65 research outputs found
Carlos Fernández Casado y José Acuña: los primeros puentes de altura estricta. Jaén, 1933-1935
The bridge design catalogue “Puentes de altura Estricta” (Strict Height Bridges) was one of the greatest creations of the brilliant spanish civil engineer Carlos Fernandez Casado. It was designed at the early 1930’s. It had a great relevance in the Spanish Civil Engineering of the 20th century. Nevertheless, its origins are little known.
The first materializations of the “Collection” were six bridges that were constructed in the Jaén province, between 1933 and 1935. They were possible thanks to the determined support of other civil engineer, Jose Acuña y Gómez de la Torre. Later also he carried out the work himself.
With this research its process of design and construction is reconstructed. Also bridges are described as they have come to the present day. With all this it is expected its great value as heritage elements be recognized.La “Colección de Puentes de Altura Estricta” fue una de las mayores creaciones del genial ingeniero de caminos español Carlos Fernández Casado. Fue diseñada a principios de los años 1930 y tuvo una gran trascendencia en la Ingeniería civil española del siglo XX. No obstante, sus orígenes son poco conocidos.
Las primeras materializaciones de la “Colección” fueron seis puentes que se construyeron en la provincia de Jaén, entre 1933 y 1935. Fueron posibles gracias al decidido apoyo que prestó otro ingeniero de caminos, José Acuña y Gómez de la Torre. Posteriormente también se hizo cargo de su ejecución material.
Con esta investigación se pretende reconstruir su proceso de diseño y construcción. También se describen los puentes tal como han llegado hasta nuestros días. Con todo ello se espera contribuir a que sea reconocido su gran valor como elementos patrimoniales
Denoising using local projective subspace methods
In this paper we present denoising algorithms for enhancing noisy signals based on Local ICA (LICA), Delayed AMUSE (dAMUSE)
and Kernel PCA (KPCA). The algorithm LICA relies on applying ICA locally to clusters of signals embedded in a high-dimensional
feature space of delayed coordinates. The components resembling the signals can be detected by various criteria like estimators of
kurtosis or the variance of autocorrelations depending on the statistical nature of the signal. The algorithm proposed can be applied
favorably to the problem of denoising multi-dimensional data. Another projective subspace denoising method using delayed coordinates
has been proposed recently with the algorithm dAMUSE. It combines the solution of blind source separation problems with denoising
efforts in an elegant way and proofs to be very efficient and fast. Finally, KPCA represents a non-linear projective subspace method that
is well suited for denoising also. Besides illustrative applications to toy examples and images, we provide an application of all algorithms
considered to the analysis of protein NMR spectra.info:eu-repo/semantics/publishedVersio
Efecto protector del aceite de oliva en hipercolesterolemias adquiridas. Estudio estructural de testículo e hígado de conejos protegidos e hipercolesterolémicos
La hipercolesterolemia constituye por sí misma o en coacción con otros factores etiológicos la causa de patologías comprendidas dentro de la llamada epidemia silenciosa. Entre las que se cuentan la hipertensión arterial, hipercolesterolemia, diabetes no diagnosticada, entre otras que llevan a trastornos crónicos de alta morbi-mortalidad. Entre otros factores de estas patologías, la ingesta elevada de grasas de origen animal lleva a una hipercolesterolemia adquirida y abre la puerta a un sobre peso que coadyuva a las patologías antes descriptas
March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity.
In transplantation, donor dendritic cells (do-DCs) initiate the alloimmune response either by direct interaction with host T cells or by transferring intact donor MHC to host DCs. However, how do-DCs can be targeted for improving allograft survival is still unclear. Here we show CD103+ DCs are the major do-DC subset involved in the acute rejection of murine skin transplants. In the absence of CD103+ do-DCs, less donor MHC-II is carried to host lymph nodes, fewer allogenic T cells are primed and allograft survival is prolonged. Incubation of skin grafts with the anti-inflammatory mycobacterial protein DnaK reduces donor MHC-II on CD103+DCs and prolongs graft survival. This effect is mediated through IL-10-induced March1, which ubiquitinates and decreases MHC-II levels. Importantly, in vitro pre-treatment of human DCs with DnaK reduces their ability to prime alloreactive T cells. Our findings demonstrate a novel therapeutic approach to dampen alloimmunity by targeting donor MHC-II on CD103+DCs
The Social and Political Dimensions of the Ebola Response: Global Inequality, Climate Change, and Infectious Disease
The 2014 Ebola crisis has highlighted public-health vulnerabilities in Liberia, Sierra
Leone, and Guinea – countries ravaged by extreme poverty, deforestation and
mining-related disruption of livelihoods and ecosystems, and bloody civil wars in
the cases of Liberia and Sierra Leone. Ebola’s emergence and impact are grounded
in the legacy of colonialism and its creation of enduring inequalities within African
nations and globally, via neoliberalism and the Washington Consensus. Recent
experiences with new and emerging diseases such as SARS and various strains of
HN influenzas have demonstrated the effectiveness of a coordinated local and
global public health and education-oriented response to contain epidemics. To what
extent is international assistance to fight Ebola strengthening local public health and
medical capacity in a sustainable way, so that other emerging disease threats, which
are accelerating with climate change, may be met successfully? This chapter
considers the wide-ranging socio-political, medical, legal and environmental factors
that have contributed to the rapid spread of Ebola, with particular emphasis on the
politics of the global and public health response and the role of gender, social
inequality, colonialism and racism as they relate to the mobilization and
establishment of the public health infrastructure required to combat Ebola and other
emerging diseases in times of climate change
De novo transcriptome reconstruction and annotation of the Egyptian rousette bat
Background
The Egyptian Rousette bat (Rousettus aegyptiacus), a common fruit bat species found throughout Africa and the Middle East, was recently identified as a natural reservoir host of Marburg virus. With Ebola virus, Marburg virus is a member of the family Filoviridae that causes severe hemorrhagic fever disease in humans and nonhuman primates, but results in little to no pathological consequences in bats. Understanding host-pathogen interactions within reservoir host species and how it differs from hosts that experience severe disease is an important aspect of evaluating viral pathogenesis and developing novel therapeutics and methods of prevention.
Results
Progress in studying bat reservoir host responses to virus infection is hampered by the lack of host-specific reagents required for immunological studies. In order to establish a basis for the design of reagents, we sequenced, assembled, and annotated the R. aegyptiacus transcriptome. We performed de novo transcriptome assembly using deep RNA sequencing data from 11 distinct tissues from one male and one female bat. We observed high similarity between this transcriptome and those available from other bat species. Gene expression analysis demonstrated clustering of expression profiles by tissue, where we also identified enrichment of tissue-specific gene ontology terms. In addition, we identified and experimentally validated the expression of novel coding transcripts that may be specific to this species.
Conclusion
We comprehensively characterized the R. aegyptiacus transcriptome de novo. This transcriptome will be an important resource for understanding bat immunology, physiology, disease pathogenesis, and virus transmission
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