Prevalence of uterine curettages at Instituto da Mulher Dona Lindu in 2014 - Manaus - AM, Brazil / Prevalência de Curetagens uterinas no Instituto da Mulher Dona Lindu no ano de 2014 – Manaus – AM, Brasil

Uterine curettage is a medical-gynecological procedure whose function is to remove remnants of an abortion, whether spontaneous or induced. In Manaus, as well as data from other public maternities in all of Brazil, most of the abortions occur in young patients and are presumably induced. For this reason, our objective was to present a descriptive analysis of the data on the curettage procedure as well as to highlith the most prevalent age group at the Instituto da mulher Dona Lindu, Manaus-Am in 2014. Despite the continuing need for more research, in order to suggest more effective measures about sexual health education, the findings of the present study that at least half of abortions are induced and occurred in girls aged 14 to 18 years corroborate with most of the research on the subject

O uso de AAS em pacientes com fatores de risco para Pré-eclâmpsia

The present article aims to conduct a literature review on the use of aspirin for the prevention of preeclampsia. Preeclampsia is a multisystem condition that manifests after the 20th week of pregnancy with elevated blood pressure and proteinuria in women with no prior history of hypertension. Google Scholar and the CAPES journal were used as search engines, using the terms "aspirin," "pre-eclampsia," and "prevention" between the years 2018 to 2023. The results demonstrate that aspirin is effective in preventing preterm preeclampsia in high-risk women but does not show efficacy in women with pre-existing cardiovascular diseases. The medication should be administered in doses above 100 mg at night for better treatment effectiveness.O presente artigo tem por objetivo realizar uma varredura da literatura vigente sobre o uso da aspirina para prevenção de pré-eclâmpsia. A pré-eclâmpsia é uma condição multissistêmica que se manifesta após a 20ª semana de gestação com elevação de pressão arterial e proteinúria em mulheres sem histórico prévio de hipertensão. Foram utilizados como motores de busca os indexadores Google Scholar, além do periódico CAPES por meio dos termos “aspirin”, “pre-eclampsia” e “prevention” entre os anos de 2018 a 2023. Os resultados demonstram que a aspirina é eficaz para prevenção de pré-eclâmpsia pré-termo em mulheres de alto risco, porém não apresenta eficácia em mulheres com doenças cardiovasculares prévias. A medicação deve ser administrada em doses acima de 100 mg à noite para melhor eficácia do tratamento

Relação entre esporte, resiliência, qualidade de vida e ansiedade

BACKGROUND: The practice of sports has beneficial effects on cardiorespiratory and muscle systems, behavioral function, and mental health. However, the influence of elite sports on the development of resilience is not known. OBJECTIVES: The objective of the present study was to compare resilience, quality of life, and anxiety in ex-athletes of artistic gymnastic and other sports with non-athletic individuals. METHODS: Ex-artistic gymnastics athletes (n = 17), ex-athletes of other sports (n = 15), and non-athletic individuals (n = 30) were recruited. Structured anamneses as well as depression, anxiety, resilience and quality of life scales were applied in all groups. RESULTS: Significant difference between groups were found in resilience (p = 0.001), anxiety (p = 0.049), general health status (p = 0.044), and emotional aspects of quality of life (p = 0.002). Ex-athletes showed greater resilience and better quality of life regarding to emotional aspects than non-athletes. DISCUSSION: Sport seems to contribute to the development of a more resilient profile and better quality of life.CONTEXTO: A prática de esportes apresenta efeitos benéficos para o sistema cardiorrespiratório e muscular, para a função comportamental e para a saúde mental. Entretanto, não se sabe o papel do esporte de alto nível na construção de perfis resilientes. OBJETIVOS: O objetivo do presente estudo foi comparar resiliência, qualidade de vida e ansiedade de ex-atletas de alto rendimento de ginástica artística, de outros esportes e indivíduos não atletas. MÉTODOS: Participaram do estudo ex-atletas de ginástica artística (n = 17), de outras modalidades (n = 15) e indivíduos não atletas (n = 30). Foram utilizadas as seguintes escalas e questionários: Inventário de Depressão de Beck, Inventário de Ansiedade Traço e Estado (IDATE T e E), Escala de Resiliência e Questionário de Qualidade de Vida SF-36®. RESULTADOS: Foi observada diferença significativa entre os grupos na resiliência (p = 0,001), IDATE T (p = 0,049), estado geral de saúde (p = 0,044) e aspectos emocionais da qualidade de vida (p = 0,002), indicando que o grupo de ex-atletas apresentou maior resiliência e melhor aspecto emocional que não atletas. CONCLUSÃO: O esporte parece favorecer a construção de um perfil mais resiliente, além de contribuir para melhor qualidade de vida

Lower insulin-dose adjusted A1c (IDAA1c) is associated with less complications in Individuals with Type 1 Diabetes treated with hematopoetic stem-cell transplantation and conventional therapy

Objective: To evaluate the association between insulin-dose adjusted A1C (IDAA1c) and microvascular complications (MC) and hypoglycemia in a representative Brazilian population of Type 1 diabetes mellitus (T1DM) patients. Research Design and Methods: This was a cross-sectional study based on a previous study, “Microvascular Complications in Type 1 Diabetes: a comparative analysis of patients treated with autologous nonmyeloablative hematopoietic stem-cell transplantation (AHST) and conventional medical therapy (CT)”. The 168 patients in that study (144 from CT plus 24 from AHST) were re-subdivided into two groups, according to their IDAA1c values (30 patients had IDAA1c ≤ 9; 138 had IDAA1c > 9). Then, the prevalence of MC (diabetic renal disease, neuropathy, and retinopathy), hypoglycemia (blood glucose <60 mg/dL), and severe hypoglycemic (episode of hypoglycemia that required the assistance of another person to treat) events were compared between the groups. The groups were well-matched on these factors: duration of disease, sex, and age at the time of diagnosis of T1DM. Results: After an average of 8 years after diagnosis, only 6.6% (2/30) of the patients from IDAA1c ≤ 9 group developed any MC, whereas 21.0% (29/138) from the IDAA1c > 9 group had at least one complication (p = 0.044). Regarding hypoglycemic events, the proportion of individuals who reported at least 1 episode of hypoglycemia in the last month was 43.3 and 64.7% from the IDAA1c ≤ 9 and IDAA1c > 9 groups, respectively (p = 0.030). Regarding severe hypoglycemia, the proportion of patients presenting at least one episode in the last month and the rate of episode/patient/month were similar between groups (6.7 vs. 13.2%; p = 0.535; and 0.1/patient/month vs. 0.25/patient/month; p = 0.321). Conclusion: In a representative Brazilian population of T1DM patients, those with IDAA1c ≤ 9 presented a lower frequency of MC, as well as fewer episodes of hypoglycemia, in the month prior to the analysis.publishedVersio

A systematic review of the prevalence, risk factors, and impact of pelvic floor dysfunctions in nurses

Aim To investigate the prevalence, risk factors, and impact of pelvic floor dysfunctions in female nurses. Design A systematic review. Data Sources Searches were conducted in the following five electronic databases: PubMed/Medline, LILACS, SCIELO, Cochrane Library, and CINAHL. There were no period or language limitations. Review Methods Data extraction and synthesis were conducted and the appraisal of the quality of the studies was performed using the Joanna Briggs Institute critical appraisal tool checklist for prevalence data. Results A total of 15 studies were included. The symptoms investigated were lower urinary tract symptoms, including urinary incontinence and its subtypes, sexual dysfunctions, constipation, faecal incontinence, and dual incontinence. Overall, prevalence ranged from 9.9% to 89.6%. Associated factors related to occupational roles were lifting heavy weights and poor bladder habits. Quality of life was significantly worse for nurses with pelvic floor disorders. Conclusion Pelvic floor dysfunctions are very common among female nurses, considerably affecting their quality of life. Additional studies are needed to investigate the impact on work productivity, causal relationships with the occupation and the performance of prevention and treatment interventions directed toward this population38614921503CAPES - Coordenação de Aperfeiçoamento de Pessoal e Nível Superiorsem informaçãosem informaçãoFUNCAP - FUNDAÇÃO CEARENSE DE APOIO AO DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGIC

Role of leptin in the pathogenesis of breast cancer

Leptin is a small polypeptide codified by the Obese Gene (OB), deeply related with the body fat mass and energetic balance. Due to its diverse biological effects and downstream signal transducers, multiple classifications have been attributed to leptin, as hormone, cytokine, adypokine, growth factor, and developmental factor, among others. This scenario gives us an idea of the size of the potential biological effects generated by this molecule. The concentration of leptin in the body is determined by the amount of adipose tissue; therefore, hyperleptinemia is a common finding in obese individuals. In addition, high levels of circulating leptin may confer a poor prognosis for any pathological condition. Although leptin history has been reported for more than 20 years, its relationship with cancer has gained notoriety in the past ten years, where studies focused on discussing the issue of obesity as a strong risk factor for cancer developing. Further, growing evidences have pointed leptin as a pivotal mediator of immune response, which aggravates the scenario of cancer occurrence in the presence of obesity. Therefore, leptin can present at least two faces in the pathogenesis of breast cancer, acting by immune and non-immune mechanisms. In this paper we review the dynamic of the leptin axis in breast cancer and further discuss its role in disease, immunopathogenesis and prognosis

Microvascular Complications in Type 1 Diabetes: A Comparative Analysis of Patients Treated with Autologous Nonmyeloablative Hematopoietic Stem-Cell Transplantation and Conventional Medical Therapy

ObjectiveTo explore the impact on microvascular complications, long-term preservation of residual B-cell function and glycemic control of patients with type 1 diabetes treated with autologous nonmyeloablative hematopoietic stem-cell transplantation (AHST) compared with conventional medical therapy (CT).Research design and methodsCross-sectional data of patients treated with AHST were compared with patients who received conventional therapy from the Brazilian Type 1 Diabetes Study Group, the largest multicenter observational study in type 1 diabetes mellitus in Brazil. Both groups of patients had diabetes for 8 years on average. An assessment comparison was made on the presence of microvascular complications, residual function of B cell, A1c, and insulin dose of the patients.ResultsAfter a median of 8 years of diagnosis, none of the AHST-treated patients (n = 24) developed microvascular complications, while 21.5% (31/144) had at least one (p &lt; 0.005) complication in the CT group (n = 144). Furthermore, no case of nephropathy was reported in the AHST group, while 13.8% of CT group (p &lt; 0.005) developed nephropathy during the same period. With regard of residual B-cell function, the percentage of individuals with predicted higher C-peptide levels (IDAA1C ≤ 9) was about 10-fold higher in the AHST group compared with CT (75 vs. 8.3%) (p &lt; 0.001) group. Among AHST patients, 54.1% (13/24) had the HbA1c &lt; 7.0 compared with 13.1% in the CT (p &lt; 0.001) group.ConclusionPatients with newly diagnosed type 1 diabetes treated with AHST presented lower prevalence of microvascular complications, higher residual B-cell function, and better glycemic control compared with the CT group