8 research outputs found
Ginger extract ameliorates phosphamidon induced hepatotoxicity
574-584Organophosphorus
(OP) compounds commonly used as pesticides in agriculture cause serious health problems to living
beings. The present study enumerates the ameliorating effect of ginger extract
(GE) against phosphamidon (PHO, an organophosphorus insecticide) induced
hepatotoxicity. GE was prepared from dried ginger and characterized for
compound profile and antioxidant activity. Eight groups of albino rats (n=6)
were treated with 1/5th lethal dose of PHO for 5-20 days. Out of the
treated 8 groups, 4 were simultaneously fed with GE (1 mg/kg body wt.) along
with PHO. Alterations in the levels of hepatocellular oxidative stress (OS)
markers in the treated groups indicated an enhanced generation of reactive
oxygen species (ROS) and oxidative stress (OS). Upregulation of apoptotic
markers, DNA fragmentation and appearance of apoptotic nuclei suggested
induction of apoptosis in the liver cell that was found to be attenuated after
GE treatment. Moreover, no toxicity and mortality was observed up to 100
mg/kg dose of GE for 30 days in the rat model studied. <span style="mso-bidi-font-weight:
bold">Thus, GE can be considered as an effective, economical and safe extract
to circumvent PHO-induced hepatotoxicity.
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