clusterBMA: Bayesian model averaging for clustering

Various methods have been developed to combine inference across multiple sets of results for unsupervised clustering, within the ensemble clustering literature. The approach of reporting results from one `best' model out of several candidate clustering models generally ignores the uncertainty that arises from model selection, and results in inferences that are sensitive to the particular model and parameters chosen. Bayesian model averaging (BMA) is a popular approach for combining results across multiple models that offers some attractive benefits in this setting, including probabilistic interpretation of the combined cluster structure and quantification of model-based uncertainty. In this work we introduce clusterBMA, a method that enables weighted model averaging across results from multiple unsupervised clustering algorithms. We use clustering internal validation criteria to develop an approximation of the posterior model probability, used for weighting the results from each model. From a consensus matrix representing a weighted average of the clustering solutions across models, we apply symmetric simplex matrix factorisation to calculate final probabilistic cluster allocations. In addition to outperforming other ensemble clustering methods on simulated data, clusterBMA offers unique features including probabilistic allocation to averaged clusters, combining allocation probabilities from 'hard' and 'soft' clustering algorithms, and measuring model-based uncertainty in averaged cluster allocation. This method is implemented in an accompanying R package of the same name

Fast Steering Mirror Disturbance Effects on Overall System Optical Performance for the Large Ultraviolet/optical/infrared Surveyor (LUVOIR) Concept Using a Non-Contact Vibration Isolation and Precision Pointing System

As the optical performance requirements of space telescopes get more stringent, the need to analyze all possible error sources early in the mission design becomes critical. One large telescope with tight performance requirements is the Large Ultraviolet / Optical / Infrared Surveyor (LUVOIR) concept. The LUVOIR concept includes a 15-meter-diameter segmented-aperture telescope with a suite of serviceable instruments operating over a range of wavelengths between 100nm to 2.5um. Using an isolation architecture that involves no mechanical contact between the telescope and the host spacecraft structure allows for tighter performance metrics than current space-based telescopes being flown. Because of this separation, the spacecraft disturbances can be greatly reduced and disturbances on the telescope payload contribute more to the optical performance error. A portion of the optical performance error comes from the disturbances generated from the motion of the Fast Steering Mirror (FSM) on the payload. Characterizing the effects of this disturbance gives insight into the specifications on the FSM needed to achieve the tight optical performance requirements of the overall system. Through analysis of the LUVOIR finite element model and linear optical model given a range of input disturbances at the FSM, the optical performance of the telescope and recommendations for FSM specifications can be determined. The LUVOIR observatory control strategy consists of a multi-loop control architecture including the spacecraft Attitude Control System (ACS), Vibration Isolation and Precision Pointing System (VIPPS), and FSM. This paper focuses on the control loop containing the FSM disturbances and their effects on the telescope optical performance

Overview of the Optomechanical Design of the LUVOIR Instruments

The Large Ultraviolet/Optical/Infrared Surveyor (LUVOIR) is a space telescope being submitted for review to the 2020 Decadal Survey in Astronomy and Astrophysics. Its science objectives include both direct imaging and spectral characterization of habitable exoplanets around sun-like stars, the study of planet, star, and galaxy formation, the transfer of matter between different galaxies, and the remote sensing of objects within the Solar System. Two architectures have been designed: a 15 m diameter on-axis telescope (LUVOIR-A) and an 8 m off-axis telescope (LUVOIR-B). This paper discusses the opto-mechanical design of the three LUVOIR instruments: the High Definition Imager (HDI), the LUVOIR UV Multi-object Spectrograph (LUMOS), and the Extreme Coronagraph for Living Planetary Systems (ECLIPS). For both the LUVOIR-A and LUVOIR-B variants of each instrument, optical design specifications are presented including first-order constraints, packaging requirements, and optical performance metrics. These factors are used to illustrate the final design of each instrument and LUVOIR as a whole. In addition to the optical designs, mechanical models are presented for each instrument showing the optical mounts, mechanisms, support structure, etc

Preliminary Jitter Stability Results for the Large UV/Optical/Infrared (LUVOIR) Surveyor Concept Using a Non-Contact Vibration Isolation and Precision Pointing System

The need for high payload dynamic stability and ultra-stable mechanical systems is an overarching technology need for large space telescopes such as the Large Ultraviolet / Optical / Infrared (LUVOIR) Surveyor concept. The LUVOIR concept includes a 15-meter-diameter segmented-aperture telescope with a suite of serviceable instruments operating over a range of wavelengths between 100nm to 2.5 um. Wavefront error (WFE) stability of less than 10 picometers RMS of uncorrected system WFE per wavefront control step represents a drastic performance improvement over current space-based telescopes being fielded. Through the utilization of an isolation architecture that involves no mechanical contact between the telescope and the host spacecraft structure, a system design is realized that maximizes the telescope dynamic stability performance without driving stringent technology requirements on spacecraft structure, sensors or actuators. Through analysis of the LUVOIR finite element model and linear optical model, the wavefront error and Line-Of-Sight (LOS) jitter performance is discussed in this paper when using the Vibration Isolation and Precision Pointing System (VIPPS) being developed cooperatively with Lockheed Martin in addition to a multi-loop control architecture. The multi-loop control architecture consists of the spacecraft Attitude Control System (ACS), VIPPS, and a Fast Steering Mirror on the instrument. While the baseline attitude control device for LUVOIR is a set of Control Moment Gyroscopes (CMGs), Reaction Wheel Assembly (RWA) disturbance contribution to wavefront error stability and LOS stability are presented to give preliminary results in this paper. CMG disturbance will be explored in further work to be completed

The Large UV/Optical/Infrared Surveyor (LUVOIR): Decadal Mission Concept Study Update

In preparation for the 2020 Decadal Survey in Astronomy and Astrophysics, NASA commissioned the study of four large mission concepts: the Large UV/Optical/Infrared Surveyor (LUVOIR), the Habitable Exoplanet Imager (HabEx), the far-infrared surveyor Origins Space Telescope (OST), and the X-ray surveyor Lynx. The LUVOIR Science and Technology Definition Team (STDT) has identified a broad range of science objectives for LUVOIR that include the direct imaging and spectral characterization of habitable exoplanets around sun-like stars, the study of galaxy formation and evolution, the exchange of matter between galaxies, star and planet formation, and the remote sensing of Solar System objects. The LUVOIR Study Office, located at NASA's Goddard Space Flight Center (GSFC), is developing two mission concepts to achieve the science objectives. LUVOIR-A is a 15-meter segmented-aperture observatory that would be launched in an 8.4-m extended fairing on the Space Launch System (SLS) Block 2 configuration. LUVOIR-B is an 8-meter unobscured segmented aperture telescope that fits in a smaller, conventional 5-meter fairing, but still requires the lift capacity of the SLS Block 1B Cargo vehicle. Both concepts include a suite of serviceable instruments: the Extreme Coronagraph for Living Planetary Systems (ECLIPS), an optical/near-infrared coronagraph capable of delivering 10 (sup minus10) contrast at inner working angles as small as 2 lambda divided by D; the LUVOIR UV Multi-object Spectrograph (LUMOS), which will provide low- and medium-resolution UV (100-400 nanometer) multi-object imaging spectroscopy in addition to far-UV imaging; the High Definition Imager (HDI), a high-resolution wide-field-of-view NUV-Optical-NIR imager. LUVOIR-A also has a fourth instrument, Pollux, a high-resolution UV spectro-polarimeter being contributed by Centre National d'Etudes Spatiales (CNES). This paper provides an overview of the LUVIOR science objectives, design drivers, and mission concepts

The Large UV/Optical/Infrared Surveyor (LUVOIR): Decadal Mission Study Update

NASA commissioned the study of four large mission concepts, including the Large Ultraviolet / Optical / Infrared (LUVOIR) Surveyor, to be evaluated by the 2020 Decadal Survey in Astrophysics. In response, the Science and Technology Definition Team (STDT) identified a broad range of science objectives for LUVOIR that include the direct imaging and spectral characterization of habitable exoplanets around sun-like stars, the study of galaxy formation and evolution, the exchange of matter between galaxies, star and planet formation, and the remote sensing of Solar System objects. To meet these objectives, the LUVOIR Study Office, located at NASA's Goddard Space Flight Center (GSFC), completed the first design iteration of a 15-m segmented-aperture observatory that would be launched by the Space Launch System (SLS) Block 2 configuration. The observatory includes four serviceable instruments: the Extreme Coronagraph for Living Planetary Systems (ECLIPS), an optical / near-infrared coronagraph capable of delivering 10(exp -10) contrast at inner working angles as small as 2 lambda/D; the LUVOIR UV Multi-object Spectrograph (LUMOS), which will provide low- and medium-resolution UV (100 - 400 nm) multi-object imaging spectroscopy in addition to far-UV imaging; the High Definition Imager (HDI), a high-resolution wide-field-of-view NUV-Optical-NIR imager; and Pollux, a high-resolution UV spectro-polarimeter being contributed by Centre National d'Etudes Spatiales (CNES). The study team has executed a second design iteration to further improve upon the 15-m concept, while simultaneously studying an 8-m concept. In these proceedings, we provide an update on these two architectures

The Large UV/Optical/Infrared Surveyor (LUVOIR): Decadal Mission Concept Design Update

In preparation for the 2020 Astrophysics Decadal Survey, NASA has commissioned the study of four large mission concepts, including the Large Ultraviolet / Optical / Infrared (LUVOIR) Surveyor. The LUVOIR Science and Technology Definition Team (STDT) has identified a broad range of science objectives including the direct imaging and spectral characterization of habitable exoplanets around sun-like stars, the study of galaxy formation and evolution, the epoch of reionization, star and planet formation, and the remote sensing of Solar System bodies. NASAs Goddard Space Flight Center (GSFC) is providing the design and engineering support to develop executable and feasible mission concepts that are capable of the identified science objectives. We present an update on the first of two architectures being studied: a 15-meter-diameter segmented-aperture telescope with a suite of serviceable instruments operating over a range of wavelengths between 100 nm to 2.5 microns. Four instruments are being developed for this architecture: an optical / near-infrared coronagraph capable of 10(exp -10) contrast at inner working angles as small as 2 lambda/D; the LUVOIR UV Multi-object Spectrograph (LUMOS), which will provide low- and medium-resolution UV (100 400 nm) multi-object imaging spectroscopy in addition to far-UV imaging; the High Definition Imager (HDI), a high-resolution wide-field-of-view NUV-Optical-IR imager; and a UV spectro-polarimeter being contributed by Centre National dEtudes Spatiales (CNES). A fifth instrument, a multi-resolution optical-NIR spectrograph, is planned as part of a second architecture to be studied in late 2017

Biomarkers for the diagnosis of heart failure in people with diabetes: A consensus report from diabetes technology society.

Diabetes Technology Society assembled a panel of clinician experts in diabetes, biomarker screening, and heart failure to review the current evidence on biomarker screening of people with diabetes (PWD) for heart failure (HF), who are, by definition, at risk for HF (Stage A HF). This consensus report reviews features of HF in PWD from the perspectives of 1) epidemiology, 2) classification of stages, 3) pathophysiology, 4) biomarkers for diagnosing, 5) biomarker assays, 6) diagnostic accuracy of biomarkers, 7) benefits of biomarker screening, 8) consensus recommendations for biomarker screening, 9) stratification of Stage B HF, 10) echocardiographic screening, 11) management of Stage A and Stage B HF, and 12) future directions. The Diabetes Technology Society panel recommends 1) biomarker screening with one of two circulating natriuretic peptides (B-type natriuretic peptide or N-terminal prohormone of B-type natriuretic peptide), 2) beginning screening five years following diagnosis of type 1 diabetes (T1D) and at the diagnosis of type 2 diabetes (T2D), 3) beginning routine screening no earlier than at age 30 years for T1D (irrespective of age of diagnosis) and at any age for T2D, 4) screening annually, and 5) testing any time of day. The panel also recommends that an abnormal biomarker test defines asymptomatic preclinical HF (Stage B HF). This diagnosis requires follow-up using transthoracic echocardiography for classification into one of four subcategories of Stage B HF, corresponding to risk of progression to symptomatic clinical HF (Stage C HF). These recommendations will allow identification and management of Stage A and Stage B HF in PWD to prevent progression to Stage C HF or advanced HF (Stage D HF)