RTK: efficient rarefaction analysis of large datasets

Motivation: The rapidly expanding microbiomics field is generating increasingly larger datasets, characterizing the microbiota in diverse environments. Although classical numerical ecology methods provide a robust statistical framework for their analysis, software currently available is inadequate for large datasets and some computationally intensive tasks, like rarefaction and associated analysis. Results: Here we present a software package for rarefaction analysis of large count matrices, as well as estimation and visualization of diversity, richness and evenness. Our software is designed for ease of use, operating at least 7x faster than existing solutions, despite requiring 10x less memory. Availability and implementation: C ++ and R source code (GPL v.2) as well as binaries are available from https://github.com/hildebra/Rarefaction and from CRAN (https://cran.r-project.org/). Contact: [email protected], [email protected]

KESIAPSIAGAAN DALAM MENGANTISIPASI BENCANA DI PERPUSTAKAAN DAN PUSAT ARSIP

This article covers disaster preparedness, kinds of disaster and its recovery procedures and restoration of library materials and archives damaged caused by flood. Step by step on disaster prevention, disaster preparedness and early warning system are also included in this article

Determination Of 2-Pyrone-4, 6-Decarboxylic Acid Precurors From Oil Palm Tree Using Different Extraction Process

The precursors of 2-pyrone-4,6-dicarboxylic acid (PDC) were investigated from selected oil palm cultivars in Malaysia. The studied cultivars include Dura x Pisifera (Dura x URT), Dura x Tenera, Deli dura x AVROS, Dumpy x Yangambi x AVROS, Deli dura x yangambi, Deli dura x Pisifera x H&C. All samples were divided into 11 parts; outer bark, trunk (inner part), frond (rachis and petiole), leaves, fruits (flesh, albumen and kernel shell) and empty fruit bunch (EFB fiber, midrib spine leaflets and stalk of fruit bunch). Subcritical water extraction and alkaline subcritical water extraction were chosen to investigate the optimum conditions to produce PDC precursors. Oil palm trunk powder (inner part) was used in both extractions to find the optimum condition of PDC precursors. Three parameters were used for subcritical water extraction that includes temperatures, times and volumes of water. For alkaline subcritical water extraction four parameters were used which were concentrations, temperatures, times and volume of sodium hydroxide (NaOH) solutions. The results indicated that, optimum condition for subcritical water extraction was at 200°C, 40-60 min and 100 ml. While for alkaline subcritical water extraction showed the best presence of PDC precursors at 0.1M, 180°C, 20 min and 100 ml of NaOH solvent. From the results Dura x Pisifera (Dura x URT) showed high total yield of PDC precursors of 8.40%. While trunk (inner part) and kernel shell consisted high yield of total PDC precursors. Results obtained from high performance liquid chromatography (HPLC) and confirmed by nuclear magnetic resonance (NMR) showed that the ρ-hydroxybenzoic acid was the main precursor of PDC in the oil palm biomass

Habilidades blandas y liderazgo transformacional en docentes de la institución educativa 51022 Diego Quispe Tito Cusco 2022

La presente investigación, tiene como objetivo analizar la relación de las habilidades blandas con el liderazgo transformacional en los docentes de la institución educativa 51022 Diego Quispe Tito Cusco 2022, su importancia reside especialmente en el manejo que tienen los docentes de las habilidades blandas y el liderazgo transformacional. La investigación es de tipo básico, no experimental de nivel correlacional transversal, para el recojo de la información se ha empleado la técnica, cuyo instrumento es el cuestionario, para la variable habilidades blandas un cuestionario con 29 ítems, con una escala de valoración nunca, a veces y siempre, y para el liderazgo transformacional el cuestionario Multifactorial del Liderazgo (MQL), adaptado al contexto educativo con una escala de valoración nunca, a veces y siempre, la muestra lo forman 40 docentes de la institución educativa 51022 Diego Quispe Tito del distrito de San Sebastián, la información hallada fue procesada por medio del software SPSS V. 25, y para comprobar la hipótesis general se aplicó la prueba de la Tau b de Kendall. En conclusión, queda demostrado que entre las variables habilidades blandas y liderazgo transformacional en la institución educativa 51022 Diego Quispe Tito Cusco, existe correlación directa y significativa, evidenciando un nivel de desarrollo que es de vital importancia que todo líder educativo debe considerar para gestionar y transformar la institución educativa, de acuerdo a la Prueba de Tau b de Kendall, el P valor = 0.000 es < α = 0.05, existe suficiente evidencia estadística para aceptar H

Potensi perisian 'Microsoft Projek' di dalam kerja-kerja penyelenggaraan bangunan

Setiap bangunan amat penting untuk mempunyai sistem penyelenggaraan yang berkualiti tinggi. Pengetahuan tentang kecacatan bangunan dan penyelenggaraan perlu diketahui.Pada masa ini bidang penyelenggaraan bangunan adalah salah satu daripada industri yang penting dan telah dikuatkuasakan oleh Kementerian Perumahan dan Kerajaan Tempatan Malaysia.Secara teorinya jika sesebuah bangunan telah diselenggara dengan baik, kecacatan tidak akan berlaku. Walaubagaimanapun, struktur dan kekemasan bangunan perlu di buat pemeriksaan secara berkala dan setiap kecacatan perlu diambil tindakan dan tentukan cara ia boleh dielakkan dari berlaku lagi.Dalam masa yang sama jadual penyelenggaraan boleh disusun secara berkala dan semua kerja pembaikan dan penyiasatan kecacatan boleh disimpan dan direkod untuk rujukan masa depan.Kebanyakkan bangunan telah mempunyai pasukan dan sistem penyelenggaraan sendiri.Walau begitu sepatutnya setiap bangunan perlu mempunyai prosedur laporan yang seragam dalam penyelenggaraan bangunan. Sesetengah syarikat telah ada sistem pencegahan penyelenggaraan sendiri dan sesetengahnya pula telah ada sistem kawalan penyelenggaraan yang baik.Prosedur laporan yang seragam bagi kerja sivil dan awam dalam penyelenggaraan bangunan amat penting dalam penyelenggaraan bangunan.Bagi memudahkan kerja – kerja dijalankan satu perisian telah digunakan iaitu Microsof Project dalam menyediakan penjadualan kerja

Global Burden of Sickle Cell Anaemia in Children under Five, 2010-2050: Modelling Based on Demographics, Excess Mortality, and Interventions

The global burden of sickle cell anaemia (SCA) is set to rise as a consequence of improved survival in high-prevalence low- and middle-income countries and population migration to higher-income countries. The host of quantitative evidence documenting these changes has not been assembled at the global level. The purpose of this study is to estimate trends in the future number of newborns with SCA and the number of lives that could be saved in under-five children with SCA by the implementation of different levels of health interventions.First, we calculated projected numbers of newborns with SCA for each 5-y interval between 2010 and 2050 by combining estimates of national SCA frequencies with projected demographic data. We then accounted for under-five mortality (U5m) projections and tested different levels of excess mortality for children with SCA, reflecting the benefits of implementing specific health interventions for under-five patients in 2015, to assess the number of lives that could be saved with appropriate health care services. The estimated number of newborns with SCA globally will increase from 305,800 (confidence interval [CI]: 238,400-398,800) in 2010 to 404,200 (CI: 242,500-657,600) in 2050. It is likely that Nigeria (2010: 91,000 newborns with SCA [CI: 77,900-106,100]; 2050: 140,800 [CI: 95,500-200,600]) and the Democratic Republic of the Congo (2010: 39,700 [CI: 32,600-48,800]; 2050: 44,700 [CI: 27,100-70,500]) will remain the countries most in need of policies for the prevention and management of SCA. We predict a decrease in the annual number of newborns with SCA in India (2010: 44,400 [CI: 33,700-59,100]; 2050: 33,900 [CI: 15,900-64,700]). The implementation of basic health interventions (e.g., prenatal diagnosis, penicillin prophylaxis, and vaccination) for SCA in 2015, leading to significant reductions in excess mortality among under-five children with SCA, could, by 2050, prolong the lives of 5,302,900 [CI: 3,174,800-6,699,100] newborns with SCA. Similarly, large-scale universal screening could save the lives of up to 9,806,000 (CI: 6,745,800-14,232,700) newborns with SCA globally, 85% (CI: 81%-88%) of whom will be born in sub-Saharan Africa. The study findings are limited by the uncertainty in the estimates and the assumptions around mortality reductions associated with interventions.Our quantitative approach confirms that the global burden of SCA is increasing, and highlights the need to develop specific national policies for appropriate public health planning, particularly in low- and middle-income countries. Further empirical collaborative epidemiological studies are vital to assess current and future health care needs, especially in Nigeria, the Democratic Republic of the Congo, and India

EAACI position paper on occupational rhinitis

The present document is the result of a consensus reached by a panel of experts from European and non-European countries on Occupational Rhinitis (OR), a disease of emerging relevance which has received little attention in comparison to occupational asthma. The document covers the main items of OR including epidemiology, diagnosis, management, socio-economic impact, preventive strategies and medicolegal issues. An operational definition and classification of OR tailored on that of occupational asthma, as well as a diagnostic algorithm based on steps allowing for different levels of diagnostic evidence are proposed. The needs for future research are pointed out. Key messages are issued for each item