Inclusión de microorganismos eficientes en dietas para pollos parrilleros machos de la línea cobb 500

El objetivo fue evaluar la inclusión de microorganismos eficientes (ME) en dietas para pollos parrilleros machos. Para ello, se utilizaron 125 pollos de la línea Cobb 500 de un día de edad, los cuales se distribuyeron en cinco tratamientos, cinco repeticiones y cinco pollos por repetición. Lostratamientos evaluados fueron: T1(dieta control positivo con zinc bacitracina), T2 (dieta control negativo sin zinc bacitracina y sin ME), T3 (dieta control negativo más 5 mL ME/kg de alimento), T4 (dieta control negativo más 10 mL ME/kg de alimento) y T5 (dieta control negativo más 15 mL ME/kg de alimento). Las evaluaciones estadísticas se realizaron utilizando un Diseño Completamente al Azar (DCA) con contrastes ortogonales. Los análisis de varianza fueron procesados con el software estadístico Infostat/Professional v. 2018p. Los resultados indicaron que, la ganancia diaria de peso y conversión alimenticia no fueron influenciados (p>0,05) por la inclusión de ME. Sin embargo, en la fase de producción el consumo diario de alimento si resultó influenciado (p>0,05). Además, el mejor beneficio neto y mérito económico se atribuye a los pollos alimentados con dietas control positivo y negativo. Se concluye que a la inclusión de ME en dietas para pollos parrilleros, no mejora los índices productivos y económicos

La agricultura familiar relacionado con los objetivos de desarrollo sostenible uno y dos en los distritos de Rupa Rupa y Castillo Grande, región Huánuco

El objetivo de la investigacion fue evaluar la relación del aporte de la agricultura familiar para el cumplimiento de los objetivos de desarrollo sostenible uno y dos al 2030, asimismo caracterizar y tipificar la agricultura familiar en los distritos de Rupa Rupa y Castillo Grande, región Huánuco. Se trabajó con una muestra de 60 fundos familiares con un nivel de investigación descriptivo y tipo cualitativo-explicativo. Se utilizó el modelo estadístico que corresponde a un diseño completamente al azar, asimismo la prueba de media DGC para determinar diferencias significativas entre los tipos de sistemas. Los resultados mostraron que la agricultura familiar aporta al cumplimiento de los objetivos de desarrollo sostenible uno y dos al 2030 en los distritos de Rupa Rupa y Castillo Grande, debido a que son sistemas integrales de producción, tipificado como un agroecosistema biodiverso, constituida por componentes agrícola, forestal y pecuario, y el funcionamiento de este sistema, está instalado en un área de terreno cuya superficie trabajada en promedio va de 1 a 5 ha y son de manejo familiar, dando soporte a la disminución de la pobreza, y el hambre con una mejor nutrición y promoción de una agricultura con un enfoque agroecológico. Estos sistemas se diferenciaron en tres conglomerados, el primero agrupó al 41.67%, el segundo al 38.83% y el tercero al 20% del total de fundos evaluados, sobresaliendo el conglomerado 1, seguido del 2 y finalmente el tercero, con diferencias estadísticas entre ellos

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

State of the climate in 2018

In 2018, the dominant greenhouse gases released into Earth’s atmosphere—carbon dioxide, methane, and nitrous oxide—continued their increase. The annual global average carbon dioxide concentration at Earth’s surface was 407.4 ± 0.1 ppm, the highest in the modern instrumental record and in ice core records dating back 800 000 years. Combined, greenhouse gases and several halogenated gases contribute just over 3 W m−2 to radiative forcing and represent a nearly 43% increase since 1990. Carbon dioxide is responsible for about 65% of this radiative forcing. With a weak La Niña in early 2018 transitioning to a weak El Niño by the year’s end, the global surface (land and ocean) temperature was the fourth highest on record, with only 2015 through 2017 being warmer. Several European countries reported record high annual temperatures. There were also more high, and fewer low, temperature extremes than in nearly all of the 68-year extremes record. Madagascar recorded a record daily temperature of 40.5°C in Morondava in March, while South Korea set its record high of 41.0°C in August in Hongcheon. Nawabshah, Pakistan, recorded its highest temperature of 50.2°C, which may be a new daily world record for April. Globally, the annual lower troposphere temperature was third to seventh highest, depending on the dataset analyzed. The lower stratospheric temperature was approximately fifth lowest. The 2018 Arctic land surface temperature was 1.2°C above the 1981–2010 average, tying for third highest in the 118-year record, following 2016 and 2017. June’s Arctic snow cover extent was almost half of what it was 35 years ago. Across Greenland, however, regional summer temperatures were generally below or near average. Additionally, a satellite survey of 47 glaciers in Greenland indicated a net increase in area for the first time since records began in 1999. Increasing permafrost temperatures were reported at most observation sites in the Arctic, with the overall increase of 0.1°–0.2°C between 2017 and 2018 being comparable to the highest rate of warming ever observed in the region. On 17 March, Arctic sea ice extent marked the second smallest annual maximum in the 38-year record, larger than only 2017. The minimum extent in 2018 was reached on 19 September and again on 23 September, tying 2008 and 2010 for the sixth lowest extent on record. The 23 September date tied 1997 as the latest sea ice minimum date on record. First-year ice now dominates the ice cover, comprising 77% of the March 2018 ice pack compared to 55% during the 1980s. Because thinner, younger ice is more vulnerable to melting out in summer, this shift in sea ice age has contributed to the decreasing trend in minimum ice extent. Regionally, Bering Sea ice extent was at record lows for almost the entire 2017/18 ice season. For the Antarctic continent as a whole, 2018 was warmer than average. On the highest points of the Antarctic Plateau, the automatic weather station Relay (74°S) broke or tied six monthly temperature records throughout the year, with August breaking its record by nearly 8°C. However, cool conditions in the western Bellingshausen Sea and Amundsen Sea sector contributed to a low melt season overall for 2017/18. High SSTs contributed to low summer sea ice extent in the Ross and Weddell Seas in 2018, underpinning the second lowest Antarctic summer minimum sea ice extent on record. Despite conducive conditions for its formation, the ozone hole at its maximum extent in September was near the 2000–18 mean, likely due to an ongoing slow decline in stratospheric chlorine monoxide concentration. Across the oceans, globally averaged SST decreased slightly since the record El Niño year of 2016 but was still far above the climatological mean. On average, SST is increasing at a rate of 0.10° ± 0.01°C decade−1 since 1950. The warming appeared largest in the tropical Indian Ocean and smallest in the North Pacific. The deeper ocean continues to warm year after year. For the seventh consecutive year, global annual mean sea level became the highest in the 26-year record, rising to 81 mm above the 1993 average. As anticipated in a warming climate, the hydrological cycle over the ocean is accelerating: dry regions are becoming drier and wet regions rainier. Closer to the equator, 95 named tropical storms were observed during 2018, well above the 1981–2010 average of 82. Eleven tropical cyclones reached Saffir–Simpson scale Category 5 intensity. North Atlantic Major Hurricane Michael’s landfall intensity of 140 kt was the fourth strongest for any continental U.S. hurricane landfall in the 168-year record. Michael caused more than 30 fatalities and $25 billion (U.S. dollars) in damages. In the western North Pacific, Super Typhoon Mangkhut led to 160 fatalities and$6 billion (U.S. dollars) in damages across the Philippines, Hong Kong, Macau, mainland China, Guam, and the Northern Mariana Islands. Tropical Storm Son-Tinh was responsible for 170 fatalities in Vietnam and Laos. Nearly all the islands of Micronesia experienced at least moderate impacts from various tropical cyclones. Across land, many areas around the globe received copious precipitation, notable at different time scales. Rodrigues and Réunion Island near southern Africa each reported their third wettest year on record. In Hawaii, 1262 mm precipitation at Waipā Gardens (Kauai) on 14–15 April set a new U.S. record for 24-h precipitation. In Brazil, the city of Belo Horizonte received nearly 75 mm of rain in just 20 minutes, nearly half its monthly average. Globally, fire activity during 2018 was the lowest since the start of the record in 1997, with a combined burned area of about 500 million hectares. This reinforced the long-term downward trend in fire emissions driven by changes in land use in frequently burning savannas. However, wildfires burned 3.5 million hectares across the United States, well above the 2000–10 average of 2.7 million hectares. Combined, U.S. wildfire damages for the 2017 and 2018 wildfire seasons exceeded $40 billion (U.S. dollars)

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Taller de Supervisión de Casos - PS46 201701

Este curso corresponde a la especialidad clínica en la carrera de Psicología; es de caracter teórico-práctico, dirigido a los estudiantes del 10º ciclo, que busca desarrollar las conpetencias de Comunicación Oral y Pensamiento crítico a nivel avanzado y la competencia específica de Intervención y Evaluación a nivel intermedio. El presente curso, da a los alumnos la oportunidad de ejercer o acompañar el abordaje clínico de un consultante, a manera de paciente, en una situación real, debidamente supervisada. Los participantes del taller trabajarán tanto desde el enfoque psicodinámico como cognitivo, poniendo en práctica la especificidad y diferenciación de cada perspectiva

Taller de Supervisión de Casos - PS46 201801

Este curso corresponde a la especialidad clínica en la carrera de Psicología; es de caracter teórico-práctico, dirigido a los estudiantes del 10º ciclo, que busca desarrollar las conpetencias de Comunicación Oral y Pensamiento crítico a nivel avanzado y la competencia específica de Intervención y Evaluación a nivel intermedio. El presente curso, da a los alumnos la oportunidad de ejercer o acompañar el abordaje clínico de un consultante, a manera de paciente, en una situación real, debidamente supervisada. Los participantes del taller trabajarán tanto desde el enfoque psicodinámico como cognitivo, poniendo en práctica la especificidad y diferenciación de cada perspectiva

Taller de Supervisión de Casos - PS46 201702

Este curso corresponde a la especialidad clínica en la carrera de Psicología; es de caracter teórico-práctico, dirigido a los estudiantes del 10º ciclo, que busca desarrollar las conpetencias de Comunicación Oral y Pensamiento crítico a nivel avanzado y la competencia específica de Intervención y Evaluación a nivel intermedio. El presente curso, da a los alumnos la oportunidad de ejercer o acompañar el abordaje clínico de un consultante, a manera de paciente, en una situación real, debidamente supervisada. Los participantes del taller trabajarán tanto desde el enfoque psicodinámico como cognitivo, poniendo en práctica la especificidad y diferenciación de cada perspectiva

Taller de Supervisión de Casos - PS46 201801

Este curso corresponde a la especialidad clínica en la carrera de Psicología; es de carácter teórico-práctico, dirigido a los estudiantes del 10º ciclo, que busca desarrollar las competencias de Comunicación Oral y Pensamiento crítico a nivel avanzado y la competencia específica de Intervención y Evaluación a nivel intermedio. El presente curso, da a los alumnos la oportunidad de ejercer o acompañar el abordaje clínico de un consultante, a manera de paciente, en una situación real, debidamente supervisada. Los participantes del taller trabajarán tanto desde el enfoque psicodinámico como cognitivo, poniendo en práctica la especificidad y diferenciación de cada perspectiva