首都大学東

Suppression of HIV-1 replication in peripheral blood mononuclear cells by fasudil

Fasudil is a potent inhibitor for various protein kinases such as myosin light chain kinase and protein kinase C. It has been used as a drug for improvement of intracranial vasospasm and following ischaemic diseases. In this report, we demonstrate that fasudil suppressed the replication of human immunodeficiency virus type 1 (HIV-1) in mitogen-activated peripheral blood mononuclear cells. Our finding shows that fasudil may be useful as a new and distinct chemotherapeutic agent against HIV-1 infection

On the Treatment of Rayons with Synthetic Resins by Means of an Improved Method. (XVII) The Special Core-Resin Treatment Prior to Dyeing with Some Functional Finish Which may be Followed by Mechanical One (III). Dyeing and Functional Finish After Peeling off the First Outer and Skin layer Resin

In continuation of the foregoing paper of this series (XVl) the present one deals with the functional dyeing as well as the second resin finish intended for the outer layer upon the fiber，which had been core-resin treated and then peeled off the unavailing first resin on the skin and outer layers in order to give the place for the dye and the second resin. 1t was found that the fiber as treated above，properly choosing the dye and the second resin， showed to have a good balance with reference to the properties in compressional resilience， knot strength， and 1ight fastness of the dyeing. The present method in view is considered to be advantageous in that the fiber can be core-resin treated in white state in tow form (or in any other form also)， so that it can be processed on the part of the maker and be stocked， and then can be dyed at any stage before the end product on the part of the spinner or finisher as required， say， in staple， yarn or fabric stat

Prevalence of the metabolic syndrome in elderly and middle-aged Japanese

AbstractBackground/PurposeDiagnosis and management of the metabolic syndrome (MetS) are beneficial for successful aging. In spite of several criteria for MetS, there is little information on cardiometabolic risk clustering in elderly Japanese. The purpose of this study was, therefore, to determine the relationship between age-associated changes in obesity and metabolic components in the Japanese.MethodsWe analyzed data from the nationwide survey conducted in 2000. Using Adult Treatment Panel III (ATP III) and Japanese diagnostic criteria for MetS, we analyzed 2366 people aged from 40 to 79 years (men, 1425 and women, 941) from the total participants.ResultsThe prevalence of MetS was almost three fold higher by modified ATP III, International Diabetes Federation, and Japanese criteria, in elderly women than in middle-aged women, whereas no difference was found between middle-aged and elderly men by the three criteria. A marked increase in the prevalence of MetS was found by modified ATP III and International Diabetes Federation criteria compared with that by the Japanese criteria in women. Among the risk factors, the prevalence of central obesity and dyslipidemia increased only in women and that of high fasting glucose and high blood pressure increased in both genders with aging. Among the MetS subjects who fulfilled the modified ATP III criteria, more clustering of risk was observed in elderly than in middle-aged subjects, especially in women. Blood pressure increased and triglyceride decreased in both genders, and non-high-density-lipoprotein cholesterol decreased in elderly men. The prevalence of dyslipidemia decreased in elderly men.ConclusionAging is an important factor that affects the metabolic abnormality, and aging of the population would lead to increase in the prevalence of MetS. Therefore, the development of better approaches to the prevention and management of MetS is necessary for successful aging in our society

Role of Src in angiopoietin 1-induced capillary morphogenesis of endothelial cells: Effect of chronic hypoxia on Src inhibition by PP2.

Signal transduction pathways leading to angiopoietin 1 (Ang1)-induced capillary morphogenesis by endothelial cells remain poorly defined. Angiogenic cellular responses by endothelial cells may be modulated in vivo by chronic hypoxia, such as that induced by tumors. Here, we studied Ang1-induced capillary morphogenesis in human umbilical-vein endothelial cells (HUVECs) cultured chronically under normoxic (21% oxygen) or hypoxic (1.5% oxygen) conditions. Downregulation of Src using a small interfering RNA (siRNA) inhibited Ang1-induced capillary morphogenesis of HUVECs cultured under both conditions by blocking cell spreading and protrusion. Ang1 upregulated the Src-dependent secretion of vascular endothelial growth factor-A (VEGF-A). Blockade of endogenous VEGF-A also inhibited Ang1-induced capillary morphogenesis. Addition of exogenous VEGF-A restored cell spreading and protrusion, leading to Ang1-induced capillary morphogenesis of Src siRNA-treated HUVECs, suggesting that Ang1-induced VEGF-A secretion through Src was required for capillary morphogenesis. PP2 inhibited both Ang1-induced capillary morphogenesis and Src activation in HUVECs cultured under normoxic conditions, but the PP2 activity was significantly impaired in HUVECs cultured under hypoxic conditions. Expression of multidrug resistance-associated protein 1 (MRP 1) was upregulated in hypoxic HUVECs, and treatment with MRP 1 siRNA restored the inhibitory action of PP2. Taken together, our results suggest that Ang1 induces capillary morphogenesis in HUVECs through Src-dependent upregulation of endogenous VEGF-A. Conditions of chronic hypoxia impaired the effect of PP2, possibly via MRP 1

Reduced responsiveness is an essential feature of chronic fatigue syndrome: A fMRI study

BACKGROUND: Although the neural mechanism of chronic fatigue syndrome has been investigated by a number of researchers, it remains poorly understood. METHODS: Using functional magnetic resonance imaging, we studied brain responsiveness in 6 male chronic fatigue syndrome patients and in 7 age-matched male healthy volunteers. Responsiveness of auditory cortices to transient, short-lived, noise reduction was measured while subjects performed a fatigue-inducing continual visual search task. RESULTS: Responsiveness of the task-dependent brain regions was decreased after the fatigue-inducing task in the normal and chronic fatigue syndrome subjects and the decrement of the responsiveness was equivalent between the 2 groups. In contrast, during the fatigue-inducing period, although responsiveness of auditory cortices remained constant in the normal subjects, it was attenuated in the chronic fatigue syndrome patients. In addition, the rate of this attenuation was positively correlated with the subjective sensation of fatigue as measured using a fatigue visual analogue scale, immediately before the magnetic resonance imaging session. CONCLUSION: Chronic fatigue syndrome may be characterised by attenuation of the responsiveness to stimuli not directly related to the fatigue-inducing task