The Heiress

Shy and plain young girl Catherine Sloper falls desperately in love with the charming and handsome Morris Townsend. Catherine’s father, a successful doctor, forbids their marriage, fearing that the attraction Morris feels for Catherine may be more for her fortune than for her character. Catherine’s love for Morris is genuine but haunted by doubts regarding her appearance and lack of worldly experience. Her fears are realized when her proposed plan of an elopement fails to succeed, and she retreats into a world of loneliness. But when Morris returns and proposes to her once again, she responds in a shockingly unexpected way. His reaction leaves us to wonder whether Morris is sincere in his love for Catherine, or is rather the fulfillment of Catherine’s fears.https://digitalcommons.cedarville.edu/theatre_productions/1045/thumbnail.jp

Anne of Green Gables

When aging brother and sister Matthew and Marilla Cuthbert send to the orphanage in Nova Scotia for a boy to help them on the farm, they get more than they bargained for, 11-year-old Anne Shirley. This swift yet theatrical adaptation of the classic novel is an all-ages crowd-pleaser.https://digitalcommons.cedarville.edu/theatre_productions/1050/thumbnail.jp

Four Comic One-Act Plays

These fast-paced comedies have been collected to be performed together as one entertaining show. All rooted in farce comedy, each explores the frustrating, exasperating, and fun-to-watch situations that happen to people in various social settings. The five short plays are “An Unwilling Martyr,” which presents an overburdened man dealing with ludicrous chores and obligations; “The Anniversary,” which takes a look at frenetic scenes at a bank; “The Wedding,” which depicts a social setting where the mother-of-the-bride causes some awkward but hilarious gaffes; “The Bear,” where a widow unable to pay her rent turns the tables on her landlord; and “The Proposal,” where a suitor winds up in a battle over property. The production will feature Russian music and dancing in a colorful and exciting show set in the social world of the 1890s.https://digitalcommons.cedarville.edu/theatre_productions/1048/thumbnail.jp

The Comedy of Errors

This earliest of Shakespeare’s comedies is set in the ancient Greek town of Ephesus, where two sets of brothers had been separated in infancy during a tragic shipwreck long ago. Antipholus of Syracuse and his servant Dromio arrive in town, not knowing that it is the home of Antipholus of Ephesus and his servant, Dromio. Ephesian law forbids anyone from Syracuse to come into the town, and if caught doing so, will be put to death unless able to pay an enormous ransom. Egeon, father of the Antipholus twins, convinces the ruler of Ephesus to give him one day to find his long lost son. He is granted the time, and comic misadventures unfold as themes of mistaken identity, romantic disasters, false accusations and confusion take place. The befuddlement of the characters is even more fun for the audience to watch since we can tell the twins apart, but the characters cannot!https://digitalcommons.cedarville.edu/theatre_productions/1044/thumbnail.jp

Silent Sky

Henrietta Leavitt is excited to land a job at the prestigious Harvard Observatory in the early 1900s. Once on the job, she soon realizes she was not hired to be an astronomer, but to serve with a group of female “computers” who merely chart the stars for a man who thinks women are not worthy to be astronomers. Henrietta persists in making her mark within the astronomical society, but finds as she measures the light and distance of stars that she must also take measure of her life on Earth. As a result, she has to choose between her dedication to science, her family, or the possibility of love. Based on the true story of 19th-century astronomer Henrietta Leavitt, the play explores a woman’s place in society during a time of immense scientific discoveries, when women’s ideas were dismissed and credited to men in the field. Leavitt’s story changes the way we see and understand both the glory of the heavens and our purpose on the Earth.https://digitalcommons.cedarville.edu/theatre_productions/1049/thumbnail.jp

The Beams Are Creaking

The inspiring, powerful, true story of Dietrich Bonhoeffer, the German theologian who defied the Nazis and ultimately led an assassination attempt against Hitler. Part political thriller, part love story, and leavened with moments of humor, it is filled with a compassion that reaffirms one’s faith in man.https://digitalcommons.cedarville.edu/theatre_productions/1052/thumbnail.jp

Meet Me in St. Louis

It is the summer of 1903, and the Smith family eagerly anticipates the opening of the 1904 World’s Fair. Memorable musical numbers include Have Yourself a Merry Little Christmas, The Boy Next Door, The Trolley Song, and Whenever I’m with You. A delightful show for all ages!https://digitalcommons.cedarville.edu/theatre_productions/1051/thumbnail.jp

Hepatitis C virus quasispecies and pseudotype analysis from acute infection to chronicity in HIV-1 co-infected individuals

HIV-1 infected patients who acquire HCV infection have higher rates of chronicity and liver disease progression than patients with HCV mono-infection. Understanding early events in this pathogenic process is important. We applied single genome sequencing of the E1 to NS3 regions and viral pseudotype neutralization assays to explore the consequences of viral quasispecies evolution from pre-seroconversion to chronicity in four co-infected individuals (mean follow up 566 days). We observed that one to three founder viruses were transmitted. Relatively low viral sequence diversity, possibly related to an impaired immune response, due to HIV infection was observed in three patients. However, the fourth patient, after an early purifying selection displayed increasing E2 sequence evolution, possibly related to being on suppressive antiretroviral therapy. Viral pseudotypes generated from HCV variants showed relative resistance to neutralization by autologous plasma but not to plasma collected from later time points, confirming ongoing virus escape from antibody neutralization

The rise and fall of the king : the correlation between FO Aquarii's low states and the White Dwarf's Spindown

The intermediate polar FO Aquarii experienced its first-reported low-accretion states in 2016, 2017, and 2018. We establish that these low states occurred shortly after the system's white dwarf (WD) began spinning down, after having spent a quarter-century spinning up. FO Aquarii is the only intermediate polar whose period derivative has undergone a sign change, and it has now done so twice. By combining our spin-pulse timings with previous data, we determine that the WD's spin period has varied quasi-sinusoidally since the system's discovery, and an extrapolation predicts that the white dwarf was spinning down during newly discovered low states in photographic plates from 1964, 1965, and 1974. Thus, FO Aquarii's low states appear to occur exclusively during epochs of spindown. Additionally, our time-series photometry of the 2016-18 low states reveals that the mode of accretion is extremely sensitive to the accretion rate; when the system is fainter than V~14.0, the accretion onto the WD is largely stream-fed, but when it is brighter, it is almost exclusively disk-fed. The system's grazing eclipse remained detectable throughout all observations, confirming the uninterrupted presence of a disk-like structure, regardless of the accretion state. Our observations are consistent with theoretical predictions that during the low states, the accretion disk dissipates into a ring of diamagnetic blobs. Finally, a new XMM-Newton observation from 2017 indicates that the system's anomalously soft X-ray spectrum and diminished X-ray luminosity in the wake of the 2016 low state appear to be long-lasting changes compared to pre-2016 observations.peer-reviewe

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

Background So far, more than 170 loci have been associated with circulating lipid levels through genomewide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this study we aimed to identify more new rare and low-frequency functional variants associated with circulating lipid levels. Methods We used the 1000 Genomes Project as a reference panel for the imputations of GWAS data from ~60 000 individuals in the discovery stage and ~90 000 samples in the replication stage. Results Our study resu