1H. Liver X receptor-like receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Liver X and farnesoid X receptors (LXR and FXR, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [68]) are members of a steroid analogue-activated nuclear receptor subfamily, which form heterodimers with members of the retinoid X receptor family. Endogenous ligands for LXRs include hydroxycholesterols (OHC), while FXRs appear to be activated by bile acids. In humans and primates, NR1H5P is a pseudogene. However, in other mammals, it encodes a functional nuclear hormone receptor that appears to be involved in cholesterol biosynthesis [71]

1H. Liver X receptor-like receptors in GtoPdb v.2023.1

Liver X and farnesoid X receptors (LXR and FXR, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [76, 3]) are members of a steroid analogue-activated nuclear receptor subfamily, which form heterodimers with members of the retinoid X receptor family. Endogenous ligands for LXRs include hydroxycholesterols (OHC), while FXRs appear to be activated by bile acids. In humans and primates, NR1H5P is a pseudogene. However, in other mammals, it encodes a functional nuclear hormone receptor that appears to be involved in cholesterol biosynthesis [80]

Performance Evaluation of MC-CDMA Systems with Single User Detection Technique using Kernel and Linear Adaptive Method, Journal of Telecommunications and Information Technology, 2021, nr 4

Among all the techniques combining multi-carrier modulation and spread spectrum, the multi-carrier code division multiple access (MC-CDMA) system is by far the most widely studied. In this paper, we present the performance of the MC-CDMA system associated with key single-user detection techniques. We are interested in problems related to identification and equalization of mobile radio channels, using the kernel method in Hilbert space with a reproducing kernel, and a linear adaptive algorithm, for MC-CDMA systems. In this context, we tested the efficiency of these algorithms, considering practical frequency selective fading channels, called broadband radio access network (BRAN), standardized for MC-CDMA systems. As far as the equalization problem encountered after channel identification is concerned, we use the orthogonality restoration combination (ORC) and the minimum mean square error (MMSE) equalizer techniques to correct the distortion of the channel. Simulation results demonstrate that the kernel algorithm is efficient for practical channel

An Extended Version of the Proportional Adaptive Algorithm Based on Kernel Methods for Channel Identification with Binary Measurements, Journal of Telecommunications and Information Technology, 2022, nr 3

In recent years, kernel methods have provided an important alternative solution, as they offer a simple way of expanding linear algorithms to cover the non-linear mode as well. In this paper, we propose a novel recursive kernel approach allowing to identify the finite impulse response (FIR) in non-linear systems, with binary value output observations. This approach employs a kernel function to perform implicit data mapping. The transformation is performed by changing the basis of the data In a high-dimensional feature space in which the relations between the different variables become linearized. To assess the performance of the proposed approach, we have compared it with two other algorithms, such as proportionate normalized least-meansquare (PNLMS) and improved PNLMS (IPNLMS). For this purpose, we used three measurable frequency-selective fading radio channels, known as the broadband radio access Network (BRAN C, BRAN D, and BRAN E), which are standardized by the European Telecommunications Standards Institute (ETSI), and one theoretical frequency selective channel, known as the Macchi’s channel. Simulation results show that the proposed algorithm offers better results, even in high noise environments, and generates a lower mean square error (MSE) compared with PNLMS and IPNLMS

Ethnobotanical Survey of Medicinal Plants Used in the Traditional Treatment of Depression and Anxiety in Fez-Meknes Region

Depression and anxiety represent a major mental health problem in the world. The majority of Moroccan people use traditional medicine for their health needs, including various forms of depression and anxiety. The aim of this work is to make an inventory of plant species used in folk medicine for the management of depression and anxiety in Fez-Meknes regions. Established questionnaires were administered to 243 interviews in 4 communities within Fez-Meknes region. With traditional health practitioners, herbalists and consumer. Plant species belonging to 31 families were reported. The most frequently cited families are Lamiaceae followed by Asteraceae, Apiaceae and Verbenaceae. Leaves were the major plant parts used forming 58% solely and 73 mixed with other parts. This was followed by seeds 17%, flowers 6%, roots 2% and fruits, bark (1% each). The current survey represents a useful documentation, which can use to preserving knowledge on the use of medicinal plants in this region and to explore the phytochemical and pharmacological potential of medicinal plants.Peer reviewe

Pedomorphosis revisited: thyroid hormone receptors are functional in Necturus maculosus

Heterochrony, a difference in developmental timing, is a central concept in modern evolutionary biology. An example is pedomorphosis, retention of juvenile characteristics in sexually mature adults, a phenomenon largely represented in salamanders. The mudpuppy ( Necturus maculosus ) is an obligate pedomorphic amphibian, never undergoing metamorphosis. Thyroid hormone induces tissue transformation in metamorphosing species and this action is mediated by nuclear thyroid hormone (TH) receptors (TRs). The absence of metamorphosis in Necturus has been attributed to a resistance to TH action as treatment with exogenous TH fails to induce transformation. The failure to metamorphose could be due to the lack of TR expression in target tissues, or to a loss of TR function. Toward understanding the molecular basis for the failure of Necturus tissues to respond to TH, and the ultimate cause for the expression of the obligate pedomorphic life history, we characterized the structure, function, and expression of TR genes in Necturus . Strikingly, we found that Necturus TRΑ and TRΒ genes encode fully functional TR proteins. These TRs bind both DNA and TH and can transactivate target genes in response to TH. Both TRΑ and TRΒ are expressed in various tissues. TH treatment in vivo induced expression in the gill of some but not all genes known to be activated by TH in anuran larvae, caused whole organism metabolic effects, but induced no external morphological changes in adults or larvae. Thus, Necturus possesses fully functional TRs and its tissues are not generally resistant to the actions of TH. Rather, the absence of metamorphosis may be due to the loss of TH-dependent control of key genes required for tissue transformation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75694/1/j.1525-142X.2006.00099.x.pd

Unexpected Novel Relational Links Uncovered by Extensive Developmental Profiling of Nuclear Receptor Expression

Nuclear receptors (NRs) are transcription factors that are implicated in several biological processes such as embryonic development, homeostasis, and metabolic diseases. To study the role of NRs in development, it is critically important to know when and where individual genes are expressed. Although systematic expression studies using reverse transcriptase PCR and/or DNA microarrays have been performed in classical model systems such as Drosophila and mouse, no systematic atlas describing NR involvement during embryonic development on a global scale has been assembled. Adopting a systems biology approach, we conducted a systematic analysis of the dynamic spatiotemporal expression of all NR genes as well as their main transcriptional coregulators during zebrafish development (101 genes) using whole-mount in situ hybridization. This extensive dataset establishes overlapping expression patterns among NRs and coregulators, indicating hierarchical transcriptional networks. This complete developmental profiling provides an unprecedented examination of expression of NRs during embryogenesis, uncovering their potential function during central nervous system and retina formation. Moreover, our study reveals that tissue specificity of hormone action is conferred more by the receptors than by their coregulators. Finally, further evolutionary analyses of this global resource led us to propose that neofunctionalization of duplicated genes occurs at the levels of both protein sequence and RNA expression patterns. Altogether, this expression database of NRs provides novel routes for leading investigation into the biological function of each individual NR as well as for the study of their combinatorial regulatory circuitry within the superfamily

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