The Effect of Insulin Like Growth Factor-1 on Recovery of Facial Nerve Crush Injury

Objectives The aim of this study is to investigate the efficacy of locally applied insulin-like growth factor 1 (IGF-1) on the recovery of facial nerve functions after crush injury in a rabbit model. Methods The rabbits were randomly assigned into three groups. Group 1 consisted of the rabbits with crush injury alone; group 2, the animals applied saline solution onto the crushed facial nerve and group 3, IGF-1 implemented to the nerve in the same manner. Facial nerve injury was first electrophysiologically studied on 10th and 42nd days of the procedure. The damage to the facial nerves was then investigated histopathologically, after sacrification of the animals. Results In the electrophysiological study, compound muscle action potential amplitudes of the crushed nerves in the second group were decreased. In pathological specimens of the first and second groups, the orders of axons were distorted; demyelination and proliferation of Schwann cells were observed. However, in IGF-1 treated group axonal order and myelin were preserved, and Schwann cell proliferation was close to normal (P<0.05). Conclusion Local application of IGF-1 in a slow releasing gel was found efficacious in the recovery of the facial nerve crush injury in rabbits. IGF-1 was considered worthy of being tried in clinical studies in facial nerve injury cases

Effect of Colchicine on Secondary Acute Lung Injury in an Experimental Sepsis Model in Rats

Introduction: An irregular systemic inflammatory response in sepsis can induce acute lung injury (ALI), which is characterized by the exaggerated inflammation of the lung tissue. Colchicine inhibits several inflammatory pathways which may prevent sepsis-induced secondary lung injury. We aimed to examine the histopathological effects of colchicine on lung tissue in a lipopolysaccharide (LPS)-induced sepsis model in rats. Materials and Methods: Twenty-eight rats were randomly divided into the following four groups: “sham” (n=6), “colchicine only” (n=6), “sepsis only” (n=8) and “sepsis+colchicine” (n=8). In the “sham” group, 0.9% NaCl was administered intraperitoneally (IP) and intragastrically (IG). In the “Colchicine only” group, 0.9% NaCl was administered IP and colchicine was administered IG. Sepsis was induced in the “sepsis only” and “sepsis+colchicine” groups by administering of 1 mg/kg of LPS IP at the 0-time point. In the “sepsis+colchicine” group, colchicine was additionally given IG at the 90th minute. An observational sepsis scoring system was used to evaluate the signs of sepsis. Subsequently, the rats were sacrificed at the 24th hour. The lung tissues were examined according to the American Thorax Association’s assessment report on ALI in animals. Results: The histopathological lung injury score in the “sepsis+colchicine” group was significantly higher than in the “sham” group (0.23±0.18 vs. 0±0; p<0.05) and was significantly lower than in the “sepsis only” group (0.23±0.18 vs. 0.57±0.14; p<0.001). Evaluation of the lung damage score revealed that colchicine suppressed the increase in alveolar and interstitial neutrophil counts and limited the increase in hyaline membrane counts and alveolar wall thickness in the “sepsis+colchicine” group when compared with the “sepsis only” group. Conclusion: In our experimental sepsis rat model, administration of colchicine for sepsis limited the secondary lung damage

An Examination of the Opinions of the University Students About Feminism and Gender Roles

Gender discrimination adversely affected women in all areas of social life, especially in the fields of education, work, marriage and family life. Feminism has emerged to draw attention to the these impacts of gender discrimination and to reduce it's negative consequences. Social transformation is necessary to ensure gender justice. One of the important steps for achieving this transformation is to educate the youth and increase their awareness. This study was conducted with the aim to determine Dumlupinar University, School of Health students' opinions on feminism and gender roles. The population of this study consists of 1293 students. Sample is comprised of 846 students who accepted to enrolled in the study. Data have been collected with using a questionnaire and assessed with percentiles, Kruskal-Walls and Mann-Whitney U-Tests. 43.3% of students defined feminism as “a style of thought that advocates women are more superior than men” and 31.9% of them as “a style of thought that advocates the equity of social opportunity”. It was identified that male students have more traditional opinions on gender roles related to work, social, marriage and family life. This study has revealed that male students have more conventional opinions in the fields of in working and married life, while the male and female students have egalatirian opinions in the propositions about social life and family life. Besides, the results of the study have revealed that opinions of students on gender roles related to work, social, marriage and family life exhibit statistically significant differences among the departments for all of the statements given. It was observed that midwifery students have more egalitarian views. Also, it was determined that upper class students have more egalitarian opinions. As a result of our study, it has been seen that university students still have a traditional perspective on social gender roles. According to the results of the questionnaire we can state that the youth do not understand feminism with all its aspects and digest it. Therefore, the awareness of the university students about feminism and gender should be increased. It is also considered to be useful the creation of student groups advocating gender equity in universities

Extranodal Rosai-Dorfman disease with bilateral orbital involvement: Report of a case treated with systemic steroid alone

Safiye Yilmaz1, Melih Ture1, Ahmet Maden1, Mine Tunakan21Department of Ophthalmology, 2Department of Pathology, Izmir Atat&amp;uuml;rk Training and Research Hospital, Izmir, TurkeyAbstract: We report the case of a 41-year-old female with bilateral orbital Rosai-Dorfman disease (RDD) and the result of corticosteroid therapy. The patient developed a swollen mass of bilateral upper and lower eye-lid over a six-month period. Diagnosis was based on the characteristic histopathologic features. She was treated with oral corticosteroids 60 mg/per day for ten days and the dose of corticostreoid was tapered every week. She is currently being treated with 10 mg/per day for 4 months. In general, the prognosis is good, with experiencing remission following a course of oral corticosteroids. There is no evidence that corticosteroids are beneficial in the treatment of RDD in the literature, but data regarding such treatment are sparse. A more formalized surveillance of these cases would help to define more clearly the natural history of the disease and the effects of various treatment modalities.Keywords: Rosai-Dorfman Disease, orbital involvement, treatment, corticosteroi