Northern Shrimp (Pandalus borealis ) Stock on Flemish Cap According to 1988-1996 surveys

23 páginas, 4 figuras, 5 tablas.-- Scientific Council MeetingPeer reviewe

The complex association between the antioxidant defense system and clinical status in early psychosis

Oxidative stress is a pathophysiological mechanism potentially involved in psychiatric disorders. The objective of this study was to assess the relationship between total antioxidant status (TAS) and the functional status of patients with a first episode of psychosis at the onset of the disease. For this purpose, a sample of 70 patients aged between 9 and 17 years with a first episode of psychosis were followed up for a period of two years. Blood samples were drawn to measure TAS levels at three time points: at baseline, at one year, and at two years. Clinical symptoms and functioning were also assessed at the same time points using various scales. Linear regression analysis was performed to investigate the relationship between TAS and clinical status at each assessment, adjusting for potential confounding factors. The distribution of clinical variables was grouped in different percentiles to assess the dose-response in the relation between clinical variables and TAS. At baseline, patient's score on Children's Global Assessment Scale (CGAS) was directly and significantly associated with TAS with a monotonic increase in percentiles, and surprising this association was reversed after one and two years of follow-up with a monotonic decrease. In summary at the onset of the illness, TAS is positively related to clinical status, whereas as the illness progresses this correlation is reversed and becomes negative. This may be the result of an adaptive response.This study has been funded by Instituto de Salud Carlos III through the projects PI14/01900, PI16/01164 (Co-funded by European Regional Development Fund/European Social Fund, "Investing in your future"); the Basque Foundation for Health Innovation and Research (BIOEF); Networking Center for Biomedical Research in Mental Health (CIBERSAM) and the University of the Basque Country (GIC12/84). The psychiatric research department in University Hospital Araba is supported by the Stanley Research Foundation (03-RC-003). Sainza Garcia has a PhD fellowship from the University of the Basque Country. The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication

The complex association between the antioxidant defense system and clinical status in early psychosis

Oxidative stress is a pathophysiological mechanism potentially involved in psychiatric disorders. The objective of this study was to assess the relationship between total antioxidant status (TAS) and the functional status of patients with a first episode of psychosis at the onset of the disease. For this purpose, a sample of 70 patients aged between 9 and 17 years with a first episode of psychosis were followed up for a period of two years. Blood samples were drawn to measure TAS levels at three time points: at baseline, at one year, and at two years. Clinical symptoms and functioning were also assessed at the same time points using various scales. Linear regression analysis was performed to investigate the relationship between TAS and clinical status at each assessment, adjusting for potential confounding factors. The distribution of clinical variables was grouped in different percentiles to assess the dose-response in the relation between clinical variables and TAS. At baseline, patient's score on Children's Global Assessment Scale (CGAS) was directly and significantly associated with TAS with a monotonic increase in percentiles, and surprising this association was reversed after one and two years of follow-up with a monotonic decrease. In summary at the onset of the illness, TAS is positively related to clinical status, whereas as the illness progresses this correlation is reversed and becomes negative. This may be the result of an adaptive response

Age Structure of Roughhead Grenadier (Macrourus perglax) 3LM, 1993-1994

15 páginas, 3 figuras, 12 tablas.-- Scientific Council MeetingThe age-length keys and catch distribution by age of roughhead grenadier are presented in this paper for 3LM Divisions in 1993 and 1994.Age was determined by reading otoliths. Growth was expressed by von Bertalanffy formula. The results confirmed the slow growth and multiaged structure of roughhead grenadier.Peer reviewe

Age Structure of Roughhead Grenadier (Macrourus berglax) on Flemish Cap, 1995

5 páginas, 2 figuras, 3 tablas.-- Scientific Council MeetingPeer reviewe

Northern Shrimp (Pandalus borealis) on Flemish Cap in July 1995

7 páginas, 2 figuras, 5 tablas.-- Scientific Council MeetingPeer reviewe

Northern Shrimp (Pandalus borealis) on Flemish Cap in July 1994

6 páginas, 1 figura, 4 tablas.-- Scientific Council MeetingPeer reviewe

Identificación de diferencias en la resolución de problemas de conteo entre alumnos de Primaria y Bachillerato

En este artículo se analizan comparativamente las estrategias empleadas por alumnos de sexto de primaria y alumnos de bachillerato en la resolución de un mismo problema de combinatoria.Se compara también en ambos niveles la evolución de su grado de implicación afectiva en relación con la dificultad y el tipo de tarea propuesta. Las conclusiones apuntan a una mayor libertad al proponer estrategias de solución en los alumnos de primaria que en los de Bachillerato y una variabilidad extrema de la implicación afectiva de los estudiantes de primaria que no se da en los estudiantes de bachillerato, que tiende a estabilizarse en un grado medio-altoEn este artículo se analizan comparativamente las estrategias empleadas por alumnos de sexto de primaria y alumnos de bachillerato en la resolución de un mismo problema de combinatoria.Se compara también en ambos niveles la evolución de su grado de implicación afectiva en relación con la dificultad y el tipo de tarea propuesta. Las conclusiones apuntan a una mayor libertad al proponer estrategias de solución en los alumnos de primaria que en los de Bachillerato y una variabilidad extrema de la implicación afectiva de los estudiantes de primaria que no se da en los estudiantes de bachillerato, que tiende a estabilizarse en un grado medio-alt

Identificación de diferencias en la resolución de problemas de conteo entre alumnos de primaria y bachillerato

Resumen basado en el de la publicaciónSe analizan comparativamente las estrategias empleadas por alumnos de sexto de Educación Primaria y alumnos de Bachillerato en la resolución de un mismo problema de combinatoria. Se compara también en ambos niveles la evolución de su grado de implicación afectiva en relación con la dificultad y el tipo de tarea propuesta. Las conclusiones apuntan a una mayor libertad al proponer estrategias de solución en los alumnos de primaria que en los de Bachillerato y una variabilidad extrema de la implicación afectiva de los estudiantes de primaria que no se da en los estudiantes de Bachillerato, que tiende a estabilizarse en un grado medio-alto.CantabriaES

Effectiveness of a novel gene nanotherapy based on putrescine for cancer treatment

Gene therapy has long been proposed for cancer treatment. However, the use of therapeutic nucleic acids presents several limitations such as enzymatic degradation, rapid clearance, and poor cellular uptake and efficiency. In this work we propose the use of putrescine, a precursor for higher polyamine biosynthesis for the preparation of cationic nanosystems for cancer gene therapy. We have formulated and characterized putrescine-sphingomyelin nanosystems (PSN) and studied their endocytic pathway and intracellular trafficking in cancer cells. After loading a plasmid DNA (pDNA) encoding the apoptotic Fas Ligand (FasL), we proved their therapeutic activity by measuring the cell death rate after treatment of MDA-MB-231 cells. We have also used xenografted zebrafish embryos as a first in vivo approach to demonstrate the efficacy of the proposed PSN-pDNA formulation in a more complex model. Finally, intratumoral and intraperitoneal administration to mice-bearing MDA-MB-231 xenografts resulted in a significant decrease in tumour cell growth, highlighting the potential of the developed gene therapy nanoformulation for the treatment of triple negative breast cancer.This research was funded by Instituto de Salud Carlos III (ISCIII) and the European Regional Development Fund (FEDER) (grant numbers: CB16/12/00328, PI18/00176; AC18/00045; CIBERONC; CB16/12/00295), by ERA-NET EURONANOMED III project METASTARG (grant number JTC2018-045), by Roche-Chus Joint Unit, Axencia Galega de Innovación (GAIN), Consellería de Economía, Emprego e Industria (IN853B 2018/03), by the Spanish Ministry of Economy and Innovation (PID2019-104644RB-I00), and by the AECC Scientific Foundation (FC_AECC PROYE19036MOR). S. L. and P. H. also acknowledge the funding given by GAIN (IN606A-2019/003 and IN606A-2018/019). G. M. B. thanks the financial support given. We gratefully thank Raquel Antón Segurado for her technical support in scanning transmission electron microscopy, Montserrat García Lavandeira and Marta Picado for their technical support with confocal imaging, Lidia Martínez and Saleta Morales for their technical support cell culture maintenance and treatment, and all the co-workers in our laboratories for the help and discussion day by day. Funding for open access charge: Universidade de Santiago de Compostela/CISUG