172 research outputs found
Insensitivity to verb conjugation patterns in French children with SLI
Specific language impairment (SLI) is characterized by persistent difficulties that affect language
abilities in otherwise normally developing children (Leonard, 2014). It remains challenging to
identify young children affected by SLI in French. We tested oral production of the passé
composé tense in 19 children in kindergarten and first grade with SLI aged from 5;6 to 7;4 years.
All children were schooled in a French environment, but with different linguistic backgrounds.
We used an Android application, Jeu de verbes (Marquis et al., 2012), with six verbs in each of
four past participle categories (ending in -Ă©, -i, -u, and Other irregulars). We compared their
results and error types to those of control children (from Marquis, 2012â2014) matched for
gender, age, languages spoken at home, and parental education. Results show that children with
SLI do not master the passé composé in the same way as typical French children do, at later ages
than previously shown in the literature. This task shows potential for oral language screening in
French-speaking children in kindergarten and first grade, independently of language background
Effets du niveau dâĂ©ducation des parents sur la productivitĂ© morphologique des enfants en français en dĂ©but de scolarisation
Certaines recherches indiquent que le niveau dâĂ©ducation de la mĂšre influence la qualitĂ© du langage de lâenfant (ex. Tamis-LeMonda, Shannon, Cabrera, et al. 2004). Il existerait Ă©galement une corrĂ©lation entre le niveau dâĂ©ducation de la mĂšre et les habiletĂ©s de conjugaison des verbes de lâenfant Ă trois ans (ex. SilvĂ©n, Ahtola et Niemi 2003). Dans la prĂ©sente Ă©tude, nous avons testĂ© la productivitĂ© morphologique chez 109 enfants (58 filles et 51 garçons), de maternelle et de premiĂšre annĂ©e, et vĂ©rifiĂ© si cette productivitĂ© pouvait ĂȘtre corrĂ©lĂ©e Ă lâĂ©ducation parentale. Certains participants Ă©taient francophones (L1), et dâautres multilingues (MUL), mais tous Ă©taient scolarisĂ©s en français. Nous avons utilisĂ© la procĂ©dure Jeu de verbes (Marquis, Royle, Gonnerman, et al. 2012) qui comporte des verbes dont les participes passĂ©s se terminent par /e/, /i/, /y/ ou sont idiosyncratiques (par ex. mort /mŃŃ/) et avons Ă©tabli un score de performance pour chaque enfant. Nous avons par la suite fait des analyses corrĂ©lationnelles entre ce score et le niveau dâĂ©ducation de la mĂšre, du pĂšre, et la moyenne du niveau dâĂ©ducation des deux parents. Les rĂ©sultats indiquent quâil existe un lien entre lâĂ©ducation parentale et les performances des enfants en productivitĂ© morphologique.Research shows that a motherâs educational level can influence the
quality of the childâs language (e.g., Tamis-LeMonda, Shannon, Cabrera,
et al. 2004). There is also a correlation between maternal education
level and a three years old childâs skills with verb conjugation (SilvĂ©n,
Ahtola and Niemi 2003). In this study, we tested morphological abilities
of 109 children (58 girls and 51 boys), either in kindergarten or in first
grade, and tested whether these abilities were correlated with parental
education. Some participants were French speakers (L1), and others
multilinguals (MUL), but all were educated in French. We used the Jeu
de verbes procedure (Marquis, Royle, Gonnerman, et al. 2012), which
includes verbs with past participles ending in /e/, /i/, /y/ or that are
idiosyncratic (e.g. mort /mŃŃ/) and established a performance score
for each child. We then correlated this score with the motherâs, the
fatherâs, and the average parental education level. Results indicate
a link between parental education and childrenâs performances on
the morphological task
In-home Telerehabilitation for Older Persons with Chronic Obstructive Pulmonary Disease: A Pilot Study
The purpose of this pilot study was to investigate the efficacy of in-home telerehabilitation for people with Chronic Obstructive Pulmonary Disease (COPD). Three community-living elders with COPD were recruited in a rehabilitation outpatient group and by direct referrals from pneumologists with outpatients who have COPD. A pre/post-test design without a control group was used for this pilot study. Telerehabilitation sessions (15 sessions) were conducted by two trained physioÂtherapists from a service center to the patientâs home. Locomotor function (walking performance) and quality of life were measured in person prior to and at the end of the treatment by an independent assessor. Clinical outcomes improved for all subjects except for locomotor function in the first participant. In-home telerehabilitation for people with COPD is a realistic alternative to dispense rehabilitation services for patients requiring physical therapy follow-up.
Rapports de pouvoir : race, genre et nation dans la couverture montréalaise des JO de Berlin
Le sport est depuis toujours un facteur de hiĂ©rarchisation des groupes sociaux. Dans une perspective de rapport de pouvoir, il sert tout autant Ă rĂ©affirmer les diverses relations inĂ©galitaires entre les groupes Ă lâintĂ©rieur dâune sociĂ©tĂ© quâĂ poser ou illustrer les relations conflictuelles entre nations. Le prĂ©sent texte explore la façon dont les journaux participent Ă lâinterprĂ©tation et Ă la construction de ces rapports dans le cadre de la couverture des Jeux olympiques de 1936. Lâanalyse aborde dâabord la question de la race, particuliĂšrement la « mise en valeur » des athlĂštes noirs. On dĂ©couvre ainsi que, paradoxalement, le racisme ambiant permet la mise en place dâun dĂ©bat de fond sur la question. La rĂ©flexion se poursuit ensuite avec les rapports de genre en montrant comment les journaux marginalisent les accomplissements des sportives afin dâĂ©viter une remise en question des schĂ©mas traditionnels. Finalement, les Olympiades sont aussi lâoccasion pour les journaux de construire un rĂ©cit national fort Ă travers diverses stratĂ©gies discursives. Ă bien des Ă©gards, les JO permettent de construire une identitĂ© canadienne qui cherche Ă transcender les rĂ©gionalismes. LâomniprĂ©sence de lâexpression de ces rapports de pouvoir offre nĂ©anmoins aux journalistes lâoccasion de rĂ©flĂ©chir Ă ces questions
Les Jeux olympiques de Berlin dans lâarĂšne mĂ©diatique montrĂ©alaise
Les Jeux olympiques de Berlin en 1936 sont lâun des moments forts de la lutte idĂ©ologique qui se dĂ©roule alors sur la scĂšne internationale et MontrĂ©al nây Ă©chappe pas. Le prĂ©sent article explore lâhypothĂšse que cet Ă©vĂ©nement aurait rendu plus lisibles les clivages identitaires et politiques de la sociĂ©tĂ© quĂ©bĂ©coise, Ă partir de lâanalyse de la couverture quâoffre des JO un Ă©chantillon substantiel de journaux montrĂ©alais. La premiĂšre partie de cette Ă©tude dĂ©crit les caractĂ©ristiques de la couverture des Jeux, replacĂ©e sur la facture usuelle des journaux, et rĂ©vĂšle la dĂ©pendance des pĂ©riodiques montrĂ©alais Ă lâendroit des agences de presse nord-amĂ©ricaines. Le recours massif aux agences crĂ©e lâillusion dâun rĂ©cit unique ressassĂ© partout, fait de tableaux et de petites anecdotes. Cependant, grĂące aux textes dans lesquels sâaffirme une subjectivitĂ©, dans les chroniques sportives, entre autres, le lecteur de lâĂ©poque est mis en contact avec lâexpression de jugements individuels desquels se dĂ©gage une interprĂ©tation proprement montrĂ©alaise des Jeux olympiques, qui fait une place Ă des enjeux dĂ©bordant le caractĂšre strictement sportif de lâĂ©vĂ©nement pour toucher aux questions de politique internationale. LâhypothĂšse initiale se rĂ©vĂšle finalement insatisfaisante, les JO paraissant avoir jouĂ© le rĂŽle dâun catalyseur modifiant provisoirement lâĂ©conomie du systĂšme des journaux montrĂ©alais, rĂ©organisĂ© autour dâimpĂ©ratifs moraux irrĂ©ductibles aux clivages sociaux et identitaires locaux
Parental transfer of the antimicrobial protein LBP/BPI protects Biomphalaria glabrata eggs against oomycete infections
Copyright: © 2013 Baron et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work was funded by ANR (ANR-07-BLAN-0214 and ANR-12-EMMA-00O7-01), CNRS and INRA. PvW was financially supported by the BBSRC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD
Effects of long-term strontium ranelate treatment on vertebral fracture risk in postmenopausal women with osteoporosis
Vertebral fractures are a major adverse consequence of osteoporosis. In a large placebo-controlled trial in postmenopausal women with osteoporosis, strontium ranelate reduced vertebral fracture risk by 33% over 4 years, confirming the role of strontium ranelate as an effective long-term treatment in osteoporosis. INTRODUCTION: Osteoporotic vertebral fractures are associated with increased mortality, morbidity, and loss of quality-of-life (QoL). Strontium ranelate (2 g/day) was shown to prevent bone loss, increase bone strength, and reduce vertebral and peripheral fractures. The preplanned aim of this study was to evaluate long-term efficacy and safety of strontium ranelate. METHODS: A total of 1,649 postmenopausal osteoporotic women were randomized to strontium ranelate or placebo for 4 years, followed by a 1-year treatment-switch period for half of the patients. Primary efficacy criterion was incidence of patients with new vertebral fractures over 4 years. Lumbar bone mineral density (BMD) and QoL were also evaluated. RESULTS: Over 4 years, risk of vertebral fracture was reduced by 33% with strontium ranelate (risk reduction = 0.67, p < 0.001). Among patients with two or more prevalent vertebral fractures, risk reduction was 36% (p < 0.001). QoL, assessed by the QUALIOST(R), was significantly better (p = 0.025), and patients without back pain were greater (p = 0.005) with strontium ranelate than placebo over 4 years. Lumbar BMD increased over 5 years in patients who continued with strontium ranelate, while it decreased in patients who switched to placebo. Emergent adverse events were similar between groups. CONCLUSION: In this 4- and 5-year study, strontium ranelate is an effective and safe treatment for long-term treatment of osteoporosis in postmenopausal women
Condensed Mitotic Chromosome Structure at Nanometer Resolution Using PALM and EGFP- Histones
Photoactivated localization microscopy (PALM) and related fluorescent biological imaging methods are capable of providing very high spatial resolutions (up to 20 nm). Two major demands limit its widespread use on biological samples: requirements for photoactivatable/photoconvertible fluorescent molecules, which are sometimes difficult to incorporate, and high background signals from autofluorescence or fluorophores in adjacent focal planes in three-dimensional imaging which reduces PALM resolution significantly. We present here a high-resolution PALM method utilizing conventional EGFP as the photoconvertible fluorophore, improved algorithms to deal with high levels of biological background noise, and apply this to imaging higher order chromatin structure. We found that the emission wavelength of EGFP is efficiently converted from green to red when exposed to blue light in the presence of reduced riboflavin. The photon yield of red-converted EGFP using riboflavin is comparable to other bright photoconvertible fluorescent proteins that allow <20 nm resolution. We further found that image pre-processing using a combination of denoising and deconvolution of the raw PALM images substantially improved the spatial resolution of the reconstruction from noisy images. Performing PALM on Drosophila mitotic chromosomes labeled with H2AvD-EGFP, a histone H2A variant, revealed filamentous components of âŒ70 nm. This is the first observation of fine chromatin filaments specific for one histone variant at a resolution approximating that of conventional electron microscope images (10â30 nm). As demonstrated by modeling and experiments on a challenging specimen, the techniques described here facilitate super-resolution fluorescent imaging with common biological samples
Regulation of BRCA1 expression and its relationship to sporadic breast cancer
Germ-line mutations in the BRCA1 tumour suppressor gene contribute to familial breast tumour formation, but there is no evidence for direct mutation of the BRCA1 gene in the sporadic form of the disease. In contrast, decreased expression of the BRCA1 gene has been shown to be common in sporadic tumours, and the magnitude of the decrease correlates with disease progression. BRCA1 expression is also tightly regulated during normal breast development. Determining how these developmental regulators of BRCA1 expression are co-opted during breast tumourigenesis could lead to a better understanding of sporadic breast cancer aetiology and the generation of novel therapeutic strategies aimed at preventing sporadic breast tumour progression
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