244 research outputs found
Recommended from our members
A Prospective Controlled Study of Magnetic Resonance Imaging of the Brain in Gay Men and Parenteral Drug Users with Human Immunodeficiency Virus Infection
To detect the earliest structural changes in the brain in human immunodeficiency virus (HIV) infection, 118 gay men and 115 parenteral drug users enrolled in a study of the natural history of HIV infection underwent magnetic resonance imaging evaluations. Routine T2-weighted and heavily T2-weighted scans for quantification of brain water were obtained, blinded to HIV serostatus. Atrophy and foci of increased signal did not correlate with any medical, immunologic, neurologic, or neuropsychologic parameters in the group as a whole, or in the gay men or parenteral drug user subgroups. Three subjects had progressive multifocal leukoencephalopathy and one had central nervous system lymphoma. In a subgroup in whom intracranial water percent was calculated, correlations were found with CD4 counts and CD4/CD8 ratios. We conclude that standard magnetic resonance imaging of the brain does not differentiate asymptomatic and mildly symptomatic HIV-positive individuals from HIV-negative individuals, regardless of risk group. However, intracranial water percent may distinguish HIV-positive from HIV-negative individuals because it correlates with raw CD4 counts and CD4/CD8 ratios
The DINGO database of axial pile load tests for the UK:settlement prediction in fine-grained soils
Regulation of Artificial Intelligence in Selected Jurisdictions
Comparative Summary
This report examines the emerging regulatory and policy landscape surrounding artificial intelligence (AI) in jurisdictions around the world and in the European Union (EU). In addition, a survey of international organizations describes the approach that United Nations (UN) agencies and regional organizations have taken towards AI. As the regulation of AI is still in its infancy, guidelines, ethics codes, and actions by and statements from governments and their agencies on AI are also addressed. While the country surveys look at various legal issues, including data protection and privacy, transparency, human oversight, surveillance, public administration and services, autonomous vehicles, and lethal autonomous weapons systems, the most advanced regulations were found in the area of autonomous vehicles, in particular for the testing of such vehicles.
The Oxford Dictionary defines AI as “the theory and development of computer systems able to perform tasks normally requiring human intelligence, such as visual perception, speech recognition, decision-making, and translation between languages.” The majority of surveyed jurisdictions see AI in a positive light and aspire to become leaders in the field. Many countries have therefore developed or are in the process of developing national AI or digital strategies and action plans. Canada was the first country to launch such a national AI strategy in 2017. The strategies and action plans highlight, among others things, the need to develop ethical and legal frameworks to ensure that AI is developed and applied based on the country’s values and fundamental rights. Many countries have established specific commissions to look into these issues. However, with the exception of the EU, no jurisdiction has yet published such specific ethical or legal frameworks for AI. In December 2018, an expert group of the European Commission released draft AI ethics guidelines that set out a framework for designing trustworthy AI. South Korea in 2008 enacted a general law on the “intelligent robot industry” that, among other things, authorized the government to enact and promulgate a charter on intelligent robot ethics. However, it appears that no such charter has yet been enacted.
Some countries have taken the first steps to use AI in the area of justice. In Portugal, a legal assistance tool will be launched that conducts research on the requests made and learns from them. In the future, it might be used to predict the probability of success of a judicial process. Likewise, in France the Courts of Appeals of Rennes and Douai tested predictive justice software on various appeals cases in 2017.
Many of the surveyed countries are contracting parties to the 1968 Vienna Convention on Road Traffic, an international agreement with the objective to “facilitate international road traffic and to increase road safety through the adoption of uniform traffic rules.” A 2016 amendment to the Convention on Road Traffic removed legal obstacles for the contracting parties to allow transferring driving tasks to automated technologies. Countries that have enacted regulations to allow for the testing of autonomous vehicles on public roads generally require that a human driver be present in the car who can take over the driving functions if necessary. As an exception, the Netherlands and Lithuania have passed legislation that allows the experimental use of self-driving vehicles without a human driver present in the car on public roads. Israel passed a regulation and a directive for experimentation in autonomous vehicles. Authorization to conduct experiments in autonomous vehicles requires, among others, a review by a professional committee. Spain, Qatar, and the United Arab Emirates authorize the testing without a human driver present on a case-by-case basis, but have not enacted specific legislation. New Zealand, unlike other countries, has no specific legal requirement for vehicles to have drivers. However, the government has not received any formal requests to test autonomous vehicles on public roads. In Singapore and the Province of Ontario, Canada, it is up to the discretion of the responsible authority to approve driverless testing. Other testing requirements for autonomous vehicles may include insurance, the transmission of certain data to the government, or accident recorders in the vehicle. Finland allows the testing of autonomous vehicles, but one political party has suggested forbidding nonautonomous vehicles as a long-term goal.
With regard to lethal autonomous weapons systems (LAWS), countries regularly meet in the Governmental Group of Experts (GGE) of the Convention on Certain Conventional Weapons (CCW) to discuss the applicability of international humanitarian law norms to LAWS. The majority of countries agree that meaningful human control is necessary for LAWS. Countries either support the adoption of a new, legally-binding treaty to ban the use of LAWS; support the adoption of a political declaration as a middle ground to develop a shared understanding of the challenges posed by LAWS; oppose the adoption of a treaty as basic principles remain ill-defined; or think that no action is necessary at this point.
The following visuals give an overview of the different positions and actions that countries have taken with regard to national AI strategies and actions plans, autonomous vehicles, and LAWS
Initiatives to Counter Fake News in Selected Countries: Argentina, Brazil, Canada, China, Egypt, France, Germany, Israel, Japan, Kenya, Malaysia, Nicaragua, Russia, Sweden, United Kingdom
Comparative Summary by Peter Roudik, Director of Legal Research
This report examines the legal approaches of fifteen countries, representing all regions of the world, to the emerging problem of manipulation with “fake news” using mass and social media, especially the impact of fake news on ongoing political processes and elections, and the legislative measures undertaken to counteract the dissemination of false information. Fake news as a phenomenon is not new and has been known since ancient times, but the present-day proliferation of digital and social media platforms, which allow for much broader distribution of information to a global audience, makes the need to counter fake news much more acute. With the exception of Japan, which appears to be the only country in this study where fake news scandals are limited to newspapers and tweeted messages that have no outside influence, a fact explained by the difficulty of the Japanese language for foreigners, the widespread distribution of false information and its impact on decision making and democratic processes is becoming a challenge worldwide. In 2017, a parliamentary committee in Egypt identified the dissemination of 53,000 false rumors over a period of two months. In Germany, 59% of survey participants stated that they had encountered fake news, and in some segments of the population this number was up to almost 80%. In Kenya, a country where 90% of the population has access to high-speed internet, 90% of surveyed users said that they received false or inaccurate information regarding the recent elections through social media.
The countries included in this study are addressing the fake news problem through one or more of the following four approaches:
• In the absence of legislation that expressly addresses the objectivity of news posted on social media, some of the surveyed countries apply relevant provisions of existing civil, criminal, administrative, and other laws regulating the media, elections, and anti-defamation (Canada, Japan, Nicaragua, Sweden, and the United Kingdom), even though these laws, enacted in the pre-internet era, do not always reflect current technological and telecommunications developments.
• Others are choosing to enact new and more focused legislation that imposes sanctions on social media networks that spread false news, usually imposing fines and ordering the removal of information identified as false (China, Egypt, France, Germany, Israel, Malaysia, and Russia). In Malaysia and Egypt these provisions apply extraterritorially.
• Another option reflected in the country surveys is to engage election authorities and digital platforms to secure a well-informed electorate, either by identifying and blocking fake news, providing fact-checking resources for the general public, or through the mass publication of “real” news during election season and beyond (Argentina, the UK, China, and Malaysia). Argentina, for example, is considering legislation that would create a Commission for the Verification of Fake News within the National Election Chamber. During national election campaigns, the Commission would recognize, label, and prevent the distribution of news considered “of doubtful credibility.” Both the UK and China have programs in place to systematically rebut fake news by publishing reliable information, while Malaysia provides a fact-checking portal.
• Some of the countries are also addressing the issue in a more general way by educating citizens about the dangers of fake news (Sweden and Kenya). Sweden starts at a young age, having enlisted a famous cartoon character to teach children about the dangers of fake news through a cartoon strip that illustrates what happens to the bear’s super-strength when false rumors are circulated about him. The US Embassy in Kenya launched a media literacy campaign in 2018, initially aimed at the Kenya chapter of the Young African Leaders Initiative, with the specific goal of stopping the dissemination of fake news.
Among the countries surveyed, there is no common position regarding the definition of “fake news” and its scope. The UK government attempts to avoid use of the term altogether, instead using the words “disinformation” and “misinformation.” Countries with established anti-fake news laws have more elaborate terminology. Malaysian legislation defines fake news as “any news, information, data and reports, which is or are wholly or partly false, whether in the form of features, visuals or audio recordings or in any other form capable of suggesting words or ideas.” Russia passed a law penalizing the publication of fake news in March 2019, defining the term as “socially-significant false information distributed under the guise of truthful messages if they create a threat of endangering people’s lives, health, or property; create possibilities for mass violations of public order or public security; or may hinder the work of transportation and social infrastructure, credit institutions, lines of communications, industry, and energy enterprises.” China has made it a crime to “fabricate false information on [a] dangerous situation, epidemic, disaster or alert and disseminate such information via [an] information network or any other media while clearly knowing that it is fabricated, thereby seriously disturbing public order.” Relying on the 1881 Freedom of the Press Law, France has made it illegal to “disturb public peace through the publication, dissemination, or reproduction of fake news in bad faith.” The bad-faith publication, dissemination, or reproduction of forged or altered items, or items falsely attributed to third parties, is also prohibited.
Broad definitions are usually found in the laws of those countries that are rated low in indices related to freedom of speech, and such laws are often viewed by human rights organizations as government attempts to further restrict free speech and stifle opposition. The new Malaysian government tried unsuccessfully to repeal a 2018 act under which the government is required to “take measures to remove” the publication of recognized false information and imprison the publisher for up to six years. In Canada and Kenya courts have found anti-fake news provisions unconstitutional as a violation of freedom of expression and have thus suspended the implementation of such provisions.
Following the events of the United States 2016 election campaign, several countries introduced legal mechanisms aimed at protecting the integrity of the democratic process, although depending on country specifics these laws apply to varied actors. In Sweden, the focus was on self-regulation by professional organizations of journalists and other media providers and strengthening ethics rules. This solution followed the European Union’s approach where an EU-wide voluntary Code of Practice on Disinformation has been introduced. However, in view of the inadequacy of voluntary measures taken by social media platforms, Germany enacted the Network Enforcement Act in 2017. While this Act does not create new obligations for social media, it The Law Library of Congress 3 Initiatives to Counter Fake News: Comparative Summary imposes heavy fines for noncompliance with existing legislation and creates rules for the investigation and removal of illegal content hosted by networks with a very large number of registered users. French law also provides for special preventive measures that need to be implemented by operators of large-scale online platforms. Russian law distinguishes between news published by online media, news aggregators, and individual social network users. There are specific rules for the removal of information and the liability of authors, publishers, and internet providers depending on the type of the online platform.
Some countries are also taking steps to prevent foreign influence in their national elections. Interesting examples include an Israeli bill targeting foreign propaganda that, if passed, would allow the head of the Central Election Commission, who serves as a Supreme Court justice, to issue injunctions preventing the receipt of prohibited donations, monetary or otherwise, under current law. Under French law, a judge may order any measures necessary to stop the online dissemination of misleading information during the three months preceding an election. During the same period, foreign television broadcasts may be suspended if they deliver false information.
The governments of several countries included in this report recognize that a substantive response to disinformation could be an effective way to tackle fake news. The British government’s position is that it is more important to inform citizens of the facts than to simply rebut false information. For this purpose, a Rapid Response Unit within the executive branch monitors news and engages with the public online. In China, a government online platform called “Refuting Rumors” was launched to broadcast “real” news sourced from government agencies and state-owned media. A similar web portal allowing the public to check the authenticity of news found online has been established in Malaysia. In addition, Kenya and Sweden have general education campaigns aimed at young people in place to counter the fake news trend, as noted above.
The individual country surveys that follow analyze current and proposed initiatives to limit the spread of false information undertaken at the national level, each country’s challenges associated with these efforts, and efforts undertaken by national governments to secure the validity and accuracy of legal information
A calcineurin–Hoxb13 axis regulates growth mode of mammalian cardiomyocytes
10.1038/s41586-020-2228-6Nature5827811271-27
Rubber Clay Nanocomposites
The use of nanofillers allows the development of nanocomposites with improved properties and novel applications. The technological goal is possible due to the new compounding method that allows a particle dispersion in the nanometer scale increasing the specific surface area.Fil: Cova Sánchez, Mariajose. Instituto Nacional de Tecnología Industrial. Instituto Nacional de Tecnología Industrial - Caucho; Argentina. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación e Ingeniería Ambiental; ArgentinaFil: Bacigalupe, Alejandro. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación e Ingeniería Ambiental; Argentina. Instituto Nacional de Tecnología Industrial. Instituto Nacional de Tecnología Industrial - Caucho; ArgentinaFil: Escobar, Mariano Martin. Instituto Nacional de Tecnología Industrial. Instituto Nacional de Tecnología Industrial - Caucho; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mansilla, Marcela Angela. Instituto Nacional de Tecnología Industrial. Instituto Nacional de Tecnología Industrial - Caucho; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Protocol for the development of a multidisciplinary clinical practice guideline for the care of patients with chronic subdural haematoma
Introduction: A common neurosurgical condition, chronic subdural haematoma (cSDH) typically affects older people with other underlying health conditions. The care of this potentially vulnerable cohort is often, however, fragmented and suboptimal. In other complex conditions, multidisciplinary guidelines have transformed patient experience and outcomes, but no such framework exists for cSDH. This paper outlines a protocol to develop the first comprehensive multidisciplinary guideline from diagnosis to long-term recovery with cSDH. Methods: The project will be guided by a steering group of key stakeholders and professional organisations and will feature patient and public involvement. Multidisciplinary thematic working groups will examine key aspects of care to formulate appropriate, patient-centered research questions, targeted with evidence review using the GRADE framework. The working groups will then formulate draft clinical recommendations to be used in a modified Delphi process to build consensus on guideline contents. Conclusions: We present a protocol for the development of a multidisciplinary guideline to inform the care of patients with a cSDH, developed by cross-disciplinary working groups and arrived at through a consensus-building process, including a modified online Delphi.</p
Influence of literacy on representation of time in musical stimuli:An exploratory cross-cultural study in the UK, Japan, and Papua New Guinea
Identification and characterization of antibacterial compound(s) of cockroaches (Periplaneta americana)
Infectious diseases remain a significant threat to human health, contributing to more than 17 million deaths, annually. With the worsening trends of drug resistance, there is a need for newer and more powerful antimicrobial agents. We hypothesized that animals living in polluted environments are potential source of antimicrobials. Under polluted milieus, organisms such as cockroaches encounter different types of microbes, including superbugs. Such creatures survive the onslaught of superbugs and are able to ward off disease by producing antimicrobial substances. Here, we characterized antibacterial properties in extracts of various body organs of cockroaches (Periplaneta americana) and showed potent antibacterial activity in crude brain extract against methicillin-resistant Staphylococcus aureus and neuropathogenic E. coli K1. The size-exclusion spin columns revealed that the active compound(s) are less than 10 kDa in molecular mass. Using cytotoxicity assays, it was observed that pre-treatment of bacteria with lysates inhibited bacteria-mediated host cell cytotoxicity. Using spectra obtained with LC-MS on Agilent 1290 infinity liquid chromatograph, coupled with an Agilent 6460 triple quadruple mass spectrometer, tissues lysates were analyzed. Among hundreds of compounds, only a few homologous compounds were identified that contained isoquinoline group, chromene derivatives, thiazine groups, imidazoles, pyrrole containing analogs, sulfonamides, furanones, flavanones, and known to possess broad-spectrum antimicrobial properties, and possess anti-inflammatory, anti-tumour, and analgesic properties. Further identification, characterization and functional studies using individual compounds can act as a breakthrough in developing novel therapeutics against various pathogens including superbugs
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.
BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112
- …