Laurence-Moon-Bardet-Biedl Syndrome: A Rare Case Report

Introduction: Laurence-Moon-Bardet-Biedl syndrome (LMBBS) is a rare autosomal-recessive disorder, which is characterized principally by cardinal symptoms of marked central obesity, retinal dystrophy, polydactyly, mental retardation, hypogonadism and renal dysfunction. Case presentation: We report a case of a 20-year-old male who presented to us with history of fever, vomiting and dizziness. He was incidentally diagnosed as a case of LMBBS as the patient was having polydactyly, retinitis pigmentosa, central obesity, hypogonadism and low IQ. Conclusion: Laurence-Moon-Bardet-Biedl syndrome is a very rare syndrome with very low incidence; hence, we are reporting this case. In addition, we advice more diligent approach from various specialties, so that this syndrome can be picked up at an early age

Mirizzi Syndrome: A Rare Cause of Obstructive Jaundice

Mirizzi syndrome was first described by Pablo Luis Mirrizi. The incidence of this syndrome ranges from 0.05% to 4%. Thisrare condition is caused by the obstruction of common hepatic duct or common bile duct due to compression caused byseveral impacted stones or a single large impacted gallstone in Hartmann’s pouch. The clinical presentations may vary fromno symptoms to severe cholangitis. It is a rare cause of obstructive jaundice and hence we are reporting a case to emphasizethat while evaluating a case of obstructive jaundice, one must consider Mirizzi syndrome as a differential diagnosis

ENDOPHYTES FROM THE AQUATIC PLANT NELUMBO NUCIFERA: DIVERSITY PROFILE AND ACTIVITY CHARACTERIZATION

Objective: Endophytes represent a niche habitat for the study of novel bio-and chemo diversity. Nelumbo nucifera is an aquatic plant that has not been characterized for endophyte diversity. This study was undertaken with the objective of isolating endophytes from submerged and aerial part of N. nucifera, study the diversity profile of the isolated endophytes and their antimicrobial, antioxidant, and siderophore production capacity.Methods: Endophytes were isolated from aerial and submerged parts of N. nucifera on different media (Starch Casein Nitrate, Glucose Yeast Extract, Nutrient and Potato Dextrose agar). These were further characterized for morphology (colony characteristics, Gram reaction), physiological characteristics (carbon, nitrogen utilization) and activity (antimicrobial, antioxidant, siderophore production). After dereplication, twelve isolates were studied further.Results: All endophyte isolates were Gram-positive bacteria, and one was a fungus. Isolate L-300 showed the highest antioxidant capacity (238 AAE g FW-1) and L-201 least (10 AAE g FW-1. Antimicrobial activity was exhibited against bacteria and fungal targets, with 50% endophytes active against both bacteria and fungi. Isolates L-003 and L-207 exhibited activity against Gram-negative clinical isolates as also fungi. Siderophore production was shown by 58% isolates with L-208 showing maximum activity.Conclusion: This is the first report on profiling of endophytes from N. nucifera. Results show that aquatic plants harbor diverse microbial population. Many promising isolates (such as L-003, L-211, L-214 and L-300) have been characterized in this study and results obtained of antioxidant, antimicrobial and siderophore production capacity demonstrate further utility in polypharmacological studies for identifying compounds of pharmaceutical and other industrial interest.Â

Quality by Design: A new practice for production of pharmaceutical products

This is the advanced approach for development of pharmaceutical product with full range and specified limits of variables during procurements, storage and manufacturing process with a qualification, at desired level of quality within the limits of low and higher values of variables to ensures  the Pharmaceutical product Quality by design (QbD) of manufacturing a finished product. The Quality by Design is depicted and a portion of its components recognized and process parameters with quality characteristics are identified for every unit activity. Advantages, openings and steps engaged with Quality by Design of Pharmaceutical items are depicted. The point of the pharmaceutical advancement is to plan a quality item and it’s assembling procedure to reliably convey the proposed execution of the item. Quality can't be tried into items however quality ought to be worked in by outline. It incorporates the Quality target item profile, basic quality traits and key parts of Quality by Design. It likewise gives correlation between item quality by end item testing and item quality by Quality by Design. The establishment of Quality by Design is ICH Guidelines. It depends on the ICH Guidelines Q8 for pharmaceutical improvement, Q9 for quality hazard administration, Q10 for pharmaceutical quality frameworks. It moreover gives utilization of Quality by Design in pharmaceutical improvement and assembling of pharmaceuticals. Keywords: Quality by Design, Design Space, Target Product Quality Profile, Critical Quality Attribute

Comparative Evaluation of Two Different Marketed Brands of Enalapril maleate

Efficacy of pharmaceuticals dosage form generally depends on their formulation properties and manufacturing methods, hence it is likely that the quality of dosage form may vary. Renin acts on angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin-converting enzyme (ACE). Angiotensin II, a potent vasoconstrictor increases blood pressure by increasing vasopressin production and aldosterone secretion. Enalaprilat, the active metabolite of enalapril, inhibits ACE, hence decreases levels of angiotensin II resulting in less vasoconstriction and decreased blood pressure. The study was exclusively experimental that used IP and other standard books to check in vitro quality of enalapril maleate tablet using different analytical techniques and procedure. Test for weight variation, hardness, friability, disintegration time, and dissolution were conducted. The dissolution test was performed at pH 6.8 for both the brands of the tablet. Further all the tablets passed weight variation, hardness, friability and disintegration test as per the pharmacopoeial standard. Hence we can conclude that both the brands of tablets are equal and both the brands contain equal quantity of active pharmaceutical ingredient (API). Both the brands having higher and lower costs exert similar action. Keywords: Enalapril maleate, In Vitro, Dissolution test, Enalapri

Long- and short-range correlations and their event-scale dependence in high-multiplicity pp collisions at 1as = 13 TeV

Two-particle angular correlations are measured in high-multiplicity proton-proton collisions at s = 13 TeV by the ALICE Collaboration. The yields of particle pairs at short-( 06\u3b7 3c 0) and long-range (1.6 < | 06\u3b7| < 1.8) in pseudorapidity are extracted on the near-side ( 06\u3c6 3c 0). They are reported as a function of transverse momentum (pT) in the range 1 < pT< 4 GeV/c. Furthermore, the event-scale dependence is studied for the first time by requiring the presence of high-pT leading particles or jets for varying pT thresholds. The results demonstrate that the long-range \u201cridge\u201d yield, possibly related to the collective behavior of the system, is present in events with high-pT processes as well. The magnitudes of the short- and long-range yields are found to grow with the event scale. The results are compared to EPOS LHC and PYTHIA 8 calculations, with and without string-shoving interactions. It is found that while both models describe the qualitative trends in the data, calculations from EPOS LHC show a better quantitative agreement for the pT dependency, while overestimating the event-scale dependency. [Figure not available: see fulltext.

f0(980) production in inelastic pp collisions at s = 5.02 TeV

The measurement of the production of f0(980) in inelastic pp collisions at sqrt(s) = 5.02 TeV is presented. This is the first reported measurement of inclusive f0(980) yield at LHC energies. The production is measured at midrapidity, |y| pi+pi- hadronic decay channel using the ALICE detector. The pT-differential yields are compared to those of pions, protons and ϕ mesons as well as to predictions from the HERWIG 7.2 QCD-inspired Monte Carlo event generator and calculations from a coalescence model that uses the AMPT model as an input. The ratio of the pT-integrated yield of f0(980) relative to pions is compared to measurements in e+e- and pp collisions at lower energies and predictions from statistical hadronisation models and HERWIG 7.2. A mild collision energy dependence of the f0(980) to pion production is observed in pp collisions from SPS to LHC energies. All considered models underpredict the pT-integrated 2f0(980)/(pi+ + pi-) ratio. The prediction from the canonical statistical hadronisation model assuming a zero total strangeness content of f0(980) is consistent with the data within 1.9σ and is the closest to the data. The results provide an essential reference for future measurements of the particle yield and nuclear modification in p–Pb and Pb–Pb collisions, which have been proposed to be instrumental to probe the elusive nature and quark composition of the f0(980) scalar meson

Neutral to charged kaon yield fluctuations in Pb – Pb collisions at sNN=2.76 TeV

We present the first measurement of event-by-event fluctuations in the kaon sector in Pb – Pb collisions at √sNN = 2.76 TeV with the ALICE detector at the LHC. The robust fluctuation correlator νdyn is used to evaluate the magnitude of fluctuations of the relative yields of neutral and charged kaons, as well as the relative yields of charged kaons, as a function of collision centrality and selected kinematic ranges. While the correlator νdyn[K+, K− ] exhibits a scaling approximately in inverse proportion of the charged particle multiplicity, νdyn[K0 S , K± ] features a significant deviation from such scaling. Within uncertainties, the value of νdyn[K0S , K± ] is independent of the selected transverse momentum interval, while it exhibits a pseudorapidity dependence. The results are compared with HIJING, AMPT and EPOS–LHC predictions, and are further discussed in the context of the possible production of disoriented chiral condensates in central Pb – Pb collisions