The effect of moderate intensity endurance training and lipid lowering genistein in Streptozotocin induced diabetic rats

زمینه و هدف: دیابت بیماری مزمنی است که موجب افزایش پروفایل لیپیدی می شود. هدف از تحقیق حاضر بررسی تأثیر تمرین استقامتی با شدت متوسط و کاهنده لیپیدی جنستئین در موش های دیابتی بود. روش بررسی: 48 سر موش دیابتی انتخاب و در 6 گروه 8 سری (1) کنترل هفته اول، (2) کنترل هفته آخر، (3) تمرین استقامتی با شدت متوسط، (4) مصرف جنستئین، (5) تمرین استقامتی همراه با جنستئین و (6) شم تقسیم شدند و جهت بررسی اثرات القای دیابت 16 سر موش سالم در 2 گروه کنترل هفته اول و کنترل هفته آخر تقسیم شدند. در مدت 8 هفته موش های گروه های 3 و 5 سه جلسه در هفته و هر جلسه 60 دقیقه با سرعت 10 تا 17 متر بر دقیقه روی نوارگردان دویدند و گروه های 4 و 5 روزانه 30 میلی گرم بر کیلوگرم وزن بدن جنستئین مصرف نمودند. جهت تحلیل یافته­ ها از آنالیز واریانس یکطرفه و آزمون تعقیبی توکی استفاده شد (0/05≥P). یافته ها: القای دیابت اثر معنی داری بر کاهش HDL و افزایش TG، Cho، LDL و VLDL موش های صحرایی دارد (05/0≥P)؛ تمرین استقامتی، مصرف جنستئین و تمرین استقامتی همراه با جنستئین اثر معنی داری بر افزایش HDL و کاهش TG، Cho، LDL و VLDL موش های صحرایی دیابتی دارد (0/05≥P). همچنین تمرین استقامتی همراه با جنستئین نسبت به مصرف جنستئین اثر بیشتری بر کاهش LDL و افزایش HDL دارد (0/05≥P). نتیجه گیری: تمرین استقامتی با شدت متوسط و کاهنده لیپیدی جنستئین دارای اثرات تعاملی در موش های دیابتی شده با استروپتوزوتوسین می باشند

Validation of the Interpretative Narrations of the Alternative Tribe (verse 54 sura Ma'edah) with Emphasis on Fakhr-Razi's Perspective

One of the most challenging verses of the Quran is the verse 54 of Sura Ma’edah. This verse is about coming of an alternative nation of apostates. Fakhr-Razi, introducing Abu Bakr as the only example of the verse, considers this verse to be the most compelling reason to prove his righteousness and tries to consolidate his view by other narrations. This descriptive-analytic study, focusing on the Fakhr-Razi’s view, first presents the five general views and arguments of each group regarding alternative tribe, then by validating documents of the traditions based on ‘Ammeh ( Sunni ) sources, proves that their narrational reasons are not authentic. Eventually, it will be proved that the first instance of the verse is Imam Ali (as) and his true companions, and the final example of the verse is Imam Zaman (AS) – may God hasten his reappearance- and his companions

Promoting Children's Creativity through Designing Urban Environments

One of the principles of developed countries is the existence of a talented innovative work force. Children and adolescents, as the creative assets of the future, are the basis and principle of the cities' dynamism and stability in the future; therefore, providing an open space for the creative talents of children and adolescents to flourish for providing the city's future need for them is necessary. Lack of proper standards for designing and open spaces in accordance with the needs of the children has led to studies regarding the attendance to the basic wishes and needs of children like health, transportation, support and education and the growth and flourishment of the children's creativity, as one of the child-friendly standards of cities has been pointed out.  With the belief that the physical environment must provide the conditions for living and flourishing the talents and capabilities of children through creating appropriate grounds, the goal of this study is to present a design guide in which guidelines are presented in order to improve environmental qualities of urban environments to educate the children's creativity.  In this study, which is of the interdisciplinary and practical nature, the descriptive-analytic approach has been used. Therefore, first through the study of the theoretical basis in the field of flourishing the children's creativity and analyzing it, the effective factors on nurturing children's creativity are found and then, the approaches of the child-friendly city and creative city are studied and analyzed and then, their coefficients in devising the design guide has been utilized. This guideline includes the principles and guidelines of urban design. These principles are comfort and convenience, connection with nature, complicatedness and mystery, creativity and innovativeness, flexibility, social interaction and collaboration with the children

A Change of Heart: Improving Speech Emotion Recognition through Speech-to-Text Modality Conversion

Speech Emotion Recognition (SER) is a challenging task. In this paper, we introduce a modality conversion concept aimed at enhancing emotion recognition performance on the MELD dataset. We assess our approach through two experiments: first, a method named Modality-Conversion that employs automatic speech recognition (ASR) systems, followed by a text classifier; second, we assume perfect ASR output and investigate the impact of modality conversion on SER, this method is called Modality-Conversion++. Our findings indicate that the first method yields substantial results, while the second method outperforms state-of-the-art (SOTA) speech-based approaches in terms of SER weighted-F1 (WF1) score on the MELD dataset. This research highlights the potential of modality conversion for tasks that can be conducted in alternative modalities

Genetic Influence of Candidate Osteoporosis Genes in Saudi Arabian Population: A Pilot Study

Background and Objectives. The purpose of the present study is to find the genes and SNP that influence BMD and postmenopausal Saudi women. Material and Methods. Two-hundred ethnic Saudi Arabian women with a diagnosis of postmenopausal osteoporosis were the subjects of this study. Baseline blood hematology, biochemistry, and bone panel were done. Blood was collected, and three TaqMan-MGB probes were used to analyze SNP variants in ALOX15 (rs7220870), LRP5 (C 25752205 10), and TNFRSF11B (C 11869235 10). Results. The variant of ALOX15 17p13 showed that the BMD of the spine was lower in the AA allele (P value <0.002) and fractures were highest at 50% compared to CC allele. In the TNFRSF11B gene, BMD of the hip and spine was significantly higher in the GG allele and the history of fractures was significantly higher in GG group. With regard to the LRP5 (C 25752205 10) gene, there was no significant difference between allele groups. Conclusion(s). This study shows that the genetic influence of osteoporosis in the Caucasian and Saudi Arabians population is similar. We believe that the same genetic markers that influence osteoporosis in the Caucasian race could be used for further studies in the Saudi Arabian population

Preparation and evaluation of clove oil in emu oil self-emulsion for hair conditioning and hair loss prevention

Introduction: From a consumer perspective, developing a hair care formulation that offers multi-purpose products to enhance routine hair care such as conditioning, cleaning and grooming hair and stimulating hair follicles is important. Eugenol comprising about 70 of clove essential oil shows an androgenic activity and stimulates hair root to feed and hence could be a good candidate for developing an anti-hair loss formulation. Thus in hair research, hair follicle is of great interest. The aim of this study was to develop a self-emulsifying product containing eugenol in emu oil as a carrier.Methods: Eugenol was identified in clove oil extraction by UV spectrophotometer. Emu oil was characterized according to national oil standards. All formulations were prepared and best one was selected for further pharmaceutical examinations such as pH, particle size, content uniformity and drug release. The optimum formulation was clinically evaluated on rats back compared with minoxidil standard lotion as a positive control and distilled water as a negative control.Results: The selected formulation was demonstrated to condition hair with grooming and enhanced hair growth with longer lag time compared with minoxidil but after one week the hair growth accelerated.Conclusion: The formulation containing clove oil in emu oil self-emulsion shows a conditioning and grooming property with hair shaft repair and hair growth