Food Additive Evidence in Food Supplements Most Commonly Consumed by Cancer Patients

The goal of this research is to highlight food additives in the formulations of food supplements consumed by cancer patients. It is a survey conducted at the Cancer treatment center in Annaba to collect a list of food supplements used by these patients. Following a screening of their ingredients for incorporated food additives, which we then classified according to the degree of toxicity, these supplements were classified according to their origin (local or imported). Our findings show that these various groups of dietary supplements contain a variety of food additives with varying degrees of toxicity, such as colorants (E422), acidity regulators (E330), preservatives (E202), stabilizers (E420i), emulsifiers (E322), conditioning agents (E460), thickeners (E441), and so on

Enquête sur l’association entre les habitudes alimentaires, l’anthropométrie et le cancer colorectal: Etude cas-témoins dans une population de l’Est Algérien 2016-2017 [Survey on the association between eating habits, anthropometry and colorectal cancer: Case-control study in a population of eastern Algeria 2016-2017]

Résumé Introduction. Des facteurs comme l’obésité et l’alimentation sont impliqués dans la carcinogenèse colique. Objectif. Une étude rétrospective cas-témoins est menée afin d’évaluer l’association de ces facteurs avec le cancer colorectal (CCR) dans une population de l’Est Algérien. Matériel et méthodes. L’enquête a été réalisée entre avril 2016 et août 2017, au niveau de l'Etablissement Public Hospitalier de Bekaria à Tébessa et des Centres Anti-Cancer de Batna et d’Annaba. Soixante quatre patients atteints de CCR âgés de 51±12 et 64 témoins dont l’âge moyen était de 51±17 ans ont été recrutés. Le questionnaire utilisé a permis de collecter les informations concernant l’âge, le sexe, les mesures anthropométriques, les habitudes alimentaires et la fréquence de consommation de quelques aliments. Résultats. Une association significative est notée entre l’obésité et la prévalence du CCR (37,5 % des patients vs 20,31 % des témoins, p=0,048). L’indice de masse corporelle (IMC) moyen des patients était plus élevé que celui des témoins. La prévalence du cancer atteint son maximum entre 50 et 59 ans. La consommation des céréales et des œufs est retenue comme facteur protecteur du CCR (p=0,046 et 0,028). Les témoins consomment plus de pâtes que les patients (P=0,054). Conclusion. Cette étude met en évidence l’association entre le cancer colorectal, l’obésité et la consommation de certains aliments chez les patients atteints de CCR. [Abstract Introduction. Factors such obesity and diet are involved in colon carcinogenesis. Objective. A retrospective case-control study was done to evaluate the association of these factors with colorectal cancer (CRC) in eastern Algeria population. Material and methods. This study was conducted between April 2016 and August 2017, at the Bekaria public hospital in Tebessa, and the Anti-Cancer Centers of Batna and Annaba. Sixty four patients with CRC aged 51±12 years and 64 controls with mean age of 51±17 years. The questionnaire used allowed to collect the following informations: age, gender, anthropometric measurements, eating habits, and consumption frequency of some foods. Results. A significant association was found between obesity and prevalence of CRC (37.5% vs 20.3%, p=0.048). The average body mass index (BMI) of patients was higher than that of the controls. The prevalence of cancer reached its maximum between 50 and 59 years old. Consumption of cereals and eggs was retained as a protective factor for CRC (p=0.046 and p=0.028). Controls consumed more pasta than CRC patients (p=0.054). Conclusion. This study highlights the association between colorectal cancer, obesity and the consumption of certain foods in patients with CRC.

Prevalence of papillomaviruses, polyomaviruses, and herpesviruses in triple-negative and inflammatory breast tumors from algeria compared with other types of breast cancer tumors.

The possible role of viruses in breast cancer etiology remains an unresolved question. We hypothesized that if some viruses are involved, it may be in a subgroup of breast cancers only. Epidemiological arguments drove our interest in breast cancer subgroups that are more frequent in Africa, namely inflammatory breast cancer (IBC) and triple-negative breast cancer. We tested whether viral prevalence was significantly higher in these subgroups.One hundred fifty-five paraffin-embedded malignant breast tumors were randomly selected at the pathology laboratory of the University Hospital of Annaba (Algeria) to include one third of IBC and two thirds of non-IBC. They were tested for the presence of DNA from 61 viral agents (46 human papillomaviruses, 10 polyomaviruses, and 5 herpesviruses) using type-specific multiplex genotyping assays, which combine multiplex PCR and bead-based Luminex technology.Viral DNA was found in 22 (17.9%) of 123 tumors. The most prevalent viruses were EBV1 and HPV16. IBC tumors carried significantly more viruses (any type) than non-IBC tumors (30% vs. 13%, p<0.04). Similarly, triple-negative tumors displayed higher virus-positivity than non-triple-negative tumors (44% vs. 14%, p<0.009).Our results suggest an association between the presence of viral DNA and aggressive breast cancer phenotypes (IBC, triple-negative). While preliminary, they underline the importance of focusing on subgroups when studying viral etiology in breast cancer. Further studies on viruses in breast cancer should be conducted in much larger samples to confirm these initial findings

Presence/absence of viral DNA in 123 breast cancer tumors.

<p>Presence/absence of viral DNA in 123 breast cancer tumors.</p

Presence/absence of viral DNA in IBC/non-IBC tumors, stratified by triple-negative status.

<p>*Fisher exact chi-square test</p><p>Presence/absence of viral DNA in IBC/non-IBC tumors, stratified by triple-negative status.</p

Presence/absence of viral DNA according to IBC status.

<p>*Fisher exact chi-square test</p><p>**Presence of DNA of any of the following viruses: BKV, KIV, JCV, MCV, WUV, TSV, HPyV6, HPyV7, HPyV9, SV40, CMV, EBV1, EBV2, HSV1, HSV2 and 46 types of HPV (21 alpha-HPV and 25 beta-HPV)</p><p>Presence/absence of viral DNA according to IBC status.</p

Presence/absence of viral DNA according to ER/PR/HER2 status.

<p>*Fisher exact chi-square test</p><p>**Presence of DNA of any of the following viruses: BKV, KIV, JCV, MCV, WUV, TSV, HPyV6, HPyV7, HPyV9, SV40, CMV, EBV1, EBV2, HSV1, HSV2 and 46 types of HPV (21 alpha-HPV and 25 beta-HPV)</p><p>Presence/absence of viral DNA according to ER/PR/HER2 status.</p

Profile of the IBC and non-IBC patients.

<p>IBC, inflammatory breast cancer.</p><p>Profile of the IBC and non-IBC patients.</p

In situ hybridization for Epstein-Barr encoding region (EBER) in breast carcinoma shows (A) a few malignant epithelial cells and lymphocytes that express EBER (magnification x10) and (B) one malignant mammary epithelial cell with strong nuclear labeling indicating EBER expression (magnification x40).

<p>(C and D) Hematoxylin and eosin (H&E) staining performed on the same breast carcinoma (magnifications x10 and x40).</p