Pediatric Asthma Caregiver’s Quality of Life Questionnaire is a useful tool for monitoring asthma in children

PURPOSE: There is little agreement among researchers whether a caregiver’s QOL can be used to detect changes in asthma severity in children. We assessed correlation between QOL in parents and QOL in children with asthma as well as clinical parameters of asthma. We determined whether changes in caregiver’s QOL scores reflect changes in child’s QOL and their asthma control. METHODS: This was a 9-week period cohort study. One hundred and ten primary caregivers with 110 children were seen in the clinic at enrollment, at week #1, #5 and #9. At each visit, the parents completed the Pediatric Asthma Caregiver’s Quality of Life Questionnaire (PACQLQ). RESULTS: One hundred and one children and 101 caregivers completed the study. We found a significant correlation between asthma diary score in children and QOL in parents (from r = −0.46 to r = −0.53). We also found significant positive correlation between PAQLQ and PACQLQ and significant association between changes in asthma control and PACQLQ score for both domains. We observed significant change in PACQLQ of caregivers whose children obtained asthma control. CONCLUSIONS: PACQLQ is a useful tool for monitoring asthma in children. The implementation of the PACQLQ would be helpful in involving parents in therapy of their children with asthma

Mucocele in a 35-year-old patient - a case report

The article describes a case of an oral mucocele of the tongue treated with a carbon dioxide laser.

Pleomorphic adenoma of the hard palate in a 61-year-old patient

Chiżyński Adam, Osica Piotr, Stelmach Rafał, Janas- Naze Anna. Pleomorphic adenoma of the hard palate in a 61-year-old patient. Journal of Education, Health and Sport. 2017;7(10):134-141. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1000953 http://ojs.ukw.edu.pl/index.php/johs/article/view/4974 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 10.10.2017. Revised: 19.10.2017. Accepted: 20.10.2017. Pleomorphic adenoma of the hard palate in a 61-year-old patient Adam Chiżyński PhD, Piotr Osica PhD, Rafał Stelmach PhD Stud., Anna Janas- Naze PhD Assoc. Prof. Department of the Oral Surgery, Central Clinical Hospital, Medical University of Lodz Head of the Department: Anna Janas- Naze PhD Assoc. Prof. Adam Chiżyński ORCID ID: 0000-0001-8639-4378; e-mail: [email protected] Piotr Osica ORCID ID:0000-0002-6436-5442 Rafał Stelmach ORCID ID: 0000-0001-7792-5405 Anna Janas- Naze ORCID ID:0000-0001-6885-4457 Corresponding author: Adam Chiżyński Department of Oral Surgery, Medical University of Lodz 92-213 Łódź, ul. Pomorska 251, tel. 42 675 75 29 The article is financed by Medical University of Lodz as a part of stautory activity nr 503/2-163-01/503-01 Summary The article describes a case of pleomorphic adenoma in a 61-year-old patient, its diagnostic methods and treatment. Key words: pleomorphic adenoma, mixed tumor, surgical treatmen

Biomarkers of epithelial-mesenchymal transition in localized, surgically treated clear-cell renal cell carcinoma

Introduction. It has been suggested that the metastatic potential of neoplastic cells can be predicted on the basis of their biological features, including expression of proteins involved in the epithelial to mesenchymal transition (EMT). Therefore, the purpose of this work was to (1) evaluate the expression of EMT markers: ZEB2, vimentin, N-cadherin, TWIST, PTEN, survivin, E-cadherin, Ki-67 and GLUT-1, (2) assess mutation status of two genes: PIK3CA and KRAS, and (3) investigate the potential relationships between the studied biomarkers and clinicopathological factors in clear-cell renal cell carcinoma (ccRCC).Material and methods. Tumor tissue samples (embedded in paraffin blocks) from 159 patients undergoing radical nephrectomy were analyzed. Proteins expression was evaluated immunohistochemically. DNA mutations were analyzed on DNA isolated from tumor tissue and amplified by real-time PCR detection using suitable fluorescent labeled TaqMan assays.Results. One hundred and seven men and 52 women of mean age of 63.1years were enrolled. Fifty four cancers at pTNM stage I–II and 98 at pTNM III–IV stage were diagnosed. There were 30 Fuhrman grade G1, 61 Fuhrman G2, 49 Fuhrman G3 and 19 Fuhrman G4 tumors. A negative correlation between ZEB2 (p = 0.047, r = –0.172) or E-cadherin expression (p = 0.027, r = –0.191) and TNM was observed. Positive association between grade and Ki-67 (p < 0.001), survivin (p < 0.001), vimentin (p < 0.001) immunoreactivity and negative association between TWIST expression (p = 0.029) or PTEN expression (p = 0.013) were found. Ki-67 expression was positively correlated with survivin (p < 0.001, r = 0.617), vimentin (p = 0.001, r = 0.251) and N-cadherin (p = 0,009, r = 0.207) immunoreactivity which can suggest tumor aggressiveness. TWIST was negatively correlated with E-cadherin (p < 0.001, r = –0.284), vimentin (p < 0.001, r = –0.297) and N-cadherin (p < 0.002, r = –0.241). ZEB2 was not associated with ccRCC grade but was negatively correlated with E-cadherin (p = 0.055, r= –0.153) and PTEN (p = 0.006). GLUT-1 expression was inversely linked to E-cadherin expression (p = 0.022, r= –0.182). Mutations in PIK3CA and KRAS genes were not found in any of the studied ccRCC tumors.Conclusions. Low-grade tumors showed higher expression of ZEB2 and TWIST proteins than high-grade tumors, which can suggest that EMT in ccRCC begins at early stages of tumor development and, therefore, evaluation of these proteins, together with other biomarkers, may be useful for assessment of the tumor metastatic potential

Respiratory endurance training by means of a Spirotiger in extending intermittent claudication distance — a case study

According to Fontaine’s classification, intermittent claudication is a symptom of the 2nd stage of peripheralarterial occlusive disease. Intermittent claudication is described as muscle pain that occurs during walking. Patientsexperiencing it observe major reduction of exercise tolerance. Rehabilitation of patients with peripheral arterialocclusive disease uses many different training programs which lead to extension of intermittent claudicationdistance. Respiratory training is one of them and it is the training of the respiratory muscles that improves theirendurance, force, speed, coordination, and elasticity. Respiration therapy causes delayed metaboreflex, whichin turn the blood flow in lower limbs increases..We present a case of a patient who underwent percutaneous balloon angioplasty of iliac artery and then conductedrespiratory training by means of Spirotiger what resulted in further increase of claudication distance

Serum and sputum eosinophil cationic protein levels and clinical status in cystic fi brosis patients

Recent studies have emphasied the role of eosinophils and it&#8217;s metabolites in the pathogenesis of lung disease in cystic fibrosis. This study was designed to assess the relationship between serum and sputum ECP levels and clinical status of cystic fibrosis patients. Material and methods: 30 patients, aged 6-30 with moderate cystic fibrosis were recruited. Spirometry, weight and high, and Shwachman-Kulczycki score were measured, and serum and sputum samples were obtained for measurements of the eosinophil cationic protein (ECP). Results: We observed significant inverse correlation between sputum ECP levels and BMI (p < 0.001) and FEV1 (p < 0.001), and not significant inverse correlation between sputum ECP levels Shwachman-Kulczycki score (p = 0.057). There was no signifi cant correlation between sputum ECP levels and FEF25/75% and between serum ECP levels and measured clinical parameters. Conclusions: Results of this study suggest influence of eosinophil inflammation in respiratory tract on clinical status of CF patients

Mucinous breast cancer : clinical characteristics and treatment results in patients treated at the Oncology Centre in Kraków between 1952 and 2002

Aim of the study: To present the characteristics and clinical outcomes in 94 patients with mucinous breast cancer treated at the Oncology Centre in Krakow between 1952 and 2002. Material and methods: Stage I or II carcinomas were found in 66 patients (69.4%) of the presented group and in the remaining 28 patients (29.8%) stage III disease was diagnosed. In 27 cases regional lymph nodes were involved. All patients had been treated with surgery: mastectomy (90 patients) or breast-conserving treatment (4 patients). Radiotherapy was administered in 14 patients, adjuvant chemotherapy in 14 patients, and endocrine therapy in 39 patients. Results: The maximum follow-up was 257 months. Ten-year survival was as follows: 75.7% (overall survival), 82.5% (disease-free survival). During the follow- up, 4 patients developed local recurrence, 5 patients developed metastases. Second primary cancer was found in 8 patients. Conclusions: The presented results confirm the good prognosis in patients treated for mucinous breast cancer. The diagnosis of early-stage breast cancer based on mammography can allow breast-conserving treatment

Large dentigerous cysts of the mandible in a 46-year-old patient - a case report

Stelmach Rafał, Osica Piotr, Janas Anna. Large dentigerous cysts of the mandible in a 46-year-old patient - a case report. Journal of Education, Health and Sport. 2017;7(1):133-140. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.234255 http://ojs.ukw.edu.pl/index.php/johs/article/view/4157 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 754 (09.12.2016). 754 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.12.2016. Revised 20.12.2016. Accepted: 07.01.2017. Przypadek dużej torbieli zębopochodnej żuchwy u 46 letniego pacjenta - opis przypadku Large dentigerous cysts of the mandible in a 46-year-old patient - a case report Rafał Stelmach, Piotr Osica, Anna Janas Zakład Chirurgii Stomatologicznej Centralnego Szpitala Klinicznego UM w Łodzi kierownik: dr hab. n. med. prof. nadzw. Anna Janas lek. dent. Rafał Stelmach, dr n. med. Piotr Osica, dr hab. n. med. prof. nadzw. Anna Janas Adres do korespondencji: Rafał Stelmach Zakład Chirurgii Stomatologicznej UM w Łodzi 92-213 Łódź, ul. Pomorska 251 e-mail: [email protected] tel. 42 675 75 29 Praca finansowana przez Uniwersytet Medyczny w Łodzi w ramach działalności statutowej nr 503/2-163-01/503-01 Streszczenie: W pracy przedstawiono opis przypadku wyłuszczenia dużej torbieli zębopochodnej w okolicy zatrzymanego zęba 48 u 46 letniego pacjenta. Hasła indeksowe: torbiel zawiązkowa, wyłuszczenie Summary: The article presents the clinical picture and surgical treatment of large dentigerous cyst associated with impacted tooth in a 46-year-old patient. Key words: dentigerous cyst, enucleatio