The cardiovascular effects of inspired oxygen fraction in patients undergoing on-pump coronary artery surgery

زمینه و هدف: افزایش کسر دمی اکسیژن استنشاقی (FiO2)، اثرات همودینامیک منفی در افراد داوطلب و بیدار در چند مطالعه محدود داشته است. در عمل جراحی قلب به دلیل خطر تجویز نیتروس اکسید (N2O) به ویژه آمبولی هوا، از اکسیژن 100 استفاده می شود. این مطالعه با هدف بررسی اثرات قلبی عروقی اکسیژن خالص استنشاقی حین بیهوشی در مقایسه با اکسیژن 50 در جراحی بای پاس عروق کرونر انجام شده است. روش بررسی: در این مطالعه کار آزمایی بالینی دو سویه کور، تعداد 60 بیمار با سن 70-40 سال و کاندید عمل انتخابی بای پاس عروق کرونر با وضعیت فیزیکی کلاس دو و سه ASA) II، (IIIمراجعه کننده به مرکز پزشکی قلب چمران اصفهان به روش در دسترس انتخاب شدند. بیماران به طور تصادفی در دو گروه 30 نفری مورد و شاهد قرار گرفته به صورتی که بلافاصله بعد از القای بیهوشی در گروه مورد از مخلوط اکسیژن و هوا به نسبت 50-50 و در گروه شاهد از اکسیژن 100 در ادامه بیهوشی استفاده گردید. زمان های حین عمل و پس از ورود به آی سی یو، متغیرهای فشار خون، فشار ورید مرکزی (CVP)، فشار سهمی اکسیژن شریانی (PaO2)، PH شریانی، اندکس قلبی و میزان نیاز به داروی اینوتروپ ارزیابی و ثبت گردید. اطلاعات توسط آزمونهای کای دو، t، آنالیز واریانس، مشاهدات تکرار شده و من ویتنی تجزیه و تحلیل شد. یافته ها: دو گروه از نظر سن، جنس، کسر جهشی قبل عمل، مدت پمپ قلبی ریوی، مدت زمان عمل و شاخص توده بدنی، با یکدیگر شباهت داشتند )05/0(P>. متوسط فشارهای سیستول و دیاستول و همچنین سرعت ضربان قلب و اندکس قلبی در کلیه زمانهای بررسی در دو گروه تفاوت آماری قابل ملاحظه ای با یکدیگر نداشتند )05/0(P>. فراوانی نسبی نیاز به داروی اینوتروپ در گروه شاهد 3/53 (16 بیمار) و در گروه مورد 7/26 (8 بیمار) بود )05/0(

The impact of hyperglycemia or hypoalbuminemia on duration and need to mechanical ventilation in critically ill patients

چکیده: زمینه و هدف: چندین فاکتور فیزیولوژیکی علاوه بر معیارهای مکانیکی ریوی، بر روی جدا سازی بیماران بستری در واحد مراقبت های ویژه از دستگاه ونتیلاتور موثراست. هیپرگلیسمی باعث افزایش بیشتری در نیاز به ونتیلاتور می شود و به طور بارزی روزهای اتصال به دستگاه را افزایش می دهد. هدف از این مطالعه بررسی تاثیر هیپوآلبومینمی یا هیپرگلیسمی در پیش بینی نیاز به ونتیلاتور و جدا سازی از ونتیلاتور در واحد مراقبت های ویژه بوده است. روش بررسی: این مطالعه توصیفی – تحلیلی بر روی 600 بیمار بالای 16 سال در افرادی که بمدت بیش از 3 روز در واحد مراقبت های ویژه مرکز پزشکی الزهرا(س) اصفهان بستری شده بودند انجام شد. پارامترهای آلبومین سرمی، قند خون، نیاز به ونتیلاتور، مدت اتصال به ونتیلاتور بالانس مایعات و ضریب اپاچی سه (APACHE-3= Acute –physiology and chronic health evaluation) بیماران ثبت و داده ها با استفاده از آزمونهای آماری تی استیودنت، کای دو، رگرسیون کاکس، رگرسیون لوجستیک یک طرفه، آنالیز رگرسیون Multilinear و آنالیز رگرسیون لوجستیکی مولتیپل تجزیه و تحلیل شد. یافته ها: در بدو ورود میانگین غلظت قند سرمی mmol/L 2/0±3/9 و آلبومین سرمی g/l 02/0±2/30 بود. در بیماران فوت شده غلظت آلبومین سرمی بطور معنی دار کمتر و غلظت قند سرمی بطور معنی دار نسبت به افراد زنده بالاتر بود (001/0P) و قند خون (05/0r=، 05/0P>) حین بستری در واحد مراقبت های ویژه نتوانست پیش بینی کننده مدت زمان اتصال به ونتیلاتور باشد. بیماران با غلظت آلبومین سرمی کمتر از 3/30 نسبت به افراد با آلبومین سرمی نرمال با افزایش نیاز به ونتیلاتور در حد 2/0-1/0 برابر روبرو شدند. (31/1-06/1=95CI و 2/1=OR) خطر نیاز به ونتیلاتور با قند خون بالای mg/dl 200 افزایش نیافت. نتیجه گیری: بر اساس یافته های این مطالعه آلبومین و قند خون می تواند اندکس هایی از وضعیت متابولیکی بیماران باشد که در تعیین نیاز به ونتیلاتور و جداسازی از آن در دوره های طولانی مدت تنفس مکانیکی اهمیت دارد

An introduction of photobioreactor technology in mass culture of algea in order to improve the shrimp culture in Iran

Algae production in controlled condition is one one the most important subject that ought to studying . This kind of algae production can use for biosynthesis great syuffs like as vtamines and unsaturated fatty acids. For achieving this goal < this project was designed and done. At this project some procedures like steril cultivation < light controlling, remove and dissolving gases as oxygen and carbon dioxide, mixturing tank, intelligent sensor, biofilter purifying, dechloration vessel and dosing pumps are new phenomenas are used. Finally, chlorella sp from Gilan institute were culativated more than 16000000 cells per one millimeter

Fish gene bank of the Persian Gulf and Oman Sea

Genetic studies and gene banks preparation can identify guidelines for improving diversity and population structure and estimation, poaching and also the amount of cross breeding and provide genetic classification. In this study, sampling was performed from the important studied species habitats areas for the species such as: Dasyatis bennetti، Netuma thalassina, Netuma bilineata Carcharhinus leucas، Choerodon robustus، Pseudorhombus pentophthalmus ،Pseudorhombus arsius Thunnus tonggol ،Euthynnus affinis and Trichiurus lepturus. Total DNA extraction was performed using phenol - chloroform method which is the most common method for DNA extraction in order to achieve high quality of DNA was performed in the preparation of gene bank in this study. After relevant studies on this gene primers were designed and in use. After editing the sequences, nucleotide BLAST (Basic Local Alignment Search Tool) was performed using NCBI blast main page. The sequences obtained from each sample were aligned and corrected from any ambiguities and assembled using Bio edit program .Trees were generated using maximum parsimony (MP), a character-based algorithm and neighbor joining (NJ) a distance-based algorithm for phenetic analysis. The distance matrix option of MEGA4 was used to calculate genetic distance according to the Kimura 2-parameter model of sequence evolution. Based on the results obtained, the optical density of 260 to 280 nm in the samples was recorded between 1/8 - 2, indicating good quality DNA samples. Optimized PCR reaction to 16SrRNA gene amplification using the gradient between 48 - 60° C showed that the most suitable criteria for binding primers, 54 to 58 Celsius degrees respectively. The project objectives including the identification of the genetic structure of the species, and draw the phylogenetic trees using two genes 16SrRNA, making identification and registration of specified computer storage and regulate the structure and management of mentioned species by focus on genetic resources 10 species of majour commercial and noncommercial fishes in the Persia Gulf and Oman Sea through the creation of an integrated network of aquatic genetic resources in the region to try to identify genetic resources and aquatic gene bank. This type of analysis could be considered as an important tool to be used in broodstock selection in breeding programs. Also identify the species of fish named as Pseudorhombus pentophthalmus with a new haplotype and genetic differences 7% in compare to the samples recorded in the World gene Bank can considered as a major achievements of this research

Study and relocation of corals in developing area of Shahid Beheshty port, Chabahar

The conservation of coral colonies is very vital for marine organisms and human. In Chabahar Bay, the coral reefs are in danger of destruction due to the development program of Shahid Beheshti Port. In this project, over 30,000 hard corals were transported to coast of Hotel Lipar an area at a distance of 3.5-4 kms far from Shahid Beheshti Port. Also, the new techniques were used for coral reattachment and transportation. The operation has done within expert divers and consultancy of Prof. Dr. Maikle Risk. Four methods performance as pailots. Since the corals are very sensitive to turbidity and suspended sediments from land reclamation and dredging projects, therefore appropriate measures should be conducted for conservation and recovery of them.37 patches in size 5×10 meters has built with concerete. Diffent sizes of corals were separated by mechanical tools and transported to new sites and reattachment on artificial sea bottom.Three monthes after the last reattachments monitored showed that %96.93 of corals were in good health. This success was the important achievement because of innovating coral carrier and mass coral relocation. At present, the coral relocation is suggested as a good method for recovery of coral reefs after a disturbance in condition of their native habitats

Stock enhancement and estimation of growth rate of green tiger prawn (Penaeus semisulcatus) and banana shrimp (Fenneropenaeus merguiensis) released in the Persian Gulf

Present study was conducted in the Persian Gulf (Iranian waters) from 2009 to 2012. The main objective of the research was economical evalution of the stock enhancement of banana prawn (Fenneropenaeus merguiensis) and green tiger shrimp (Penaeus semisulcatus) in the studied area. Also tagging effects on the growth and mortality of tagged shrimp were studied. In banana prawn, broodstock shrimps were hatched in June. In July 2010 and 2011some of the juvenile of this species were marked by red fluorescent liquid injection and released were made at night in the estuaries of Tiab, Kolahi and Koolgan in the Hormozgan province. 84000 juveniles of banana prawn in 2010 and about 50000 in 2011 were released in this area. In Bushehr province waters, adults shrimp were reared and when juveniles reached to optimum size, some of them were tagged by red and blue coloures and were released in the coastal waters of Bandargah and Delvar. Tagging and releasing program of green tiger prawn was performed in 2010 and 2012. A total number of 8000 prawn in 2010 and about 30000 juveniles prawn in 2010 were released. Activities for recaptured shrimps were informed by posters describing the tagging program that were distributed to local peoples, as well as local magazines, and a tagging program awareness film was broadcast on national television three times prior to the shrimp fishing season and during catch season. To encourage people to report recaptures a reward of two handered thousent riales was paid for the return of each marked shrimp accompanied by information. Economical evaluation of banana prawn was performed based on releasing and recaptured program in 2011. As it mentioned in this year 50000 of juvenile shrimp were tagged and released. At the same time 4700000 of unmarked shrimp were released in this area. In the shrimp season 11 (./022%) of tagged shrimp were recaptured. Movements of tagged shrimp were northwesterly to released area. Weight average of tagged prawns was 1.2 gram. Mean weight of the recaptured prawns was 22.06±4.9 gram. Body weight Growth of the recaptured prawns was between 16-26 grams with the growth speed of 0.88-1.41 per week. The number of recaptured prawn to the released prawn was 0.022 percent. Based on the released prawns (4700000) to the recaptured percent (./022%), about 103400 of released shrimp with mean weight of 2.5 tones were observed in the Hormozgan shrimp catch. The average price of shrimp in the studied year in the local market was 85000 Rials per kilogram. These results showed that the ratio of profit is 210 milion riales. In the taggiing program of green tiger prawn in the Bushehr waters only one recaptured shrimp was observed in the catch season (2012). Total weigth and total length of this prawn was 99 gram and 22 centimeter respectively .given the small percentage of the recaptured, economical analyses was not performed on this species. The effects of tagging on the growth and mortality of green tiger prawn were studied. The present study was carried out in the shrimp research station in Bandargah and Abzistan shrimp Hatchery Company in Delvar during 2010 and 2012. The accuracy of the study was more rialable in 2012. In this year growth and mortality of juveniles that was marked by red and blue coloures, were studied in both area Bandargah and Delvar. In Bandargah, three tanks of 300 l each with 30 specimens were used for untagged shrimp as a control group, and tagged with injected liquid fluorescent during 98 days. Length and weigh of 10 specimens were measured evenly in different times. ANOVA results (α = 0.1 and α = 0.5) showed no significant differences between length growth of tagged shrimp and control group. The mortality of two groups was evaluated by numbering of remained shrimps and the average of survival was 52 percent in the tagged and 44.5 percent in tagged shrimps. In the Delvar station, Abzistan Company, the specimens were kept in the 9 tanks each 300 l that included of 30 untagged shrimps, 30 blue tagged shrimps and 30 red florescent tagged shrimp. The growth and mortality of this station were evaluated during 110 days. The growth rate of the specimens were measured and recorded evenly. The results of ANOVA (α = 0.1 and α = 0.5) showed no difference significantly in the weight growth of tagged and control groups. The mortality rates among the control group, red tagged and blue tagged were 63 percent, 59 percent and 40 percent. The mortality of the groups was differences in the two stations and it seems the management and environmental conditions were more affected on the mortalities. The results of the study show that the ratio of profit to the coast is 0.46 that is covering half of the coasts, so that the expenditures are two times more than profit. This result is the minimum of economical value of stock enhancement of shrimp. The results of study showed that the injected tags into the body tissue of shrimp has no affected on the growth rate and mortality

The fifth developing plan of Iranian Fisheries Research Institute

Accurate scientific and practical plan for achieving the goals of the Islamic Republic of Iran within the framework of Vision development 1404, is the infrastructure achieving sustainable development of the country. Order to achieve the above mentioned objectives and in order to the comprehensive development plans in the country, Iranian fisheries research organization adjust the fifth developing plan for support of executive related departments in country with mobilization a large number researchers consists of several working groups of ifro affiliated research centers. The fifth developing plan consist of three chapters for report of the forth developing plan and intrudction of research, construction plans and financial support (budjet) for period of 2011-2014 A.C

Evaluating the efficacy of infection probability score, APACHE II and APACHE III in the determination of the need for mechanical ventilation and duration of it in patients with respiratory failure

Background: Although the predictive criteria for duration of mechanical ventilation may help to evaluate the right time of disconnecting a patient from the ventilator, the efficacy of the APACHE ( Acute physiology, Age and Chronic Health Evaluation) or IPS (Infection Probability Score) systems in the prediction of the need to ventilator and its duration needs further evaluation. The study was performed in Alzahra Medical Center of Isfahan in 2006 – 2007 to evaluate the efficacy of the predicting power needing intubation (NI), mechanical ventilation (NMV), and duration of MV. Materials and Methods: One hundred eighty critically ill patients were included in this evaluative diagnostic study. On admission day in the ICU, patients' data were collected to compare the APACHE II and III, and IPS scores. The necessity of mechanical ventilation and its duration were recorded for each patient. Sensitivity, specificity, area under the curve and corrected prediction of outcome for each cut-off point were calculated for three scores. Results: The best cut-off points for prediction of NI were 50 for APACHE III, 12 for APACHE II and 12 for IPS. The Youden index had best cut-off points for APACHE III=0.62, APACHE II=0.36 and IPS=0.4. The area under the Receiver Operating Characteristic (ROC) curve was 0.63, 0.77 and 0.83 for APACHE III, APACHE II and IPS respectively. There were statistical differences between APACHE III , APACHE II and IPS in terms of Youden index and the area under the ROC curve (P<0.05). For the prediction of NMV, APACHE III yield significantly better results in the area under the ROC curve and Youden index than those of APACHE II or IPS (p<0.05). In the prediction of more than 5 days respiratory support under MV none of the three scoring systems could provide a good discrimination. Conclusion: To predict for NI or NMV, the APACHE III had better accuracy than the APACHE II or IPS. Concerning estimation of the requirement of mechanical ventilation in critically ill patients although the APACHE III showed to be sufficiently accurate the sensitivity and calibration of the scoring systems should be improved

The Effects of Sufentanil or Remifentanil Pretreatment on Propofol Injection Pain

Abstract Background and purpose: Propofol produces anesthesia with rapid recovery. However, it causes pain or discomfort during injection. The effect of remifentanil in prevention of propofol-induced injection pain was demonstrated in earlier studies. Sufentanil, an opioid analgesic, has not been studied for managing pain on injection of propofol. We have compared the efficacy of remifentanil and sufentanil for the prevention of propofol induced pain.Materials and Methods: One hundred twenty American Society of Anesthesiologists (ASA) class I-II adults undergoing elective surgery were randomly assigned into four groups of 20 each. Patients received 2 mL (10 mg) sufentanil, 2 mL of remifentanil (10 mg), 2 mL of remifentanil (20 mg), or 2 mL of saline 60 seconds prior to administering 5 mL of propofol 1%. Patients were asked whether they had pain due to propofol injection.Their pain scores were evaluated with the use of the four-point scale of Ambesh.Results: The remifentanil and sufentanil groups significantly showed lower frequency of pain than that in the saline group (p < 0.05). Median pain intensity scores were significantly lower in the group receiving remifentanil 20 mg compared with the sufentanil groups (P < 0.05). The median intensity of propofol-induced pain was statistically similar between the groups receiving sufentanil or remifentanil 10 mg and the placebo groups.Conclusion: Remifentanil 20 mg over 1 min before propofol administration is more effective than sufentanil 10 mg 1 min prior to propofol in reducing the incidence and intensity of injection pain

Relationships Between Hoffman Reflex Parameters, Trait Stress, and Athletic Performance

This study evaluated the relationships between trait stress, Hoffman reflex, and performance among 36 healthy amateur male athletes. We first obtained a trait stress questionnaire from participants and then assigned them to high- and low-stress groups. We next recorded Hoffman reflex data from the soleus and lateral gastrocnemius muscles and then examined their athletic performance on testing protocols separated by a 72-hour washout period. Performance testing utilized vertical jump height, 20 -m sprint time, and standing stork tests. There were significant correlations between (a) the standing stork test, vertical jump height, and trait stress and (b) Hmax/Mmax ratios, threshold intensity (Hth), the intensity of the Hmax, and the intensity of the Hlast. Hth, the intensity of Hmax, and the intensity of Hlast were significantly higher among the low-stress compared with the high-stress participant groups (p &lt;.05), despite participants� similar training history. We suggest that self-perceived psychological stress affects performance through neural adaptation. © The Author(s) 2018